Publications by authors named "Geoffrey Chang"

45Publications

γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.

Langmuir 2020 06 4;36(23):6569-6579. Epub 2020 Jun 4.

Chemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.0c01178DOI Listing
June 2020

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States.

Sci Rep 2019 10 22;9(1):15092. Epub 2019 Oct 22.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0378, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-50578-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805939PMC
October 2019

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.

Proc Natl Acad Sci U S A 2019 08 30;116(33):16394-16403. Epub 2019 Jul 30.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1906658116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697900PMC
August 2019

Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos.

Methods Cell Biol 2019 9;151:353-376. Epub 2019 Mar 9.

Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, San Diego, CA, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0091679X183015
Publisher Site
http://dx.doi.org/10.1016/bs.mcb.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489465PMC
July 2019

Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor.

Sci Rep 2017 12 21;7(1):17996. Epub 2017 Dec 21.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-18146-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740117PMC
December 2017

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.

Sci Adv 2016 Apr 15;2(4):e1600001. Epub 2016 Apr 15.

Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.1600001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846432PMC
April 2016

Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2.

PLoS One 2016 5;11(4):e0152969. Epub 2016 Apr 5.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821612PMC
August 2016

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.

Acta Crystallogr D Biol Crystallogr 2015 Mar 26;71(Pt 3):732-41. Epub 2015 Feb 26.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://scripts.iucr.org/cgi-bin/paper?S1399004715000978
Publisher Site
http://dx.doi.org/10.1107/S1399004715000978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356375PMC
March 2015

Distinct conformational spectrum of homologous multidrug ABC transporters.

Structure 2015 Mar 5;23(3):450-460. Epub 2015 Feb 5.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351144PMC
March 2015

In vitro nanobody discovery for integral membrane protein targets.

Sci Rep 2014 Oct 24;4:6760. Epub 2014 Oct 24.

1] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 [2] Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep06760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208029PMC
October 2014

Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein.

FEBS J 2014 Feb 17;281(3):673-82. Epub 2014 Jan 17.

Drug Resistance Mechanism and Modulation group, Ligue 2013 certified, Molecular and Structural Basis of Infectious Systems, Mixed Research Unit between the National Centre for Scientific Research and Lyon I University n°5086, Institute of Biology and Chemistry of Proteins, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.12613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663232PMC
February 2014

Transporter-mediated biofuel secretion.

Proc Natl Acad Sci U S A 2013 May 23;110(19):7642-7. Epub 2013 Apr 23.

Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1301358110
Publisher Site
http://dx.doi.org/10.1073/pnas.1301358110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651508PMC
May 2013

Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.

J Biol Chem 2012 Aug 21;287(33):27971-82. Epub 2012 Jun 21.

Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.386979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431635PMC
August 2012

A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.

PLoS One 2011 3;6(8):e22577. Epub 2011 Aug 3.

Department of Cell Biology and Biochemistry, and Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149604PMC
December 2011

Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein.

Chembiochem 2011 Apr 8;12(6):868-73. Epub 2011 Mar 8.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201100048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814162PMC
April 2011

Structure of a cation-bound multidrug and toxic compound extrusion transporter.

Nature 2010 Oct 22;467(7318):991-4. Epub 2010 Sep 22.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB105, La Jolla, California 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature09408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152480PMC
October 2010

An Escherichia coli-based cell-free system for large-scale production of functional mammalian membrane proteins suitable for X-ray crystallography.

J Mol Microbiol Biotechnol 2010 17;18(2):85-91. Epub 2010 Feb 17.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, Calif. 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000283512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919436PMC
June 2010

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.

Trends Biochem Sci 2010 Jan 12;35(1):36-42. Epub 2009 Oct 12.

Department of Pharmacology, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2009.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608440PMC
January 2010

Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA.

J Struct Biol 2009 Mar 10;165(3):169-75. Epub 2008 Dec 10.

Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CB227, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2008.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703300PMC
March 2009

X-ray structure of EmrE supports dual topology model.

Proc Natl Acad Sci U S A 2007 Nov 16;104(48):18999-9004. Epub 2007 Nov 16.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0709387104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141897PMC
November 2007

Flexibility in the ABC transporter MsbA: Alternating access with a twist.

Proc Natl Acad Sci U S A 2007 Nov 16;104(48):19005-10. Epub 2007 Nov 16.

Departments of Cell Biology and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0709388104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141898PMC
November 2007

Designing facial amphiphiles for the stabilization of integral membrane proteins.

Angew Chem Int Ed Engl 2007 ;46(37):7023-5

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.200701556DOI Listing
February 2008

Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis.

Biochemistry 2007 May 7;46(17):5218-25. Epub 2007 Apr 7.

Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi7001604DOI Listing
May 2007

Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3668. Epub 2007 Feb 20.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0700711104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805606PMC
February 2007

Structure of the multidrug transporter EmrD from Escherichia coli.

Science 2006 May;312(5774):741-4

Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/cgi/doi/10.1126/science.1125629
Publisher Site
http://dx.doi.org/10.1126/science.1125629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152482PMC
May 2006

Lipopolysaccharide stabilizes the crystal packing of the ABC transporter MsbA.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jul 15;61(Pt 7):655-8. Epub 2005 Jun 15.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92137, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1744309105016969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952464PMC
July 2005

Inverted repeat domains in membrane proteins.

FEBS Lett 2006 Jan 28;580(2):358-62. Epub 2005 Dec 28.

The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2005.12.054DOI Listing
January 2006

X-ray structure of the EmrE multidrug transporter in complex with a substrate.

Science 2005 Dec;310(5756):1950-3

Department of Molecular Biology, The Scripps Institute, 10550 North Torrey Pines Road, CB-105, Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1119776DOI Listing
December 2005

The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.

FEBS Lett 2006 Feb 1;580(4):1042-8. Epub 2005 Dec 1.

Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CB105, La Jolla, CA 92137, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2005.11.033DOI Listing
February 2006

Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharide.

Science 2005 May;308(5724):1028-31

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road CB105, La Jolla, CA 92137, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1107733DOI Listing
May 2005

The past, present and future of cell-free protein synthesis.

Trends Biotechnol 2005 Mar;23(3):150-6

Invitrogen Corporation, 1600 Faraday Avenue, Carlsbad, CA 92008, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibtech.2005.01.003DOI Listing
March 2005

Crystallography of the integral membrane protein EmrE from Escherichia coli.

Acta Crystallogr D Biol Crystallogr 2004 Dec 26;60(Pt 12 Pt 2):2399-402. Epub 2004 Nov 26.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S090744490402548XDOI Listing
December 2004

Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli.

Proc Natl Acad Sci U S A 2004 Mar 17;101(9):2852-7. Epub 2004 Feb 17.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB-105, La Jolla, CA 92037.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0400137101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC365709PMC
March 2004

Multidrug resistance ABC transporters.

Authors:
Geoffrey Chang

FEBS Lett 2003 Nov;555(1):102-5

Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. CB-105, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-5793(03)01085-8DOI Listing
November 2003

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation.

Authors:
Geoffrey Chang

J Mol Biol 2003 Jul;330(2):419-30

Department of Molecular Biology, CB-105, The Scripps Research Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0022-2836(03)00587-4DOI Listing
July 2003