Publications by authors named "Geert J L H van Leenders"

100Publications

Restricting False-positive Magnetic Resonance Imaging Scans to Reduce Overdiagnosis of Prostate Cancer.

Eur Urol 2020 Nov 5. Epub 2020 Nov 5.

Department of Radiology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2020.10.013DOI Listing
November 2020

Differential diagnosis and mutation stratification of desmoid-type fibromatosis on MRI using radiomics.

Eur J Radiol 2020 Oct 8;131:109266. Epub 2020 Sep 8.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejrad.2020.109266DOI Listing
October 2020

Automated detection of cribriform growth patterns in prostate histology images.

Sci Rep 2020 09 10;10(1):14904. Epub 2020 Sep 10.

Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

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http://dx.doi.org/10.1038/s41598-020-71942-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483768PMC
September 2020

Eight Endorsements of the International Society of Urological Pathology from the 2019 Consensus Conference on Grading of Prostatic Carcinoma.

J Urol 2020 Sep 8:101097JU0000000000001356. Epub 2020 Sep 8.

Department of Pathology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.

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http://dx.doi.org/10.1097/JU.0000000000001356DOI Listing
September 2020

The 2019 International Society of Urological Pathology Consensus Conference on Prostate Cancer Grading.

Eur Urol 2020 Aug 23. Epub 2020 Aug 23.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1016/j.eururo.2020.08.004DOI Listing
August 2020

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery.

Genomics Proteomics Bioinformatics 2020 Apr 12;18(2):104-119. Epub 2020 Aug 12.

Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou 310024, China; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou 310024, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2019.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646093PMC
April 2020

Prostate cancer growth patterns beyond the Gleason score: entering a new era of comprehensive tumour grading.

Histopathology 2020 Dec 13;77(6):850-861. Epub 2020 Sep 13.

Department of Pathology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/his.14214DOI Listing
December 2020

Intraductal carcinoma has a minimal impact on Grade Group assignment in prostate cancer biopsy and radical prostatectomy specimens.

Histopathology 2020 Nov 11;77(5):742-748. Epub 2020 Sep 11.

Department of Pathology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/his.14179DOI Listing
November 2020

Nivolumab plus ipilimumab as neoadjuvant treatment in primary advanced renal cell tumors: Cutting edges for cutting-edge surgery.

Urol Oncol 2020 05 19;38(5):553-554. Epub 2020 Mar 19.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2020.01.009DOI Listing
May 2020

Clinicopathological characteristics of glomeruloid architecture in prostate cancer.

Mod Pathol 2020 08 20;33(8):1618-1625. Epub 2020 Feb 20.

Department of Pathology, Erasmus MC, University Medical Center, P.O. Box 2040, 3000, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41379-020-0507-2DOI Listing
August 2020

PD-L1 testing in urothelial carcinoma: are we there yet?

Transl Androl Urol 2019 Dec;8(Suppl 5):S466-S468

Department of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.21037/tau.2019.10.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989841PMC
December 2019

Comparison of Tumor Volume Parameters on Prostate Cancer Biopsies.

Arch Pathol Lab Med 2020 Jan 6. Epub 2020 Jan 6.

From the Departments of Pathology (Ms Verhoef, Drs Kweldam, Kümmerlin, and van Leenders), Public Health (Mr Nieboer), Urology (Mr Nieboer, Drs Bangma and Roobol), and Radiotherapy (Dr Incrocci), Erasmus MC University Medical Center, Rotterdam, the Netherlands; and Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada (Dr van der Kwast).

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http://dx.doi.org/10.5858/arpa.2019-0361-OADOI Listing
January 2020

Multi-line fluorescence scanning microscope for multi-focal imaging with unlimited field of view.

Biomed Opt Express 2019 Dec 18;10(12):6313-6339. Epub 2019 Nov 18.

Department of Imaging Physics, Delft University of Technology, The Netherlands.

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http://dx.doi.org/10.1364/BOE.10.006313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913394PMC
December 2019

EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study).

Eur Urol 2019 Dec 3;76(6):790-813. Epub 2019 Oct 3.

Department of Urology, University Hospital Jean Monnet, St. Etienne, France.

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http://dx.doi.org/10.1016/j.eururo.2019.09.020DOI Listing
December 2019

Concordance of cribriform architecture in matched prostate cancer biopsy and radical prostatectomy specimens.

Histopathology 2019 Sep 2;75(3):338-345. Epub 2019 Aug 2.

Department of Pathology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/his.13893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851781PMC
September 2019

Three-dimensional architecture of common benign and precancerous prostate epithelial lesions.

Histopathology 2019 Jun 21;74(7):1036-1044. Epub 2019 Apr 21.

Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/his.13848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849837PMC
June 2019

PD-L1 Antibody Comparison in Urothelial Carcinoma.

Eur Urol 2019 03 27;75(3):538-540. Epub 2018 Nov 27.

Department of Pathology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2018.11.002DOI Listing
March 2019

Identifying cystogenic paracrine signaling molecules in cyst fluid of patients with polycystic kidney disease.

Am J Physiol Renal Physiol 2019 01 7;316(1):F204-F213. Epub 2018 Nov 7.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, Rotterdam , The Netherlands.

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https://www.physiology.org/doi/10.1152/ajprenal.00470.2018
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http://dx.doi.org/10.1152/ajprenal.00470.2018DOI Listing
January 2019

Concordance of PD-L1 expression in matched urothelial bladder cancer specimens.

Histopathology 2018 Dec 25;73(6):983-989. Epub 2018 Sep 25.

Department of Pathology, Erasmus Medical Centre, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1111/his.13710
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http://dx.doi.org/10.1111/his.13710DOI Listing
December 2018

Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression.

Cancer Res 2018 08 19;78(16):4671-4679. Epub 2018 Jun 19.

Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3752DOI Listing
August 2018

Metric substage according to micro and extensive lamina propria invasion improves prognostics in T1 bladder cancer.

Urol Oncol 2018 08 5;36(8):361.e7-361.e13. Epub 2018 Jun 5.

Department of Surgical Oncology (Urology), Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany; Department of Urology, Erasmus MC Cancer Institute, Erasmus MC, Rotterdam, The Netherlands; Department of Surgical Oncology (Urology), University Health Network, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2018.05.007DOI Listing
August 2018

Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.

Clin Cancer Res 2018 06 6;24(11):2678-2687. Epub 2018 Mar 6.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3512DOI Listing
June 2018

Primary Cystic Lesions of the Retrorectal Space: MRI Evaluation and Clinical Assessment.

AJR Am J Roentgenol 2017 Oct 13;209(4):790-796. Epub 2017 Jul 13.

3 Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.2214/AJR.16.17329DOI Listing
October 2017

EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study.

Int J Mol Sci 2016 Sep 29;17(10). Epub 2016 Sep 29.

Department of Urology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen 9700 RB, The Netherlands.

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http://dx.doi.org/10.3390/ijms17101650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085683PMC
September 2016

Three-dimensional microscopic analysis of clinical prostate specimens.

Histopathology 2016 Dec 21;69(6):985-992. Epub 2016 Sep 21.

Department of Pathology, Erasmus Medical Centre, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/his.13022DOI Listing
December 2016

Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia.

Am J Med 2016 Aug 18;129(8):e131-2. Epub 2016 Apr 18.

Department of Internal Medicine, IJsselland Hospital, Capelle aan den IJssel, The Netherlands.

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http://dx.doi.org/10.1016/j.amjmed.2016.03.026DOI Listing
August 2016

Comparison of RNA extraction kits and histological stains for laser capture microdissected prostate tissue.

BMC Res Notes 2016 Jan 7;9:17. Epub 2016 Jan 7.

Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13104-015-1813-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705748PMC
January 2016

The role of HOXC6 in prostate cancer development.

Prostate 2015 Dec 27;75(16):1868-76. Epub 2015 Aug 27.

Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/pros.23065DOI Listing
December 2015

Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications.

Mod Pathol 2015 May 28;28(5):695-705. Epub 2014 Nov 28.

1] Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands [2] Department of Surgical Pathology, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/modpathol.2014.154DOI Listing
May 2015

Prognostic histopathological and molecular markers on prostate cancer needle-biopsies: a review.

Biomed Res Int 2014 27;2014:341324. Epub 2014 Aug 27.

Department of Pathology, Josephine Nefkens Institute, Room Be-206, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1155/2014/341324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163394PMC
May 2016

Disease-specific death and metastasis do not occur in patients with Gleason score ≤6 at radical prostatectomy.

BJU Int 2015 Aug 7;116(2):230-5. Epub 2015 Mar 7.

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1111/bju.12879
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http://dx.doi.org/10.1111/bju.12879DOI Listing
August 2015

Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients.

Am J Surg Pathol 2014 Dec;38(12):1588-602

*Department of Anatomical Pathology †Cancer Diagnosis and Pathology Research Group §§Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital ‡University of Sydney, Sydney ††Histopath Pathology ¶¶Douglass Hanly Moir Pathology, North Ryde ‡‡Department of Anatomical Pathology, St Vincents Hospital, Darlinghurst §§§Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW ∥∥Pathology Queensland, Gold Coast University Hospital, Qld ****Department of Anatomical Pathology, Royal Children's Hospital, Parkville, Vic., Australia §Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic ∥Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam ##Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands ¶Department of Pathology, Singapore General Hospital, Singapore, Singapore #Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany **Department of Pathology, Oslo University Hospital ***Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway †††Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH ¶¶¶Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI ††††Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD ‡‡‡Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada ∥∥∥Department of Pathology, Hopital Cochin Université Paris Descartes, Paris, France ###Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee, UK.

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http://dx.doi.org/10.1097/PAS.0000000000000292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229399PMC
December 2014

Hyaline fibromatosis of Hoffa's fat pad in a patient with a mild type of hyaline fibromatosis syndrome.

Skeletal Radiol 2014 Apr 17;43(4):531-4. Epub 2013 Oct 17.

Department of Radiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00256-013-1746-9DOI Listing
April 2014

Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer.

Int J Cancer 2013 Jul 12;133(2):335-45. Epub 2013 Feb 12.

Department of Urology Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.28025DOI Listing
July 2013

A Calculator for Prostate Cancer Risk 4 Years After an Initially Negative Screen: Findings from ERSPC Rotterdam.

Eur Urol 2013 Apr 20;63(4):627-33. Epub 2012 Jul 20.

Department of Urology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2012.07.029DOI Listing
April 2013

Down-staging (

Virchows Arch 2012 Aug 10;461(2):149-56. Epub 2012 Jul 10.

Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00428-012-1277-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421107PMC
August 2012

A new and highly prognostic system to discern T1 bladder cancer substage.

Eur Urol 2012 Feb 25;61(2):378-84. Epub 2011 Oct 25.

Department of Surgical Oncology, Division of Urology, University Health Network, Princess Margaret Hospital, Toronto, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S030228381101132
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http://dx.doi.org/10.1016/j.eururo.2011.10.026DOI Listing
February 2012

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.

Authors:
Annegien Broeks Marjanka K Schmidt Mark E Sherman Fergus J Couch John L Hopper Gillian S Dite Carmel Apicella Letitia D Smith Fleur Hammet Melissa C Southey Laura J Van 't Veer Renate de Groot Vincent T H B M Smit Peter A Fasching Matthias W Beckmann Sebastian Jud Arif B Ekici Arndt Hartmann Alexander Hein Ruediger Schulz-Wendtland Barbara Burwinkel Frederik Marme Andreas Schneeweiss Hans-Peter Sinn Christof Sohn Sandrine Tchatchou Stig E Bojesen Børge G Nordestgaard Henrik Flyger David D Ørsted Diljit Kaur-Knudsen Roger L Milne Jose I Arias Pérez Pilar Zamora Primitiva Menéndez Rodríguez Javier Benítez Hiltrud Brauch Christina Justenhoven Yon-Dschun Ko Ute Hamann Hans-Peter Fischer Thomas Brüning Beate Pesch Jenny Chang-Claude Shan Wang-Gohrke Michael Bremer Johann H Karstens Peter Hillemanns Thilo Dörk Heli A Nevanlinna Tuomas Heikkinen Päivi Heikkilä Carl Blomqvist Kristiina Aittomäki Kirsimari Aaltonen Annika Lindblom Sara Margolin Arto Mannermaa Veli-Matti Kosma Jaana M Kauppinen Vesa Kataja Päivi Auvinen Matti Eskelinen Ylermi Soini Georgia Chenevix-Trench Amanda B Spurdle Jonathan Beesley Xiaoqing Chen Helene Holland Diether Lambrechts Bart Claes Thijs Vandorpe Patrick Neven Hans Wildiers Dieter Flesch-Janys Rebecca Hein Thomas Löning Matthew Kosel Zachary S Fredericksen Xianshu Wang Graham G Giles Laura Baglietto Gianluca Severi Catriona McLean Christopher A Haiman Brian E Henderson Loic Le Marchand Laurence N Kolonel Grethe Grenaker Alnæs Vessela Kristensen Anne-Lise Børresen-Dale David J Hunter Susan E Hankinson Irene L Andrulis Anna Marie Mulligan Frances P O'Malley Peter Devilee Petra E A Huijts Rob A E M Tollenaar Christi J Van Asperen Caroline S Seynaeve Stephen J Chanock Jolanta Lissowska Louise Brinton Beata Peplonska Jonine Figueroa Xiaohong R Yang Maartje J Hooning Antoinette Hollestelle Rogier A Oldenburg Agnes Jager Mieke Kriege Bahar Ozturk Geert J L H van Leenders Per Hall Kamila Czene Keith Humphreys Jianjun Liu Angela Cox Daniel Connley Helen E Cramp Simon S Cross Sabapathy P Balasubramanian Malcolm W R Reed Alison M Dunning Douglas F Easton Manjeet K Humphreys Carlos Caldas Fiona Blows Kristy Driver Elena Provenzano Jan Lubinski Anna Jakubowska Tomasz Huzarski Tomasz Byrski Cezary Cybulski Bohdan Gorski Jacek Gronwald Paul Brennan Suleeporn Sangrajrang Valerie Gaborieau Chen-Yang Shen Chia-Ni Hsiung Jyh-Cherng Yu Shou-Tung Chen Giu-Cheng Hsu Ming-Feng Hou Chiun-Sheng Huang Hoda Anton-Culver Argyrios Ziogas Paul D P Pharoah Montserrat Garcia-Closas

Hum Mol Genet 2011 Aug 19;20(16):3289-303. Epub 2011 May 19.

Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://hmg.oxfordjournals.org/content/20/16/3289.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddr228
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http://dx.doi.org/10.1093/hmg/ddr228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140824PMC
August 2011

Antibody EPR3864 is specific for ERG genomic fusions in prostate cancer: implications for pathological practice.

Mod Pathol 2011 Aug 15;24(8):1128-38. Epub 2011 Apr 15.

Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.2011.65DOI Listing
August 2011

No evidence of FGFR3 mutations in prostate cancer.

Prostate 2011 May 18;71(6):637-41. Epub 2010 Oct 18.

Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/pros.21279DOI Listing
May 2011

Performance of the prostate cancer antigen 3 (PCA3) gene and prostate-specific antigen in prescreened men: exploring the value of PCA3 for a first-line diagnostic test.

Eur Urol 2010 Oct 9;58(4):475-81. Epub 2010 Jul 9.

Erasmus MC, University Medical Centre, Department of Urology, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eururo.2010.06.039DOI Listing
October 2010

Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer.

Cancer Res 2010 Feb 19;70(3):1256-64. Epub 2010 Jan 19.

Departments of Internal Medicine, Urology, and Pathology, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2092DOI Listing
February 2010

False-negative prostate needle biopsies: frequency, histopathologic features, and follow-up.

Am J Surg Pathol 2010 Jan;34(1):35-43

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/PAS.0b013e3181c3ece9DOI Listing
January 2010