Publications Authored by Georg A Hollander

Paediatric Immunology, Department of Biomedicine, University of Basel, and The Basel University Children's Hospital, Basel, 4058, Switzerland; Developmental Immunology, Department of Paediatrics, and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.

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December 2014

Essential role for autophagy during invariant NKT cell development.

Authors:

Mariolina Salio Daniel J Puleston Till S M Mathan Dawn Shepherd Amanda J Stranks Eleni Adamopoulou Natacha Veerapen Gurdyal S Besra Georg A Hollander Anna Katharina Simon Vincenzo Cerundolo

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

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December 2014

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

Authors:

Mathias Hauri-Hohl Saulius Zuklys Georg A Holländer Steven F Ziegler

Nat Immunol 2014 Jun 13;15(6):554-61. Epub 2014 Apr 13.

1] Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA. [2] These authors contributed equally to this work.

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June 2014

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Authors:

S Rhiannon Jenkinson Joy A Williams Hyein Jeon Jingjing Zhang Takeshi Nitta Izumi Ohigashi Michael Kruhlak Saulius Zuklys Susan Sharrow Anthony Adams Larry Granger Yongwon Choi Ulrich Siebenlist Gail A Bishop Georg A Hollander Yousuke Takahama Richard J Hodes

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):21107-12. Epub 2013 Dec 9.

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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December 2013

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

Authors:

Chikako Odaka Mathias Hauri-Hohl Kazuya Takizawa Yomiko Nishikawa Masashi Yano Mitsuru Matsumoto Richard Boyd Georg A Holländer

Int Immunol 2013 Nov 8;25(11):633-42. Epub 2013 Aug 8.

Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.

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November 2013

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.

Authors:

Simone Dertschnig Gretel Nusspaumer Robert Ivanek Mathias M Hauri-Hohl Georg A Holländer Werner Krenger

Blood 2013 Aug 29;122(5):837-41. Epub 2013 May 29.

Department of Biomedicine, University of Basel and Basel University Children's Hospital, Mattenstrasse 28, Basel, Switzerland.

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August 2013

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

Authors:

Soichiro Shitara Takahiro Hara Bingfei Liang Keisuke Wagatsuma Saulius Zuklys Georg A Holländer Hiroshi Nakase Tsutomu Chiba Shizue Tani-ichi Koichi Ikuta

J Immunol 2013 Jun 17;190(12):6173-9. Epub 2013 May 17.

Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

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June 2013

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Authors:

Izumi Ohigashi Saulius Zuklys Mie Sakata Carlos E Mayer Saule Zhanybekova Shigeo Murata Keiji Tanaka Georg A Holländer Yousuke Takahama

Proc Natl Acad Sci U S A 2013 Jun 29;110(24):9885-90. Epub 2013 May 29.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.

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June 2013

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.

Authors:

Saulius Zuklys Carlos E Mayer Saule Zhanybekova Heather E Stefanski Gretel Nusspaumer Jason Gill Thomas Barthlott Stephane Chappaz Takeshi Nitta James Dooley Ruben Nogales-Cadenas Yousuke Takahama Daniela Finke Adrian Liston Bruce R Blazar Alberto Pascual-Montano Georg A Holländer

J Immunol 2012 Oct 12;189(8):3894-904. Epub 2012 Sep 12.

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and Basel University Children's Hospital, Basel 4031, Switzerland.

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October 2012

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

Authors:

Javier Lopez-Rios Dario Speziale Dimitri Robay Martina Scotti Marco Osterwalder Gretel Nusspaumer Antonella Galli Georg A Holländer Marie Kmita Rolf Zeller

Dev Cell 2012 Apr 29;22(4):837-48. Epub 2012 Mar 29.

Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.

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April 2012

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Authors:

Aikaterini S Papadopoulou James Dooley Michelle A Linterman Wim Pierson Olga Ucar Bruno Kyewski Saulius Zuklys Georg A Hollander Patrick Matthys Daniel H D Gray Bart De Strooper Adrian Liston

Nat Immunol 2011 Dec 18;13(2):181-7. Epub 2011 Dec 18.

VIB, Leuven, Belgium.

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December 2011

CD43 regulates the threshold for T cell activation by targeting Cbl functions.

Authors:

Gustavo Pedraza-Alva Lilia B Mérida Roxana del Rio Nora A Fierro Mario E Cruz-Muñoz Norma Olivares Erika Melchy Vivian Igras Georg A Holländer Steven J Burakoff Yvonne Rosenstein

IUBMB Life 2011 Oct 9;63(10):940-8. Epub 2011 Sep 9.

Instituto de Biotecnología, Departamento de Medicina Molecular y Bioprocesos, Universidad Nacional Autónoma de México, Cuernavaca, Mor. México 62210.

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October 2011

Thymic T-cell development in allogeneic stem cell transplantation.

Authors:

Werner Krenger Bruce R Blazar Georg A Holländer

Blood 2011 Jun 22;117(25):6768-76. Epub 2011 Mar 22.

Department of Biomedicine, University of Basel, and Basel University Children's Hospital, Basel, Switzerland.

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June 2011

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

Authors:

Yu Lei Adiratna Mat Ripen Naozumi Ishimaru Izumi Ohigashi Takashi Nagasawa Lukas T Jeker Michael R Bösl Georg A Holländer Yoshio Hayashi Rene de Waal Malefyt Takeshi Nitta Yousuke Takahama

J Exp Med 2011 Feb 7;208(2):383-94. Epub 2011 Feb 7.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.

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February 2011

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.

Authors:

Klaus Gossens Silvia Naus Georg A Holländer Hermann J Ziltener

PLoS One 2010 Sep 15;5(9):e12766. Epub 2010 Sep 15.

The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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September 2010

Emerging strategies to boost thymic function.

Authors:

Georg A Holländer Werner Krenger Bruce R Blazar

Curr Opin Pharmacol 2010 Aug 4;10(4):443-53. Epub 2010 May 4.

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, The University Children's Hospital (UKBB), Mattenstrasse 28, 4058 Basel, Switzerland.

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August 2010

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

Authors:

Elisabeth Fayard Gerald Moncayo Brian A Hemmings Georg A Holländer

Sci Signal 2010 Aug 17;3(135):re5. Epub 2010 Aug 17.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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August 2010

The role of the thymus in allogeneic hematopoietic stem cell transplantation.

Authors:

Werner Krenger Georg A Holländer

Swiss Med Wkly 2010 Jul 19;140:w13051. Epub 2010 Jul 19.

Department of Biomedicine, University of Basel, and Basel University Children's Hospital (UKBB), Basel, Switzerland.

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July 2010

Spatial (Tbata) expression in mature medullary thymic epithelial cells.

Authors:

Murielle Saade Magali Irla Miriam Yammine Nicolas Boulanger Geneviève Victorero Renaud Vincentelli Josef M Penninger Georg A Holländer Sophie Chauvet Catherine Nguyen

Eur J Immunol 2010 Feb;40(2):530-8

INSERM U928, Technologies Avancées pour le Génome et la Clinique, Université de la Méditerranée, Parc Scientifique de Luminy, Marseille Cedex, France.

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February 2010

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

Authors:

Eric Vroegindeweij Stijn Crobach Manami Itoi Rumi Satoh Saulius Zuklys Christiane Happe Wilfred T V Germeraad Jan J Cornelissen Tom Cupedo Georg A Holländer Hiroshi Kawamoto Willem van Ewijk

Mol Immunol 2010 Feb 27;47(5):1106-13. Epub 2009 Nov 27.

Laboratory for Lymphocyte Development, RIKEN Research Centre for Allergy and Immunology, Yokohama, Japan.

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February 2010

Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

Authors:

Ryan M Kelly Emily M Goren Patricia A Taylor Scott N Mueller Heather E Stefanski Mark J Osborn Hamish S Scott Elena A Komarova Andrei V Gudkov Georg A Holländer Bruce R Blazar

Blood 2010 Feb 4;115(5):1088-97. Epub 2009 Dec 4.

Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.

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February 2010

Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.

Authors:

Linda Kenins Jason W Gill Georg A Holländer Aleksandra Wodnar-Filipowicz

Eur J Immunol 2010 Jan;40(1):81-90

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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January 2010

Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

Authors:

Noriko Shikama Gretel Nusspaumer Georg A Holländer

Endocrinol Metab Clin North Am 2009 Jun;38(2):273-88, vii

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland.

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June 2009

The Global Thymus Network: past, present and future.

Authors:

Yousuke Takahama Takashi Saito Hiroshi Kawamoto Manami Itoi Richard L Boyd Ann Chidgey Rose Zamoyska Georg A Holländer Graham Anderson Naomi Taylor Howard T Petrie Janko Nikolich-Zugich

Trends Immunol 2009 May 8;30(5):191-2. Epub 2009 Apr 8.

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May 2009

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

Authors:

Saulius Zuklys Jason Gill Marcel P Keller Mathias Hauri-Hohl Saule Zhanybekova Gina Balciunaite Kyung-Jae Na Lukas T Jeker Katrin Hafen Noriyuki Tsukamoto Takashi Amagai Makoto M Taketo Werner Krenger Georg A Holländer

J Immunol 2009 Mar;182(5):2997-3007

Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel, and Basel University Children's Hospital, Basel, Switzerland.

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March 2009

Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.

Authors:

Georg A Holländer

Semin Immunopathol 2008 Dec;30(4):369-70

Pediatric Immunology, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland.

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December 2008

The immunopathology of thymic GVHD.

Authors:

Werner Krenger Georg A Holländer

Semin Immunopathol 2008 Dec 31;30(4):439-56. Epub 2008 Oct 31.

Department of Biomedicine, University of Basel, Basel, 4005, Switzerland.

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December 2008

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

Authors:

Lukas T Jeker Thomas Barthlott Marcel P Keller Saulius Zuklys Mathias Hauri-Hohl Chu-Xia Deng Georg A Holländer

Blood 2008 Nov 11;112(9):3688-95. Epub 2008 Aug 11.

Department of Biomedicine, Laboratory of Pediatric Immunology, University of Basel and the University Children's Hospital, Basel, Switzerland.

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November 2008

Delta-like 4 is indispensable in thymic environment specific for T cell development.

Authors:

Katsuto Hozumi Carolina Mailhos Naoko Negishi Ken-ichi Hirano Takashi Yahata Kiyoshi Ando Saulius Zuklys Georg A Holländer David T Shima Sonoko Habu

J Exp Med 2008 Oct 29;205(11):2507-13. Epub 2008 Sep 29.

Department of Immunology and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara 259-1193, Japan.

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October 2008

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Authors:

Magali Irla Stéphanie Hugues Jason Gill Takeshi Nitta Yu Hikosaka Ifor R Williams François-Xavier Hubert Hamish S Scott Yousuke Takahama Georg A Holländer Walter Reith

Immunity 2008 Sep;29(3):451-63

University of Geneva Medical School, CMU, 1 Rue Michel-Servet, CH-1211, Geneva, Switzerland.

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September 2008

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

Authors:

Mathias M Hauri-Hohl Saulius Zuklys Marcel P Keller Lukas T Jeker Thomas Barthlott Anne M Moon Jürgen Roes Georg A Holländer

Blood 2008 Aug 12;112(3):626-34. Epub 2008 May 12.

Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland.

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August 2008

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.

Authors:

Ryan M Kelly Steven L Highfill Angela Panoskaltsis-Mortari Patricia A Taylor Richard L Boyd Georg A Holländer Bruce R Blazar

Blood 2008 Jun 11;111(12):5734-44. Epub 2008 Mar 11.

Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis 55455, USA.

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June 2008

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

Authors:

Mathias Heikenwalder Marco Prinz Nicolas Zeller Karl S Lang Tobias Junt Simona Rossi Alexei Tumanov Hauke Schmidt Josef Priller Lukas Flatz Thomas Rülicke Andrew J Macpherson Georg A Holländer Sergei A Nedospasov Adriano Aguzzi

Am J Pathol 2008 Jun 15;172(6):1555-70. Epub 2008 May 15.

Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.

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June 2008

The thymus in GVHD pathophysiology.

Authors:

Werner Krenger Georg A Holländer

Best Pract Res Clin Haematol 2008 Jun;21(2):119-28

Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.

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June 2008

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.

Authors:

Linda Kenins Jason W Gill Richard L Boyd Georg A Holländer Aleksandra Wodnar-Filipowicz

J Exp Med 2008 Mar 25;205(3):523-31. Epub 2008 Feb 25.

Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.

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March 2008

Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.

N Engl J Med 2008 Mar;358(10):1018-28

University Hospital, Uppsala University, Uppsala, Sweden.

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March 2008

Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.

Authors:

Martin Guimond Warren J Leonard Rosanne Spolski Simona W Rossi Rachelle G Veenstra Georg A Hollander Crystal L Mackall Bruce R Blazar

Blood 2008 Jan;111(2):969-70

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January 2008

Deletion of PKBalpha/Akt1 affects thymic development.

Authors:

Elisabeth Fayard Jason Gill Magdalena Paolino Debby Hynx Georg A Holländer Brian A Hemmings

PLoS One 2007 Oct 3;2(10):e992. Epub 2007 Oct 3.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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October 2007

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

Authors:

Simona W Rossi Lukas T Jeker Tomoo Ueno Sachiyo Kuse Marcel P Keller Saulius Zuklys Andrei V Gudkov Yousuke Takahama Werner Krenger Bruce R Blazar Georg A Holländer

Blood 2007 May 9;109(9):3803-11. Epub 2007 Jan 9.

Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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May 2007

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

Authors:

Mathias M Hauri-Hohl Marcel P Keller Jason Gill Katrin Hafen Esther Pachlatko Thomas Boulay Annick Peter Georg A Holländer Werner Krenger

Blood 2007 May 9;109(9):4080-8. Epub 2007 Jan 9.

Department of Clinical-Biological Sciences, Laboratory of Pediatric Immunology, University of Basel Children's Hospital, Mattenstrasse 28, 4058 Basel, Switzerland.

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May 2007

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.

Authors:

Dullei Min Angela Panoskaltsis-Mortari Makoto Kuro-O Georg A Holländer Bruce R Blazar Kenneth I Weinberg

Blood 2007 Mar 30;109(6):2529-37. Epub 2006 Nov 30.

Division of Stem Cell Transplantation, Department of Pediatrics, Stanford University, CA 94304, USA.

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March 2007

Claudins provide a breath of fresh Aire.

Authors:

Georg A Holländer

Nat Immunol 2007 Mar;8(3):234-6

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March 2007

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

Authors:

Thomas Barthlott Marcel P Keller Werner Krenger Georg A Holländer

Swiss Med Wkly 2007 Mar;137 Suppl 155:9S-13S

Department of Clinical-Biological Sciences, University of Basel and the University Children's Hospital of Basel (UKBB), Basel, Switzerland.

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March 2007

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.

Authors:

Mark A Daniels Emma Teixeiro Jason Gill Barbara Hausmann Dominique Roubaty Kaisa Holmberg Guy Werlen Georg A Holländer Nicholas R J Gascoigne Ed Palmer

Nature 2006 Dec 1;444(7120):724-9. Epub 2006 Nov 1.

Laboratory of Transplantation Immunology and Nephrology, Department of Research, University Hospital-Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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December 2006

A short primer on early molecular and cellular events in thymus organogenesis and replacement.

Authors:

Thomas Barthlott Marcel P Keller Werner Krenger Georg A Holländer

Swiss Med Wkly 2006 Jun;136(23-24):365-9

Department of Clincial-Biological Sciences, University of Basel and, the University Children's Hospital of Basel (UKKB), Basel, Switzerland.

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June 2006

Leydig cell injury as a consequence of an acute graft-versus-host reaction.

Authors:

Anna-Margaretha Wagner Konstantin Beier Elli Christen Georg A Holländer Werner Krenger

Blood 2005 Apr 2;105(7):2988-90. Epub 2004 Dec 2.

Department of Research, Center for Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.

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April 2005

The role of CCL21 in recruitment of T-precursor cells to fetal thymi.

Authors:

Cunlan Liu Tomoo Ueno Sachiyo Kuse Fumi Saito Takeshi Nitta Luca Piali Hideki Nakano Terutaka Kakiuchi Martin Lipp Georg A Hollander Yousuke Takahama

Blood 2005 Jan 9;105(1):31-9. Epub 2004 Sep 9.

Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.

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January 2005

On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease.

Authors:

Werner Krenger Heike Schmidlin Gionata Cavadini Georg A Holländer

J Immunol 2004 Jun;172(12):7359-67

Pediatric Immunology, Departments of Research and Clinical-Biological Sciences, University of Basel, and University Children's Hospital of Basel, Kantonsspital, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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June 2004