Publications by authors named "Gavin Thurston"

83Publications

Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids.

Bioorg Med Chem 2020 Oct 11;28(23):115785. Epub 2020 Oct 11.

Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, United States.

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http://dx.doi.org/10.1016/j.bmc.2020.115785DOI Listing
October 2020

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Sci Transl Med 2016 09;8(358):358ra128

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1126/scitranslmed.aaf6812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450386PMC
September 2016

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy.

BMC Bioinformatics 2016 Jul 20;17:286. Epub 2016 Jul 20.

Regeneron Pharmaceuticals Inc, Old Saw Mill River Road, Tarrytown, NY, USA.

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http://dx.doi.org/10.1186/s12859-016-1150-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955262PMC
July 2016

Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts.

PLoS One 2014 13;9(11):e112371. Epub 2014 Nov 13.

Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, United States of America; Department of Cancer Pathology & Prevention, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112371PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231048PMC
August 2015

The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway.

Cold Spring Harb Perspect Med 2012 Sep 1;2(9):a006550. Epub 2012 Sep 1.

Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1101/cshperspect.a006650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426817PMC
September 2012

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.

Histopathology 2012 Apr 1;60(5):740-7. Epub 2012 Feb 1.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2559.2011.04138.xDOI Listing
April 2012

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis.

Vasc Cell 2011 Sep 18;3(1):20. Epub 2011 Sep 18.

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1186/2045-824X-3-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195111PMC
September 2011

Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors.

Cancer Biol Ther 2010 Dec 15;10(12):1326-33. Epub 2010 Dec 15.

Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047090PMC
http://dx.doi.org/10.4161/cbt.10.12.14009DOI Listing
December 2010

Angiopoietin-2-driven vascular remodeling in airway inflammation.

Am J Pathol 2010 Dec 15;177(6):3233-43. Epub 2010 Oct 15.

Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143-0425, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993300PMC
December 2010

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting.

Nat Cell Biol 2010 Oct 26;12(10):943-53. Epub 2010 Sep 26.

Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.

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http://pbsb.med.cornell.edu/pdfs/nature_jakobsson.pdf
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http://www.nature.com/doifinder/10.1038/ncb2103
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http://dx.doi.org/10.1038/ncb2103DOI Listing
October 2010

Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.

Am J Pathol 2010 Apr 18;176(4):2019-28. Epub 2010 Feb 18.

Nuffield Department of Clinical Laboratory Sciences,Weatherall Institute ofMolecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.2353/ajpath.2010.090908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843489PMC
April 2010

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

Nat Rev Mol Cell Biol 2009 Mar;10(3):165-77

Joint Research Division Vascular Biology, Medical Faculty Mannheim (CBTM), University of Heidelberg, and German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Germany.

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http://dx.doi.org/10.1038/nrm2639DOI Listing
March 2009

VEGF-mediated cross-talk within the neonatal murine thymus.

Blood 2009 Mar 16;113(12):2723-31. Epub 2008 Dec 16.

Division of Research Immunology and Bone Marrow Transplantation and Gene, Immune and Stem Cell Therapy (GISCT) Program, Childrens Hospital Los Angeles (CHLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.1182/blood-2008-06-162040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661859PMC
March 2009

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation.

Cancer Biol Ther 2008 Dec 11;7(12):1994-2003. Epub 2008 Dec 11.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932444PMC
http://dx.doi.org/10.4161/cbt.7.12.6967DOI Listing
December 2008

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Novartis Found Symp 2007 ;283:106-20; discussion 121-5, 238-41

Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA.

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March 2008

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth.

Nat Rev Cancer 2007 05;7(5):327-31

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1038/nrc2130DOI Listing
May 2007

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Nature 2006 Dec;444(7122):1032-7

Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA.

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http://dx.doi.org/10.1038/nature05355DOI Listing
December 2006

Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.

Mol Cell Biol 2007 Jan 13;27(2):595-604. Epub 2006 Nov 13.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01503-06
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http://dx.doi.org/10.1128/MCB.01503-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800809PMC
January 2007

Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling.

Am J Physiol Heart Circ Physiol 2006 Feb 19;290(2):H547-59. Epub 2005 Sep 19.

Cardiovascular Research Institute, and Dept. of Anatomy, Univ. of California, 513 Parnassus Ave., San Francisco, CA 94143-0452, USA.

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http://dx.doi.org/10.1152/ajpheart.00616.2005DOI Listing
February 2006

Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis.

Inflammation 2004 Oct;28(5):271-8

Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, USA.

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http://dx.doi.org/10.1007/s10753-004-6050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417046PMC
October 2004

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules.

Am J Physiol Heart Circ Physiol 2006 Jan 26;290(1):H107-18. Epub 2005 Aug 26.

Cardiovascular Research Institute, and Dept. of Anatomy, Univ. of California, San Francisco, CA 94143-0452, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00542.2005
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http://dx.doi.org/10.1152/ajpheart.00542.2005DOI Listing
January 2006

Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.

Development 2005 Jul 15;132(14):3317-26. Epub 2005 Jun 15.

Regeneron Pharmaceuticals Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1242/dev.01888DOI Listing
July 2005

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

Blood 2005 Jun 3;105(12):4642-8. Epub 2005 Mar 3.

Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2004-08-3327DOI Listing
June 2005

The anti-inflammatory actions of angiopoietin-1.

EXS 2005 (94):233-45

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1007/3-7643-7311-3_16DOI Listing
March 2005

Vascular endothelial growth factor and other signaling pathways in developmental and pathologic angiogenesis.

Int J Hematol 2004 Jul;80(1):7-20

Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA.

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http://dx.doi.org/10.1532/ijh97.04065DOI Listing
July 2004

Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels.

Circ Res 2004 Apr 4;94(7):984-92. Epub 2004 Mar 4.

Department of Anatomy, Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, Calif, USA.

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http://dx.doi.org/10.1161/01.RES.0000125295.43813.1FDOI Listing
April 2004

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.

Blood 2004 Jun 19;103(11):4150-6. Epub 2004 Feb 19.

Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2003-10-3685DOI Listing
June 2004

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.

J Clin Invest 2004 Feb;113(4):516-27

Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5175, USA.

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http://www.jci.org/articles/view/18420
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http://dx.doi.org/10.1172/JCI18420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC338257PMC
February 2004

Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis.

Authors:
Gavin Thurston

Cell Tissue Res 2003 Oct 12;314(1):61-8. Epub 2003 Aug 12.

Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

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http://dx.doi.org/10.1007/s00441-003-0749-6DOI Listing
October 2003

Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage.

Authors:
Gavin Thurston

J Anat 2002 Jun;200(6):575-80

Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570748PMC
http://dx.doi.org/10.1046/j.1469-7580.2002.00061.xDOI Listing
June 2002