Geoffrey M Wahl

Geoffrey M Wahl

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Geoffrey M Wahl

Geoffrey M Wahl

Publications by authors named "Geoffrey M Wahl"

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Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.

Life Sci Alliance 2020 Jan 20;3(1). Epub 2020 Jan 20.

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA

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http://dx.doi.org/10.26508/lsa.201900623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971368PMC
January 2020

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.

Cell Rep 2019 Dec;29(11):3448-3459.e6

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948147PMC
December 2019

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Cancer Cell 2018 09 30;34(3):466-482.e6. Epub 2018 Aug 30.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152943PMC
September 2018

Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.

NPJ Breast Cancer 2017 19;3:14. Epub 2017 Apr 19.

Huntsman Cancer Institute, The University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112 USA.

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http://dx.doi.org/10.1038/s41523-017-0012-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460241PMC
April 2017

Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis.

NPJ Breast Cancer 2017 24;3:16. Epub 2017 Apr 24.

Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037 USA.

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http://www.nature.com/articles/s41523-017-0018-6
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http://dx.doi.org/10.1038/s41523-017-0018-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460261PMC
April 2017

A Critical Examination of the "Bad Luck" Explanation of Cancer Risk.

Cancer Prev Res (Phila) 2015 Sep 29;8(9):762-4. Epub 2015 Jun 29.

Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849411PMC
September 2015

Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.

Cell Rep 2015 Sep 10;12(12):2035-48. Epub 2015 Sep 10.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591253PMC
September 2015

A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time.

Cell Rep 2014 Dec 20;9(5):1946-1958. Epub 2014 Nov 20.

Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269221PMC
December 2014

CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.

Stem Cell Reports 2014 Apr 3;2(4):427-39. Epub 2014 Apr 3.

Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.stemcr.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986630PMC
April 2014

AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.

Mol Cell Biol 2014 Jan 4;34(2):148-57. Epub 2013 Nov 4.

Department of Biochemistry & Molecular Biology, Tulane University School of Medicine and Tulane Cancer Center, New Orleans, Louisiana, USA.

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http://dx.doi.org/10.1128/MCB.00670-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911293PMC
January 2014

Stem cells and the developing mammary gland.

J Mammary Gland Biol Neoplasia 2013 Jun 27;18(2):209-19. Epub 2013 Apr 27.

Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.1007/s10911-013-9284-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161372PMC
June 2013

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Proc Natl Acad Sci U S A 2013 Apr 4;110(17):6991-6. Epub 2013 Apr 4.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1303671110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637696PMC
April 2013

MDM2, MDMX and p53 in oncogenesis and cancer therapy.

Nat Rev Cancer 2013 Feb 10;13(2):83-96. Epub 2013 Jan 10.

Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1038/nrc3430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161369PMC
February 2013

Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.

J Biol Chem 2012 Jun 3;287(25):20898-903. Epub 2012 May 3.

Department of Biochemistry and Molecular Biology and Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.336875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375513PMC
June 2012

What a difference a phosphate makes: life or death decided by a single amino acid in MDM2.

Cancer Cell 2012 May;21(5):595-6

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.04.033DOI Listing
May 2012

p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.

Genes Cancer 2011 Apr;2(4):404-19

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1947601911410224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135646PMC
April 2011

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.

Proc Natl Acad Sci U S A 2010 Dec 13;107(52):22745-50. Epub 2010 Dec 13.

The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1073/pnas.1017001108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012457PMC
December 2010

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Cancer Cell 2010 Nov;18(5):411-22

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561081000426
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http://dx.doi.org/10.1016/j.ccr.2010.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050021PMC
November 2010

The p53 orchestra: Mdm2 and Mdmx set the tone.

Trends Cell Biol 2010 May 19;20(5):299-309. Epub 2010 Feb 19.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096289241000033
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http://dx.doi.org/10.1016/j.tcb.2010.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910097PMC
May 2010

Linking the p53 tumour suppressor pathway to somatic cell reprogramming.

Nature 2009 Aug 9;460(7259):1140-4. Epub 2009 Aug 9.

Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature08311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735889PMC
August 2009

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Mol Cancer Res 2009 Jan;7(1):1-11

Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629357PMC
January 2009

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death.

Cell Cycle 2008 Jul;7(13):1973-82

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625302PMC
http://dx.doi.org/10.4161/cc.7.13.6072DOI Listing
July 2008

MDM2 and MDM4: p53 regulators as targets in anticancer therapy.

Int J Biochem Cell Biol 2007 8;39(7-8):1476-82. Epub 2007 Apr 8.

Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 rue d'Ulm, 75728 Paris Cedex 05, France.

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http://linkinghub.elsevier.com/retrieve/pii/S135727250700112
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http://dx.doi.org/10.1016/j.biocel.2007.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043116PMC
October 2007

Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.

Proc Natl Acad Sci U S A 2007 Jul 17;104(30):12365-70. Epub 2007 Jul 17.

Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0701497104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941475PMC
July 2007

Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.

Mol Cell Biol 2007 Feb 11;27(4):1425-32. Epub 2006 Dec 11.

Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00999-06
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http://dx.doi.org/10.1128/MCB.00999-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800716PMC
February 2007

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.

Nat Rev Cancer 2006 Dec;6(12):909-23

Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 rue d'Ulm, 75248 Paris Cedex 05, France.

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http://www.nature.com/articles/nrc2012
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http://dx.doi.org/10.1038/nrc2012DOI Listing
December 2006

Hdmx modulates the outcome of p53 activation in human tumor cells.

J Biol Chem 2006 Nov 13;281(44):33036-44. Epub 2006 Aug 13.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M605405200DOI Listing
November 2006

RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses.

Nucleic Acids Res 2006 Jul 26;34(13):e92. Epub 2006 Jul 26.

The Salk Institute for Biological Studies, Gene expression Laboratory, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkl518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540739PMC
July 2006

Explaining the biological activity of transactivation-deficient p53 variants.

Nat Genet 2006 Apr;38(4):395-6; author reply 396-7

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http://dx.doi.org/10.1038/ng0406-395DOI Listing
April 2006

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Cancer Cell 2006 Apr;9(4):273-85

The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.03.014DOI Listing
April 2006

Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.

Nucleic Acids Res 2005 Oct 4;33(17):e147. Epub 2005 Oct 4.

Division of Biological Sciences, University of California at San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1093/nar/gni145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1243804PMC
October 2005

Initiation of DNA replication at the human beta-globin 3' enhancer.

Nucleic Acids Res 2005 5;33(14):4412-24. Epub 2005 Aug 5.

Developmental Biology Program, Hospital for Sick Children Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/nar/gki747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183104PMC
August 2005

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.

Proc Natl Acad Sci U S A 2005 Jul 8;102(29):10188-93. Epub 2005 Jul 8.

The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0503068102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177381PMC
July 2005

p53 must be competent for transcriptional regulation to suppress tumor formation.

Oncogene 2005 May;24(22):3563-73

Department of Oncology-Pathology, Karolinska Institutet, CCK R8:05, Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.onc.1208354DOI Listing
May 2005

A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation.

Cell Cycle 2005 Mar 2;4(3):411-7. Epub 2005 Mar 2.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.4161/cc.4.3.1522DOI Listing
March 2005

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.

J Biol Chem 2004 Dec 6;279(51):53015-22. Epub 2004 Oct 6.

Discovery Oncology, Roche Research Center, Hoffmann-La Roche Inc., 340 Kingsland St., Nutley, NJ 07110, USA.

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http://dx.doi.org/10.1074/jbc.M410233200DOI Listing
December 2004

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.

EMBO J 2004 Apr 18;23(7):1547-56. Epub 2004 Mar 18.

Department of Biology, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC391059PMC
April 2004

Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1.

J Virol 2003 Nov;77(21):11767-80

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC229350PMC
http://dx.doi.org/10.1128/jvi.77.21.11767-11780.2003DOI Listing
November 2003