Geoffrey L Smith

Geoffrey L Smith

UNVERIFIED PROFILE

Are you Geoffrey L Smith?   Register this Author

Register author
Geoffrey L Smith

Geoffrey L Smith

Publications by authors named "Geoffrey L Smith"

Are you Geoffrey L Smith?   Register this Author

100Publications

1351Reads

31Profile Views

Leaky scanning translation generates a second A49 protein that contributes to vaccinia virus virulence.

J Gen Virol 2020 May 24;101(5):533-541. Epub 2020 Feb 24.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.001386DOI Listing
May 2020

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an HO-Dependent Mechanism.

Redox Biol 2020 01 22;28:101361. Epub 2019 Oct 22.

CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisbon, 1749-024, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2019.101361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838802PMC
January 2020

Smallpox in the Post-Eradication Era.

Viruses 2020 Jan 24;12(2). Epub 2020 Jan 24.

Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v12020138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077202PMC
January 2020

Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice.

Front Immunol 2019 31;10:1780. Epub 2019 Jul 31.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685358PMC
July 2019

Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.

J Biol Chem 2019 04 28;294(16):6416-6429. Epub 2019 Feb 28.

From the Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.006561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484134PMC
April 2019

NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.

Proc Natl Acad Sci U S A 2019 03 28;116(12):5699-5704. Epub 2019 Feb 28.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1813504116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431142PMC
March 2019

How Does Vaccinia Virus Interfere With Interferon?

Adv Virus Res 2018 16;100:355-378. Epub 2018 Feb 16.

University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.aivir.2018.01.003DOI Listing
December 2018

Vaccinia Virus Protein C6: A Multifunctional Interferon Antagonist.

Authors:
Geoffrey L Smith

Adv Exp Med Biol 2018 ;1052:1-7

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-10-7572-8_1DOI Listing
November 2018

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.

J Gen Virol 2018 06 20;99(6):790-804. Epub 2018 Apr 20.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://www.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/jgv.0.001034DOI Listing
June 2018

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.

Viruses 2018 02 28;10(3). Epub 2018 Feb 28.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v10030101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869494PMC
February 2018

Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.

J Gen Virol 2017 Dec;98(12):3086-3092

Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.000946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845699PMC
December 2017

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Authors:
Javier Egea Isabel Fabregat Yves M Frapart Pietro Ghezzi Agnes Görlach Thomas Kietzmann Kateryna Kubaichuk Ulla G Knaus Manuela G Lopez Gloria Olaso-Gonzalez Andreas Petry Rainer Schulz Jose Vina Paul Winyard Kahina Abbas Opeyemi S Ademowo Catarina B Afonso Ioanna Andreadou Haike Antelmann Fernando Antunes Mutay Aslan Markus M Bachschmid Rui M Barbosa Vsevolod Belousov Carsten Berndt David Bernlohr Esther Bertrán Alberto Bindoli Serge P Bottari Paula M Brito Guia Carrara Ana I Casas Afroditi Chatzi Niki Chondrogianni Marcus Conrad Marcus S Cooke João G Costa Antonio Cuadrado Pham My-Chan Dang Barbara De Smet Bilge Debelec-Butuner Irundika H K Dias Joe Dan Dunn Amanda J Edson Mariam El Assar Jamel El-Benna Péter Ferdinandy Ana S Fernandes Kari E Fladmark Ulrich Förstermann Rashid Giniatullin Zoltán Giricz Anikó Görbe Helen Griffiths Vaclav Hampl Alina Hanf Jan Herget Pablo Hernansanz-Agustín Melanie Hillion Jingjing Huang Serap Ilikay Pidder Jansen-Dürr Vincent Jaquet Jaap A Joles Balaraman Kalyanaraman Danylo Kaminskyy Mahsa Karbaschi Marina Kleanthous Lars-Oliver Klotz Bato Korac Kemal Sami Korkmaz Rafal Koziel Damir Kračun Karl-Heinz Krause Vladimír Křen Thomas Krieg João Laranjinha Antigone Lazou Huige Li Antonio Martínez-Ruiz Reiko Matsui Gethin J McBean Stuart P Meredith Joris Messens Verónica Miguel Yuliya Mikhed Irina Milisav Lidija Milković Antonio Miranda-Vizuete Miloš Mojović María Monsalve Pierre-Alexis Mouthuy John Mulvey Thomas Münzel Vladimir Muzykantov Isabel T N Nguyen Matthias Oelze Nuno G Oliveira Carlos M Palmeira Nikoletta Papaevgeniou Aleksandra Pavićević Brandán Pedre Fabienne Peyrot Marios Phylactides Gratiela G Pircalabioru Andrew R Pitt Henrik E Poulsen Ignacio Prieto Maria Pia Rigobello Natalia Robledinos-Antón Leocadio Rodríguez-Mañas Anabela P Rolo Francis Rousset Tatjana Ruskovska Nuno Saraiva Shlomo Sasson Katrin Schröder Khrystyna Semen Tamara Seredenina Anastasia Shakirzyanova Geoffrey L Smith Thierry Soldati Bebiana C Sousa Corinne M Spickett Ana Stancic Marie José Stasia Holger Steinbrenner Višnja Stepanić Sebastian Steven Kostas Tokatlidis Erkan Tuncay Belma Turan Fulvio Ursini Jan Vacek Olga Vajnerova Kateřina Valentová Frank Van Breusegem Lokman Varisli Elizabeth A Veal A Suha Yalçın Olha Yelisyeyeva Neven Žarković Martina Zatloukalová Jacek Zielonka Rhian M Touyz Andreas Papapetropoulos Tilman Grune Santiago Lamas Harald H H W Schmidt Fabio Di Lisa Andreas Daiber

Redox Biol 2017 10 18;13:94-162. Epub 2017 May 18.

Molecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458069PMC
October 2017

Tagging of the vaccinia virus protein F13 with mCherry causes aberrant virion morphogenesis.

J Gen Virol 2017 Oct;98(10):2543-2555

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.000917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725974PMC
October 2017

Vaccinia virus evasion of regulated cell death.

Immunol Lett 2017 06 31;186:68-80. Epub 2017 Mar 31.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2017.03.015DOI Listing
June 2017

Vaccinia virus egress mediated by virus protein A36 is reliant on the F12 protein.

J Gen Virol 2017 Jun 20;98(6):1500-1514. Epub 2017 Jun 20.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.000816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656793PMC
June 2017

Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer.

Open Biol 2017 05;7(5)

Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.170045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451544PMC
May 2017

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.

PLoS Pathog 2016 Dec 1;12(12):e1005955. Epub 2016 Dec 1.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131898PMC
December 2016

17 Century Variola Virus Reveals the Recent History of Smallpox.

Curr Biol 2016 12 8;26(24):3407-3412. Epub 2016 Dec 8.

McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Biology, McMaster University, Hamilton, ON L8S 4L8, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1Z8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2016.10.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196022PMC
December 2016

Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activation.

J Gen Virol 2016 09 16;97(9):2346-2351. Epub 2016 Jun 16.

Department of Pathology, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.000525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042131PMC
September 2016

Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators.

Vaccine 2016 09 17;34(40):4827-34. Epub 2016 Aug 17.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022402PMC
September 2016

Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence.

PLoS Pathog 2015 Sep 3;11(9):e1005151. Epub 2015 Sep 3.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom; Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559412PMC
September 2015

Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration.

J Biol Chem 2015 May 24;290(18):11785-801. Epub 2015 Feb 24.

From the Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.637306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416878PMC
May 2015

Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family.

J Biol Chem 2015 Mar 20;290(10):5991-6002. Epub 2015 Jan 20.

From the Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.624650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358236PMC
March 2015

Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex.

PLoS Pathog 2015 Mar 11;11(3):e1004723. Epub 2015 Mar 11.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1004723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356562PMC
March 2015

A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism.

J Gen Virol 2015 Feb 28;96(Pt 2):395-407. Epub 2014 Oct 28.

Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.069591-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298679PMC
February 2015

Intracellular sensing of viral DNA by the innate immune system.

Microbes Infect 2014 Dec 12;16(12):1002-12. Epub 2014 Oct 12.

Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2014.09.010DOI Listing
December 2014

Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues.

J Gen Virol 2014 Sep 8;95(Pt 9):2038-2049. Epub 2014 Jun 8.

Department of Virology, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.065664-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135091PMC
September 2014

Rapid spreading and immune evasion by vaccinia virus.

Authors:
Geoffrey L Smith

Adv Exp Med Biol 2014 ;808:65-76

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-81-322-1774-9_6DOI Listing
July 2014

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.

PLoS Pathog 2013 3;9(10):e1003649. Epub 2013 Oct 3.

Section of Virology, Department of Medicine, Imperial College London, Norfolk Place, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789764PMC
May 2014

Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.

J Virol 2014 Mar 26;88(6):3092-102. Epub 2013 Dec 26.

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02627-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957909PMC
March 2014

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.

J Gen Virol 2013 Nov 2;94(Pt 11):2367-2392. Epub 2013 Sep 2.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.055921-0DOI Listing
November 2013

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence.

J Gen Virol 2013 Sep 12;94(Pt 9):2070-2081. Epub 2013 Jun 12.

Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.054114-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749055PMC
September 2013

Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection.

J Gen Virol 2013 Jul 11;94(Pt 7):1647-1657. Epub 2013 Apr 11.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.052670-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709632PMC
July 2013

A mechanism for induction of a hypoxic response by vaccinia virus.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12444-9. Epub 2013 Jul 8.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1302140110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725076PMC
July 2013

Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy.

J Gen Virol 2013 May 3;94(Pt 5):1121-1126. Epub 2013 Jan 3.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.049700-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709586PMC
May 2013

Transport and stability of the vaccinia virus A34 protein is affected by the A33 protein.

J Gen Virol 2013 Apr 19;94(Pt 4):720-725. Epub 2012 Dec 19.

Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.049486-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709683PMC
April 2013

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.

Elife 2012 Dec 18;1:e00047. Epub 2012 Dec 18.

Department of Virology , Imperial College London , London , United Kingdom ; Department of Pathology , University of Cambridge , Cambridge , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524801PMC
December 2012

Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus.

EMBO J 2012 Nov 18;31(21):4204-20. Epub 2012 Sep 18.

Section of Virology, Faculty of Medicine, Imperial College London, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2012.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492727PMC
November 2012

Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence.

J Gen Virol 2012 Oct 12;93(Pt 10):2098-2108. Epub 2012 Jul 12.

Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.045070-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541790PMC
October 2012

Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions.

J Gen Virol 2012 Sep 23;93(Pt 9):1876-1886. Epub 2012 May 23.

Section of Virology, Division of Infectious Diseases, Faculty of Medicine, Imperial College London, St Mary's campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.043943-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709573PMC
September 2012

Le virus de la vaccine, un virus qui se propage plus vite qu'il ne se réplique.

Virologie (Montrouge) 2012 Apr;16(2):119-121

St Mary's campus, Imperial College London, Faculty of Medicine, Section of Virology, Division of Infectious Diseases, Norfolk Place, London W2 1PG, Royaume-Uni, University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge, CB21QP, Royaume-Uni.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/vir.2012.0442DOI Listing
April 2012

Serological responses in humans to the smallpox vaccine LC16m8.

J Gen Virol 2011 Oct 29;92(Pt 10):2405-2410. Epub 2011 Jun 29.

Section of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.034207-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347799PMC
October 2011

How vaccinia virus has evolved to subvert the host immune response.

J Struct Biol 2011 Aug 17;175(2):127-34. Epub 2011 Mar 17.

Division of Structural Biology and Oxford Protein Production Facility, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2011.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477310PMC
August 2011

The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice.

J Clin Invest 2011 Jan 22;121(1):296-307. Epub 2010 Dec 22.

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI42056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007137PMC
January 2011

Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.

J Gen Virol 2010 Sep 2;91(Pt 9):2221-9. Epub 2010 Jun 2.

Imperial College London, St Mary's Campus, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.021998-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052519PMC
September 2010

Vaccinia virus B5 protein affects the glycosylation, localization and stability of the A34 protein.

J Gen Virol 2010 Jul 3;91(Pt 7):1823-7. Epub 2010 Mar 3.

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.020677-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052527PMC
July 2010

Caspases in virus-infected cells contribute to recognition by CD8+ T lymphocytes.

J Immunol 2010 May 26;184(9):5193-9. Epub 2010 Mar 26.

Centro Nacional de Microbiología, Instituto de Salud Carlos III, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1000050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202692PMC
May 2010

Repulsion of superinfecting virions: a mechanism for rapid virus spread.

Science 2010 Feb 21;327(5967):873-876. Epub 2010 Jan 21.

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1183173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202693PMC
February 2010

Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection.

J Gen Virol 2008 Nov;89(Pt 11):2877-2881

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.2008/004119-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886957PMC
November 2008

Vaccinia virus morphogenesis and dissemination.

Trends Microbiol 2008 Oct 12;16(10):472-9. Epub 2008 Sep 12.

Department of Virology, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tim.2008.07.009DOI Listing
October 2008

Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence.

J Gen Virol 2008 Oct;89(Pt 10):2377-2387

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.2008/004895-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885005PMC
October 2008

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

PLoS Pathog 2008 Aug 15;4(8):e1000128. Epub 2008 Aug 15.

The Division of Structural Biology and the Oxford Protein Production Facility, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.ppat.1000128
Publisher Site
http://dx.doi.org/10.1371/journal.ppat.1000128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494871PMC
August 2008

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.

PLoS Pathog 2008 Feb;4(2):e22

Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.ppat.0040022
Publisher Site
http://dx.doi.org/10.1371/journal.ppat.0040022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233672PMC
February 2008

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS Pathog 2008 Jan;4(1):e5

The Division of Structural Biology and The Oxford Protein Production Facility, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.0040005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211551PMC
January 2008

Structure of CrmE, a virus-encoded tumour necrosis factor receptor.

J Mol Biol 2007 Sep 3;372(3):660-71. Epub 2007 Jul 3.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics and Oxford Protein Production Facility Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2007.06.082DOI Listing
September 2007

Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.

J Gen Virol 2007 Jul;88(Pt 7):1917-21

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.82815-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884953PMC
July 2007

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence.

J Gen Virol 2007 Jun;88(Pt 6):1667-76

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.82748-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885618PMC
June 2007

Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus.

Proc Natl Acad Sci U S A 2007 Jun 21;104(23):9822-7. Epub 2007 May 21.

Department of Biochemistry and Molecular Biology, University Hospital Cancer Center, New Jersey Medical School, Newark, NJ 07103, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0610352104
Publisher Site
http://dx.doi.org/10.1073/pnas.0610352104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887573PMC
June 2007

A new inhibitor of apoptosis from vaccinia virus and eukaryotes.

PLoS Pathog 2007 Feb;3(2):e17

Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.0030017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803007PMC
February 2007

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

J Biol Chem 2006 Dec 5;281(48):36652-61. Epub 2006 Oct 5.

National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M605584200DOI Listing
December 2006

Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination.

Nat Med 2006 Nov 5;12(11):1310-5. Epub 2006 Nov 5.

Department of Virology, Faculty of Medicine, Imperial College London, St. Mary's Campus, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm1457DOI Listing
November 2006

Genome sequence diversity and clues to the evolution of variola (smallpox) virus.

Science 2006 Aug 27;313(5788):807-12. Epub 2006 Jul 27.

Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1125134DOI Listing
August 2006

Vaccinia virus strain Western Reserve protein B14 is an intracellular virulence factor.

J Gen Virol 2006 Jun;87(Pt 6):1451-8

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.81736-0DOI Listing
June 2006

Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model.

J Gen Virol 2006 Jun;87(Pt 6):1521-9

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.81854-0DOI Listing
June 2006

Intradermal immune response after infection with Vaccinia virus.

J Gen Virol 2006 May;87(Pt 5):1157-61

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.81556-0DOI Listing
May 2006

Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.

J Gen Virol 2006 Apr;87(Pt 4):809-16

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.81427-0DOI Listing
April 2006

Ligand-induced and nonfusogenic dissolution of a viral membrane.

Proc Natl Acad Sci U S A 2006 Apr 3;103(15):5989-94. Epub 2006 Apr 3.

Department of Virology, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0601025103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1424662PMC
April 2006

B and CTL responses to the ALK protein in patients with ALK-positive ALCL.

Int J Cancer 2006 Feb;118(3):688-95

Nuffield Department of Clinical Laboratory Sciences, Leukaemia Research Fund Immunodiagnostics Unit, John Radcliffe Hospital, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21410DOI Listing
February 2006

Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy.

J Gen Virol 2006 Jan;87(Pt 1):29-38

Department of Virology, Faculty of Medicine, Imperial College London, UK.

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.81417-0DOI Listing
January 2006

Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy.

J Gen Virol 2005 Nov;86(Pt 11):2955-2960

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.81265-0DOI Listing
November 2005

Vaccinia virus intracellular enveloped virions move to the cell periphery on microtubules in the absence of the A36R protein.

J Gen Virol 2005 Nov;86(Pt 11):2961-2968

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.81260-0DOI Listing
November 2005

Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model.

J Gen Virol 2005 Jun;86(Pt 6):1589-1596

Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.80904-0DOI Listing
June 2005

Entry of the vaccinia virus intracellular mature virion and its interactions with glycosaminoglycans.

J Gen Virol 2005 May;86(Pt 5):1279-1290

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.80831-0DOI Listing
May 2005

An investigation of the therapeutic value of vaccinia-immune IgG in a mouse pneumonia model.

J Gen Virol 2005 Apr;86(Pt 4):991-1000

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.80660-0DOI Listing
April 2005

The exit of vaccinia virus from infected cells.

Virus Res 2004 Dec;106(2):189-97

Department of Virology, Faculty of Medicine, Imperial College London, St. Mary's Campus Norfolk Place, London W2 1PG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2004.08.015DOI Listing
December 2004