Publications by authors named "Gene W Yeo"

100Publications

Base editing: advances and therapeutic opportunities.

Nat Rev Drug Discov 2020 Oct 19. Epub 2020 Oct 19.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41573-020-0084-6DOI Listing
October 2020

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.

Genes Dev 2020 Oct 10;34(19-20):1330-1344. Epub 2020 Sep 10.

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.339895.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528705PMC
October 2020

Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.

Proc Natl Acad Sci U S A 2020 09 26;117(36):22204-22213. Epub 2020 Aug 26.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.2000643117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486754PMC
September 2020

Large-scale tethered function assays identify factors that regulate mRNA stability and translation.

Nat Struct Mol Biol 2020 Oct 17;27(10):989-1000. Epub 2020 Aug 17.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41594-020-0477-6DOI Listing
October 2020

GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Neuron 2020 Sep 15;107(6):1124-1140.e11. Epub 2020 Jul 15.

Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.06.027DOI Listing
September 2020

The DEAD-box protein Hera is a general RNA binding protein and plays a key role in tRNA metabolism.

RNA 2020 Nov 15;26(11):1557-1574. Epub 2020 Jul 15.

University of Muenster, Institute for Physical Chemistry, 48149 Muenster, Germany.

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http://dx.doi.org/10.1261/rna.075580.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566566PMC
November 2020

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.

Genes Dev 2020 Aug 2;34(15-16):1089-1105. Epub 2020 Jul 2.

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1101/gad.338178.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397853PMC
August 2020

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.

Mol Cell 2020 04;78(1):9-29

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202378PMC
April 2020

RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering.

Nat Cell Biol 2020 02 3;22(2):143-150. Epub 2020 Feb 3.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41556-019-0454-7DOI Listing
February 2020

The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.

Curr Biol 2020 03 23;30(5):865-876.e7. Epub 2020 Jan 23.

Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.12.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147385PMC
March 2020

Direct RNA sequencing enables mA detection in endogenous transcript isoforms at base-specific resolution.

RNA 2020 01 17;26(1):19-28. Epub 2019 Oct 17.

Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1261/rna.072785.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913132PMC
January 2020

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.

Cell Stem Cell 2019 11 3;25(5):622-638.e13. Epub 2019 Oct 3.

Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247364PMC
November 2019

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Cell Stem Cell 2019 10 29;25(4):558-569.e7. Epub 2019 Aug 29.

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Kavli Institute for Brain and Mind and Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778040PMC
October 2019

Peptide Brush Polymers for Efficient Delivery of a Gene Editing Protein to Stem Cells.

Angew Chem Int Ed Engl 2019 10 18;58(44):15646-15649. Epub 2019 Sep 18.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/anie.201904894DOI Listing
October 2019

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.

Neuron 2019 09 1;103(5):802-819.e11. Epub 2019 Jul 1.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728177PMC
September 2019

Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

Front Mol Neurosci 2019 11;12:150. Epub 2019 Jun 11.

Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI) Mind and Brain, Adelaide, SA, Australia.

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http://dx.doi.org/10.3389/fnmol.2019.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580186PMC
June 2019

Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.

Cell Rep 2019 04;27(5):1356-1363.e3

Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508666PMC
April 2019

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing.

Cell Rep 2019 04;27(4):1244-1253.e4

Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.095DOI Listing
April 2019

Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions.

Neuron 2019 04;102(2):294-320

Department of Neurology, The Sean M. Healey and AMG Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273193027
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http://dx.doi.org/10.1016/j.neuron.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545120PMC
April 2019

A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.

Mol Cell 2019 01 6;73(2):304-313.e3. Epub 2018 Dec 6.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338497PMC
January 2019

RBP-Maps enables robust generation of splicing regulatory maps.

RNA 2019 02 9;25(2):193-204. Epub 2018 Nov 9.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

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http://rnajournal.cshlp.org/lookup/doi/10.1261/rna.069237.11
Publisher Site
http://dx.doi.org/10.1261/rna.069237.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348990PMC
February 2019

Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.

Front Mol Neurosci 2018 10;11:261. Epub 2018 Aug 10.

Laboratory for Human Neurophysiology and Genetics, South Australian Health and Medical Research Institute (SAHMRI) Mind and Brain, Adelaide, SA, Australia.

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http://dx.doi.org/10.3389/fnmol.2018.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096303PMC
August 2018

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.

Cell Stem Cell 2018 Jul;23(1):123-131.e6

Department of Stem Cell Biology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany; IZKF Junior Research Group 3 and BMBF Research Group Neuroscience, Interdisciplinary Center for Clinical Research, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.stem.2018.06.015DOI Listing
July 2018

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys.

RNA 2018 09 29;24(9):1255-1265. Epub 2018 Jun 29.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1261/rna.066951.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097662PMC
September 2018

Sequence, Structure, and Context Preferences of Human RNA Binding Proteins.

Mol Cell 2018 06 7;70(5):854-867.e9. Epub 2018 Jun 7.

Department of Biology, MIT, Cambridge, MA, USA; Department of Biological Engineering, MIT, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062212PMC
June 2018

Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9.

Nucleic Acids Res 2018 08;46(14):7323-7338

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1093/nar/gky348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101491PMC
August 2018

Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels.

Mol Cell 2018 03;69(6):1005-1016.e7

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92037, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Molecular Engineering Laboratory, A★STAR, Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659731PMC
March 2018

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.

Cell 2018 01;172(3):590-604.e13

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92039, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore; Molecular Engineering Laboratory, A(∗)STAR, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969999PMC
January 2018

Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas.

Bioconjug Chem 2018 01 29;29(1):126-135. Epub 2017 Dec 29.

Department of Chemistry, Materials Science and Engineering, Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993044PMC
January 2018

Short poly(A) tails are a conserved feature of highly expressed genes.

Nat Struct Mol Biol 2017 Dec 6;24(12):1057-1063. Epub 2017 Nov 6.

Division of Biology, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nsmb.3499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877826PMC
December 2017

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.

Nucleic Acids Res 2017 Dec;45(21):12509-12528

Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, Québec H2W 1R7, Canada.

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http://dx.doi.org/10.1093/nar/gkx963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716212PMC
December 2017

Advances and challenges in the detection of transcriptome-wide protein-RNA interactions.

Wiley Interdiscip Rev RNA 2018 01 29;9(1). Epub 2017 Aug 29.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/wrna.1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739989PMC
January 2018

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.

Nat Struct Mol Biol 2017 Oct 28;24(10):816-824. Epub 2017 Aug 28.

State Key Laboratory of Virology and Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1038/nsmb.3455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766049PMC
October 2017

Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.

Cell 2017 Aug 10;170(5):899-912.e10. Epub 2017 Aug 10.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Stem Cell Program, University of California at San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA, USA; Molecular Engineering Laboratory, A(∗)STAR, Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873302PMC
August 2017

Variation in single-nucleotide sensitivity of eCLIP derived from reverse transcription conditions.

Methods 2017 08 5;126:29-37. Epub 2017 Aug 5.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Stem Cell Program, University of California at San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA, USA; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Molecular Engineering Laboratory, A*STAR, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582984PMC
August 2017

Genetic mutations in RNA-binding proteins and their roles in ALS.

Hum Genet 2017 09 31;136(9):1193-1214. Epub 2017 Jul 31.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117593, Singapore.

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http://dx.doi.org/10.1007/s00439-017-1830-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602095PMC
September 2017

Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.

Mol Cell 2017 Jul 29;67(1):148-161.e5. Epub 2017 Jun 29.

Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Molecular Engineering Laboratory, A(∗)STAR, Singapore 138632, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540791PMC
July 2017

Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.

Cell Metab 2017 May;25(5):1160-1175.e11

Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501713PMC
May 2017

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.

Stem Cell Reports 2017 04;8(4):1101-1111

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390243PMC
April 2017

CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins.

Methods 2017 04 18;118-119:50-59. Epub 2016 Dec 18.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA; Stem Cell Program, University of California at San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA, USA; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Molecular Engineering Laboratory, A*STAR, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411315PMC
April 2017

Making the cut in the dark genome.

Science 2016 11;354(6313):705-706

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.aak9849DOI Listing
November 2016

From Protein-RNA Predictions toward a Peptide-RNA Code.

Mol Cell 2016 11;64(3):437-438

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Molecular Engineering Laboratory, A(∗)STAR, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.023DOI Listing
November 2016

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.

Neuron 2016 Nov 20;92(4):780-795. Epub 2016 Oct 20.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; Molecular Engineering Laboratory, A(∗)STAR, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123850PMC
November 2016

Pairing beyond the Seed Supports MicroRNA Targeting Specificity.

Mol Cell 2016 10 6;64(2):320-333. Epub 2016 Oct 6.

Division of Biology, University of California, San Diego, La Jolla, CA 92093-0349, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074850PMC
http://dx.doi.org/10.1016/j.molcel.2016.09.004DOI Listing
October 2016

SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes.

Mol Cell 2016 10 6;64(2):282-293. Epub 2016 Oct 6.

Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore; Molecular Engineering Laboratory, A(∗)STAR, 138673 Singapore, Singapore. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074894PMC
http://dx.doi.org/10.1016/j.molcel.2016.09.003DOI Listing
October 2016

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.

Cell Chem Biol 2016 Nov 13;23(11):1372-1382. Epub 2016 Oct 13.

Myocardial Pathophysiology Program, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain; National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.09.010DOI Listing
November 2016

Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.

Genome Med 2016 Sep 21;8(1):94. Epub 2016 Sep 21.

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel, 4070, Switzerland.

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http://dx.doi.org/10.1186/s13073-016-0347-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031259PMC
September 2016

Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins.

Adv Exp Med Biol 2016 ;907:61-88

Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/978-3-319-29073-7_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569382PMC
July 2017

Experimental and Computational Considerations in the Study of RNA-Binding Protein-RNA Interactions.

Adv Exp Med Biol 2016 ;907:1-28

Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California, La Jolla, CA, USA.

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http://link.springer.com/10.1007/978-3-319-29073-7_1
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http://dx.doi.org/10.1007/978-3-319-29073-7_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522005PMC
July 2017

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.

Cell Rep 2016 06 26;15(10):2200-2213. Epub 2016 May 26.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899142PMC
June 2016

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.

Nature 2016 Apr;532(7600):508-511

Department of Biochemistry and Biomedical Sciences, Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1038/nature17665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880456PMC
April 2016

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.

Cell Rep 2016 Apr 7;15(3):666-679. Epub 2016 Apr 7.

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Molecular Engineering Laboratory, A(∗)STAR, Singapore 1190777, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 1190777, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839292PMC
April 2016

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

Cell 2016 Apr 24;165(2):396-409. Epub 2016 Mar 24.

Ludwig Institute for Cancer Research, San Diego, CA 92093, USA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826293PMC
April 2016

Programmable RNA Tracking in Live Cells with CRISPR/Cas9.

Cell 2016 Apr 17;165(2):488-96. Epub 2016 Mar 17.

Department of Cellular and Molecular Medicine and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Materials Science and Engineering Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 1190777, Singapore. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30204-5.pdf
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http://dx.doi.org/10.1016/j.cell.2016.02.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826288PMC
April 2016

Blurred Boundaries: The RNA Binding Protein Lin28A Is Also an Epigenetic Regulator.

Mol Cell 2016 Jan;61(1):1-2

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Molecular Engineering Laboratory, A(∗)STAR, 138673 Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117549 Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.018DOI Listing
January 2016

A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.

Cell Rep 2015 Oct 1;13(2):326-36. Epub 2015 Oct 1.

Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607666PMC
October 2015

Reply to: "CD8(+) T cell diversification by asymmetric cell division".

Nat Immunol 2015 Sep;16(9):893-4

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/ni.3234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758127PMC
September 2015

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.

Mol Cell 2015 Aug;59(3):413-25

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673969PMC
August 2015

Applications of Cas9 as an RNA-programmed RNA-binding protein.

Bioessays 2015 Jul 16;37(7):732-9. Epub 2015 Apr 16.

Department of Cellular and Molecular Medicine, Stem Cell Program, and Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/bies.201500001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672944PMC
July 2015

Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.

PLoS Genet 2015 Apr 2;11(4):e1005123. Epub 2015 Apr 2.

Department of Cellular and Molecular Medicine, Moores UCSD Cancer Center and Institute for Genomic Medicine, University of California, San Diego School of Medicine, La Jolla, California, United States of America; Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California, United States of America; Biomedical Sciences Graduate Program, University of California, San Diego School of Medicine, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383553PMC
April 2015

The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.

Annu Rev Biochem 2015 11;84:325-54. Epub 2015 Mar 11.

Department of Molecular Genetics, Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210; email:

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http://www.annualreviews.org/doi/10.1146/annurev-biochem-080
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http://dx.doi.org/10.1146/annurev-biochem-080111-092106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804868PMC
December 2015

RNA-binding proteins in neurodegeneration: Seq and you shall receive.

Trends Neurosci 2015 Apr 9;38(4):226-36. Epub 2015 Mar 9.

Department of Cellular and Molecule Medicine, Institute for Genomic Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA, USA; Department of Physiology, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403644PMC
April 2015

Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development.

Circulation 2015 Apr 4;131(14):1278-1290. Epub 2015 Mar 4.

Gene Expression Laboratory (L.K., A.A., I.S.-M., T.H., T.B.N., P.R., E.N., M.N.K., C.R.E., J.C.I.B.) and Integrative Genomics Core (C.B.), Salk Institute for Biological Studies, La Jolla, CA; University of California San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, Institute for Genomic Medicine, Sanford Consortium for Regenerative Medicine, La Jolla (L.K., T.B.N., D.A.N., G.W.Y.); and Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain (J.M.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443804PMC
April 2015