Georg A Hollander

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

• Authors:
• Qianxin Wu,
• Quentin R V Ferry,
• Toni A Baeumler,
• Yale S Michaels,
• Dimitrios M Vitsios,
• Omer Habib,
• Roland Arnold,
• Xiaowei Jiang,
• Stefano Maio,
• Bruno R Steinkraus,
• Marta Tapia,
• Paolo Piazza,
• Ni Xu,
• Georg A Holländer,
• Thomas A Milne,
• Jin-Soo Kim,
• Anton J Enright,
• Andrew R Bassett,
• Tudor A Fulga

• December 2017

Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT.

• Authors:
• Angela R Smith,
• Ioanna A Rota,
• Stefano Maio,
• Michel J Massaad,
• Troy C Lund,
• Luigi D Notarangelo,
• Georg A Holländer,
• Bruce R Blazar

• October 2017

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

• Authors:
• Michelle J Smith,
• Dawn K Reichenbach,
• Sarah L Parker,
• Megan J Riddle,
• Jason Mitchell,
• Kevin C Osum,
• Mahmood Mohtashami,
• Heather E Stefanski,
• Brian T Fife,
• Avinash Bhandoola,
• Kristin A Hogquist,
• Georg A Holländer,
• Juan Carlos Zúñiga-Pflücker,
• Jakub Tolar,
• Bruce R Blazar

• May 2017

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.

• Authors:
• Carlos E Mayer,
• Saulius Žuklys,
• Saule Zhanybekova,
• Izumi Ohigashi,
• Hong-Ying Teh,
• Stephen N Sansom,
• Noriko Shikama-Dorn,
• Katrin Hafen,
• Iain C Macaulay,
• Mary E Deadman,
• Chris P Ponting,
• Yousuke Takahama,
• Georg A Holländer

• April 2016

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.

• Authors:
• Rumi Satoh,
• Kiyokazu Kakugawa,
• Takuwa Yasuda,
• Hisahiro Yoshida,
• Maria Sibilia,
• Yoshimoto Katsura,
• Ben Levi,
• Jakub Abramson,
• Yoko Koseki,
• Haruhiko Koseki,
• Willem van Ewijk,
• Georg A Hollander,
• Hiroshi Kawamoto

• January 2016

Evolution of the immune system in humans from infancy to old age.

• Authors:
• A Katharina Simon,
• Georg A Hollander,
• Andrew McMichael

• December 2015

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors.

• Authors:
• Izumi Ohigashi,
• Saulius Zuklys,
• Mie Sakata,
• Carlos E Mayer,
• Yoko Hamazaki,
• Nagahiro Minato,
• Georg A Hollander,
• Yousuke Takahama

• November 2015

A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage.

• Authors:
• Thomas Barthlott,
• Angela J T Bosch,
• Caroline Berkemeier,
• Rubén Nogales-Cadenas,
• Lukas T Jeker,
• Marcel P Keller,
• Alberto Pascual-Montano,
• Georg A Holländer

• June 2015

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD.

• Authors:
• Simone Dertschnig,
• Mathias M Hauri-Hohl,
• Madeleine Vollmer,
• Georg A Holländer,
• Werner Krenger

• April 2015

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

• Authors:
• Stephen N Sansom,
• Noriko Shikama-Dorn,
• Saule Zhanybekova,
• Gretel Nusspaumer,
• Iain C Macaulay,
• Mary E Deadman,
• Andreas Heger,
• Chris P Ponting,
• Georg A Holländer

• December 2014

Essential role for autophagy during invariant NKT cell development.

• Authors:
• Mariolina Salio,
• Daniel J Puleston,
• Till S M Mathan,
• Dawn Shepherd,
• Amanda J Stranks,
• Eleni Adamopoulou,
• Natacha Veerapen,
• Gurdyal S Besra,
• Georg A Hollander,
• Anna Katharina Simon,
• Vincenzo Cerundolo

• December 2014

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

• Authors:
• Mathias Hauri-Hohl,
• Saulius Zuklys,
• Georg A Holländer,
• Steven F Ziegler

• June 2014

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

• Authors:
• S Rhiannon Jenkinson,
• Joy A Williams,
• Hyein Jeon,
• Jingjing Zhang,
• Takeshi Nitta,
• Izumi Ohigashi,
• Michael Kruhlak,
• Saulius Zuklys,
• Susan Sharrow,
• Anthony Adams,
• Larry Granger,
• Yongwon Choi,
• Ulrich Siebenlist,
• Gail A Bishop,
• Georg A Hollander,
• Yousuke Takahama,
• Richard J Hodes

• December 2013

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

• Authors:
• Chikako Odaka,
• Mathias Hauri-Hohl,
• Kazuya Takizawa,
• Yomiko Nishikawa,
• Masashi Yano,
• Mitsuru Matsumoto,
• Richard Boyd,
• Georg A Holländer

• November 2013

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.

• Authors:
• Simone Dertschnig,
• Gretel Nusspaumer,
• Robert Ivanek,
• Mathias M Hauri-Hohl,
• Georg A Holländer,
• Werner Krenger

• August 2013

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

• Authors:
• Soichiro Shitara,
• Takahiro Hara,
• Bingfei Liang,
• Keisuke Wagatsuma,
• Saulius Zuklys,
• Georg A Holländer,
• Hiroshi Nakase,
• Tsutomu Chiba,
• Shizue Tani-ichi,
• Koichi Ikuta

• June 2013

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

• Authors:
• Izumi Ohigashi,
• Saulius Zuklys,
• Mie Sakata,
• Carlos E Mayer,
• Saule Zhanybekova,
• Shigeo Murata,
• Keiji Tanaka,
• Georg A Holländer,
• Yousuke Takahama

• June 2013

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.

• Authors:
• Saulius Zuklys,
• Carlos E Mayer,
• Saule Zhanybekova,
• Heather E Stefanski,
• Gretel Nusspaumer,
• Jason Gill,
• Thomas Barthlott,
• Stephane Chappaz,
• Takeshi Nitta,
• James Dooley,
• Ruben Nogales-Cadenas,
• Yousuke Takahama,
• Daniela Finke,
• Adrian Liston,
• Bruce R Blazar,
• Alberto Pascual-Montano,
• Georg A Holländer

• October 2012

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

• Authors:
• Javier Lopez-Rios,
• Dario Speziale,
• Dimitri Robay,
• Martina Scotti,
• Marco Osterwalder,
• Gretel Nusspaumer,
• Antonella Galli,
• Georg A Holländer,
• Marie Kmita,
• Rolf Zeller

• April 2012

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

• Authors:
• Aikaterini S Papadopoulou,
• James Dooley,
• Michelle A Linterman,
• Wim Pierson,
• Olga Ucar,
• Bruno Kyewski,
• Saulius Zuklys,
• Georg A Hollander,
• Patrick Matthys,
• Daniel H D Gray,
• Bart De Strooper,
• Adrian Liston

• December 2011

CD43 regulates the threshold for T cell activation by targeting Cbl functions.

• Authors:
• Gustavo Pedraza-Alva,
• Lilia B Mérida,
• Roxana del Rio,
• Nora A Fierro,
• Mario E Cruz-Muñoz,
• Norma Olivares,
• Erika Melchy,
• Vivian Igras,
• Georg A Holländer,
• Steven J Burakoff,
• Yvonne Rosenstein

• October 2011

Thymic T-cell development in allogeneic stem cell transplantation.

• Authors:
• Werner Krenger,
• Bruce R Blazar,
• Georg A Holländer

• June 2011

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

• Authors:
• Yu Lei,
• Adiratna Mat Ripen,
• Naozumi Ishimaru,
• Izumi Ohigashi,
• Takashi Nagasawa,
• Lukas T Jeker,
• Michael R Bösl,
• Georg A Holländer,
• Yoshio Hayashi,
• Rene de Waal Malefyt,
• Takeshi Nitta,
• Yousuke Takahama

• February 2011

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.

• Authors:
• Klaus Gossens,
• Silvia Naus,
• Georg A Holländer,
• Hermann J Ziltener

• September 2010

Emerging strategies to boost thymic function.

• Authors:
• Georg A Holländer,
• Werner Krenger,
• Bruce R Blazar

• August 2010

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

• Authors:
• Elisabeth Fayard,
• Gerald Moncayo,
• Brian A Hemmings,
• Georg A Holländer

• August 2010

The role of the thymus in allogeneic hematopoietic stem cell transplantation.

• Authors:
• Werner Krenger,
• Georg A Holländer

• July 2010

Spatial (Tbata) expression in mature medullary thymic epithelial cells.

• Authors:
• Murielle Saade,
• Magali Irla,
• Miriam Yammine,
• Nicolas Boulanger,
• Geneviève Victorero,
• Renaud Vincentelli,
• Josef M Penninger,
• Georg A Holländer,
• Sophie Chauvet,
• Catherine Nguyen

• February 2010

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

• Authors:
• Eric Vroegindeweij,
• Stijn Crobach,
• Manami Itoi,
• Rumi Satoh,
• Saulius Zuklys,
• Christiane Happe,
• Wilfred T V Germeraad,
• Jan J Cornelissen,
• Tom Cupedo,
• Georg A Holländer,
• Hiroshi Kawamoto,
• Willem van Ewijk

• February 2010

Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

• Authors:
• Ryan M Kelly,
• Emily M Goren,
• Patricia A Taylor,
• Scott N Mueller,
• Heather E Stefanski,
• Mark J Osborn,
• Hamish S Scott,
• Elena A Komarova,
• Andrei V Gudkov,
• Georg A Holländer,
• Bruce R Blazar

• February 2010

Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.

• Authors:
• Linda Kenins,
• Jason W Gill,
• Georg A Holländer,
• Aleksandra Wodnar-Filipowicz

• January 2010

Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

• Authors:
• Noriko Shikama,
• Gretel Nusspaumer,
• Georg A Holländer

• June 2009

The Global Thymus Network: past, present and future.

• Authors:
• Yousuke Takahama,
• Takashi Saito,
• Hiroshi Kawamoto,
• Manami Itoi,
• Richard L Boyd,
• Ann Chidgey,
• Rose Zamoyska,
• Georg A Holländer,
• Graham Anderson,
• Naomi Taylor,
• Howard T Petrie,
• Janko Nikolich-Zugich

• May 2009

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

• Authors:
• Saulius Zuklys,
• Jason Gill,
• Marcel P Keller,
• Mathias Hauri-Hohl,
• Saule Zhanybekova,
• Gina Balciunaite,
• Kyung-Jae Na,
• Lukas T Jeker,
• Katrin Hafen,
• Noriyuki Tsukamoto,
• Takashi Amagai,
• Makoto M Taketo,
• Werner Krenger,
• Georg A Holländer

• March 2009

Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.

• Authors:
• Georg A Holländer

• December 2008

The immunopathology of thymic GVHD.

• Authors:
• Werner Krenger,
• Georg A Holländer

• December 2008

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

• Authors:
• Lukas T Jeker,
• Thomas Barthlott,
• Marcel P Keller,
• Saulius Zuklys,
• Mathias Hauri-Hohl,
• Chu-Xia Deng,
• Georg A Holländer

• November 2008

Delta-like 4 is indispensable in thymic environment specific for T cell development.

• Authors:
• Katsuto Hozumi,
• Carolina Mailhos,
• Naoko Negishi,
• Ken-ichi Hirano,
• Takashi Yahata,
• Kiyoshi Ando,
• Saulius Zuklys,
• Georg A Holländer,
• David T Shima,
• Sonoko Habu

• October 2008

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

• Authors:
• Magali Irla,
• Stéphanie Hugues,
• Jason Gill,
• Takeshi Nitta,
• Yu Hikosaka,
• Ifor R Williams,
• François-Xavier Hubert,
• Hamish S Scott,
• Yousuke Takahama,
• Georg A Holländer,
• Walter Reith

• September 2008

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

• Authors:
• Mathias M Hauri-Hohl,
• Saulius Zuklys,
• Marcel P Keller,
• Lukas T Jeker,
• Thomas Barthlott,
• Anne M Moon,
• Jürgen Roes,
• Georg A Holländer

• August 2008

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.

• Authors:
• Ryan M Kelly,
• Steven L Highfill,
• Angela Panoskaltsis-Mortari,
• Patricia A Taylor,
• Richard L Boyd,
• Georg A Holländer,
• Bruce R Blazar

• June 2008

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

• Authors:
• Mathias Heikenwalder,
• Marco Prinz,
• Nicolas Zeller,
• Karl S Lang,
• Tobias Junt,
• Simona Rossi,
• Alexei Tumanov,
• Hauke Schmidt,
• Josef Priller,
• Lukas Flatz,
• Thomas Rülicke,
• Andrew J Macpherson,
• Georg A Holländer,
• Sergei A Nedospasov,
• Adriano Aguzzi

• June 2008

The thymus in GVHD pathophysiology.

• Authors:
• Werner Krenger,
• Georg A Holländer

• June 2008

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.

• Authors:
• Linda Kenins,
• Jason W Gill,
• Richard L Boyd,
• Georg A Holländer,
• Aleksandra Wodnar-Filipowicz

• March 2008

Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.

• Authors:
• Mohammad Alimohammadi,
• Peyman Björklund,
• Asa Hallgren,
• Nora Pöntynen,
• Gabor Szinnai,
• Noriko Shikama,
• Marcel P Keller,
• Olov Ekwall,
• Sarah A Kinkel,
• Eystein S Husebye,
• Jan Gustafsson,
• Fredrik Rorsman,
• Leena Peltonen,
• Corrado Betterle,
• Jaakko Perheentupa,
• Göran Akerström,
• Gunnar Westin,
• Hamish S Scott,
• Georg A Holländer,
• Olle Kämpe

• March 2008

Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.

• Authors:
• Martin Guimond,
• Warren J Leonard,
• Rosanne Spolski,
• Simona W Rossi,
• Rachelle G Veenstra,
• Georg A Hollander,
• Crystal L Mackall,
• Bruce R Blazar

• January 2008

Deletion of PKBalpha/Akt1 affects thymic development.

• Authors:
• Elisabeth Fayard,
• Jason Gill,
• Magdalena Paolino,
• Debby Hynx,
• Georg A Holländer,
• Brian A Hemmings

• October 2007

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

• Authors:
• Simona W Rossi,
• Lukas T Jeker,
• Tomoo Ueno,
• Sachiyo Kuse,
• Marcel P Keller,
• Saulius Zuklys,
• Andrei V Gudkov,
• Yousuke Takahama,
• Werner Krenger,
• Bruce R Blazar,
• Georg A Holländer

• May 2007

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

• Authors:
• Mathias M Hauri-Hohl,
• Marcel P Keller,
• Jason Gill,
• Katrin Hafen,
• Esther Pachlatko,
• Thomas Boulay,
• Annick Peter,
• Georg A Holländer,
• Werner Krenger

• May 2007

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

• Authors:
• Dullei Min,
• Angela Panoskaltsis-Mortari,
• Makoto Kuro-O,
• Georg A Holländer,
• Bruce R Blazar,
• Kenneth I Weinberg

• March 2007

Claudins provide a breath of fresh Aire.

• Authors:
• Georg A Holländer

• March 2007

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

• Authors:
• Thomas Barthlott,
• Marcel P Keller,
• Werner Krenger,
• Georg A Holländer

• March 2007

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.

• Authors:
• Mark A Daniels,
• Emma Teixeiro,
• Jason Gill,
• Barbara Hausmann,
• Dominique Roubaty,
• Kaisa Holmberg,
• Guy Werlen,
• Georg A Holländer,
• Nicholas R J Gascoigne,
• Ed Palmer

• December 2006

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

• Authors:
• Thomas Barthlott,
• Marcel P Keller,
• Werner Krenger,
• Georg A Holländer

• June 2006

Leydig cell injury as a consequence of an acute graft-versus-host reaction.

• Authors:
• Anna-Margaretha Wagner,
• Konstantin Beier,
• Elli Christen,
• Georg A Holländer,
• Werner Krenger

• April 2005

The role of CCL21 in recruitment of T-precursor cells to fetal thymi.

• Authors:
• Cunlan Liu,
• Tomoo Ueno,
• Sachiyo Kuse,
• Fumi Saito,
• Takeshi Nitta,
• Luca Piali,
• Hideki Nakano,
• Terutaka Kakiuchi,
• Martin Lipp,
• Georg A Hollander,
• Yousuke Takahama

• January 2005

On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease.

• Authors:
• Werner Krenger,
• Heike Schmidlin,
• Gionata Cavadini,
• Georg A Holländer

• June 2004

Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells.

• Authors:
• Jean-Marc Waldburger,
• Simona Rossi,
• Georg A Hollander,
• Hans-Reimer Rodewald,
• Walter Reith,
• Hans Acha-Orbea

• May 2003

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.

• Authors:
• Simona Frigerio,
• Tobias Junt,
• Bao Lu,
• Craig Gerard,
• Urs Zumsteg,
• Georg A Holländer,
• Luca Piali

• December 2002

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.

• Authors:
• Gina Balciunaite,
• Marcel P Keller,
• Egle Balciunaite,
• Luca Piali,
• Saulius Zuklys,
• Yves D Mathieu,
• Jason Gill,
• Richard Boyd,
• Daniel J Sussman,
• Georg A Holländer

• November 2002

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.

• Authors:
• Jason Gill,
• Mark Malin,
• Georg A Holländer,
• Richard Boyd

• July 2002

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.

• Authors:
• Simona Rossi,
• Bruce R Blazar,
• Catherine L Farrell,
• Dimitry M Danilenko,
• David L Lacey,
• Kenneth I Weinberg,
• Werner Krenger,
• Georg A Holländer

• July 2002

Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitis.

• Authors:
• Simona Frigerio,
• Georg A Holländer,
• Urs Zumsteg

Open Access Could Transform Drug Discovery: A Case Study of JQ1.

• Authors:
• Zeeshaan Arshad,
• James Smith,
• Mackenna Roberts,
• Wen Hwa Lee,
• Ben Davies,
• Kim Bure,
• Georg A Hollander,
• Sue Dopson,
• Chas Bountra,
• David Brindley

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

• Authors:
• Saulius Žuklys,
• Adam Handel,
• Saule Zhanybekova,
• Fatima Govani,
• Marcel Keller,
• Stefano Maio,
• Carlos E Mayer,
• Hong Ying Teh,
• Katrin Hafen,
• Giuseppe Gallone,
• Thomas Barthlott,
• Chris P Ponting,
• Georg A Holländer

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice.

• Authors:
• Reema Jain,
• Julie M Sheridan,
• Antonia Policheni,
• Melanie Heinlein,
• Luke C Gandolfo,
• Grant Dewson,
• Gordon K Smyth,
• Stephen N Sansom,
• Nai Yang Fu,
• Jane E Visvader,
• Georg A Holländer,
• Andreas Strasser,
• Daniel H D Gray