Geoffrey M Thiele

Geoffrey M Thiele

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Geoffrey M Thiele

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Surface nano-modification by ion beam-assisted deposition alters the expression of osteogenic genes in osteoblasts.

Proc Inst Mech Eng H 2019 Jun 21:954411919858018. Epub 2019 Jun 21.

3 VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1177/0954411919858018DOI Listing
June 2019

HLA-DRB1 Haplotypes, Shared Epitope, and Disease Outcomes in US Veterans with Rheumatoid Arthritis.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Veterans Affairs (VA) Nebraska-Iowa Health Care System; Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA. Funding provided by UNMC Internal Medicine Scientist Development Award, UNMC Physician-Scientist Training Program, UNMC Mentored Scholars Program, US National Institute of General Medical Sciences (U54GM115458), National Institute on Alcohol Abuse and Alcoholism (R25AA020818), and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (2P50AR60772). M. Zhao, MD, VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC; L. Mauer, MD, VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC; H. Sayles, MS, Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC, and Department of Biostatistics, College of Public Health, UNMC; G.W. Cannon, MD, VA Salt Lake City and University of Utah; A. Reimold, MD, Dallas VA and University of Texas Southwestern; G.S. Kerr, MD, Washington DC VAMC, Georgetown University and Howard University; J.F. Baker, MD, MSCE, Corporal Michael J. Crescenz VA and University of Pennsylvania; G.M. Thiele, PhD, VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC; B.R. England, MD, VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC; T.R. Mikuls, MD, MSPH, VA Nebraska-Iowa Healthcare System, and Division of Rheumatology and Immunology, Department of Internal Medicine, UNMC. Address correspondence to Dr. T.R. Mikuls, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, Nebraska 68198-6270, USA. E-mail: Accepted for publication October 30, 2018.

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http://dx.doi.org/10.3899/jrheum.180724DOI Listing
March 2019

Review: Precision Cut Liver Slices for the Evaluation of Fatty Liver and Fibrosis.

Curr Mol Pharmacol 2017 ;10(3):249-254

Experimental Immunology Laboratory at the Omaha Veterans Administration Medical Center, Research Services 151, 4101 Woolworth Avenue, Omaha, NE 68105. United States.

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http://dx.doi.org/10.2174/1874467208666150817112345DOI Listing
February 2019

Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid.

J Pharm Biomed Anal 2019 Feb 9;164:460-466. Epub 2018 Nov 9.

Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Veteran Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183205
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http://dx.doi.org/10.1016/j.jpba.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298802PMC
February 2019

Sex differences impact the lung-bone inflammatory response to repetitive inhalant lipopolysaccharide exposures in mice.

J Immunotoxicol 2018 12;15(1):73-81

a Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine , University of Nebraska Medical Center , Omaha , NE , USA.

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http://dx.doi.org/10.1080/1547691X.2018.1460425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122601PMC
December 2018

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival.

Clin Exp Metastasis 2018 12 16;35(8):797-818. Epub 2018 Oct 16.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6495, USA.

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http://link.springer.com/10.1007/s10585-018-9941-7
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http://dx.doi.org/10.1007/s10585-018-9941-7DOI Listing
December 2018

Immune regulation and anti-cancer activity by lipid inflammatory mediators.

Int Immunopharmacol 2018 Dec 14;65:580-592. Epub 2018 Nov 14.

University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183092
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http://dx.doi.org/10.1016/j.intimp.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322683PMC
December 2018

Novel Antioxidant Properties of Doxycycline.

Int J Mol Sci 2018 Dec 17;19(12). Epub 2018 Dec 17.

Department of Internal Medicine, University of Nebraska Medical Center, 982650 Nebraska Medical Center, Omaha, NE 68198-2265, USA.

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http://www.mdpi.com/1422-0067/19/12/4078
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http://dx.doi.org/10.3390/ijms19124078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321135PMC
December 2018

N-Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol-Fed Rats.

Alcohol Clin Exp Res 2018 07 27;42(7):1206-1216. Epub 2018 May 27.

Veteran Affairs Nebraska-Western Iowa Health Care System , Omaha, Nebraska.

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http://doi.wiley.com/10.1111/acer.13765
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http://dx.doi.org/10.1111/acer.13765DOI Listing
July 2018

Lipid Inflammatory Mediators in Cancer Progression and Therapy.

Adv Exp Med Biol 2017 ;1036:145-156

University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1007/978-3-319-67577-0_10DOI Listing
June 2018

Long-Chain Omega-3 Polyunsaturated Fatty Acids Modulate Mammary Gland Composition and Inflammation.

J Mammary Gland Biol Neoplasia 2018 06 25;23(1-2):43-58. Epub 2018 Mar 25.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1007/s10911-018-9391-5DOI Listing
June 2018

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications.

BMJ 2018 04 23;361:k1036. Epub 2018 Apr 23.

Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA

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http://dx.doi.org/10.1136/bmj.k1036DOI Listing
April 2018

Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.

Am J Physiol Gastrointest Liver Physiol 2018 03 28;314(3):G418-G430. Epub 2017 Dec 28.

Experimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.

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http://dx.doi.org/10.1152/ajpgi.00183.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899239PMC
March 2018

Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.

Int Immunopharmacol 2018 Mar 2;56:113-118. Epub 2018 Feb 2.

Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, United States; Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, United States.

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http://dx.doi.org/10.1016/j.intimp.2018.01.022DOI Listing
March 2018

The subgingival microbiome in patients with established rheumatoid arthritis.

Rheumatology (Oxford) 2018 Mar 19. Epub 2018 Mar 19.

Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, USA.

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http://dx.doi.org/10.1093/rheumatology/key052DOI Listing
March 2018

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology.

J Nutr Biochem 2018 02 4;52:92-102. Epub 2017 Oct 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2017.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996979PMC
February 2018

A role for B cells in organic dust induced lung inflammation.

Respir Res 2017 12 22;18(1):214. Epub 2017 Dec 22.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE, USA.

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http://dx.doi.org/10.1186/s12931-017-0703-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741951PMC
December 2017

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging.

Redox Biol 2017 10 2;13:588-593. Epub 2017 Aug 2.

Department of Internal Medicine, University of Nebraska Medical Center, 982650 Nebraska Medical Center, Omaha, NE 68198-2265, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552384PMC
October 2017

Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss.

PLoS One 2016 1;11(8):e0158735. Epub 2016 Aug 1.

Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158735PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968800PMC
August 2017

A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice.

J Nutr Biochem 2017 04 27;42:149-159. Epub 2017 Jan 27.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, NE, USA; VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2017.01.011DOI Listing
April 2017

Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis.

Curr Opin Rheumatol 2017 01;29(1):57-64

Veterans Affairs Nebraska-Western Iowa Healthcare System and Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000356DOI Listing
January 2017

Systemic IL-6 Effector Response in Mediating Systemic Bone Loss Following Inhalation of Organic Dust.

J Interferon Cytokine Res 2017 01 22;37(1):9-19. Epub 2016 Nov 22.

1 Pulmonary, Critical Care, Sleep & Allergy Division, University of Nebraska Medical Center , The Nebraska Medical Center, Omaha, Nebraska.

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http://dx.doi.org/10.1089/jir.2016.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240004PMC
January 2017

Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.

J Toxicol Environ Health A 2015 5;78(19):1201-16. Epub 2015 Oct 5.

a Pulmonary, Critical Care, Sleep & Allergy Division , University of Nebraska Medical Center , Omaha , Nebraska , USA.

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http://dx.doi.org/10.1080/15287394.2015.1075165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706168PMC
April 2016

Antibodies against malondialdehyde-acetaldehyde adducts can help identify patients with abdominal aortic aneurysm.

J Vasc Surg 2016 Feb 25;63(2):477-84. Epub 2015 Feb 25.

Department of Surgery, University of Nebraska Medical Center, Omaha, Neb. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07415214140170
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http://dx.doi.org/10.1016/j.jvs.2014.08.117DOI Listing
February 2016

Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis?

J Allergy Clin Immunol 2016 Jan;137(1):28-34

Division of Rheumatology, Department of Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Neb; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, Neb.

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http://dx.doi.org/10.1016/j.jaci.2015.10.024DOI Listing
January 2016

Aldehyde-modified proteins as mediators of early inflammation in atherosclerotic disease.

Free Radic Biol Med 2015 Dec 4;89:409-18. Epub 2015 Nov 4.

Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.09.003DOI Listing
December 2015

Unique antibody responses to malondialdehyde-acetaldehyde (MAA)-protein adducts predict coronary artery disease.

PLoS One 2014 11;9(9):e107440. Epub 2014 Sep 11.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE, United States of America; Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, United States of America; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161424PMC
October 2015

Induction of autophagy markers is associated with attenuation of miR-133a in diabetic heart failure patients undergoing mechanical unloading.

Am J Transl Res 2015 15;7(4):683-96. Epub 2015 Apr 15.

Department of Cellular, Integrative Physiology, University of Nebraska Medical Center Omaha, NE 68198, USA ; Department of Anesthesiology, University of Nebraska Medical Center Omaha, NE 68198, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455344PMC
June 2015

Associations of toll-like receptor (TLR)-4 single nucleotide polymorphisms and rheumatoid arthritis disease progression: an observational cohort study.

Int Immunopharmacol 2015 Feb 5;24(2):346-352. Epub 2015 Jan 5.

University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198-6270, USA; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, 4101 Woolworth Ave, Omaha, NE 68105, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15675769140050
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http://dx.doi.org/10.1016/j.intimp.2014.12.030DOI Listing
February 2015

The Link Between Periodontitis and Rheumatoid Arthritis: A Periodontist's Perspective.

Curr Oral Health Rep 2015;2:20-29

Omaha Veterans Affairs Medical Center (VAMC) and Nebraska Arthritis Outcomes Research Center, Division of Rheumatology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198-3025 USA.

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http://dx.doi.org/10.1007/s40496-014-0040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312393PMC
January 2015

Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver.

Hepatol Int 2014 Sep 29;8 Suppl 2:432-8. Epub 2013 Dec 29.

Research Service (151), VA Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue (151), Omaha, NE, 68105, USA.

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http://dx.doi.org/10.1007/s12072-013-9511-7DOI Listing
September 2014

Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.

Hepatology 2014 Jul 28;60(1):146-57. Epub 2014 May 28.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA; College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon, South Korea.

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http://dx.doi.org/10.1002/hep.27036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077916PMC
July 2014

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis.

Am J Physiol Gastrointest Liver Physiol 2014 Feb 27;306(3):G208-17. Epub 2013 Nov 27.

Experimental Immunology Laboratory, Veterans Affairs Nebraska-Western Iowa Health Care System (VA NWIHCS), Omaha, Nebraska;

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http://dx.doi.org/10.1152/ajpgi.00124.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920111PMC
February 2014

IL-6 and its receptors in coronary artery disease and acute myocardial infarction.

Cytokine 2013 Jun 10;62(3):395-400. Epub 2013 Apr 10.

Experimental Immunology, Research in Cardiovascular Disease Laboratory, The University of Nebraska Medical Center, Wittson Hall Room 3004, 986350 Nebraska Medical Center, Omaha, NE 68198-6350, United States.

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http://dx.doi.org/10.1016/j.cyto.2013.03.020DOI Listing
June 2013

Susceptibility to T cell-mediated liver injury is enhanced in asialoglycoprotein receptor-deficient mice.

Int Immunopharmacol 2013 May 26;16(1):17-26. Epub 2013 Mar 26.

Research Service (151), VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.

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http://dx.doi.org/10.1016/j.intimp.2013.03.012DOI Listing
May 2013

Titanium implant with nanostructured zirconia surface promotes maturation of peri-implant bone in osseointegration.

Proc Inst Mech Eng H 2013 May 8;227(5):510-22. Epub 2013 Mar 8.

Experimental Immunology Laboratory, Veterans Affairs Nebraska-Western Iowa Health Care System (VA NWIHCS), Research Services 151, Omaha, NE, USA.

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http://dx.doi.org/10.1177/0954411913479300DOI Listing
May 2013

Polyclonal antibody to soman-tyrosine.

Chem Res Toxicol 2013 Apr 21;26(4):584-92. Epub 2013 Mar 21.

Eppley Institute, University of Nebraska Medical Center , Omaha, Nebraska 68198-5950, United States.

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http://dx.doi.org/10.1021/tx400027nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732541PMC
April 2013

Ultrasound imaging in an animal model of vascular inflammation following balloon injury.

Ultrasound Med Biol 2012 Sep 3;38(9):1552-8. Epub 2012 Jul 3.

Department of Internal Medicine, Division of Cardiology, Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2012.05.011DOI Listing
September 2012

A method for the making and utility of gadolinium-labeled albumin microbubbles.

Magn Reson Imaging 2012 Jan 6;30(1):96-103. Epub 2011 Nov 6.

Experimental Immunology, Research in Cardiovascular Disease Laboratory at the University of Nebraska Medical Center, Division of Cardiology, Department of Internal Medicine, 982265 Nebraska Medical Center, Omaha, NE 68198-2265, USA.

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http://dx.doi.org/10.1016/j.mri.2011.07.023DOI Listing
January 2012

Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment.

Biochem Biophys Res Commun 2012 Jan 28;417(1):262-7. Epub 2011 Nov 28.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, United States.

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http://dx.doi.org/10.1016/j.bbrc.2011.11.097DOI Listing
January 2012

Soluble CD14 and CD14 polymorphisms in rheumatoid arthritis.

J Rheumatol 2011 Dec 15;38(12):2509-16. Epub 2011 Sep 15.

Department of Medicine, Division of Rheumatology and Immunology, Omaha Veterans Affairs Medical Center and University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.3899/jrheum.110378DOI Listing
December 2011

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates.

Mol Pharm 2011 Aug 12;8(4):1043-51. Epub 2011 Apr 12.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, USA.

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http://dx.doi.org/10.1021/mp2000555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148351PMC
August 2011

Associations of disease activity and treatments with mortality in men with rheumatoid arthritis: results from the VARA registry.

Rheumatology (Oxford) 2011 Jan 21;50(1):101-9. Epub 2010 Jul 21.

Department of Medicine, Omaha Veterans Affairs Medical Center (VAMC), University of Nebraska, Omaha, NE 68198-6270, USA.

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http://dx.doi.org/10.1093/rheumatology/keq232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108313PMC
January 2011

Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites.

Alcohol Clin Exp Res 2010 Dec 22;34(12):2126-36. Epub 2010 Sep 22.

Experimental Immunology Laboratory, Department of Internal Medicine, Section of Rheumatology, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2010.01309.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014581PMC
December 2010

Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury.

J Biol Chem 2010 Dec 21;285(52):40645-53. Epub 2010 Oct 21.

Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-6350, USA.

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http://dx.doi.org/10.1074/jbc.M110.134809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003363PMC
December 2010

Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis.

Free Radic Biol Med 2010 Nov 6;49(10):1480-6. Epub 2010 Aug 6.

Experimental Immunology Laboratory, Section of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952714PMC
November 2010

Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis.

Am J Physiol Gastrointest Liver Physiol 2010 Sep 1;299(3):G661-8. Epub 2010 Jul 1.

Veterans Affairs Medical Center and the Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA.

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http://dx.doi.org/10.1152/ajpgi.00287.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950678PMC
September 2010

Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation.

Am J Physiol Lung Cell Mol Physiol 2009 Oct 31;297(4):L767-76. Epub 2009 Jul 31.

Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1152/ajplung.00107.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770789PMC
October 2009

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines.

Vaccine 2009 May 10;27(22):2981-8. Epub 2009 Mar 10.

Experimental Immunology Laboratory, Omaha Veterans Administration Medical Center, Research Services 151, Omaha, NE 68105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X0900354
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http://dx.doi.org/10.1016/j.vaccine.2009.02.105DOI Listing
May 2009

Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease.

World J Gastroenterol 2009 Mar;15(10):1209-18

Department of Internal Medicine, University of Nebraska Medical Center, 986350 Nebraska Medical Center, Omaha, NE 68198-6350, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658861PMC
http://dx.doi.org/10.3748/wjg.15.1209DOI Listing
March 2009

Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis.

Int Immunopharmacol 2009 Jan 9;9(1):38-42. Epub 2008 Oct 9.

Department of Medicine, Nebraska Arthritis Outcomes Research Center (NAORC), University of Nebraska Medical Center and Omaha Veterans Affairs Medical Center, Omaha, NE, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156757690800291
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http://dx.doi.org/10.1016/j.intimp.2008.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748386PMC
January 2009

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.

Pharm Res 2008 Dec 23;25(12):2910-9. Epub 2008 Jul 23.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1007/s11095-008-9683-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593120PMC
December 2008

Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde.

Int Immunopharmacol 2008 Aug 28;8(8):1112-8. Epub 2008 Apr 28.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, United States.

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http://dx.doi.org/10.1016/j.intimp.2008.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518647PMC
August 2008

An in vitro method of alcoholic liver injury using precision-cut liver slices from rats.

Biochem Pharmacol 2008 Aug 21;76(3):426-36. Epub 2008 May 21.

Experimental Immunology Laboratory, University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/j.bcp.2008.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845461PMC
August 2008

The Development of Novel Therapies for Rheumatoid Arthritis.

Expert Opin Ther Pat 2008 Jul;18(7):723-738

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1517/13543776.18.7.723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491719PMC
July 2008

Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption.

Methods Mol Biol 2008 ;447:235-57

Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, OH, USA.

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http://dx.doi.org/10.1007/978-1-59745-242-7_17DOI Listing
May 2008

Immunological response in alcoholic liver disease.

World J Gastroenterol 2007 Oct;13(37):4938-46

Omaha VA Medical Center, Research Service 151, Rm 325, 4101 Woolworth Avenue, Omaha, NE 68105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434616PMC
http://dx.doi.org/10.3748/wjg.v13.i37.4938DOI Listing
October 2007

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells.

Hepatology 2007 Jan;45(1):53-61

Liver Study Unit, The Omaha Veterans Affairs (VA) Medical Center, Omaha, NE 68105, USA.

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http://dx.doi.org/10.1002/hep.21442DOI Listing
January 2007

Chronic ethanol treatment impairs Rac and Cdc42 activation in rat hepatocytes.

Alcohol Clin Exp Res 2006 Jul;30(7):1208-13

Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2006.00135.xDOI Listing
July 2006

Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins.

Mol Pharmacol 2005 Nov 16;68(5):1423-30. Epub 2005 Aug 16.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, Omaha, NE 68105, USA.

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http://dx.doi.org/10.1124/mol.105.016121DOI Listing
November 2005

Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol.

Biochem Pharmacol 2005 Nov 3;70(11):1593-600. Epub 2005 Oct 3.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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http://dx.doi.org/10.1016/j.bcp.2005.08.014DOI Listing
November 2005

RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease.

Alcohol Clin Exp Res 2005 Sep;29(9):1753-7

University of Massachusetts Medical Center, Department of Medicine, Worcester, MA 01605-2324, USA.

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September 2005

Recent advances in alcohol-induced adduct formation.

Alcohol Clin Exp Res 2005 Jul;29(7):1310-6

University of Nebraska Medical Center and the Veterans Administration Medical Center, Omaha, Nebraska, USA.

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July 2005

Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines.

Chem Res Toxicol 2005 May;18(5):817-24

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://dx.doi.org/10.1021/tx0500676DOI Listing
May 2005

Halothane potentiates the alcohol-adduct induced TNF-alpha release in heart endothelial cells.

BMC Anesthesiol 2005 Apr 12;5(1). Epub 2005 Apr 12.

University of Nebraska Medical Center, Department of Internal Medicine, 988090 Nebraska Medical Center, Omaha, NE, 68198-3025, USA.

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http://dx.doi.org/10.1186/1471-2253-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090549PMC
April 2005

Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.

Alcohol Clin Exp Res 2004 Dec;28(12):1931-8

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2004

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.

Front Biosci 2004 Sep 1;9:3145-55. Epub 2004 Sep 1.

University of Nebraska Medical Center, Department of Internal Medicine, 988090 Nebraska Medical Center, Omaha, NE 68198-8090, USA.

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September 2004

Immunologic mechanisms of alcoholic liver injury.

Semin Liver Dis 2004 Aug;24(3):273-87

University of Nebraska Medical Center, Department of Internal Medicine, Section of Rheumatology and Immunology, Nebraska Medical Center, Omaha, Nebraska 68198-3205, USA.

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http://dx.doi.org/10.1055/s-2004-832940DOI Listing
August 2004