Publications by authors named "Ge Yao"

80 Publications

Dual Interface Protection for High Performance and Excellent Long-Term Stability of Organic Solar Cells.

ACS Appl Mater Interfaces 2021 Dec 29;13(48):57664-57672. Epub 2021 Nov 29.

School of Material Science and Engineering, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.

Stability is still the main barrier to the commercial application of organic solar cells (OSCs), although the maximal power conversion efficiency (PCE) value has exceeded 19%. The encapsulation technique is an effective and vital way to guarantee the long-term stabilities of OSCs, but it can only avoid the penetration of water and oxygen from the environment. Herein, we introduced a structure that provides dual interface protection by using commercially available and chemically stable polyvinylidene fluoride (PVDF) as the cathode interface protection layer working as the cathode interlayer (CIL) and poly(styrene-comethyl-methacrylate) (PS-r-PMMA) as the anode interface protection layer between the poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate) (PEDOT:PSS) and the active layer. With this structure, both the migration of impurities caused by degradation of the interfacial layer and the infiltration of oxygen and water in the air can be prevented. PVDF can effectively provide optimal electron transfer by improving the surface potential of active layers and lowering the work function of the Al electrode. PS-r-PMMA can improve the hydrophobicity of PEDOT:PSS and induce optimized phase separation, facilitating charge transfer. After storage in an air environment with a humidity of approximately 60% for 3600 h, the device based on the PM6:IT-4F blend film with dual interface protection showed a decrease in its PCE value from 13.43 to 10.90%, retaining 81.2% of its original PCE value, in contrast to the sharp decrease in the PCE value from 13.66 to 0.74% of the device without dual interface protection. The dual interface protection design could also be useful in the high-performance PM6:Y6 system, which shows a champion PCE of 15.39% and shows potential for the effective fabrication of stable OSCs in the future.
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http://dx.doi.org/10.1021/acsami.1c15792DOI Listing
December 2021

Boosting the K-adsorption capacity in edge-nitrogen doped hierarchically porous carbon spheres for ultrastable potassium ion battery anodes.

Nanoscale 2021 Dec 2;13(46):19634-19641. Epub 2021 Dec 2.

Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, 230026, China.

Although carbon materials have great potential for potassium ion battery (KIB) anodes due to their structural stability and abundant carbon-containing resources, the limited K-intercalated capacity impedes their extensive applications in energy storage devices. Current research studies focus on improving the surface-induced capacitive behavior to boost the potassium storage capacity of carbon materials. Herein, we designed edge-nitrogen (pyridinic-N and pyrrolic-N) doped carbon spheres with a hierarchically porous structure to achieve high potassium storage properties. The electrochemical tests confirmed that the edge-nitrogen induced active sites were conducive for the adsorption of K, and the hierarchical porous structure promoted the generation of stable solid electrolyte interphase (SEI) films, both of which endow the resulting materials with a high reversible capacity of 381.7 mA h g at 0.1 A g over 200 cycles and an excellent rate capability of 178.2 mA h g at 5 A g. Even at 5 A g, the long-term cycling stability of 5000 cycles was achieved with a reversible capacity of 190.1 mA h g. This work contributes to deeply understand the role of the synergistic effect of edge-nitrogen induced active sites and the hierarchical porous structure in the potassium storage performances of carbon materials.
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http://dx.doi.org/10.1039/d1nr06665jDOI Listing
December 2021

Cell-derived extracellular vesicles and membranes for tissue repair.

J Nanobiotechnology 2021 Nov 17;19(1):368. Epub 2021 Nov 17.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.

Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the treatment of various diseases. Researchers expected that these cells would mediate tissue repair and regeneration through their multipotency. However, increasing evidence has suggested that in most stem cell therapies, the paracrine effect but not cell differentiation or regeneration is the major driving force of tissue repair. Additionally, ethical and safety problems have limited the application of stem cell therapies. Therefore, nonliving cell-derived techniques such as extracellular vesicle (EV) therapy and cell membrane-based therapy to fulfil the unmet demand for tissue repair are important. Nonliving cell-derived biomaterials are safer and more controllable, and their efficacy is easier to enhance through bioengineering approaches. Here, we described the development and evolution from cell therapy to EV therapy and cell membrane-based therapy for tissue repair. Furthermore, the latest advances in nonliving cell-derived therapies empowered by advanced engineering techniques are emphatically reviewed, and their potential and challenges in the future are discussed.
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http://dx.doi.org/10.1186/s12951-021-01113-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600774PMC
November 2021

Numerical Analysis on Erosion and Optimization of a Blast Furnace Main Trough.

Materials (Basel) 2021 Aug 26;14(17). Epub 2021 Aug 26.

State Key Laboratory of Advanced Special Steel, Shanghai Key Laboratory of Advanced Ferrometallurgy, Department of Materials Engineering, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China.

The main trough of a blast furnace (BF) is a main passage for hot metal and molten slag transportation from the taphole to the torpedo and the slag handling. Its appropriate working status and controlled erosion ensure a safe, stable, high-efficiency and low-cost continuous production of hot metal. In this work, the tapping process of a main trough of a BF in the east of China was numerically studied with the help of a CFD library written in C++, called OpenFOAM, based on the use of the Finite Volume Method (FVM). The results show that turbulence intensity downstream of the hot metal impact position becomes weaker and the turbulence area becomes larger in the main trough. During the tapping, thermal stress of wall refractory reaches the maximum value of 1.7 × 107 Pa at the 4 m position in the main trough. Furthermore, baffles in the main trough placed between 5.8 m and 6.2 m were found to control and reduce the impact of the turbulence on the refractory life. The metal flowrate upstream of the baffles can be decreased by 6%, and the flow velocity on the upper sidewall and bottom wall decrease by 9% and 7%, respectively, compared with the base model. By using baffles, the minimum fatigue life of the refractory in the main trough increases by 15 tappings compared with the base model, so the period between the maintenance stops can be prolonged by about 2 days.
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http://dx.doi.org/10.3390/ma14174851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432703PMC
August 2021

Mining long-COVID symptoms from Reddit: characterizing post-COVID syndrome from patient reports.

Authors:
Abeed Sarker Yao Ge

JAMIA Open 2021 Jul 2;4(3):ooab075. Epub 2021 Sep 2.

Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, Georgia, USA.

Our objective was to mine Reddit to discover long-COVID symptoms self-reported by users, compare symptom distributions across studies, and create a symptom lexicon. We retrieved posts from the subreddit and extracted symptoms via approximate matching using an expanded meta-lexicon. We mapped the extracted symptoms to standard concept IDs, compared their distributions with those reported in recent literature and analyzed their distributions over time. From 42 995 posts by 4249 users, we identified 1744 users who expressed at least 1 symptom. The most frequently reported long-COVID symptoms were (55.2%), (51.2%), (48.4%), (32.8%), and (28.9%) among users reporting at least 1 symptom. Comparison with recent literature revealed a large variance in reported symptoms across studies. Temporal analysis showed several persistent symptoms up to 15 months after infection. The spectrum of symptoms identified from Reddit may provide early insights about long-COVID.
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http://dx.doi.org/10.1093/jamiaopen/ooab075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411371PMC
July 2021

Palladium-Catalyzed Domino Aminocarbonylation of Alkynols: Direct and Selective Synthesis of Itaconimides.

JACS Au 2021 Aug 9;1(8):1257-1265. Epub 2021 Jul 9.

Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, Rostock 18059, Germany.

The first direct and selective synthesis of substituted itaconimdes by palladium-catalyzed aminocarbonylation of alkynols is reported. Key to the success of this transformation is the use of a novel catalyst system involving ligand and appropriate reaction conditions. In the protocol here presented, easily available propargylic alcohols react with -nucleophiles including aryl- and alkylamines as well as aryl hydrazines to provide a broad variety of interesting heterocycles with high catalyst activity and excellent selectivity. The synthetic utility of the protocol is demonstrated in the synthesis of natural product with aminocarbonylation as the key step. Mechanistic studies and control experiments reveal the crucial role of the hydroxyl group in the substrate for the control of selectivity.
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http://dx.doi.org/10.1021/jacsau.1c00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397365PMC
August 2021

[Mechanism of Xinfeng Capsules improving rheumatoid arthritis based on CD19~+B cells regulating FAK/CAPN/PI3K pathway].

Zhongguo Zhong Yao Za Zhi 2021 Jul;46(14):3705-3711

Graduate School of Anhui University of Chinese Medicine Hefei 230031,China.

To observe the effect of Xinfeng Capsules on rheumatoid arthritis (RA) B lymphocytes,inflammatory mediators,FAK/CAPN/PI3K pathway,in order to explore the mechanism of Xinfeng Capsules in improving clinical symptoms of RA.Joint and systemic symptoms of RA patients were observed,and laboratory indicators[hemoglobin (HGB),platelet count (PLT),erythrocyte sedimentation (ESR),immunoglobulin (Ig) G,Ig A,Ig M,rheumatoid factor (RF),anti-cyclic citrulline antibody (CCP-AB),C-reactive protein (CRP)]were detected.ELISA was used to detect serum interleukin (IL)-1β,IL-10,IL-33,chemokine 5 (CCL5),and vascular endothelial growth factor (VEGF).CD3~-CD19~+B cells were measured by flow cytometry.Western blot was used to detect FAK,p-FAK,CAPN,PI3K protein.The results showed that Xinfeng Capsules could significantly alleviate RA joint and systemic symptoms and improve clinical efficacy.And Xinfeng Capsules could increase HGB,decrease PLT,CCP-AB,CRP,ESR index,upregulate IL-10 expression,and down-regulate IL-1β,IL-33,CCL5,VEGF,CD3~-CD19~+B cells,FAK,p-FAK,CAPN,PI3K expressions (P<0.01).Based on the above results,Xinfeng Capsules may reduce the expression of CD3~-CD19~+,regulate the balance of inflammatory cytokines and chemokines,inhibit abnormal activation of FAK/CAPN/PI3K pathway,and improve clinical symptoms of RA.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20201120.501DOI Listing
July 2021

Simultaneous Determination of Aerosol Inorganic and Organic Nitrogen by Thermal Evolution and Chemiluminescence Detection.

Environ Sci Technol 2021 09 16;55(17):11579-11589. Epub 2021 Aug 16.

Division of Environment and Sustainability, Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.

Inorganic nitrogen (IN) and organic nitrogen (ON) molecules constitute a significant part of atmospheric aerosol. Unlike IN, the total ON quantity remains largely unquantified due to a lack of a simple and direct measurement method. This analytical deficiency hinders the quantitative assessment of the various environmental and health effect impacts by aerosol ON. In this work, we developed an analyzer system that utilizes programmed thermal evolution of carbonaceous and nitrogenous aerosols and chemiluminescence detection coupled with the multivariate curve resolution data treatment to achieve simultaneous quantification of IN and ON. The system is capable of detecting IN and ON as low as 96 ng N per sample on a small filter aliquot (1 cm) without any pretreatment. This method breakthrough opens the door to quantifying an important pool of aerosol N that was analytically inaccessible in the past and holds the promise to quantifying IN and ON in other environmental samples. As a demonstration, quantification of aerosol ON at an urban site in Hong Kong, China, in samples spanning over a year reveals ON constituting a significant fraction (9-52%) of the total aerosol nitrogen and having major source origins in both secondary formation and primary emissions.
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http://dx.doi.org/10.1021/acs.est.1c04876DOI Listing
September 2021

Palladium-Catalyzed Cascade Carbonylation to α,β-Unsaturated Piperidones via Selective Cleavage of Carbon-Carbon Triple Bonds.

Angew Chem Int Ed Engl 2021 Oct 6;60(41):22393-22400. Epub 2021 Sep 6.

Leibniz-Institut für Katalyse e. V., Albert-Einstein-Straße 29a, 18059, Rostock, Germany.

A direct and selective synthesis of α,β-unsaturated piperidones by a new palladium-catalyzed cascade carbonylation is described. In the presented protocol, easily available propargylic alcohols react with aliphatic amines to provide a broad variety of interesting heterocycles. Key to the success of this transformation is a remarkable catalytic cleavage of the present carbon-carbon triple bond by using a specific catalyst with 2-diphenylphosphinopyridine as ligand and appropriate reaction conditions. Mechanistic studies and control experiments revealed branched unsaturated acid 11 as crucial intermediate.
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http://dx.doi.org/10.1002/anie.202108120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519052PMC
October 2021

A dynamic and multilocus metabolic regulation strategy using quorum-sensing-controlled bacterial small RNA.

Cell Rep 2021 07;36(3):109413

Hunan Key Laboratory of Economic Crops, Genetic Improvement, and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PRC. Electronic address:

Metabolic regulation strategies have been developed to redirect metabolic fluxes to production pathways. However, it is difficult to screen out target genes that, when repressed, improve yield without affecting cell growth. Here, we report a strategy using a quorum-sensing system to control small RNA transcription, allowing cell-density-dependent repression of target genes. This strategy is shown with convenient operation, dynamic repression, and availability for simultaneous regulation of multiple genes. The parameters A, A, and R (3-oxohexanoyl-homoserine lactone [AHL] concentrations at which half of the maximum repression and the maximum repression were reached and value of the maximum repression when AHL was added manually, respectively) are defined and introduced to characterize repression curves, and the variant LuxR is identified as the most suitable tuning factor for shake flask culture. Moreover, it is shown that dynamic overexpression of the Hfq chaperone is the key to combinatorial repression without disruptions on cell growth. To show a broad applicability, the production titers of pinene, pentalenene, and psilocybin are improved by 365.3%, 79.5%, and 302.9%, respectively, by applying combinatorial dynamic repression.
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http://dx.doi.org/10.1016/j.celrep.2021.109413DOI Listing
July 2021

Preventive behaviours and family inequalities during the COVID-19 pandemic: a cross-sectional study in China.

Infect Dis Poverty 2021 Jul 20;10(1):100. Epub 2021 Jul 20.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China.

Background: The coronavirus disease 2019 (COVID-19) pandemic is an international public health threat, and people's participation in disease-related preventive behaviours is the key to controlling infectious diseases. This study aimed to assess the differences in adopting preventive behaviours among populations to explore potential individual and household factors and inequalities within families.

Methods: This online survey was conducted in April 2020. The directional stratified convenient sampling method was used to select 4704 participants from eight provinces in eastern, central, and western China. The questionnaire included demographic information, household variables, and five target prevention behaviours. The chi-squared test, binary multilevel model, and Mantel-Haenszel hierarchical analysis were used for data analysis in the study.

Results: Approximately 71.2% of the participants had appropriate outdoor prevention, and 32.9% of the participants had indoor protection in place. Sharing behaviours (P < 0.001) and education level (P < 0.001) were positively associated with adopting preventive measures. The inhibiting effect of household crowding and stimulating effect of high household income on preventive behaviours were determined in this study. Household size was negatively associated with living area (β = -0.057, P < 0.05) and living style (β = -0.077, P < 0.05). Household income was positively associated with age (β = 0.023, P < 0.05), and relationship with friends (β = 0.053, P < 0.05). Vulnerable groups, such as older adults or women, are more likely to have inadequate preventive behaviours. Older adults (OR = 1.53, 95% CI 1.09-2.15), women (OR = 1.37, 95% CI 1.15-1.64), and those with more than 2 suspected symptoms (OR = 1.85, 95% CI 1.07-3.19) were more likely to be affected by the inhibiting effect of household crowding, while the stimulating effect of high household income was limited in these groups.

Conclusions: Inequalities in COVID-19 prevention behaviours exist between families and inadequate adoption of prevention by vulnerable groups are noteworthy. This study expands the research perspective by emphasizing the role of household factors in preventive behaviours and by focusing on family inequalities. The government should use traditional media as a platform to enhance residents' public health knowledge. Targeted additional wage subsidies, investments in affordable housing, financial support for multigenerational households, and temporary relocation policies may deserve more attention. Communities could play a critical role in COVID-19 prevention.
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http://dx.doi.org/10.1186/s40249-021-00884-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290209PMC
July 2021

Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma.

Biomed Res Int 2021 3;2021:7020637. Epub 2021 Jun 3.

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.

Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic biomarker for HCC is urgently needed. Overwhelming evidence has demonstrated the regulatory roles of small nucleolar RNA (snoRNA) in carcinogenesis. This study is aimed at analyzing the expression of a snoRNA, SNORA52, in HCC and exploring the correlation between its expression and various clinical characteristics of HCC patients. By using quantitative real-time PCR, we found that SNORA52 was downregulated in HCC cell lines ( < 0.05) and HCC tissues ( < 0.001). Correlation analysis showed that the expression of SNORA52 was obviously associated with tumor size ( = 0.011), lesion number ( = 0.007), capsular invasion ( = 0.011), tumor differentiation degree ( = 0.046), and TNM stage ( = 0.004). The disease-free survival (DFS) and overall survival (OS) analysis showed that patients with lower SNORA52 expression had a worse prognosis ( < 0.001). Univariate and multivariate Cox regression analysis showed that SNORA52 expression was a completely independent prognostic factor to predict DFS ( = 0.009) and OS ( = 0.012) of HCC patients. Overall, our findings showed SNORA52 expression levels were downregulated in HCC tissues and correlated with multiple clinical variables, and SNORA52 was an independent prognostic factor for HCC patients, which suggested that SNORA52 could function as a potential diagnostic and prognostic biomarker for HCC patients.
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http://dx.doi.org/10.1155/2021/7020637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203349PMC
October 2021

Do pit vipers assess their venom? Defensive tactics of Deinagkistrodon acutus shift with changed venom reserve.

Toxicon 2021 Aug 6;199:101-108. Epub 2021 Jun 6.

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, Sichuan, China. Electronic address:

To maximize survival probability, animals must assess predation risks and adopt flexible defensive strategies based on specific conditions. Pit vipers utilize venom for predation and self-defense, and venom status significantly influences its effectiveness. Thus, pit vipers may evaluate their venom reserve and adopt corresponding defensive tactics. Twenty-three sharp-snouted pit vipers (Deinagkistrodon acutus) were grouped by different venom status and were subjected to eight behavior trials. Subjects' defensive behaviors were recorded and analyzed. Results showed that the normal venom group displayed stable responses across the trials. The low venom group showed fewer strikes and more fleeing behaviors at the end of experiments. After given prolonged intervals for replenishing the venom, significant increases of strike behaviors were observed in the replenishing venom group. These results demonstrated the capability of adopting flexible defensive tactics based on varied venom reserve and provided new evidence for venom-status-recognition.
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http://dx.doi.org/10.1016/j.toxicon.2021.06.003DOI Listing
August 2021

3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents.

Nat Commun 2021 05 31;12(1):3257. Epub 2021 May 31.

Leibniz-Institute for Catalysis, Albert-Einstein-Str. 29a, Rostock, 18059, Germany.

The selective synthesis of fluorinated organic molecules continues to be of major importance for the development of bioactive compounds (agrochemicals and pharmaceuticals) as well as unique materials. Among the established synthetic toolbox for incorporation of fluorine-containing units, efficient and general reagents for introducing -CF- groups have been largely neglected. Here, we present the synthesis of 3,3-difluoropropen-1-yl ammonium salts (DFPAs) as stable, and scalable gem-difluoromethylation reagents, which allow for the direct reaction with a wide range of fascinating nucleophiles. DFPAs smoothly react with N-, O-, S-, Se-, and C-nucleophiles under mild conditions without necessity of metal catalysts with exclusive regioselectivity. In this way, the presented reagents also permit the straightforward preparation of many analogues of existing pharmaceuticals.
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http://dx.doi.org/10.1038/s41467-021-23504-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167079PMC
May 2021

Synergetic effect of growth factor and topography on fibroblast proliferation.

Biomed Phys Eng Express 2020 11 18;6(6). Epub 2020 Nov 18.

The First Affiliated Hospital, Jinan University, Guangzhou 510630, People's Republic of China.

An innovative basic fibroblast growth factor (bFGF)-loaded polycaprolactone (PCL) fibrous membrane with highly aligned structure is developed for guided tissue regeneration (GTR). The aligned membrane is fabricated by electrospinning. In order to make efficient use of bFGF, PCL electrospun fibrous membrane is firstly surface-coated by self-polymerization of dopamine, and followed by immobilization of heparin via covalent conjugation to the polydopamine (PDA) layer. Subsequently, bFGF is loaded by binding to heparin. The loading yield of bFGF on heparin-immobilized PDA-coated PCL membrane significantly increases to around 7 times as compared with that of pure PCL membrane. NIH-3T3 cells show an enhanced proliferation and exhibit a stretched morphology aligned along the direction of the fibers on the aligned membranes. However, aligned bFGF-loaded PCL membrane exhibit a similar morphology but a highest cell density prolonged till 9 days. The synergetic effect of growth factor and topography would effectively regulate cell proliferation.
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http://dx.doi.org/10.1088/2057-1976/abc8e2DOI Listing
November 2020

High-Throughput Screening of a Single-Atom Alloy for Electroreduction of Dinitrogen to Ammonia.

ACS Appl Mater Interfaces 2021 Apr 2;13(14):16336-16344. Epub 2021 Apr 2.

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, Zhejiang, China.

Exploring electrocatalysts with high activity, selectivity, and stability is essential for the development of applicable electrocatalytic ammonia synthesis technology. By performing density functional theory calculations, we systematically investigated the potential of a series of transition-metal-doped Au-based single-atom alloys (SAAs) as promising electrocatalysts for nitrogen reduction reaction (NRR). The overall process for the Au-based electrocatalyst suffers from the limiting potential arising from the first hydrogenation step of the reduction of *N to *NNH. However, SAAs showed to be favorable toward lowering free energy barriers by increasing the binding strength of N. According to simulation results, three descriptors were proposed to describe the first hydrogenation step Δ(*N → *NNH): Δ(*NNH), d-band center, and d/√E. Eight doped elements (Ti, V, Nb, Ru, Ta, Os, W, and Mo) were initially screened out with a limiting potential ranging from -0.75 to -0.30 V. Particularly, Mo- and W-doped systems possess the best activity with a limiting potential of -0.30 V each. Then, the intrinsic relationship between the structure and potential performance was analyzed using machine learning. The selectivity, feasibility, and stability of these candidates were also evaluated, confirming that SAA containing Mo, Ru, Ta, and W could be outstanding NRR electrocatalysts. This work not only broadens our understanding of SAA application in electrocatalysis, but also leads to the discovery of novel NRR electrocatalysts.
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http://dx.doi.org/10.1021/acsami.1c01098DOI Listing
April 2021

Identification of hub genes in triple-negative breast cancer by integrated bioinformatics analysis.

Gland Surg 2021 Feb;10(2):799-806

Department of Cancer Institute, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Background: Triple negative breast cancer (TNBC) is usually aggressive and accompanied by a poor prognosis. The molecular biological mechanism of TNBC pathogenesis is still unclear, and requires more detailed research. The aim of this study was to screen and verify potential biomarkers of TNBC, and provide new clues for the treatment and diagnosis of TNBC.

Methods: In this work, GSE76250 was downloaded from the Gene Expression Omnibus (GEO) database and included 165 TNBC samples and 33 paired normal breast tissues. The R software and its related software package were used for data processing and analysis. Compared with normal tissues, genes with a false discovery rate (FDR) <0.01 and log fold change (logFC) ≥1 or ≤-1 were identified as differentially expressed genes (DEGs) by limma package. Survival prognoses were analyzed by Kaplan-Meier plotter database.

Results: In total, 160 up-regulated and 180 down-regulated genes were identified. The biological mechanism of enrichment analysis presented that DEGs were significantly enriched in chromosome segregation, extracellular matrix, and extracellular matrix structural constituent, among others. A total of 8 hub genes ( and ) were identified by the protein-protein interaction network (PPIN) and Cytoscape software. Survival prognosis of these hub genes showed that they were negatively correlated with overall survival.

Conclusions: The 8 hub genes and pathways that were identified might be involved in tumorigenesis and become new candidate biomarkers for TNBC treatment.
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http://dx.doi.org/10.21037/gs-21-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944053PMC
February 2021

Heteroatom-doped carbon materials with interconnected channels as ultrastable anodes for lithium/sodium ion batteries.

Dalton Trans 2021 Mar 10;50(12):4335-4344. Epub 2021 Mar 10.

Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China.

Carbon materials have been extensively investigated as promising negative electrode materials for lithium/sodium ion batteries. However, most common carbon materials always suffer from limitations in regards to high reversible capacity and long-term cycling stability because of their low theoretical specific capacities and sluggish kinetics. Herein, we report a facile MOF-derived strategy for the synthesis of nitrogen/oxygen co-doped porous carbon polyhedra (NOPCP) with abundant channel-connected cavities with their inner surface decorated with a large number of N and O atoms, which can provide a large number of active sites (defects and edge doping sites) for the sorption of Li/Na. These cavities can also be considered as "ponds" where the electrolyte is stored, which shortens the diffusion distance of ions during the discharge/charge process. When evaluated as an anode material for LIBs, NOPCP-600 delivers a high reversible capacity of 1663 mA h g at 0.1 A g after 120 cycles and superior cycling stability with a capacity of 667 mA h g after 1000 cycles at 2 A g. For SIBs, NOPCP-600 delivers a high reversible capacity of 313 mA h g at 0.1 A g after 100 cycles and an excellent long-term cycling stability of 228 mA h g at 1 A g after 2000 cycles.
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http://dx.doi.org/10.1039/d1dt00243kDOI Listing
March 2021

A conformally adapted all-in-one hydrogel coating: towards robust hemocompatibility and bactericidal activity.

J Mater Chem B 2021 03 8;9(11):2697-2708. Epub 2021 Mar 8.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

Hospital-acquired infections and thrombosis caused by bacteria attached to the device surface, or fibrin crosslinking owing to platelet accumulation/activation, are major healthcare challenges that cause morbidity and mortality. To prevent these, surface coating technologies are considered an efficient tool that can combine hemocompatibility and bactericidal activity. In this study, surface-initiated polymerization was conducted to form an all-in-one hydrogel coating that could adapt to diverse medical devices. Different monomer ratios (acrylamide/acrylic acid) were used to adjust the antimicrobial agent loading capacity. The hydrogel coating obtained by a simple dip-absorbing method showed good hemocompatibility and maintained efficient bactericidal activity. We also explored the loading and release of antimicrobial agents with different molecular sizes, including nano-Ag particles, antibiotics, and antimicrobial peptides. The inhibition zone test and confocal laser scanning microscopy revealed that the hydrogel coating could maintain remarkable antimicrobial and antifouling properties for four weeks. Furthermore, the hydrogel coating decreased the platelet adhesion/activation without risk of hemolysis. The ex vivo blood circulation study confirmed the antithrombotic properties of the hydrogel coating. Such all-in-one hydrogel coatings that maintain high cell viability and exhibit both hemocompatibility and bactericidal activity possess the potential for applications in blood-contacting devices.
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http://dx.doi.org/10.1039/d1tb00021gDOI Listing
March 2021

The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus.

Cell Discov 2021 Feb 23;7(1):11. Epub 2021 Feb 23.

Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, BGI, Shenzhen, Guangdong, 518083, China.

Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C. betulinus) as a representative, we sequenced and assembled the first Conus genome with original identification of 133 genome-widely distributed conopeptide genes. After integration of our genomics, transcriptomics, and peptidomics data in the same species, we established a primary genetic central dogma of diverse conopeptides, assuming a rough number ratio of ~1:1:1:10s for the total genes: transcripts: proteins: post-translationally modified peptides. This ratio may be special for this worm-hunting Conus species, due to the high diversity of various Conus genomes and the big number ranges of conopeptide genes, transcripts, and peptides in previous reports of diverse Conus species. Only a fraction (45.9%) of the identified conotopeptide genes from our achieved genome assembly are transcribed with transcriptomic evidence, and few genes individually correspond to multiple transcripts possibly due to intraspecies or mutation-based variances. Variable peptide processing at the proteomic level, generating a big diversity of venom conopeptides with alternative cleavage sites, post-translational modifications, and N-/C-terminal truncations, may explain how the 133 genes and ~123 transcripts can generate thousands of conopeptides in the venom of individual C. betulinus. We also predicted many conopeptides with high stereostructural similarities to the putative analgesic ω-MVIIA, addiction therapy AuIB and insecticide ImI, suggesting that our current genome assembly for C. betulinus is a valuable genetic resource for high-throughput prediction and development of potential pharmaceuticals.
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http://dx.doi.org/10.1038/s41421-021-00244-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900195PMC
February 2021

Computational design of a polymorph for 2D III-V orthorhombic monolayers by first principles calculations: excellent anisotropic, electronic and optical properties.

Phys Chem Chem Phys 2021 Feb;23(6):3771-3778

National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China.

Using first principles calculations, we have designed a new polymorph for two-dimensional (2D) III-V group materials with an orthorhombic phase, including BN, BP, BAs, AlN, AlP, and GaN, and investigated their structural, electronic, and optical properties. The phonon dispersion calculations have shown that BN, BP, AlN, and GaN possess excellent dynamic stabilities. The 2D BN is a direct semiconductor, and its bandgap predicted by PBE and HSE calculations is 0.76 and 1.73 eV, respectively. The calculated mobilities of the BN, AlN, and GaN monolayers have shown their high conductivities, and the monolayered AlN and GaN possess strong anisotropic carrier transport characters. The 2D AlN and AlP and GaN monolayers are found to be indirect semiconductors with bandgaps in the range of 0.66-1.65 eV. The 2D BN and BP monolayers exhibit extremely high and anisotropic absorbance, and their absorption energy range covers the whole solar spectrum, rendering them potential candidates for applications in solar cells. More importantly, their optical properties are shown to have highly anisotropic optical absorbance, making them promising candidates for manufacturing anisotropic optoelectronic devices. Our computational study not only provides a new class of 2D materials to enrich the material genome database, but also paves the way for practical applications of 2D III-V materials for electronic and optoelectronic devices.
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http://dx.doi.org/10.1039/d0cp05909aDOI Listing
February 2021

Crosslinking porcine aortic valve by radical polymerization for the preparation of BHVs with improved cytocompatibility, mild immune response, and reduced calcification.

J Biomater Appl 2021 04 21;35(9):1218-1232. Epub 2021 Jan 21.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, PR China.

Over one million artificial heart valve transplantations are performed each year due to valvular stenosis or regurgitation. Among them, bioprosthetic heart valves (BHVs) are increasingly being used because of the absence of the need for lifelong anticoagulation. Almost all of the commercial BHVs are treated with Glutaraldehyde (GLUT). As GLUT-treated BHVs are prone to calcification and structural degradation, their durability is greatly reduced with a service life of only 12-15 years. The physiological structure and mechanical properties of the porcine aortic valve (PAV) are closer to that of a human heart valve, so in this study, PAV is used as the model to explore the comprehensive properties of the prepared BHVs by radical polymerization crosslinking method. We found that PAV treated by radical polymerization crosslinking method showed similar ECM stability and biaxial mechanical properties with GLUT-treated PAV. However, radical polymerization crosslinked PAV exhibited better cytocompatibility and endothelialization potential in vitro cell experiment as better anticalcification potential and reduced immune response than GLUT-treated PAV through subcutaneous animal experiments in rats. To conclude, a novel crosslinking method of non-glutaraldehyde fixation of xenogeneic tissues for the preparation of BHVs is expected.
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http://dx.doi.org/10.1177/0885328220984066DOI Listing
April 2021

Efficient Palladium-Catalyzed Carbonylation of 1,3-Dienes: Selective Synthesis of Adipates and Other Aliphatic Diesters.

Angew Chem Int Ed Engl 2021 Apr 3;60(17):9527-9533. Epub 2021 Mar 3.

Leibniz-Institut für Katalyse e. V., Albert-Einstein-Straße 29a, 18059, Rostock, Germany.

The dicarbonylation of 1,3-butadiene to adipic acid derivatives offers the potential for a more cost-efficient and environmentally benign industrial process. However, the complex reaction network of regioisomeric carbonylation and isomerization pathways, make a selective and direct transformation particularly difficult. Here, we report surprising solvent effects on this palladium-catalysed process in the presence of 1,2-bis-di-tert-butylphosphin-oxylene (dtbpx) ligands, which allow adipate diester formation from 1,3-butadiene, carbon monoxide, and methanol with 97 % selectivity and 100 % atom-economy under scalable conditions. Under optimal conditions a variety of di- and triesters from 1,2- and 1,3-dienes can be obtained in good to excellent yields.
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http://dx.doi.org/10.1002/anie.202015329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251817PMC
April 2021

Preaggregation Matching of Donors and Acceptors in Solution Accounting for Thermally Stable Non-Fullerene Solar Cells.

ACS Appl Mater Interfaces 2020 Dec 17;12(52):58082-58093. Epub 2020 Dec 17.

School of Material Science and Engineering, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.

The mechanism of how the solvent type influences photovoltaic performance and thermal stability of non-fullerene organic solar cells remains unexplored. In this article, the well-known PTB7-Th was selected as a donor, while F8IC was used as an acceptor. The PTB7-Th:F8IC processed from chloroform (CF) exhibited a superiorly higher power conversion efficiency (PCE) of 10.5%, in contrast to the specimen processed from chlorobenzene (CB) of 6.8%. In addition, upon thermal annealing at 160 °C for 120 min, the device processed from CF was more stable than that processed from CB. The incorporation of perylene diimide derivative TBDPDI-C, serving as the third additive, could also obviously improve the PCE value and thermal stability of PTB7-Th:F8IC processed from CB. According to ultraviolet spectroscopy, atomic force microscopy, transmission electron microscopy, and grazing incidence wide-angle X-ray scattering analyses, the enhanced photovoltaic performance and thermal stability are mainly attributed to formation of PTB7-Th nanofibers and appropriate aggregation of F8IC. The interaction free energy calculated using water and diiodomethane contact angles reveals that PTB7-Th well disperses in CB and tends to aggregate in CF, while F8IC aggregates strongly in CB. The preaggregation matching of the donor and acceptor in solution is essential for the optimization of morphology, efficiency, and thermal stability. The findings in this article could provide useful guidelines to fabricate efficient and thermally stable organic solar cells simply by analyzing the surface energy of components processed from different solvents.
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http://dx.doi.org/10.1021/acsami.0c17049DOI Listing
December 2020

A Novel Approach for Measuring the Thickness of Refractory of Metallurgical Vessels.

Materials (Basel) 2020 Dec 10;13(24). Epub 2020 Dec 10.

State Key Laboratory of Advanced Special Steel, Shanghai Key Laboratory of Advanced Ferrometallurgy and the Science and Technology Commission of Shanghai Municipality, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China.

The advancement of metallurgical vessels, such as blast furnaces, shaft furnaces, and torpedo ladles, can be better controlled and expanded for a greater lifespan if the thickness of the refractory lining wear is known and predicted. In the past, various methods including radioactive tracers, infrared (IR) thermography, electromagnetic waves, ultrasonic tomography, and temperature field have been tested to determine the thickness of the refractory wall. However, for various reasons, these methods have failed to be effective. This paper presents a novel method-electromotive force (EMF)-for predicting the thickness of refractory lining wear in vessels, including a small-scale vessel in the laboratory, an industrial torpedo ladle, and in the two refining hearths of blast furnaces. The experimental results show that the magnitude of the EMF signal increases with a decrease in wall thickness. Prediction values of the refractory wall thickness are consistent with measured ones. The relative error of EMF measurement for the torpedo ladle is around 6.8%. The EMF measurement of blast furnace hearths is quite accurate, and the relative error is less than 11%.
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http://dx.doi.org/10.3390/ma13245645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763349PMC
December 2020

Overexpression of β-Ketoacyl-CoA Synthase From L. Improves Salt Tolerance in .

Front Plant Sci 2020 12;11:564385. Epub 2020 Nov 12.

Shandong Provincial Key Laboratory of Microbial Engineering, School of Biologic Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

Grape ( L.) is a fruit tree with high salt tolerance and high nutritional value, medicinal value, and economic value. Suberin in roots is characterized by long-chain fatty acids and is thought to be related to the salt tolerance of grape. The key enzyme in the fatty acid elongation process is β-ketoacyl-CoA synthase (KCS). The function and the regulatory mechanism of in response to salt stress in grape are unclear. In this study, was isolated from L. A real-time quantitative polymerase chain reaction analysis showed that salt stress enhanced transcription levels in grapes. Overexpression of increased the tolerance to salt stress in during the germination and seedling stages. The improved salt tolerance was the result of the combined contributions of multiple mechanisms including the regulation of expression of ion transporters and channels, accumulation of osmotic regulating substances, and maintenance of membrane stability. The results of this study are valuable information on plant salt tolerance and provide a theoretical basis for the molecular mechanism of grape salt tolerance.
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http://dx.doi.org/10.3389/fpls.2020.564385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688582PMC
November 2020

[Inflammation caused by different immune cell subsets is involved in bone destruction of rheumatoid arthritis].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Nov;36(11):1026-1031

Department of Rheumatology, First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China.

Objective To observe the relationship of rheumatoid arthritis (RA) bone destruction with T cells, regulatory T cells (Tregs), CD19 B cells and immune inflammation. Methods The study enrolled randomly 20 RA patients (RA group) and 20 normal controls (NC group). Bone mineral density was measured by DXEA dual energy X-ray bone densitometer. The serum levels of γ-interferon (IFN-γ) of Th1 cells, interleukin-4 (IL-4) of Th2 cells, IL-17, type I procollagen amino terminal propeptide (PINP), type I collagen carboxy terminal peptide (CTx), receptor activator of NF-κB ligand (RANKL) and osteoprotectin (OPG) were detected by ELISA. T-cell subsets, Tregs, CD19 B cells in peripheral blood were measured by flow cytometry. Spearman method was used to analyze the correlations of T cells, Treg and CD19 B cells with bone density and Th1 and Th2 cytokines. Results The bone mineral density T value of the RA group was lower than that of the NC group. The bone mineral density T value of the double forearm was lower than that of the lumbar spine in the RA group. Compared with the NC group, the expression of IFN-γ, IL-17, Th1/Th2 cells, CTx, RANKL increased, and IL-4, PINP decreased in the RA group. Compared with the NC group, the expression of CD4/CD8 T cells, CD19 B cells increased, and CD8 T cells, CD4CD25 Tregs decreased in the RA group. Correlation analysis showed that CD8 T cells were positively correlated with Th1/Th2 cells and IL-17, while CD4 CD25 Tregs were negatively correlated with CTx, and CD19 B cells were negatively correlated with OPG in RA. Conclusion T cells and CD19 B cells may participate in the process of bone destruction in RA by mediating inflammatory immunity.
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November 2020

LncRNA BACE1-AS Promotes Autophagy-Mediated Neuronal Damage Through The miR-214-3p/ATG5 Signalling Axis In Alzheimer's Disease.

Neuroscience 2021 02 13;455:52-64. Epub 2020 Nov 13.

Shaanxi Key Laboratory of Chinese Medicine Encephalopathy, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, PR China. Electronic address:

Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by progressive memory loss and cognitive dysfunction. Long non-coding RNAs (lncRNAs) have been shown to be among the most promising biomarkers and therapeutic targets of AD. Here, we aimed to investigate whether lncRNA BACE1-AS plays a role in the potential mechanisms of AD. The expression of BACE1-AS, miR-214-3p and ATG5 mRNA was detected using qRT-PCR. The expression of the LC3, P62, ATG5, Bcl-2, p-Tau and cleaved-caspase 3 proteins was examined using western blot analysis. Cell apoptosis, cytotoxicity and ROS levels were estimated using flow cytometry, an LDH kit and a DCFH-DA assay, respectively. The interaction between BACE1-AS or ATG5 and miR-214-3p was validated using a dual-luciferase reporter assay. HE staining and a TUNEL assay were employed to evaluate hippocampal neuronal injury. The BACE1-AS level was found to be upregulated in serum samples of AD patients, brain tissues of AD transgenic (Tg) mice and Aβ-treated SH-SY5Y cells. Autophagy activity was increased in both Tg mice and Aβ-treated cells. BACE1-AS knockdown alleviated Aβ-induced cell injury. Rapamycin abolished the protective effects of sh BACE1-AS against Aβ induced cell injury. BACE1-AS indirectly regulated ATG5 expression by binding miR-214-3p. The miR-214-3p inhibitor reversed the protective effects of sh BACE1-AS and sh ATG5 against Aβ-induced cell injury. Knockdown of BACE1-AS alleviated neuronal injury by repressing autophagy in vivo. Our findings demonstrate that silencing of BACE1-AS alleviated neuronal injury by regulating autophagy through the miR-214-3p/ATG5 signalling axis in AD.
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http://dx.doi.org/10.1016/j.neuroscience.2020.10.028DOI Listing
February 2021

The role of allyl ammonium salts in palladium-catalyzed cascade reactions towards the synthesis of spiro-fused heterocycles.

Nat Commun 2020 10 23;11(1):5383. Epub 2020 Oct 23.

Leibniz-Institute for Catalysis, Albert-Einstein-Str. 29a, 18059, Rostock, Germany.

There is a continuous need for designing new and improved synthetic methods aiming at minimizing reaction steps while increasing molecular complexity. In this respect, catalytic, one-pot cascade methodologies constitute an ideal tool for the construction of complex molecules with high chemo-, regio-, and stereoselectivity. Herein, we describe two general and efficient cascade procedures for the synthesis of spiro-fused heterocylces. This transformation combines selective nucleophilic substitution (S2'), palladium-catalyzed Heck and C-H activation reactions in a cascade manner. The use of allylic ammonium salts and specific Pd catalysts are key to the success of the transformations. The synthetic utility of these methodologies is showcased by the preparation of 48 spiro-fused dihydrobenzofuranes and indolines including a variety of fluorinated derivatives.
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http://dx.doi.org/10.1038/s41467-020-19110-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584656PMC
October 2020

A Systematic Review and Meta-Analysis of Immune-Related Adverse Events of Anti-PD-1 Drugs in Randomized Controlled Trials.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820967454

Henan Key Laboratory of Cancer Epigenetics; Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Objective: We aimed to evaluate immune-related adverse events occurring in clinical trials of anti-programmed cell death 1 (PD-1) drugs, compared with control treatments, including chemotherapy, targeted drugs, or placebo. Further we compared the occurrence of immune -related events in patients treated with different anti-PD-1 drugs.

Data Sources: Randomized controlled trial (RCT) data were sourced from PubMed, Embase, and the Cochrane Central Register of Controlled Trials combined with https://clinicaltrials.gov.

Methods: Randomized controlled trial of anti-PD-1 drugs compared with control treatments published between January 1, 1970 and March 1,2019, were searched and data on trial patient characteristics, and adverse events extracted, reviewed, and subjected to meta-analysis.

Results: Eighteen Randomized controlled trials were included in our study. The Randomized controlled trials compared nivolumab (n = 12), pembrolizumab (n = 6), with chemotherapy (n = 13), targeted drugs (n = 2), or placebo (n = 3). Compared with the control group, the risk of any immune-related adverse events in patients treated with anti-PD-1 drugs was increased (RR, 2.65; 95% confidence interval, 1.84-3.83; < 0.00001). Of the immune-related adverse events, the risk rates of pneumonitis (risk ratio, 2.10; 95% CI, 0.85-5.18), colitis (2.96;1.62-5.38), hypophysitis(4.79;1.54-14.89), hypothyroidism(7.87;5.36-11.57), hyperthyroidism (7.03;4.35-11.34), rash (1.58;0.98-2.54), pruritus (2.28; 1.38-3.76), and hepatitis (9.31;2.18-39.85) were increased by anti-PD-1 drugs. Further, the risk of immune-related adverse events was similar for patients treated with pembrolizumab and nivolumab ( = 0.14).

Conclusions: In addition to previously reported organ-specific immune-related adverse events, we found that the risk of hyperthyroidism was also increased, in anit-PD-1-treated patients, relative to control treatments. The risk of total immune-related adverse events, was similar for pembrolizumab and nivolumab.
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http://dx.doi.org/10.1177/1533033820967454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588773PMC
November 2021
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