Publications

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
Nat Immunol 2016 Oct 22;17(10):1206-1215. Epub 2016 Aug 22.
Department of Biomedicine, University Children's Hospital and University of Basel, Basel, Switzerland.

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.
PLoS Genet 2016 Jan 20;12(1):e1005776. Epub 2016 Jan 20.
Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.


Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.
Genome Res 2014 Dec 15;24(12):1918-31. Epub 2014 Sep 15.
Paediatric Immunology, Department of Biomedicine, University of Basel, and The Basel University Children's Hospital, Basel, 4058, Switzerland; Developmental Immunology, Department of Paediatrics, and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;


IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.
J Immunol 2013 Jun 17;190(12):6173-9. Epub 2013 May 17.
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.


CD43 regulates the threshold for T cell activation by targeting Cbl functions.
IUBMB Life 2011 Oct 9;63(10):940-8. Epub 2011 Sep 9.
Instituto de Biotecnología, Departamento de Medicina Molecular y Bioprocesos, Universidad Nacional Autónoma de México, Cuernavaca, Mor. México 62210.



Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
J Immunol 2009 Mar;182(5):2997-3007
Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel, and Basel University Children's Hospital, Basel, Switzerland.

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
Blood 2008 Aug 12;112(3):626-34. Epub 2008 May 12.
Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland.


Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
Am J Pathol 2008 Jun 15;172(6):1555-70. Epub 2008 May 15.
Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.


Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
Blood 2007 May 9;109(9):3803-11. Epub 2007 Jan 9.
Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.
Blood 2007 May 9;109(9):4080-8. Epub 2007 Jan 9.
Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel Children's Hospital, Mattenstrasse 28, 4058 Basel, Switzerland.

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