Georg A Hollander

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Georg A Hollander

Publications by authors named "Georg A Hollander"

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67Publications

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Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT.

Blood Adv 2017 Oct 23;1(23):2083-2087. Epub 2017 Oct 23.

Division of Blood and Marrow Transplant, Department of Pediatrics, University of Minnesota, Minneapolis, MN.

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October 2017

Open Access Could Transform Drug Discovery: A Case Study of JQ1.

Expert Opin Drug Discov 2016 ;11(3):321-32

c Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences , University of Oxford , Oxford , UK.

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October 2016

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.

PLoS Genet 2016 Jan 20;12(1):e1005776. Epub 2016 Jan 20.

Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.

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January 2016

Evolution of the immune system in humans from infancy to old age.

Proc Biol Sci 2015 Dec;282(1821):20143085

Nuffield Department of Medicine Research Building, University of Oxford, Old Road Campus, Oxford OX3 7FZ, UK

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December 2015

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors.

Cell Rep 2015 Nov 5;13(7):1432-1443. Epub 2015 Nov 5.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan. Electronic address:

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November 2015

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD.

Blood 2015 Apr 17;125(17):2720-3. Epub 2015 Feb 17.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland; and.

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April 2015

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

Genome Res 2014 Dec 15;24(12):1918-31. Epub 2014 Sep 15.

Paediatric Immunology, Department of Biomedicine, University of Basel, and The Basel University Children's Hospital, Basel, 4058, Switzerland; Developmental Immunology, Department of Paediatrics, and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.

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December 2014

Essential role for autophagy during invariant NKT cell development.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

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December 2014

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

Nat Immunol 2014 Jun 13;15(6):554-61. Epub 2014 Apr 13.

1] Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA. [2] These authors contributed equally to this work.

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June 2014

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

Int Immunol 2013 Nov 8;25(11):633-42. Epub 2013 Aug 8.

Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.

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November 2013

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.

Blood 2013 Aug 29;122(5):837-41. Epub 2013 May 29.

Department of Biomedicine, University of Basel and Basel University Children's Hospital, Mattenstrasse 28, Basel, Switzerland.

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August 2013

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

J Immunol 2013 Jun 17;190(12):6173-9. Epub 2013 May 17.

Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

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June 2013

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Proc Natl Acad Sci U S A 2013 Jun 29;110(24):9885-90. Epub 2013 May 29.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.

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June 2013

CD43 regulates the threshold for T cell activation by targeting Cbl functions.

IUBMB Life 2011 Oct 9;63(10):940-8. Epub 2011 Sep 9.

Instituto de Biotecnología, Departamento de Medicina Molecular y Bioprocesos, Universidad Nacional Autónoma de México, Cuernavaca, Mor. México 62210.

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October 2011

Thymic T-cell development in allogeneic stem cell transplantation.

Blood 2011 Jun 22;117(25):6768-76. Epub 2011 Mar 22.

Department of Biomedicine, University of Basel, and Basel University Children's Hospital, Basel, Switzerland.

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June 2011

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.

PLoS One 2010 Sep 15;5(9):e12766. Epub 2010 Sep 15.

The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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September 2010

Emerging strategies to boost thymic function.

Curr Opin Pharmacol 2010 Aug 4;10(4):443-53. Epub 2010 May 4.

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, The University Children's Hospital (UKBB), Mattenstrasse 28, 4058 Basel, Switzerland.

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August 2010

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

Sci Signal 2010 Aug 17;3(135):re5. Epub 2010 Aug 17.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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August 2010

The role of the thymus in allogeneic hematopoietic stem cell transplantation.

Swiss Med Wkly 2010 Jul 19;140:w13051. Epub 2010 Jul 19.

Department of Biomedicine, University of Basel, and Basel University Children's Hospital (UKBB), Basel, Switzerland.

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July 2010

Spatial (Tbata) expression in mature medullary thymic epithelial cells.

Eur J Immunol 2010 Feb;40(2):530-8

INSERM U928, Technologies Avancées pour le Génome et la Clinique, Université de la Méditerranée, Parc Scientifique de Luminy, Marseille Cedex, France.

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February 2010

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

Mol Immunol 2010 Feb 27;47(5):1106-13. Epub 2009 Nov 27.

Laboratory for Lymphocyte Development, RIKEN Research Centre for Allergy and Immunology, Yokohama, Japan.

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February 2010

Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

Endocrinol Metab Clin North Am 2009 Jun;38(2):273-88, vii

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland.

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June 2009

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

J Immunol 2009 Mar;182(5):2997-3007

Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel, and Basel University Children's Hospital, Basel, Switzerland.

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March 2009

Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.

Semin Immunopathol 2008 Dec;30(4):369-70

Pediatric Immunology, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.

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December 2008

The immunopathology of thymic GVHD.

Semin Immunopathol 2008 Dec 31;30(4):439-56. Epub 2008 Oct 31.

Department of Biomedicine, University of Basel, Basel, 4005, Switzerland.

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December 2008

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

Blood 2008 Nov 11;112(9):3688-95. Epub 2008 Aug 11.

Department of Biomedicine, Laboratory of Pediatric Immunology, University of Basel and the University Children's Hospital, Basel, Switzerland.

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November 2008

Delta-like 4 is indispensable in thymic environment specific for T cell development.

J Exp Med 2008 Oct 29;205(11):2507-13. Epub 2008 Sep 29.

Department of Immunology and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara 259-1193, Japan.

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October 2008

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

Blood 2008 Aug 12;112(3):626-34. Epub 2008 May 12.

Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland.

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August 2008

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

Am J Pathol 2008 Jun 15;172(6):1555-70. Epub 2008 May 15.

Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.

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June 2008

The thymus in GVHD pathophysiology.

Best Pract Res Clin Haematol 2008 Jun;21(2):119-28

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.

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June 2008

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.

J Exp Med 2008 Mar 25;205(3):523-31. Epub 2008 Feb 25.

Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.

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March 2008

Deletion of PKBalpha/Akt1 affects thymic development.

PLoS One 2007 Oct 3;2(10):e992. Epub 2007 Oct 3.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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October 2007

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

Blood 2007 May 9;109(9):3803-11. Epub 2007 Jan 9.

Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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May 2007

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

Blood 2007 May 9;109(9):4080-8. Epub 2007 Jan 9.

Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel Children's Hospital, Mattenstrasse 28, 4058 Basel, Switzerland.

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May 2007

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

Blood 2007 Mar 30;109(6):2529-37. Epub 2006 Nov 30.

Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University, CA 94304, USA.

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March 2007

Claudins provide a breath of fresh Aire.

Nat Immunol 2007 Mar;8(3):234-6

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March 2007

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

Swiss Med Wkly 2007 Mar;137 Suppl 155:9S-13S

Department of Clinical-Biological Sciences, University of Basel and the University Children's Hospital of Basel (UKBB), Basel, Switzerland.

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March 2007

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.

Nature 2006 Dec 1;444(7120):724-9. Epub 2006 Nov 1.

Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital-Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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December 2006

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

Swiss Med Wkly 2006 Jun;136(23-24):365-9

Department of Clincial-Biological Sciences, University of Basel and, the University Children's Hospital of Basel (UKKB), Basel, Switzerland.

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June 2006

Leydig cell injury as a consequence of an acute graft-versus-host reaction.

Blood 2005 Apr 2;105(7):2988-90. Epub 2004 Dec 2.

Department of Research, Center for Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

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April 2005

The role of CCL21 in recruitment of T-precursor cells to fetal thymi.

Blood 2005 Jan 9;105(1):31-9. Epub 2004 Sep 9.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.

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January 2005

On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease.

J Immunol 2004 Jun;172(12):7359-67

Pediatric Immunology, Departments of Research and Clinical-Biological Sciences, University of Basel, and University Children's Hospital of Basel, Kantonsspital, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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June 2004

Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells.

Blood 2003 May 27;101(9):3550-9. Epub 2002 Dec 27.

Institute of Biochemistry and Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.

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May 2003

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.

Nat Med 2002 Dec 4;8(12):1414-20. Epub 2002 Nov 4.

Pediatric Immunology, Department of Research and the University Children's Hospital, Basel, Switzerland.

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December 2002

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.

Nat Immunol 2002 Nov 15;3(11):1102-8. Epub 2002 Oct 15.

Pediatric Immunology, Department of Research and Clinical-biological Sciences, and the Children's Hospital, University of Basel, Basel, Switzerland.

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November 2002

Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitis.

Horm Res 2002 ;57(3-4):94-104

University Children's Hospital, and Department of Clinical and Biological Science, Basel, Switzerland.

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October 2002

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.

Nat Immunol 2002 Jul 17;3(7):635-42. Epub 2002 Jun 17.

Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Melbourne 3181, Australia.

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July 2002