Geoffrey Otton

Geoffrey Otton

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Geoffrey Otton

Geoffrey Otton

Publications by authors named "Geoffrey Otton"

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Nucleotide excision repair protein ERCC1 and tumour-infiltrating lymphocytes are potential biomarkers of neoadjuvant platinum resistance in high grade serous ovarian cancer.

Gynecol Oncol 2018 11 5;151(2):306-310. Epub 2018 Sep 5.

Hunter Medical Research Institute and School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.08.030DOI Listing
November 2018

Identification of nine new susceptibility loci for endometrial cancer.

Authors:
Tracy A O'Mara Dylan M Glubb Frederic Amant Daniela Annibali Katie Ashton John Attia Paul L Auer Matthias W Beckmann Amanda Black Manjeet K Bolla Hiltrud Brauch Hermann Brenner Louise Brinton Daniel D Buchanan Barbara Burwinkel Jenny Chang-Claude Stephen J Chanock Chu Chen Maxine M Chen Timothy H T Cheng Christine L Clarke Mark Clendenning Linda S Cook Fergus J Couch Angela Cox Marta Crous-Bous Kamila Czene Felix Day Joe Dennis Jeroen Depreeuw Jennifer Anne Doherty Thilo Dörk Sean C Dowdy Matthias Dürst Arif B Ekici Peter A Fasching Brooke L Fridley Christine M Friedenreich Lin Fritschi Jenny Fung Montserrat García-Closas Mia M Gaudet Graham G Giles Ellen L Goode Maggie Gorman Christopher A Haiman Per Hall Susan E Hankison Catherine S Healey Alexander Hein Peter Hillemanns Shirley Hodgson Erling A Hoivik Elizabeth G Holliday John L Hopper David J Hunter Angela Jones Camilla Krakstad Vessela N Kristensen Diether Lambrechts Loic Le Marchand Xiaolin Liang Annika Lindblom Jolanta Lissowska Jirong Long Lingeng Lu Anthony M Magliocco Lynn Martin Mark McEvoy Alfons Meindl Kyriaki Michailidou Roger L Milne Miriam Mints Grant W Montgomery Rami Nassir Håkan Olsson Irene Orlow Geoffrey Otton Claire Palles John R B Perry Julian Peto Loreall Pooler Jennifer Prescott Tony Proietto Timothy R Rebbeck Harvey A Risch Peter A W Rogers Matthias Rübner Ingo Runnebaum Carlotta Sacerdote Gloria E Sarto Fredrick Schumacher Rodney J Scott V Wendy Setiawan Mitul Shah Xin Sheng Xiao-Ou Shu Melissa C Southey Anthony J Swerdlow Emma Tham Jone Trovik Constance Turman Jonathan P Tyrer Celine Vachon David VanDen Berg Adriaan Vanderstichele Zhaoming Wang Penelope M Webb Nicolas Wentzensen Henrica M J Werner Stacey J Winham Alicja Wolk Lucy Xia Yong-Bing Xiang Hannah P Yang Herbert Yu Wei Zheng Paul D P Pharoah Alison M Dunning Peter Kraft Immaculata De Vivo Ian Tomlinson Douglas F Easton Amanda B Spurdle Deborah J Thompson

Nat Commun 2018 08 9;9(1):3166. Epub 2018 Aug 9.

Department of Public Health and Primary Care, University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, CB1 8RN, UK.

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http://dx.doi.org/10.1038/s41467-018-05427-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085317PMC
August 2018

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

Cancer Med 2018 05 2;7(5):1978-1987. Epub 2018 Apr 2.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1002/cam4.1445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943470PMC
May 2018

Human Papillomavirus-Associated Adenocarcinoma In Situ of the Vestibule.

J Low Genit Tract Dis 2017 10;21(4):e45-e47

1Department of Pathology, Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia; 2Hunter Centre for Gynaecological Cancer, John Hunter Hospital, New Lambton Heights, New South Wales, Australia; 3The Royal Women's Hospital and Murdoch Children's Research Institute, Parkville, Victoria, Australia; 4Department of Microbiology and Infectious Diseases Laboratory Services, Murdoch Childrens Research Institute, Parkville, Australia; and 5Anatomical Pathology, Pathology North, Hunter New England, New Lambton, New South Wales, Australia.

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http://Insights.ovid.com/crossref?an=00128360-201710000-0002
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http://dx.doi.org/10.1097/LGT.0000000000000347DOI Listing
October 2017

Expression of renin-angiotensin system (RAS) components in endometrial cancer.

Endocr Connect 2017 Jan 12;6(1):9-19. Epub 2016 Dec 12.

School of Biomedical Sciences and PharmacyUniversity of Newcastle, Newcastle, New South Wales, Australia

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http://dx.doi.org/10.1530/EC-16-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302162PMC
January 2017

Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer.

Cancer Epidemiol Biomarkers Prev 2016 11 22;25(11):1503-1510. Epub 2016 Aug 22.

Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093082PMC
November 2016

Five endometrial cancer risk loci identified through genome-wide association analysis.

Nat Genet 2016 06 2;48(6):667-674. Epub 2016 May 2.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/ng.3562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907351PMC
June 2016

Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families.

Cancer Med 2016 05 25;5(5):929-41. Epub 2016 Jan 25.

School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

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http://doi.wiley.com/10.1002/cam4.628
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http://dx.doi.org/10.1002/cam4.628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864822PMC
May 2016

Renin-angiotensin system gene polymorphisms and endometrial cancer.

Endocr Connect 2016 May 11;5(3):128-35. Epub 2016 Apr 11.

School of Biomedical Sciences and PharmacyUniversity of Newcastle, Callaghan, New South Wales, Australia
 Hunter Medical Research InstituteNew Lambton, Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.1530/EC-15-0112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002951PMC
May 2016

CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.

Endocr Relat Cancer 2016 Feb 16;23(2):77-91. Epub 2015 Nov 16.

Department of Public Health and Primary CareCentre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UKDepartment of Genetics and Computational BiologyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, AustraliaWellcome Trust Centre for Human GeneticsUniversity of Oxford, Oxford OX3 7BN, UKAcademic Department of BiochemistryRoyal Marsden Hospital, London SW3 6JJ, UKDepartment of Clinical GeneticsSt George's Hospital Medical School, London SW17 0RE, UKDepartment of OncologyCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UKDepartment of Medical Epidemiology and BiostatisticsKarolinska Institutet, Stockholm SE-171 77, SwedenDepartment of MedicineDivision of Hematology/Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USADepartment of Gynecology and ObstetricsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyInstitute of Human GeneticsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyGynaecology Research UnitHannover Medical School, Hannover 30625, GermanyClinics of Gynaecology and ObstetricsHannover Medical School, Hannover 30625, GermanyDepartment of GynaecologyJena University Hospital - Friedrich Schiller University, Jena 07743, GermanyVesalius Research CenterLeuven 3000, BelgiumLaboratory for Translational GeneticsDepartment of Oncology, University Hospitals Leuven, Leuven 3000, BelgiumDepartment of Obstetrics and GynecologyDivision of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven 3000, BelgiumDepartment of Health Sciences ResearchMayo Clinic, Rochester, Minnesota 55905, USADepartment of BiostatisticsUniversity of Kansas Medical Center, Kansas City, Kansas 66160, USADepartment of Obstetrics and GynecologyDivision of G

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http://dx.doi.org/10.1530/ERC-15-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697192PMC
February 2016

Early changes of endometrial neoplasia revealed by loss of mismatch repair gene protein expression in a patient diagnosed with Lynch syndrome.

Pathology 2016 Jan 11;48(1):78-80. Epub 2015 Dec 11.

Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia; Division of Anatomical Pathology, Pathology North, Hunter New England, New Lambton, NSW, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00313025150000
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http://dx.doi.org/10.1016/j.pathol.2015.11.003DOI Listing
January 2016

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Authors:
Timothy H T Cheng Deborah Thompson Jodie Painter Tracy O'Mara Maggie Gorman Lynn Martin Claire Palles Angela Jones Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Graham G Giles Paul Pharoah Julian Peto Angela Cox Anthony Swerdlow Fergus Couch Julie M Cunningham Ellen L Goode Stacey J Winham Diether Lambrechts Peter Fasching Barbara Burwinkel Hermann Brenner Hiltrud Brauch Jenny Chang-Claude Helga B Salvesen Vessela Kristensen Hatef Darabi Jingmei Li Tao Liu Annika Lindblom Per Hall Magdalena Echeverry de Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Samuel Aguiar Jnr Manuel R Teixeira Alison M Dunning Joe Dennis Geoffrey Otton Tony Proietto Elizabeth Holliday John Attia Katie Ashton Rodney J Scott Mark McEvoy Sean C Dowdy Brooke L Fridley Henrica M J Werner Jone Trovik Tormund S Njolstad Emma Tham Miriam Mints Ingo Runnebaum Peter Hillemanns Thilo Dörk Frederic Amant Stefanie Schrauwen Alexander Hein Matthias W Beckmann Arif Ekici Kamila Czene Alfons Meindl Manjeet K Bolla Kyriaki Michailidou Jonathan P Tyrer Qin Wang Shahana Ahmed Catherine S Healey Mitul Shah Daniela Annibali Jeroen Depreeuw Nada A Al-Tassan Rebecca Harris Brian F Meyer Nicola Whiffin Fay J Hosking Ben Kinnersley Susan M Farrington Maria Timofeeva Albert Tenesa Harry Campbell Robert W Haile Shirley Hodgson Luis Carvajal-Carmona Jeremy P Cheadle Douglas Easton Malcolm Dunlop Richard Houlston Amanda Spurdle Ian Tomlinson

Sci Rep 2015 12 1;5:17369. Epub 2015 Dec 1.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/srep17369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664893PMC
December 2015

Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.

Endocr Relat Cancer 2015 Oct;22(5):851-61

Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics

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http://dx.doi.org/10.1530/ERC-15-0319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559752PMC
October 2015

The problem of late ovarian metastases from primary cervical adenocarcinoma.

Gynecol Oncol Rep 2015 Aug 11;13:23-5. Epub 2015 Apr 11.

The Centre for Information-Based Medicine, Hunter Medical Research Institute, New Lambton Heights, Australia ; The Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S23525789150002
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http://dx.doi.org/10.1016/j.gore.2015.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563573PMC
August 2015

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Authors:
Jodie N Painter Tracy A O'Mara Jyotsna Batra Timothy Cheng Felicity A Lose Joe Dennis Kyriaki Michailidou Jonathan P Tyrer Shahana Ahmed Kaltin Ferguson Catherine S Healey Susanne Kaufmann Kristine M Hillman Carina Walpole Leire Moya Pamela Pollock Angela Jones Kimberley Howarth Lynn Martin Maggie Gorman Shirley Hodgson Ma Magdalena Echeverry De Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Erika Santos Manuel R Teixeira Luis Carvajal-Carmona Xiao-Ou Shu Jirong Long Wei Zheng Yong-Bing Xiang Grant W Montgomery Penelope M Webb Rodney J Scott Mark McEvoy John Attia Elizabeth Holliday Nicholas G Martin Dale R Nyholt Anjali K Henders Peter A Fasching Alexander Hein Matthias W Beckmann Stefan P Renner Thilo Dörk Peter Hillemanns Matthias Dürst Ingo Runnebaum Diether Lambrechts Lieve Coenegrachts Stefanie Schrauwen Frederic Amant Boris Winterhoff Sean C Dowdy Ellen L Goode Attila Teoman Helga B Salvesen Jone Trovik Tormund S Njolstad Henrica M J Werner Katie Ashton Tony Proietto Geoffrey Otton Gerasimos Tzortzatos Miriam Mints Emma Tham Per Hall Kamila Czene Jianjun Liu Jingmei Li John L Hopper Melissa C Southey Arif B Ekici Matthias Ruebner Nicola Johnson Julian Peto Barbara Burwinkel Frederik Marme Hermann Brenner Aida K Dieffenbach Alfons Meindl Hiltrud Brauch Annika Lindblom Jeroen Depreeuw Matthieu Moisse Jenny Chang-Claude Anja Rudolph Fergus J Couch Janet E Olson Graham G Giles Fiona Bruinsma Julie M Cunningham Brooke L Fridley Anne-Lise Børresen-Dale Vessela N Kristensen Angela Cox Anthony J Swerdlow Nicholas Orr Manjeet K Bolla Qin Wang Rachel Palmieri Weber Zhihua Chen Mitul Shah Juliet D French Paul D P Pharoah Alison M Dunning Ian Tomlinson Douglas F Easton Stacey L Edwards Deborah J Thompson Amanda B Spurdle

Hum Mol Genet 2015 Mar 6;24(5):1478-92. Epub 2014 Nov 6.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia,

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http://dx.doi.org/10.1093/hmg/ddu552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321445PMC
March 2015

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.

Hum Genet 2015 Feb 9;134(2):231-45. Epub 2014 Dec 9.

Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95616, USA,

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http://dx.doi.org/10.1007/s00439-014-1515-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291520PMC
February 2015

Endometrial granulomas with Levonorgestrel Intrauterine System (Mirena).

Pathology 2014 Aug;46(5):457-8

1School of Medicine and Public Health, University of Newcastle, Callaghan 2Hunter Centre for Gynaecological Cancer 3Department of Gynaecology 4Division of Anatomical Pathology, Hunter Area Pathology Service, John Hunter Hospital, New Lambton Heights, NSW, Australia.

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http://dx.doi.org/10.1097/PAT.0000000000000127DOI Listing
August 2014

Unusual locations of primary subepithelial squamous cell carcinomas of the vulva.

J Low Genit Tract Dis 2013 Oct;17(4):e8-e11

1Hunter Area Pathology Service; 2School of Medicine and Public Health, University of Newcastle; and 3Hunter New England Centre for Gynaecologic Cancer Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.1097/LGT.0b013e31827a8c95DOI Listing
October 2013

Genital melanocytic naevus and lichen sclerosus.

Pathology 2013 10;45(6):616-8

*Faculty of Health Sciences, University of Newcastle, Newcastle †HAPS, John Hunter Hospital, Newcastle ‡Hunter New England Health Service, Department of Obstetrics and Gynaecology, Maitland Hospital, Maitland §Hunter Gynaecological Cancer Service, John Hunter Hospital, Newcastle, NSW, Australia.

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http://dx.doi.org/10.1097/PAT.0b013e3283653b5dDOI Listing
October 2013

Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.

BMC Cancer 2010 Jul 21;10:382. Epub 2010 Jul 21.

Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia.

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http://dx.doi.org/10.1186/1471-2407-10-382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918576PMC
July 2010

Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.

Cancer Epidemiol 2010 Jun 8;34(3):328-37. Epub 2010 Apr 8.

Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia.

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http://dx.doi.org/10.1016/j.canep.2010.03.005DOI Listing
June 2010

Intravenous leiomyomatosis with intracardiac extension: first reported case in Australia.

Heart Lung Circ 2010 Jan 6;19(1):50-2. Epub 2009 May 6.

Department of Cardiothoracic Surgery, John Hunter Hospital, Newcastle, Australia.

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http://dx.doi.org/10.1016/j.hlc.2009.02.006DOI Listing
January 2010

Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer.

Gynecol Oncol 2009 Apr 3;113(1):109-14. Epub 2009 Feb 3.

Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia.

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http://dx.doi.org/10.1016/j.ygyno.2008.12.036DOI Listing
April 2009

Vulval Crohn's disease.

Sex Health 2009 Mar;6(1):87-9

Pacific Clinic, Level 2, 670 Hunter Street, Newcastle, NSW 2300, Australia.

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March 2009

Genetic variants in MUTYH are not associated with endometrial cancer risk.

Hered Cancer Clin Pract 2009 Jan 26;7(1). Epub 2009 Jan 26.

Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia and the Hunter Medical Research Institute, NSW, 2308, Australia.

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http://dx.doi.org/10.1186/1897-4287-7-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653716PMC
January 2009

The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor.

BMC Cancer 2008 Sep 29;8:272. Epub 2008 Sep 29.

Discipline of Medical Genetics, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, NSW, 2308, Australia.

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http://dx.doi.org/10.1186/1471-2407-8-272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567988PMC
September 2008