Dr. Geoffrey D. Clarke, PhD - University of Texas Health Science Center at San Antonio - Professor of Radiology

Dr. Geoffrey D. Clarke

PhD

University of Texas Health Science Center at San Antonio

Professor of Radiology

San Antonio, TX

Main Specialties: Abdominal Radiology, Cardiothoracic Radiology, Endocrinology Diabetes & Metabolism, Muscoskeletal Radiology

Additional Specialties: Medical Physics, MRI science

ORCID logohttps://orcid.org/0000-0003-4559-6437


Top Author

Dr. Geoffrey D. Clarke, PhD - University of Texas Health Science Center at San Antonio - Professor of Radiology

Dr. Geoffrey D. Clarke

PhD

Introduction

I have developed various proficiencies in several disciplines, including imaging physics and translational science. My initial training was in medical imaging physics and I was one of the first generation of MRI scientists to use the technology for investigating biomedical problems. At Virginia Commonwealth University, I developed imaging technologies and spectroscopic methods to study head trauma in a feline model and coronary artery disease in a canine model. Then, in Dallas, I received several grants from the American Heart Association (both regional and national) to develop MRI methods for measuring coronary flow and flow reserve. I was then recruited to San Antonio during which time I served as Chair of several national professional organizations that were involved the development of methods and standards for imaging technology assessments. I am the director of a graduate level courses in MRI and Biomedical Statistics. As the trend in Radiology is becoming dominated by advances in information technology, I concluded that this could be best leveraged by gaining a better understanding of modern molecular biology. I obtained a NIH K25 training grant in 2011, in which I focused on formal coursework in clinically-oriented research and developing a more complete understanding of the molecular biology precursors of disease in clinical populations. Through this process, I have become familiar with the problems and processes related to clinical research and the methods used in translational science. This greatly facilitated by ability to communicate with biologists. As a research medical physicist, it is my responsibility to provide effective technical support to colleagues who seek to develop practical image acquisition and analysis methods for their research programs. As Leader of the Imaging Core Research Laboratory at the Southwest National Primate Center, I advise and collaborate with a broad range of biomedical scientists, helping them to integrate imaging methods into their research programs. In addition, I continue my research into the mechanisms causing impaired cardiac function and the relationship between metabolism and heart disease in patients with diabetes.

Primary Affiliation: University of Texas Health Science Center at San Antonio - San Antonio, TX

Specialties:

Additional Specialties:

Research Interests:


View Dr. Geoffrey D. Clarke’s Resume / CV

Education

Nov 1984
University of Texas Health Science Center at Dallas
PhD
Radiological Sciences

Experience

Jan 2016
Professor
Chief, MRI Division
Research Imaging Institute, UTHSCSA

Publications

31Publications

526Reads

5Profile Views

72PubMed Central Citations

Computational modeling of human left ventricle to assess the role of trabeculae carneae on the diastolic and systolic functions.

J Biomech Eng 2019 May 22. Epub 2019 May 22.

Fellow of ASME, Department of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249; Biomedical Engineering Joint Graduate Program, UTSA-UTHSCSA, USA.

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http://dx.doi.org/10.1115/1.4043831DOI Listing
May 2019
2 Reads
1.780 Impact Factor

Intrauterine growth restriction results in persistent vascular mismatch in adulthood.

J Physiol 2018 12 21;596(23):5777-5790. Epub 2017 Nov 21.

Department of Animal Science, University of Wyoming, Laramie, WY, USA.

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http://dx.doi.org/10.1113/JP275139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265527PMC
December 2018
22 Reads
5.037 Impact Factor

Ageing changes in biventricular cardiac function in male and female baboons (Papio spp.).

J Physiol 2018 11 19;596(21):5083-5098. Epub 2018 Sep 19.

Radiology Department, University of Texas Health Science Center, San Antonio, TX, USA.

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http://dx.doi.org/10.1113/JP276338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209749PMC
November 2018
10 Reads
5.037 Impact Factor

The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.

Am J Obstet Gynecol 2018 09 11;219(3):301.e1-301.e16. Epub 2018 May 11.

Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Australia; Cincinnati Children's Hospital Medical Centre, Cincinnati, OH.

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http://dx.doi.org/10.1016/j.ajog.2018.05.007DOI Listing
September 2018
18 Reads
4.704 Impact Factor

Reduced skeletal muscle phosphocreatine concentration in type 2 diabetic patients: a quantitative image-based phosphorus-31 MR spectroscopy study.

Am J Physiol Endocrinol Metab 2018 08 6;315(2):E229-E239. Epub 2018 Mar 6.

Diabetes Division, University of Texas Health Science Center at San Antonio , San Antonio, Texas.

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http://dx.doi.org/10.1152/ajpendo.00426.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139498PMC
August 2018
53 Reads
3.785 Impact Factor

'Stiffening the sinews of the heart'.

J Physiol 2018 06 10;596(12):2279-2280. Epub 2018 May 10.

Department of Animal Science, College of Agriculture and Natural Resources, Laramie, WY, USA.

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http://dx.doi.org/10.1113/JP276234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002227PMC
June 2018
4 Reads
5.037 Impact Factor

Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons.

Int J Obes (Lond) 2018 06 30;42(5):1092-1096. Epub 2018 Jan 30.

Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1038/s41366-018-0008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019612PMC
June 2018
27 Reads
5.004 Impact Factor

Poor perinatal growth impairs baboon aortic windkessel function.

J Dev Orig Health Dis 2018 04 11;9(2):137-142. Epub 2017 Oct 11.

1Department of Radiology and Research Imaging Institute,University of Texas Health Science Center at San Antonio,San Antonio,TX,USA.

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http://dx.doi.org/10.1017/S2040174417000770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922776PMC
April 2018
5 Reads
0.765 Impact Factor

Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.

Endocrinol Diabetes Metab 2018 Apr 6;1(2):e00014. Epub 2018 Apr 6.

Diabetes Division Department of Medicine Texas Diabetes Institute University of Texas Health Science Center at San Antonio San Antonio TX USA.

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http://dx.doi.org/10.1002/edm2.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354805PMC
April 2018
24 Reads

Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons.

Int J Obes (Lond) 2017 08 24;41(8):1299-1302. Epub 2017 Mar 24.

Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1038/ijo.2017.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548625PMC
August 2017
5.004 Impact Factor

Maternal nutrient restriction during pregnancy and lactation leads to impaired right ventricular function in young adult baboons.

J Physiol 2017 07 18;595(13):4245-4260. Epub 2017 May 18.

Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1113/JP273928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491873PMC
July 2017
15 Reads
5.037 Impact Factor

Premature Brain Aging in Baboons Resulting from Moderate Fetal Undernutrition.

Front Aging Neurosci 2017 11;9:92. Epub 2017 Apr 11.

Texas Pregnancy and Life Course Health Research Center, Southwest National Primate Research Center, Texas Biomedical Research InstituteSan Antonio, TX, USA.

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http://dx.doi.org/10.3389/fnagi.2017.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386978PMC
April 2017
20 Reads
2.843 Impact Factor

Magnetic Resonance Imaging-Guided Delivery of Neural Stem Cells into the Basal Ganglia of Nonhuman Primates Reveals a Pulsatile Mode of Cell Dispersion.

Stem Cells Transl Med 2017 03 22;6(3):877-885. Epub 2016 Sep 22.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.

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http://dx.doi.org/10.5966/sctm.2016-0269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442780PMC
March 2017
17 Reads
3.596 Impact Factor

Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.

J Physiol 2017 02 17;595(4):1093-1110. Epub 2016 Dec 17.

Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

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http://dx.doi.org/10.1113/JP272908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309359PMC
February 2017
18 Reads
5.037 Impact Factor

Revitalization of pioglitazone: the optimum agent to be combined with a sodium-glucose co-transporter-2 inhibitor.

Diabetes Obes Metab 2016 May 6;18(5):454-62. Epub 2016 Apr 6.

Diabetes Division, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, TX, USA.

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http://dx.doi.org/10.1111/dom.12652DOI Listing
May 2016
2 Reads
6.360 Impact Factor

Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles.

J Med Imaging (Bellingham) 2015 Apr 9;2(2):026002. Epub 2015 Jun 9.

University of Texas Health Science Center , Research Imaging Institute, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, United States ; University of Texas Health Science Center , Department of Radiology, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, United States.

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http://dx.doi.org/10.1117/1.JMI.2.2.026002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478933PMC
April 2015
15 Reads

Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals.

Diabetes 2014 Aug 18;63(8):2812-20. Epub 2013 Dec 18.

Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX

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http://dx.doi.org/10.2337/db13-1130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113069PMC
August 2014
29 Reads
15 Citations
8.100 Impact Factor

Characterization of atherosclerotic plaque: a contrast-detail study using multidetector and cone-beam computed tomography.

J Appl Clin Med Phys 2014 Jan 6;15(1):4308. Epub 2014 Jan 6.

The University of Texas Health Science Center at San Antonio.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711236PMC
http://dx.doi.org/10.1120/jacmp.v15i1.4308DOI Listing
January 2014
5 Reads
1.110 Impact Factor

A comparison of five standard methods for evaluating image intensity uniformity in partially parallel imaging MRI.

Med Phys 2013 Aug;40(8):082302

Department of Radiology, The University of Texas Medical Branch, Galveston, TX 77550, USA.

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http://dx.doi.org/10.1118/1.4816306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745492PMC
August 2013
7 Reads
3 Citations
2.635 Impact Factor

On the use of molecular weight cutoff cassettes to measure dynamic relaxivity of novel gadolinium contrast agents: example using hyaluronic Acid polymer complexes in phosphate-buffered saline.

Radiol Res Pract 2011 16;2011:808795. Epub 2011 Nov 16.

Radiological Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1155/2011/808795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236320PMC
August 2012
4 Reads
1 Citation

Measuring signal-to-noise ratio in partially parallel imaging MRI.

Med Phys 2011 Sep;38(9):5049-57

Department of Radiology, The University of Texas Health Science Center, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1118/1.3618730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170395PMC
September 2011
2 Reads
7 Citations
2.635 Impact Factor

Routine testing of magnetic field homogeneity on clinical MRI systems.

Med Phys 2006 Nov;33(11):4299-306

Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA.

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http://dx.doi.org/10.1118/1.2359229DOI Listing
November 2006
37 Reads
2 Citations
2.635 Impact Factor

First-pass contrast-enhanced myocardial perfusion MRI using a maximum up-slope parametric map.

IEEE Trans Inf Technol Biomed 2006 Jul;10(3):574-80

Department of Radiology, University of Texas Health Science Center at San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1109/titb.2006.872058DOI Listing
July 2006
4 Reads
1 Citation
2.493 Impact Factor

Use and limitations of magnetic resonance phase-contrast assessment of coronary flow reserve in a model of collateral dependence.

Comp Med 2005 Aug;55(4):317-25

BrookeArmy Medical Center, Fort Sam Houston, Texas 78234, USA.

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August 2005
8 Reads
2 Citations
0.760 Impact Factor

Orientational dependence of intermolecular double quantum coherence (iDQC) signal from tendon tissue.

Magn Reson Med 2005 May;53(5):1183-6

Department of Radiology, University of Texas Health Science Center at San Antonio (UTHSCSA), USA.

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http://dx.doi.org/10.1002/mrm.20436DOI Listing
May 2005
4 Reads
1 Citation
3.571 Impact Factor