Gebhard Schertler

Gebhard Schertler

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Gebhard Schertler

Gebhard Schertler

Publications by authors named "Gebhard Schertler"

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Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR.

Proc Natl Acad Sci U S A 2019 Jul 27;116(29):14547-14556. Epub 2019 Jun 27.

Department of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5303 Villigen-PSI, Switzerland;

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http://dx.doi.org/10.1073/pnas.1902192116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642406PMC
July 2019

The counterion-retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation.

Commun Biol 2019 13;2:180. Epub 2019 May 13.

1Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, 558-8585 Japan.

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http://dx.doi.org/10.1038/s42003-019-0409-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513861PMC
May 2019

The Two-Photon Reversible Reaction of the Bistable Jumping Spider Rhodopsin-1.

Biophys J 2019 Apr 5;116(7):1248-1258. Epub 2019 Mar 5.

Division of Biology and Chemistry-Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland; Department of Biology, ETH Zürich, Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451042PMC
April 2019

Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

Nat Commun 2018 09 13;9(1):3712. Epub 2018 Sep 13.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1038/s41467-018-06002-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137068PMC
September 2018

Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish.

Proc Natl Acad Sci U S A 2018 06 23;115(24):6201-6206. Epub 2018 May 23.

Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1721333115DOI Listing
June 2018

The role of water molecules in phototransduction of retinal proteins and G protein-coupled receptors.

Faraday Discuss 2018 04;207(0):27-37

Division of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.

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http://dx.doi.org/10.1039/c7fd00207fDOI Listing
April 2018

Ligand channel in pharmacologically stabilized rhodopsin.

Proc Natl Acad Sci U S A 2018 04 19;115(14):3640-3645. Epub 2018 Mar 19.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland;

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http://dx.doi.org/10.1073/pnas.1718084115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889642PMC
April 2018

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.

EMBO Rep 2016 10 25;17(10):1431-1440. Epub 2016 Jul 25.

Division of Biology and Chemistry, Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland

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http://dx.doi.org/10.15252/embr.201642671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048376PMC
October 2016

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.

Nature 2016 Feb 3;530(7589):237-41. Epub 2016 Feb 3.

Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1038/nature16577DOI Listing
February 2016

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.

Cell Rep 2016 Jan 24;14(1):32-42. Epub 2015 Dec 24.

Howard Hughes Medical Institute, Brandeis University, 415 South Street, Waltham, MA 02454; Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02454. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706811PMC
January 2016

Probing Gαi1 protein activation at single-amino acid resolution.

Nat Struct Mol Biol 2015 Sep 10;22(9):686-694. Epub 2015 Aug 10.

Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland.

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http://www.nature.com/articles/nsmb.3070
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http://dx.doi.org/10.1038/nsmb.3070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876908PMC
September 2015

Membrane protein structural biology using X-ray free electron lasers.

Curr Opin Struct Biol 2015 Aug 3;33:115-25. Epub 2015 Sep 3.

Laboratory of Biomolecular Research, Paul Scherrer Institute, CH-5232 Villigen, Switzerland; Biology Department, ETH Zürich, Wolfgang-Pauli-Strasse 27, 8093 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2015.08.006DOI Listing
August 2015

Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser.

Acta Crystallogr F Struct Biol Commun 2015 Jul 27;71(Pt 7):856-60. Epub 2015 Jun 27.

Laboratory for Biomolecular Research, Paul Scherrer Institute, OFLC/103, 5232 Villigen-PSI, Switzerland.

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http://dx.doi.org/10.1107/S2053230X15009966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498706PMC
July 2015

Rhodopsin on tracks: new ways to go in signaling.

Structure 2015 Apr;23(4):606-8

Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen, Switzerland; Department of Biology, ETH Zurich, Wolfgang-Pauli-Str. 27, 8093 Zürich, Switzerland. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(15)00086-6.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261500086
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http://dx.doi.org/10.1016/j.str.2015.03.008DOI Listing
April 2015

Conformational activation of visual rhodopsin in native disc membranes.

Sci Signal 2015 Mar 10;8(367):ra26. Epub 2015 Mar 10.

Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, 40530 Gothenburg, Sweden.

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http://dx.doi.org/10.1126/scisignal.2005646DOI Listing
March 2015

Large scale expression and purification of the rat 5-HT2c receptor.

Protein Expr Purif 2015 Feb 28;106:1-9. Epub 2014 Oct 28.

Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2014.10.010DOI Listing
February 2015

Molecular mechanism of phosphorylation-dependent arrestin activation.

Curr Opin Struct Biol 2014 Dec 5;29:143-51. Epub 2014 Dec 5.

Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2014.07.006DOI Listing
December 2014

Retinal proteins - you can teach an old dog new tricks.

Biochim Biophys Acta 2014 May 25;1837(5):531-2. Epub 2014 Feb 25.

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http://dx.doi.org/10.1016/j.bbabio.2014.02.019DOI Listing
May 2014

Femtosecond X-ray diffraction from two-dimensional protein crystals.

IUCrJ 2014 Mar 28;1(Pt 2):95-100. Epub 2014 Feb 28.

Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory , 3335 Innovation Boulevard, Richland, WA 99354, USA ; Department of Molecular and Cellular Biology, University of California, Davis , 1 Shields Avenue, Davis, CA 95616, USA.

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http://dx.doi.org/10.1107/S2052252514001444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062087PMC
March 2014

Two alternative conformations of a voltage-gated sodium channel.

J Mol Biol 2013 Nov 2;425(22):4074-88. Epub 2013 Jul 2.

Paul Scherrer Institute, 5232 Villigen, Switzerland.

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http://dx.doi.org/10.1016/j.jmb.2013.06.036DOI Listing
November 2013

Structure of β-adrenergic receptors.

Methods Enzymol 2013 ;520:117-51

Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzerland.

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http://dx.doi.org/10.1016/B978-0-12-391861-1.00006-XDOI Listing
June 2013

Production of GPCR and GPCR complexes for structure determination.

Curr Opin Struct Biol 2013 Jun 24;23(3):381-92. Epub 2013 May 24.

Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.

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http://dx.doi.org/10.1016/j.sbi.2013.04.006DOI Listing
June 2013

Molecular signatures of G-protein-coupled receptors.

Nature 2013 Feb;494(7436):185-94

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://www.nature.com/doifinder/10.1038/nature11896
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http://dx.doi.org/10.1038/nature11896DOI Listing
February 2013

Ligands stabilize specific GPCR conformations: but how?

Structure 2012 Aug;20(8):1289-90

Laboratory of Biomolecular Research, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland.

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http://dx.doi.org/10.1016/j.str.2012.07.009DOI Listing
August 2012

Conserved activation pathways in G-protein-coupled receptors.

Biochem Soc Trans 2012 Apr;40(2):383-8

Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen PSI, Switzerland.

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http://dx.doi.org/10.1042/BST20120001DOI Listing
April 2012

Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin.

Biochemistry 2011 Nov 2;50(47):10399-407. Epub 2011 Nov 2.

Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.

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http://dx.doi.org/10.1021/bi201126rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390202PMC
November 2011

Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor.

Proc Natl Acad Sci U S A 2011 May 3;108(20):8228-32. Epub 2011 May 3.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1100185108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100933PMC
May 2011

Spial: analysis of subtype-specific features in multiple sequence alignments of proteins.

Bioinformatics 2010 Nov 29;26(22):2906-7. Epub 2010 Sep 29.

Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 1TP, UK.

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http://dx.doi.org/10.1093/bioinformatics/btq552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971580PMC
November 2010

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.

Nature 2010 Apr 11;464(7293):1386-9. Epub 2010 Apr 11.

Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature08948DOI Listing
April 2010

Engineering G protein-coupled receptors to facilitate their structure determination.

Curr Opin Struct Biol 2009 Aug 12;19(4):386-95. Epub 2009 Aug 12.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.sbi.2009.07.004DOI Listing
August 2009

Development and crystallization of a minimal thermostabilised G protein-coupled receptor.

Protein Expr Purif 2009 Jun;65(2):204-13

MRC Laboratory of Molecular Biology, Structural Studies, Hills Road, Cambridge CB2 0QH, UK.

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June 2009

Signal transduction: the rhodopsin story continued.

Nature 2008 May;453(7193):292-3

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http://dx.doi.org/10.1038/453292aDOI Listing
May 2008

New G-protein-coupled receptor crystal structures: insights and limitations.

Trends Pharmacol Sci 2008 Feb 14;29(2):79-83. Epub 2008 Jan 14.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1016/j.tips.2007.11.009DOI Listing
February 2008

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Nature 2007 Nov 21;450(7168):383-7. Epub 2007 Oct 21.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, Palo Alto, California 94305, USA.

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http://www.nature.com/articles/nature06325
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http://dx.doi.org/10.1038/nature06325DOI Listing
November 2007

Crystal structure of a thermally stable rhodopsin mutant.

J Mol Biol 2007 Oct 12;372(5):1179-88. Epub 2007 Mar 12.

MRC Laboratory of Molecular Biology, Structural Studies, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2007.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258155PMC
October 2007

Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.

J Biol Chem 2006 Jul 4;281(28):19426-32. Epub 2006 May 4.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M602203200DOI Listing
July 2006

Rhodopsin photointermediates in two-dimensional crystals at physiological temperatures.

Biochemistry 2006 Apr;45(15):4974-82

Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, USA.

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http://dx.doi.org/10.1021/bi0524619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556952PMC
April 2006

Protein crystallography microdiffraction.

Curr Opin Struct Biol 2005 Oct;15(5):556-62

European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble Cedex, France.

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http://dx.doi.org/10.1016/j.sbi.2005.08.013DOI Listing
October 2005

Structure of rhodopsin and the metarhodopsin I photointermediate.

Curr Opin Struct Biol 2005 Aug;15(4):408-15

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.sbi.2005.07.010DOI Listing
August 2005

Structure of bovine rhodopsin in a trigonal crystal form.

J Mol Biol 2004 Nov;343(5):1409-38

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.08.090DOI Listing
November 2004

Crystals of native and modified bovine rhodopsins and their heavy atom derivatives.

J Mol Biol 2004 Nov;343(5):1439-50

Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.08.089DOI Listing
November 2004

Electron crystallography reveals the structure of metarhodopsin I.

EMBO J 2004 Sep 26;23(18):3609-20. Epub 2004 Aug 26.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517614PMC
September 2004

Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC.

J Mol Biol 2004 Sep;342(3):697-702

Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1016/j.jmb.2004.07.088DOI Listing
September 2004

Rhodopsin photoproducts in 2D crystals.

J Mol Biol 2004 Apr;338(3):597-609

Biophysics Group, Institut für Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 9, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.jmb.2004.03.006DOI Listing
April 2004

The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy.

J Biol Chem 2003 Dec 25;278(50):50217-25. Epub 2003 Sep 25.

Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M307995200DOI Listing
December 2003

Expression and purification of truncated, non-glycosylated turkey beta-adrenergic receptors for crystallization.

Biochim Biophys Acta 2003 Feb;1610(1):133-40

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/s0005-2736(02)00716-2DOI Listing
February 2003