Publications by authors named "Gennaro De Libero"

100Publications

MR1-Restricted T Cells Are Unprecedented Cancer Fighters.

Front Immunol 2020 28;11:751. Epub 2020 Apr 28.

Experimental Immunology, Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2020.00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198878PMC
April 2020

'Bohemian Rhapsody' of MR1T cells.

Nat Immunol 2020 02;21(2):108-110

Experimental Immunology, Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41590-019-0588-6DOI Listing
February 2020

Activation of TCR Vδ1 and Vδ1Vδ2 γδ T Cells upon Controlled Infection with in Tanzanian Volunteers.

J Immunol 2020 01 4;204(1):180-191. Epub 2019 Dec 4.

Experimental Immunology, Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland;

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http://dx.doi.org/10.4049/jimmunol.1900669DOI Listing
January 2020

Isolation and Characterization of MAIT Cells from Human Tissue Biopsies.

Methods Mol Biol 2020 ;2098:23-38

Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1007/978-1-0716-0207-2_2DOI Listing
January 2020

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma.

Cell Mol Gastroenterol Hepatol 2020 22;9(2):195-218. Epub 2019 Aug 22.

Experimental Immunology, Department of Biomedicine, University of Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957799PMC
August 2019

The Conventional Nature of Non-MHC-Restricted T Cells.

Front Immunol 2018 14;9:1365. Epub 2018 Jun 14.

Experimental Immunology, Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2018.01365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010553PMC
June 2018

Editorial overview: Antigen processing.

Curr Opin Immunol 2018 06;52:iv-v

Faculty of Medicine at the University of Basel, Switzerland.

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http://dx.doi.org/10.1016/j.coi.2018.05.016DOI Listing
June 2018

Contact sensitizers trigger human CD1-autoreactive T-cell responses.

Eur J Immunol 2017 07 23;47(7):1171-1180. Epub 2017 May 23.

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.1002/eji.201746939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570453PMC
July 2017

Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis.

Vaccine 2017 03 9;35(10):1395-1402. Epub 2017 Feb 9.

Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, France. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.01.079DOI Listing
March 2017

From Immunologically Archaic to Neoteric Glycovaccines.

Vaccines (Basel) 2017 Jan 27;5(1). Epub 2017 Jan 27.

Experimental Immunology, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.3390/vaccines5010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371740PMC
January 2017

Microchip-based ultrafast serodiagnostic assay for tuberculosis.

Sci Rep 2016 10 24;6:35845. Epub 2016 Oct 24.

Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1038/srep35845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075771PMC
October 2016

Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.

Cell Chem Biol 2016 Sep;23(9):1147-1156

Experimental Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel 4031, Switzerland; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.07.021DOI Listing
September 2016

Selection of phage-displayed human antibody fragments specific for CD1b presenting the Mycobacterium tuberculosis glycolipid Ac2SGL.

Int J Mycobacteriol 2016 06 17;5(2):120-7. Epub 2016 Feb 17.

ADAPT Research Cluster, Centre for Research Initiative, Universiti Sains Malaysia, Malaysia; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.ijmyco.2015.12.002DOI Listing
June 2016

Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells.

Adv Healthc Mater 2016 06 29;5(11):1272-81. Epub 2016 Mar 29.

Institute of Bioengineeringand Nanotechnology (IBN), 31 Biopolis Way, The Nanos, #04-01, 138669, Singapore.

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http://dx.doi.org/10.1002/adhm.201600070DOI Listing
June 2016

The Immunology of CD1- and MR1-Restricted T Cells.

Annu Rev Immunol 2016 05 25;34:479-510. Epub 2016 Feb 25.

Department of Biomedicine, Basel University Hospital and Basel University, CH-4031 Basel, Switzerland; email: , ,

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http://dx.doi.org/10.1146/annurev-immunol-032414-112008DOI Listing
May 2016

Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells.

Virology 2016 Jan 14;487:285-95. Epub 2015 Nov 14.

Department of Microbiology and Immunology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo city, Tokyo 113-8602, Japan.

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http://dx.doi.org/10.1016/j.virol.2015.10.023DOI Listing
January 2016

Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner.

Eur J Immunol 2016 Jan 20;46(1):147-53. Epub 2015 Oct 20.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal.

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http://dx.doi.org/10.1002/eji.201545725DOI Listing
January 2016

Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen.

Oncoimmunology 2015 Mar 3;4(3):e970463. Epub 2014 Dec 3.

Experimental Immunology Unit; Division of Immunology, Transplantation and Infectious Diseases; San Raffaele Scientific Institute ; Milano, Italy.

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http://dx.doi.org/10.4161/21624011.2014.970463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404883PMC
March 2015

Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones.

Front Immunol 2014 15;5:679. Epub 2015 Jan 15.

Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR) , Singapore , Singapore ; Department of Biomedicine, University of Basel , Basel , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2014.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295553PMC
February 2015

Metformin as adjunct antituberculosis therapy.

Sci Transl Med 2014 Nov;6(263):263ra159

Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore. University Hospital Basel, University of Basel, Basel 4031, Switzerland.

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http://stm.sciencemag.org/content/scitransmed/6/263/263ra159
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30098
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http://dx.doi.org/10.1126/scitranslmed.3009885DOI Listing
November 2014

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice.

Nat Chem Biol 2014 Nov 5;10(11):950-6. Epub 2014 Oct 5.

1] Experimental Immunology Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland. [2] SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology and Research) Biopolis, Singapore.

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http://dx.doi.org/10.1038/nchembio.1650DOI Listing
November 2014

Nonclassical T cells and their antigens in tuberculosis.

Cold Spring Harb Perspect Med 2014 Jul 24;4(9):a018473. Epub 2014 Jul 24.

SIgN (Singapore Immunology Network), A*STAR (Agency for Science, Technology and Research), 138648 Singapore Experimental Immunology, Department of Biomedicine, University Hospital Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1101/cshperspect.a018473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143110PMC
July 2014

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.

PLoS Pathog 2014 Jun 26;10(6):e1004210. Epub 2014 Jun 26.

Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore; Program Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore; School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston Birmingham, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1004210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072808PMC
June 2014

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.

J Exp Med 2014 Jun 16;211(7):1363-77. Epub 2014 Jun 16.

Experimental Immunology, Department of Biomedicine, University Hospital Basel; Nuclear Magnetic Resonance Laboratory, Department of Chemistry; and Department of Biochemistry, Biozentrum; University of Basel, 4056 Basel, Switzerland Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research, Singapore 138648

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http://jem.rupress.org/content/211/7/1363.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20140410
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http://dx.doi.org/10.1084/jem.20140410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076585PMC
June 2014

The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis.

Front Immunol 2014 22;5:219. Epub 2014 May 22.

Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR) , Singapore , Singapore.

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http://dx.doi.org/10.3389/fimmu.2014.00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033098PMC
June 2014

Emerging technologies for monitoring drug-resistant tuberculosis at the point-of-care.

Adv Drug Deliv Rev 2014 Nov 2;78:105-17. Epub 2014 Jun 2.

Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Stanford University School of Medicine, Radiology Department, Canary Center at Stanford for Cancer Early Detection, Palo Alto, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254374PMC
November 2014

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.

Nat Commun 2014 May 15;5:3866. Epub 2014 May 15.

1] Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland [2] SIgN, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore.

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http://dx.doi.org/10.1038/ncomms4866DOI Listing
May 2014

Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells.

Bioorg Med Chem 2014 Jun 13;22(11):2966-73. Epub 2014 Apr 13.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896140025
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http://dx.doi.org/10.1016/j.bmc.2014.04.012DOI Listing
June 2014

Professional differences in antigen presentation to iNKT cells.

Immunity 2014 Jan;40(1):5-7

Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland and Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Biopolis, Singapore.

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http://dx.doi.org/10.1016/j.immuni.2013.12.008DOI Listing
January 2014

T cell recognition of non-peptidic antigens in infectious diseases.

Indian J Med Res 2013 Nov;138(5):620-31

SIgN (Singapore Immunology Network), AFNx01STAR (Agency for Science, Technology & Research), Singapore; Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland, .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928695PMC
November 2013

Simplified deoxypropionate acyl chains for Mycobacterium tuberculosis sulfoglycolipid analogues: chain length is essential for high antigenicity.

Chembiochem 2013 Dec 31;14(18):2413-7. Epub 2013 Oct 31.

Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS and Université de Toulouse, BP 64182, 205 route de Narbonne, 31077 Toulouse (France).

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http://dx.doi.org/10.1002/cbic.201300482DOI Listing
December 2013

IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.

J Immunol 2013 Apr 27;190(7):3142-52. Epub 2013 Feb 27.

Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research, Singapore 117609.

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http://www.jimmunol.org/content/190/7/3142.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1203218
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http://dx.doi.org/10.4049/jimmunol.1203218DOI Listing
April 2013

Point-of-care assays for tuberculosis: role of nanotechnology/microfluidics.

Biotechnol Adv 2013 Jul-Aug;31(4):438-49. Epub 2013 Jan 26.

Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.biotechadv.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602163PMC
January 2014

T cells specific for lipid antigens.

Immunol Res 2012 Sep;53(1-3):191-9

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Biopolis, Singapore.

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http://dx.doi.org/10.1007/s12026-012-8294-6DOI Listing
September 2012

Novel insights into lipid antigen presentation.

Trends Immunol 2012 Mar 16;33(3):103-11. Epub 2012 Feb 16.

Singapore Immunology Network, A*STAR, Singapore 138648, Singapore.

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http://dx.doi.org/10.1016/j.it.2012.01.005DOI Listing
March 2012

Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes.

Proc Natl Acad Sci U S A 2011 Aug 25;108(32):13230-5. Epub 2011 Jul 25.

Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse F-31077, France.

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http://dx.doi.org/10.1073/pnas.1105627108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156185PMC
August 2011

The HOX gene network in hepatocellular carcinoma.

Int J Cancer 2011 Dec 30;129(11):2577-87. Epub 2011 May 30.

Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy.

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http://dx.doi.org/10.1002/ijc.25941DOI Listing
December 2011

High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells.

Eur J Immunol 2011 Mar 18;41(3):602-10. Epub 2011 Jan 18.

Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, DIBIT, San Raffaele Scientific Institute, Milano, Italy.

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http://dx.doi.org/10.1002/eji.201041211DOI Listing
March 2011

The easy virtue of CD1c.

Immunity 2010 Dec;33(6):831-3

Experimental Immunology, Department of Biomedicine, University Hospital Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.immuni.2010.12.001DOI Listing
December 2010

Invariant natural killer T cells: linking inflammation and neovascularization in human atherosclerosis.

Eur J Immunol 2010 Nov 27;40(11):3268-79. Epub 2010 Oct 27.

Laboratory for Signal Transduction, Department of Biomedicine, Basel University Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1002/eji.201040619DOI Listing
November 2010

Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.

J Immunol 2010 Feb 21;184(3):1235-41. Epub 2009 Dec 21.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.jimmunol.org/content/184/3/1235.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0804140
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http://dx.doi.org/10.4049/jimmunol.0804140DOI Listing
February 2010

How the immune system detects lipid antigens.

Prog Lipid Res 2010 Apr 24;49(2):120-7. Epub 2009 Oct 24.

Experimental Immunology, Department of Biomedicine University Hospital, University of Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.plipres.2009.10.002DOI Listing
April 2010

4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens.

Chem Biodivers 2009 Oct;6(10):1688-715

Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich.

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http://dx.doi.org/10.1002/cbdv.200900045DOI Listing
October 2009

The cellular and biochemical rules of lipid antigen presentation.

Eur J Immunol 2009 Oct;39(10):2648-56

Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1002/eji.200939425DOI Listing
October 2009

Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cells.

Infect Immun 2009 Nov 31;77(11):4947-52. Epub 2009 Aug 31.

Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Roma, Italy.

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http://dx.doi.org/10.1128/IAI.00607-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772541PMC
November 2009

Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides.

Chem Biodivers 2009 May;6(5):705-24

Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH-Zürich, Wolfgang-Pauli-Strasse 10, Zürich.

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http://dx.doi.org/10.1002/cbdv.200900013DOI Listing
May 2009

Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells.

Chem Biodivers 2009 May;6(5):725-38

Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH-Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich.

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http://dx.doi.org/10.1002/cbdv.200900039DOI Listing
May 2009

Fatty acyl structures of mycobacterium tuberculosis sulfoglycolipid govern T cell response.

J Immunol 2009 Jun;182(11):7030-7

Departement Mécanismes Moléculaires des Infections Mycobactériennes, Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0804044
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http://dx.doi.org/10.4049/jimmunol.0804044DOI Listing
June 2009

Synthesis of diacylated trehalose sulfates: candidates for a tuberculosis vaccine.

Angew Chem Int Ed Engl 2008 ;47(50):9734-8

Département des Mécanismes Moléculaires des Infections, Mycobactériennes, Institut de Pharmacologie et de Biologie Structurale du CNRS, UMR 5089, Université de Toulouse III, 205 route de Narbonne, 31077 Toulouse Cedex, France.

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http://doi.wiley.com/10.1002/anie.200803835
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http://dx.doi.org/10.1002/anie.200803835DOI Listing
December 2008

Synthesis of alpha-galactosyl ceramide (KRN7000) and analogues thereof via a common precursor and their preliminary biological assessment.

J Org Chem 2008 Nov 29;73(22):9192-5. Epub 2008 Oct 29.

Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale Amedeo Avogadro, via Bovio 6, 28100 Novara, Italy.

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http://dx.doi.org/10.1021/jo8019994DOI Listing
November 2008

Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells.

Eur J Immunol 2008 Aug;38(8):2200-9

Experimental Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/eji.200838366DOI Listing
August 2008

CD1a and MHC class I follow a similar endocytic recycling pathway.

Traffic 2008 Sep 28;9(9):1446-57. Epub 2008 Jun 28.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2008.00781.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839101PMC
September 2008

Presentation of lipid antigens to T cells.

Immunol Lett 2008 Apr 15;117(1):1-8. Epub 2008 Jan 15.

Experimental Immunology, Department of Research, University Hospital, Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.imlet.2007.11.027DOI Listing
April 2008

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations.

Blood 2008 Apr 14;111(7):3863-6. Epub 2008 Jan 14.

Department of Research, Experimental Hematology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2007-09-111971DOI Listing
April 2008

How T cells get grip on lipid antigens.

Curr Opin Immunol 2008 Feb 11;20(1):96-104. Epub 2007 Dec 11.

Experimental Immunology, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.coi.2007.10.008DOI Listing
February 2008

A general and stereoselective route to alpha- or beta-galactosphingolipids via a common four-carbon building block.

J Org Chem 2007 Sep 5;72(20):7757-60. Epub 2007 Sep 5.

Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, Via Saldini 50, 20133-Milano, Italy.

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http://pubs.acs.org/doi/abs/10.1021/jo070849z
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http://dx.doi.org/10.1021/jo070849zDOI Listing
September 2007

Modification of the ceramide moiety of isoglobotrihexosylceramide on its agonist activity in stimulation of invariant natural killer T cells.

J Med Chem 2007 Jul 4;50(15):3489-96. Epub 2007 Jul 4.

Departments of Biochemistry and Chemistry, The Ohio State University, 876 Biological Sciences Building, 484 West 12th Avenue, Columbus, Ohio 43210, and Experimental Immunology, Department of Research, University Hospital Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1021/jm0701066DOI Listing
July 2007

MR1-restricted Valpha19i T cells: a second population recognizing lipid antigens?

Eur J Immunol 2007 Jul;37(7):1724-6

Experimental Immunology, Department of Research, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/eji.200737509DOI Listing
July 2007

Synthesis and evaluation of human T cell stimulating activity of an alpha-sulfatide analogue.

Bioorg Med Chem 2007 Aug 23;15(16):5529-36. Epub 2007 May 23.

Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, Via Saldini 50, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.05.044DOI Listing
August 2007

How pattern recognition receptor triggering influences T cell responses: a new look into the system.

Trends Immunol 2007 Jul 29;28(7):308-14. Epub 2007 May 29.

Lisbon Medical School, 1649-028 Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.it.2007.05.002DOI Listing
July 2007

Differential alteration of lipid antigen presentation to NKT cells due to imbalances in lipid metabolism.

Eur J Immunol 2007 Jun;37(6):1431-41

Experimental Immunology, Department of Research, University Hospital Basel, Basel, Switzerland.

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http://doi.wiley.com/10.1002/eji.200737160
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http://dx.doi.org/10.1002/eji.200737160DOI Listing
June 2007

T cell recognition of lipids: quo vadis?

Nat Immunol 2007 Mar;8(3):223-7

Gennaro De Libero is with Experimental Immunology, Department of Research, University Hospital Basel, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1038/ni0307-223DOI Listing
March 2007

How T lymphocytes recognize lipid antigens.

FEBS Lett 2006 Oct 28;580(23):5580-7. Epub 2006 Aug 28.

Experimental Immunology, Department of Research, University Hospital, University of Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.febslet.2006.08.029DOI Listing
October 2006

Mechanisms of lipid-antigen generation and presentation to T cells.

Trends Immunol 2006 Oct 5;27(10):485-92. Epub 2006 Sep 5.

Experimental Immunology, Department of Research, University Hospital, University of Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.it.2006.08.001DOI Listing
October 2006

Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.

EMBO J 2006 Aug 27;25(15):3684-92. Epub 2006 Jul 27.

CNRS, UMR5089, Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

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http://dx.doi.org/10.1038/sj.emboj.7601244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538567PMC
August 2006

Stereoselective synthesis and immunogenic activity of the C-analogue of sulfatide.

Org Lett 2006 Jul;8(15):3255-8

Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, Via Saldini 50, 20133-Milano, Italy, and Experimental Immunology, Department of Research, Basel University Hospital, Hebelstrasse 20, 4031-Basel, Switzerland.

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http://dx.doi.org/10.1021/ol061100yDOI Listing
July 2006

Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells.

J Allergy Clin Immunol 2006 May 21;117(5):1178-84. Epub 2006 Feb 21.

Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1016/j.jaci.2006.01.001DOI Listing
May 2006

Synthesis of sulfated galactocerebrosides from an orthogonal beta-D-galactosylceramide scaffold for the study of CD1-antigen interactions.

Chemistry 2006 Jul;12(21):5587-95

Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, Via Saldini 50, 20133-Milan, Italy.

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http://dx.doi.org/10.1002/chem.200501586DOI Listing
July 2006

Functional CD1a is stabilized by exogenous lipids.

Eur J Immunol 2006 May;36(5):1083-92

Experimental Immunology, Department of Research University Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1002/eji.200535544DOI Listing
May 2006

Synthesis and biological evaluation of alpha-galactosylceramide (KRN7000) and isoglobotrihexosylceramide (iGb3).

Bioorg Med Chem Lett 2006 Apr 2;16(8):2195-9. Epub 2006 Feb 2.

Department of Biochemistry, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.01.040DOI Listing
April 2006

Serum lipoproteins: Trojan horses of the immune response?

Trends Immunol 2006 Feb 27;27(2):57-9. Epub 2005 Dec 27.

Experimental Immunology, Department of Research, University Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.it.2005.12.005DOI Listing
February 2006

Human CD1-restricted T cell recognition of lipids from pollens.

J Exp Med 2005 Jul 11;202(2):295-308. Epub 2005 Jul 11.

Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy.

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http://dx.doi.org/10.1084/jem.20050773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213012PMC
July 2005

Recognition of lipid antigens by T cells.

Nat Rev Immunol 2005 Jun;5(6):485-96

Experimental Immunology, Department of Research, University Hospital, Basel 4031, Switzerland.

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http://dx.doi.org/10.1038/nri1631DOI Listing
June 2005

Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis.

J Exp Med 2004 Mar 23;199(5):649-59. Epub 2004 Feb 23.

Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et de Biologie Structurale du CNRS, Toulouse 31077, Cedex 4, France.

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http://dx.doi.org/10.1084/jem.20031097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213295PMC
March 2004

Immunology. The Robin Hood of antigen presentation.

Science 2004 Jan;303(5657):485-7

Department of Research, University Hospital Basel, Basel CH-4031, Switzerland.

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http://dx.doi.org/10.1126/science.1093953DOI Listing
January 2004

Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes.

News Physiol Sci 2003 Apr;18:71-6

Experimental Immunology, Department of Research, University Hospital, Basel, CH-4031 Basel, Switzerland.

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http://dx.doi.org/10.1152/nips.01418.2002DOI Listing
April 2003