Prof Gehad ElGhazali, MD, PhD - Clinical Immunology - Professor of clinical Immunology

Prof Gehad ElGhazali

MD, PhD

Clinical Immunology

Professor of clinical Immunology

Abu Dhabi, Abu Dhabi | United Arab Emirates

Main Specialties: Clinical & Laboratory Immunology

Additional Specialties: Clinical immunology

ORCID logohttps://orcid.org/0000-0001-9514-3765


Top Author

Prof Gehad ElGhazali, MD, PhD - Clinical Immunology - Professor of clinical Immunology

Prof Gehad ElGhazali

MD, PhD

Introduction

PhD clinical Inmunology
American board
Swedish board

Primary Affiliation: Clinical Immunology - Abu Dhabi, Abu Dhabi , United Arab Emirates

Specialties:

Additional Specialties:

Research Interests:


View Prof Gehad ElGhazali’s Resume / CV

Education

Oct 2008
American Board ML Immunology
ABMLI
Clinical Immunology
Sep 2000 - Jun 2004
Uppsala Universitet Medicinska fakulteten
MD, PhD
Clinical Immunology
May 1999
Stockholm university
PhD
Immunology

Experience

Sep 2013 - Sep 2013
Sheikh Khalifa Medical City
Consultant and Service Lead Immunologist

Publications

50Publications

1205Reads

32Profile Views

Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

Authors:
Eric Scott

2016

Nature genetics

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Gulf region, North Africa, and Central Asia 13, has resulted in an elevated burden of recessive disease4. Here we generated a whole exome GME variome from 1,111 unrelated subjects. We detected substantial diversity from sub-geographies, continental and subregional admixture, several ancient founder populations with little evidence of bottlenecks. Measured consanguinity was an order-of-magnitude above that of other sampled populations, and included an increased burden of runs of homozygosity (ROH), but no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved GME recessive conditions reduced the number of potential disease-causing variants by 4–7-fold. These results reveal the variegated GME genetic architecture and support future human genetic discoveries in Mendelian and population genetics.

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December 2019

Microcephaly and intracranial calcifications: Not always TORCH infection!

J Paediatr Child Health 2019 Aug;55(8):1000-1001

Department of Immunology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1111/jpc.14535DOI Listing
August 2019
11 Reads
1.193 Impact Factor

Good outcome of the single-center pediatric kidney transplant program in Abu Dhabi.

Authors:
Kumar G et al.

Pediatr Transplant. 2019 Aug 13:e13566.

Pediatric transplantation

Abstract

Renal transplantation is the treatment of choice for ESRD in children. It is associated with better quality of life, growth of children, and improved long-term survival. The aim of the study was to evaluate the outcomes of pediatric renal transplantation at a tertiary care center in UAE. A retrospective chart review was undertaken for all the pediatric renal transplants performed at Sheikh Khalifa Medical City, Abu Dhabi, UAE, over the past 9 years. The study evaluated the demographic data, outcomes, and complications of pediatric renal transplantation. The post-transplantation outcomes including surgical complications, documented infections, graft rejection, graft and patient survival, effect on growth, and eGFR were reviewed. Between 2010 and 2018, 30 pediatric patients underwent renal transplantation. The follow-up period ranged from 1 to 9 years with a mean of 3.3 years. The mean age of the patients at the time of transplant was 9.8 years, and 56.7% were males. Prior to the transplantation, the majority of the recipients were on peritoneal dialysis (70.0%). Main source of renal donation at our center was from LRD, chiefly from parents. Patient survival at 1 and 5 years was 100% and 96.7%, respectively. Graft survival at 1 and 5 years was 96.7% and 83.3%, respectively. During the 9-year follow-up period, 5 (16.7%) recipients experienced rejection episode. This study demonstrates that during 5-year period, pediatric kidney transplantation program has achieved optimal patient (96.7%) and graft (83.3%) survival rates and is comparable to well-established centers.

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August 2019
4 Reads

Identification of a novel HLA-C allele, HLA-C*16:123N, in an Emirati blood donor.

HLA 2019 Jun 18;93(6):505-506. Epub 2019 Mar 18.

Department of Immunology and Histocompatibility, Sheikh Khalifa Medical City, Pathology and Lab Medicine Services, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1111/tan.13468DOI Listing
June 2019
4 Reads

Human Leukocyte Antigen (HLA) class I and II datasets for sudanese.

Data Brief 2019 Jun 21;24:104027. Epub 2019 May 21.

Department of Immunology, Pathology and Laboratory Medicine Services, Sheikh Khalifa Medical City, Abu Dhabi, P.O Box 51900, United Arab Emirates.

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http://dx.doi.org/10.1016/j.dib.2019.104027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545336PMC
June 2019
7 Reads

Antibody responses to P. falciparum Apical Membrane Antigen 1(AMA-1) in relation to haemoglobin S (HbS), HbC, G6PD and ABO blood groups among Fulani and Masaleit living in Western Sudan.

Acta Trop 2018 Jun 24;182:115-123. Epub 2018 Feb 24.

Department of clinical Immunology, PaLMS-Sheikh Khalifa Medical City, P.O. Box 51900, Abu Dhabi, United Arab Emirates; Department of Microbiology and Immunology, Faculty of Medicine, University of Khartoum, Sudan.

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X173121
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http://dx.doi.org/10.1016/j.actatropica.2018.02.030DOI Listing
June 2018
27 Reads
2.270 Impact Factor

Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus.

J Steroid Biochem Mol Biol 2018 01 18;175:119-124. Epub 2017 Mar 18.

Faculty of Biomedical Engineering, Khalifa University of Science, Technology & Research, Abu Dhabi, United Arab Emirates; College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.03.012DOI Listing
January 2018
12 Reads
3.628 Impact Factor

Relationship between MTHFR C677T and A1298C gene polymorphisms and complications of type 2 diabetes mellitus in an Emirati population.

Meta Gene 2016 Sep 17;9:70-5. Epub 2016 Apr 17.

Khalifa University Center of Biotechnology, Abu Dhabi, United Arab Emirates; Faculty of Biomedical Engineering, Khalifa University of Science, Technology & Research, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1016/j.mgene.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856855PMC
September 2016
46 Reads

Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases.

J Allergy Clin Immunol 2016 07 28;138(1):241-248.e3. Epub 2016 Feb 28.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, Paris, France; Paris Descartes University, Imagine Institute, Paris, France; Center for the Study of Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.041DOI Listing
July 2016
237 Reads
11.476 Impact Factor

Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).

Hum Immunol 2016 Jan 2;77(1):110-114. Epub 2015 Nov 2.

Mafraq Hospital and Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

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https://linkinghub.elsevier.com/retrieve/pii/S01988859150055
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http://dx.doi.org/10.1016/j.humimm.2015.10.019DOI Listing
January 2016
14 Reads
2.138 Impact Factor

Seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: a gender disparity.

World J Gastroenterol 2014 Nov;20(42):15830-6

Yousif A Abu-Zeid, Department of Biology, College of Science, United Arab Emirates University, Al Ain, Abu Dhabi AE-AZ, United Arab Emirates.

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http://dx.doi.org/10.3748/wjg.v20.i42.15830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229550PMC
November 2014
9 Reads
2.369 Impact Factor

Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis.

Hum Immunol 2014 Jun 6;75(6):536-40. Epub 2014 Mar 6.

Mafraq Hospital and Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1016/j.humimm.2014.02.023DOI Listing
June 2014
12 Reads
2.138 Impact Factor

Anti-citrullinated peptide antibodies and rheumatoid factor in Sudanese patients with Leishmania donovani infection.

Rev Bras Reumatol 2011 Dec;51(6):579-86

Unidade de Imunologia Clínica, Uppsala University, Suécia.

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December 2011
62 Reads
0.993 Impact Factor

Associations of multi-locus polymorphisms in an immune network with susceptibility to uncomplicated Plasmodium falciparum malaria in Daraweesh village, Eastern Sudan.

Infect Genet Evol 2011 Oct 26;11(7):1674-81. Epub 2011 Jun 26.

Department of Biochemistry, Faculty of Medicine, Arabian Gulf University (AGU), Bahrain, Sudan.

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http://dx.doi.org/10.1016/j.meegid.2011.06.015DOI Listing
October 2011
21 Reads
3.015 Impact Factor

Distribution of the major cytochrome P450 (CYP) 2C9 genetic variants in a Saudi population.

Basic Clin Pharmacol Toxicol 2011 Aug 28;109(2):111-4. Epub 2011 Mar 28.

King Saud Bin Abdulaziz University for Health Sciences, King Fahad Medical City, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1111/j.1742-7843.2011.00692.xDOI Listing
August 2011
7 Reads
2.377 Impact Factor

Activity and turnover of eosinophil and neutrophil granulocytes are altered in visceral leishmaniasis.

Int J Parasitol 2011 Mar 21;41(3-4):463-9. Epub 2010 Dec 21.

Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ijpara.2010.11.005DOI Listing
March 2011
9 Reads
3.872 Impact Factor

Effects of Plasmodium falciparum infection on the pharmacokinetics of quinine and its metabolites in pregnant and non-pregnant Sudanese women.

Eur J Clin Pharmacol 2010 Dec 18;66(12):1229-34. Epub 2010 Aug 18.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-010-0877-3DOI Listing
December 2010
5 Reads
2.966 Impact Factor

Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs.

Infect Genet Evol 2010 May 7;10(4):481-6. Epub 2010 Mar 7.

Department of Medical Biochemistry, Faculty of Medicine and Medical Sciences, Arabian Gulf University, PO Box 26671, Manama, Bahrain.

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http://linkinghub.elsevier.com/retrieve/pii/S156713481000047
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http://dx.doi.org/10.1016/j.meegid.2010.02.013DOI Listing
May 2010
33 Reads
3.015 Impact Factor

Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

Mol Med 2010 Jan-Feb;16(1-2):27-33. Epub 2009 Nov 17.

Department of Medical Biochemistry, Faculty of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

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http://dx.doi.org/10.2119/molmed.2009.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781302PMC
March 2010
13 Reads
4.508 Impact Factor

Age-dependent association between IgG2 and IgG3 subclasses to Pf332-C231 antigen and protection from malaria, and induction of protective antibodies by sub-patent malaria infections, in Daraweesh.

Vaccine 2010 Feb 28;28(7):1732-9. Epub 2009 Dec 28.

Department of Medical Biochemistry, Faculty of Medicine and Medical Sciences, Arabian Gulf University AGU, PO Box 26671, Manama, Kingdom of Bahrain.

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http://dx.doi.org/10.1016/j.vaccine.2009.12.018DOI Listing
February 2010
15 Reads
3.624 Impact Factor

Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria.

Malar J 2009 Dec 22;8:306. Epub 2009 Dec 22.

Department of Biochemistry, Faculty of Medicine and Medical Sciences, Arabian Gulf University (AGU), PO Box 26671, Manama, Kingdom of Bahrain.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
Publisher Site
http://dx.doi.org/10.1186/1475-2875-8-306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805690PMC
December 2009
33 Reads
3.109 Impact Factor

FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan.

Malar J 2009 Mar 13;8:43. Epub 2009 Mar 13.

Department of Microbiology and Molecular-Biology, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
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http://dx.doi.org/10.1186/1475-2875-8-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660360PMC
March 2009
21 Reads
3.109 Impact Factor

Bimodal transmission of cerebral malaria and severe malarial anemia and reciprocal co-existence of sexual and asexual parasitemia in an area of seasonal malaria transmission.

Parasitol Res 2008 Jun;103(1):81-5

Malaria Research Centre, Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan.

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http://dx.doi.org/10.1007/s00436-008-0931-6DOI Listing
June 2008
39 Reads
2.327 Impact Factor

The profile of IgG-antibody response against merozoite surface proteins 1 and 2 in severe Plasmodium falciparum malaria in Eastern Sudan.

Parasitol Res 2008 Feb 24;102(3):401-9. Epub 2007 Nov 24.

Malaria Research Centre, Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan.

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http://dx.doi.org/10.1007/s00436-007-0777-3DOI Listing
February 2008
13 Reads
2.327 Impact Factor

Interethnic differences in carriage of haemoglobin AS and Fcgamma receptor IIa (CD32) genotypes in children living in eastern Sudan.

Acta Trop 2008 Feb 11;105(2):191-5. Epub 2007 Oct 11.

Department of Immunology, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 16, SE-10 691 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.actatropica.2007.10.003DOI Listing
February 2008
20 Reads
2.270 Impact Factor

Fc gamma RIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD).

Am J Trop Med Hyg 2007 Dec;77(6):1074-8

Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.

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December 2007
49 Reads
2.699 Impact Factor

Allelic polymorphism of MSP2 gene in severe P. falciparum malaria in an area of low and seasonal transmission.

Parasitol Res 2007 Dec 4;102(1):29-34. Epub 2007 Sep 4.

Malaria Research Centre (MalRC), Department of Biochemistry, University of Khartoum, P.O. Box 102, Khartoum, Sudan.

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http://dx.doi.org/10.1007/s00436-007-0716-3DOI Listing
December 2007
7 Reads
2.327 Impact Factor

Genetic fingerprints of parasites causing severe malaria in a setting of low transmission in Sudan.

J Mol Microbiol Biotechnol 2007 ;13(1-3):89-95

Malaria Research Centre, Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

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http://dx.doi.org/10.1159/000103600DOI Listing
November 2007
4 Reads
2.104 Impact Factor

Cystatin C as a marker of immune complex-associated renal impairment in a Sudanese population with visceral leishmaniasis.

Am J Trop Med Hyg 2006 Nov;75(5):864-8

Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan.

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http://www.ajtmh.org/content/75/5/864.full.pdf
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November 2006
7 Reads
2.699 Impact Factor

Drug resistance-virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission.

Acta Trop 2006 Feb 5;97(2):181-7. Epub 2005 Dec 5.

Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan.

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http://linkinghub.elsevier.com/retrieve/pii/S0001706X0500326
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http://dx.doi.org/10.1016/j.actatropica.2005.10.004DOI Listing
February 2006
10 Reads
2.270 Impact Factor

Cerebral malaria is frequently associated with latent parasitemia among the semi-immune population of eastern Sudan.

Microbes Infect 2005 Aug-Sep;7(11-12):1196-203

Malaria Research Center (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan.

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http://dx.doi.org/10.1016/j.micinf.2005.04.004DOI Listing
December 2005
14 Reads
2.861 Impact Factor

Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria.

Acta Trop 2003 Jul;87(2):279-85

Department of Biochemistry, Faculty of Medicine, University of Khartoum, Box 102 Khartoum, Sudan.

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http://dx.doi.org/10.1016/s0001-706x(03)00116-5DOI Listing
July 2003
12 Reads
2.270 Impact Factor

Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria.

Acta Trop 2003 Apr;86(1):55-62

Department of Immunology, Stockholm University, Sv Arrheniusv. 16F5, S-106 91 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0001-706x(03)00005-6DOI Listing
April 2003
2 Reads
2.270 Impact Factor

IgE and tumor necrosis factor in malaria infection.

Immunol Lett 1999 Jan;65(1-2):29-33

Department of Immunology, Stockholm University, Sweden.

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http://dx.doi.org/10.1016/s0165-2478(98)00120-5DOI Listing
January 1999
1 Read
2.512 Impact Factor

Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria.

Infect Immun 1997 Jan;65(1):116-21

Department of Immunology, Stockholm University, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174564PMC
January 1997
2 Reads
3.731 Impact Factor

Characterization of regulatory T-cell responses in humans induced by the P. Falciparum blood stage antigen Pf155/RESA.

Behring Inst Mitt 1994 Dec(95):97-105

Department of Immunology, Stockholm University, Sweden.

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December 1994
3 Reads

Top co-authors

Hayder A Giha
Hayder A Giha

University of Khartoum

15
Klavs Berzins
Klavs Berzins

Stockholm University

14
Amre Nasr
Amre Nasr

College of Medicine

12
Marita Troye-Blomberg
Marita Troye-Blomberg

Stockholm University

12
Mustafa I Elbashir
Mustafa I Elbashir

University of Khartoum

9
Nnaemeka C Iriemenam
Nnaemeka C Iriemenam

Wenner-Gren Institute

7
M Troye-Blomberg
M Troye-Blomberg

Stockholm University

6
Thor G Theander
Thor G Theander

Copenhagen University Hospital (Rigshospitalet)

4