Prof Gavin Reynolds, PhD - Sheffield Hallam University - Honorary Professor of Neuroscience

Prof Gavin Reynolds

PhD

Sheffield Hallam University

Honorary Professor of Neuroscience

Sheffield | United Kingdom

Main Specialties: Pharmacology

Additional Specialties: schizophrenia, antipsychotic drugs, pharmacogenetics, epigenetics

ORCID logohttps://orcid.org/0000-0001-9026-7726


Top Author

Prof Gavin Reynolds, PhD - Sheffield Hallam University - Honorary Professor of Neuroscience

Prof Gavin Reynolds

PhD

Introduction

Mar 2004 – Oct 2009 Professor and Chair of Neuroscience, Dept. of Psychiatry, School of Medicine, Dentistry & Biomedical Sciences, Queen’s University Belfast.

Jan 1990 – Feb 2004 Senior lecturer (to 1992), Reader (to 1995), Professor of Neurochemistry, Department of Biomedical Science, University of Sheffield.

Jan 1985 - Dec 1989 Wellcome Lectureship; Department of Pathology, University of Nottingham Medical School.

Jan 1982 - Dec 1984 MRC Neurochemical Pharmacology Unit, Cambridge; non-clinical Scientist with financial support from the Schizophrenia Research Fund and MRC. I was based in, and supervised the running of, the MRC Brain Tissue Bank.

1976-1981 Department of Chemical Pathology, Queen Charlotte's Hospital, London Schizophrenia Research Fund Fellowship.
Including periods totalling approx. 18 months at:
1979-1981 Neurochemistry Group, Ludwig-Boltzmann Institute for Clinical Neurobiology, Vienna, Austria; Visiting Research Worker

Primary Affiliation: Sheffield Hallam University - Sheffield , United Kingdom

Specialties:

Additional Specialties:

Education

Apr 1977
University of London
PhD
Biochemistry

Experience

Sheffield Hallam University Biosciences
Honorary Professor

Publications

112Publications

1483Reads

659Profile Views

1240PubMed Central Citations

Lower uric acid is associated with poor short-term outcome and a higher frequency of posterior arterial involvement in ischemic stroke.

Neurol Sci 2018 Jun 6;39(6):1117-1119. Epub 2018 Mar 6.

Department of Neurology, Puer People's Hospital, Puer, Yunnan, China.

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http://dx.doi.org/10.1007/s10072-018-3307-4DOI Listing
June 2018
4 Reads
1.500 Impact Factor

Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia.

Epigenomics 2018 05 24;10(5):519-524. Epub 2018 Apr 24.

Biomolecular Sciences Research Center, Sheffield Hallam University, Sheffield, UK.

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http://dx.doi.org/10.2217/epi-2017-0159DOI Listing
May 2018
9 Reads

Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.

J Psychopharmacol 2018 Mar 17;32(3):309-315. Epub 2018 Jan 17.

1 Faculty of Medical Science, Department of Anatomy, Naresuan University, Phitsanulok, Thailand.

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http://dx.doi.org/10.1177/0269881117750153DOI Listing
March 2018
11 Reads
3.593 Impact Factor

DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD.

World J Biol Psychiatry 2017 06 27;18(4):291-299. Epub 2016 Sep 27.

a Department of Psychiatry , The First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan , PR China.

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http://dx.doi.org/10.1080/15622975.2016.1224928DOI Listing
June 2017
21 Reads
4 Citations
4.183 Impact Factor

Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence.

Pharmacogenomics 2017 Jan 14;18(1):17-22. Epub 2016 Dec 14.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.

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http://dx.doi.org/10.2217/pgs-2016-0101DOI Listing
January 2017
26 Reads
3.220 Impact Factor

Modelling the cognitive and neuropathological features of schizophrenia with phencyclidine.

J Psychopharmacol 2016 11 13;30(11):1141-1144. Epub 2016 Sep 13.

Manchester Pharmacy School, University of Manchester, Manchester, UK

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http://dx.doi.org/10.1177/0269881116667668DOI Listing
November 2016
6 Reads
3 Citations
3.593 Impact Factor

TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

Int J Neuropsychopharmacol 2016 11 1;19(11). Epub 2016 Nov 1.

Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China (Drs Xu and Yuan); Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom (Dr Reynolds); Department of Neuropsychiatry, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210000, PR China (Dr Shi); Department of Neurology, Wuxi first people's Hospital, Wuxi 214000, PR China (Dr Pu); Department of Neurology, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, PR China (Dr Zhang).

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http://dx.doi.org/10.1093/ijnp/pyw070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137282PMC
November 2016
8 Reads
4.010 Impact Factor

Effect of Methamphetamine Exposure on Expression of Calcium Binding Proteins in Rat Frontal Cortex and Hippocampus.

Neurotox Res 2016 10 14;30(3):427-33. Epub 2016 May 14.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.

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http://dx.doi.org/10.1007/s12640-016-9628-2DOI Listing
October 2016
16 Reads
3.540 Impact Factor

Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain.

Epigenomics 2016 09 16;8(9):1179-83. Epub 2016 Aug 16.

Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK.

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http://dx.doi.org/10.2217/epi-2016-0050DOI Listing
September 2016
9 Reads
1 Citation

Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment.

Behav Brain Res 2016 09 24;311:210-218. Epub 2016 May 24.

Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2016.05.044DOI Listing
September 2016
35 Reads
1 Citation
3.030 Impact Factor

BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment.

J Psychopharmacol 2016 08 4;30(8):717-48. Epub 2016 May 4.

Professor of Early Intervention and Psychosis, University of Worcester, Worcester, UK.

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http://dx.doi.org/10.1177/0269881116645254DOI Listing
August 2016
55 Reads
8 Citations
3.593 Impact Factor

BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence.

Pharmacogenomics 2015 24;16(14):1541-5. Epub 2015 Sep 24.

Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

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http://dx.doi.org/10.2217/pgs.15.96DOI Listing
July 2016
10 Reads
2 Citations
3.220 Impact Factor

Does elevated peripheral benzodiazepine receptor gene expression relate to cognitive deficits in methamphetamine dependence?

Hum Psychopharmacol 2016 05 24;31(3):243-6. Epub 2016 Feb 24.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.

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http://dx.doi.org/10.1002/hup.2523DOI Listing
May 2016
10 Reads
2.192 Impact Factor

Does DNA methylation influence the effects of psychiatric drugs?

Epigenomics 2016 Mar 26;8(3):309-12. Epub 2016 Feb 26.

Department of Neuroscience & Behavior, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.

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http://dx.doi.org/10.2217/epi.15.116DOI Listing
March 2016
36 Reads
1 Citation

Polymorphisms of serotonin neurotransmission and their effects on antipsychotic drug action.

Pharmacogenomics 2014 ;15(12):1599-609

Department of Neurology, First People's Hospital of Yunnan Province, Kunming, 650021 China.

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http://dx.doi.org/10.2217/pgs.14.111DOI Listing
June 2015
7 Reads
4 Citations
3.220 Impact Factor

Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism.

Prog Neuropsychopharmacol Biol Psychiatry 2014 Oct 8;54:157-62. Epub 2014 Jun 8.

The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.pnpbp.2014.05.017DOI Listing
October 2014
18 Reads
1 Citation
3.690 Impact Factor

Analysis of sociability and preference for social novelty in the acute and subchronic phencyclidine rat.

J Psychopharmacol 2014 Oct 13;28(10):955-63. Epub 2014 Aug 13.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Belfast, UK School of Medical Sciences, Health Innovations Research Institute, RMIT University, Bundoora, VIC, Australia

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http://dx.doi.org/10.1177/0269881114544778DOI Listing
October 2014
18 Reads
3 Citations
3.593 Impact Factor

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms.

Br J Clin Pharmacol 2014 Apr;77(4):654-72

Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK.

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http://dx.doi.org/10.1111/bcp.12312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971982PMC
April 2014
14 Reads
9 Citations
3.880 Impact Factor

Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia.

Int J Neuropsychopharmacol 2014 Apr 16;17(4):645-9. Epub 2013 Dec 16.

Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK.

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http://ijnp.oxfordjournals.org/content/ijnp/17/4/645.full.pd
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http://ijnp.oxfordjournals.org/cgi/doi/10.1017/S146114571300
Publisher Site
http://dx.doi.org/10.1017/S1461145713001442DOI Listing
April 2014
24 Reads
5 Citations
4.010 Impact Factor

Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone.

Hum Psychopharmacol 2014 Jan 25;29(1):38-45. Epub 2013 Nov 25.

Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1002/hup.2366DOI Listing
January 2014
10 Reads
1 Citation
2.192 Impact Factor

Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population.

Neurosci Lett 2013 Sep 21;551:58-61. Epub 2013 Jul 21.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

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http://dx.doi.org/10.1016/j.neulet.2013.07.017DOI Listing
September 2013
14 Reads
5 Citations
2.060 Impact Factor

The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients.

Int J Neuropsychopharmacol 2013 Jul 14;16(6):1421-5. Epub 2012 Dec 14.

Department of Psychiatry, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1017/S1461145712001435DOI Listing
July 2013
17 Reads
4 Citations
4.010 Impact Factor

Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.

Pharmacogenomics 2013 Apr;14(5):505-14

Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.2217/pgs.13.25DOI Listing
April 2013
13 Reads
3.220 Impact Factor

The pharmacogenetics of antipsychotic treatment.

Authors:
Gavin P Reynolds

Handb Exp Pharmacol 2012 (212):213-39

Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK.

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http://dx.doi.org/10.1007/978-3-642-25761-2_9DOI Listing
April 2013
7 Reads

Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response.

Pharmacogenomics 2013 Feb;14(3):277-88

Department of Neuropsychiatry, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

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http://dx.doi.org/10.2217/pgs.13.1DOI Listing
February 2013
16 Reads
8 Citations
3.220 Impact Factor

Histamine and antipsychotic drug-induced weight gain.

Authors:
Gavin P Reynolds

J Psychopharmacol 2012 Dec;26(12):1608-9

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http://dx.doi.org/10.1177/0269881112463127DOI Listing
December 2012
18 Reads
1 Citation
3.593 Impact Factor

Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.

BMC Med Genet 2012 Oct 2;13:91. Epub 2012 Oct 2.

The Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, 50603 Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1186/1471-2350-13-91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502145PMC
October 2012
13 Reads
3 Citations
2.083 Impact Factor

Receptor mechanisms of antipsychotic drug atypicality.

Authors:
G P Reynolds

Eur Psychiatry 1998 ;13(1 Suppl 1):5s-8s

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http://dx.doi.org/10.1016/S0924-9338(97)89487-4DOI Listing
October 2012
8 Reads
3.440 Impact Factor

Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain - A Critical Review.

Authors:
Gavin P Reynolds

Clin Psychopharmacol Neurosci 2012 Aug 31;10(2):71-7. Epub 2012 Aug 31.

Biomedical Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.

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http://dx.doi.org/10.9758/cpn.2012.10.2.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569150PMC
August 2012
9 Reads
13 Citations

The effect of chronic antipsychotic drug on hypothalamic expression of neural nitric oxide synthase and dopamine D2 receptor in the male rat.

PLoS One 2012 13;7(4):e33247. Epub 2012 Apr 13.

Department of Neuropsychiatry, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033247PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326012PMC
August 2012
25 Reads
3 Citations
3.234 Impact Factor

Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS.

PLoS One 2011 14;6(12):e28686. Epub 2011 Dec 14.

Department of Neurology, Affiliated ZhongDa Hospital and the Institution Neuropsychiatry of Southeast University, Nanjing, Jiangsu, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237477PMC
August 2012
13 Reads
14 Citations
3.234 Impact Factor

An association between genotypic variations and protein expression of the glial glutamate transporter 2 in the human nucleus accumbens.

Neurosci Lett 2012 Aug 28;523(2):108-10. Epub 2012 Jun 28.

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

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http://dx.doi.org/10.1016/j.neulet.2012.06.052DOI Listing
August 2012
18 Reads
1 Citation
2.060 Impact Factor

Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.

J Psychopharmacol 2012 Mar 21;26(3):349-59. Epub 2011 Sep 21.

Department of Neuropsychiatry, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

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http://dx.doi.org/10.1177/0269881111414452DOI Listing
March 2012
26 Reads
10 Citations
3.593 Impact Factor

Special issue on Pharmacogenetics.

J Psychopharmacol 2012 Mar;26(3):333

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http://dx.doi.org/10.1177/0269881112439150DOI Listing
March 2012
6 Reads
3.593 Impact Factor

The dose-dependent effect of chronic administration of haloperidol, risperidone, and quetiapine on sexual behavior in the male rat.

J Sex Med 2011 Dec 8;8(12):3345-53. Epub 2010 Mar 8.

Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China.

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http://dx.doi.org/10.1111/j.1743-6109.2010.01740.xDOI Listing
December 2011
32 Reads
3 Citations
3.151 Impact Factor

Receptor mechanisms of antipsychotic drug action in bipolar disorder - focus on asenapine.

Authors:
Gavin P Reynolds

Ther Adv Psychopharmacol 2011 Dec;1(6):197-204

Biomedical Research Centre Sheffield Hallam University.

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http://dx.doi.org/10.1177/2045125311430112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736908PMC
December 2011
26 Reads
4 Citations

Sexual dysfunction in male schizophrenia: influence of antipsychotic drugs, prolactin and polymorphisms of the dopamine D2 receptor genes.

Pharmacogenomics 2011 Aug 12;12(8):1127-36. Epub 2011 Jul 12.

Neuropsychiatric Research Institute, School of Medicine, Southeast University, Nanjing, China.

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http://dx.doi.org/10.2217/pgs.11.46DOI Listing
August 2011
20 Reads
5 Citations
3.220 Impact Factor

Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.

Pharmacogenomics 2011 May 11;12(5):727-34. Epub 2011 Mar 11.

Division of Psychiatry & Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT97BL, UK.

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http://dx.doi.org/10.2217/pgs.11.16DOI Listing
May 2011
9 Reads
8 Citations
3.220 Impact Factor

Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: a magnetic resonance study.

Behav Brain Res 2011 Feb 23;217(1):122-7. Epub 2010 Oct 23.

Department of Neurology, Affiliated ZhongDa Hospital and the Institution Neuropsychiatry of Southeast University, Nanjing, Jiangsu, China.

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http://dx.doi.org/10.1016/j.bbr.2010.10.014DOI Listing
February 2011
59 Reads
17 Citations
3.030 Impact Factor

Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder.

J Psychiatr Res 2011 Jan 1;45(1):54-9. Epub 2010 Jun 1.

Department of Psychiatry, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.jpsychires.2010.05.001DOI Listing
January 2011
9 Reads
7 Citations
3.960 Impact Factor

Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats.

Eur Neuropsychopharmacol 2010 Dec;20(12):875-83

School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China.

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http://dx.doi.org/10.1016/j.euroneuro.2010.08.010DOI Listing
December 2010
20 Reads
4 Citations
4.370 Impact Factor

Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse.

Hum Mol Genet 2010 Sep 28;19(17):3402-12. Epub 2010 Jun 28.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

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http://dx.doi.org/10.1093/hmg/ddq252DOI Listing
September 2010
9 Reads
4 Citations
6.393 Impact Factor

Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism.

J Affect Disord 2010 Jun 1;123(1-3):308-11. Epub 2009 Oct 1.

Department of Neuropharmacology, Institute of Pharmacology and Toxicology AMS Ukraine, Eugene Potie str., 14, Kyiv, 03057, Ukraine.

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http://dx.doi.org/10.1016/j.jad.2009.09.007DOI Listing
June 2010
11 Reads
10 Citations
3.383 Impact Factor

The effect of chronic antipsychotic drug administration on nitric oxide synthase activity and gene expression in rat penile tissues.

Eur Neuropsychopharmacol 2010 Apr 14;20(4):211-7. Epub 2009 Nov 14.

Neuropsychiatric Research Institute, School of Clinical Medicine, Southeast University, Nanjing, China.

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http://dx.doi.org/10.1016/j.euroneuro.2009.10.002DOI Listing
April 2010
9 Reads
1 Citation
4.370 Impact Factor

Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat.

Behav Brain Res 2010 Mar 13;208(1):132-6. Epub 2009 Nov 13.

Department of Psychiatry, Queen's University Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.bbr.2009.11.018DOI Listing
March 2010
8 Reads
10 Citations
3.030 Impact Factor

Metabolic side effects of antipsychotic drug treatment--pharmacological mechanisms.

Pharmacol Ther 2010 Jan 17;125(1):169-79. Epub 2009 Nov 17.

Department of Psychiatry, Queen's University Belfast, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.pharmthera.2009.10.010DOI Listing
January 2010
9 Reads
69 Citations
9.723 Impact Factor

Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat.

Behav Brain Res 2009 Dec 22;205(2):355-9. Epub 2009 Jul 22.

Department of Psychiatry, Queen's University Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1016/j.bbr.2009.07.014DOI Listing
December 2009
7 Reads
19 Citations
3.030 Impact Factor

Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors.

Psychopharmacology (Berl) 2009 Nov 18;207(1):119-25. Epub 2009 Aug 18.

Department of Psychiatry, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, UK.

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http://dx.doi.org/10.1007/s00213-009-1639-8DOI Listing
November 2009
11 Reads
18 Citations
3.880 Impact Factor

Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat.

Behav Brain Res 2008 Dec 25;194(2):230-5. Epub 2008 Jul 25.

Division of Psychiatry and Neuroscience, Queen's University, Belfast, Northern Ireland, United Kingdom.

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http://dx.doi.org/10.1016/j.bbr.2008.07.020DOI Listing
December 2008
9 Reads
9 Citations
3.030 Impact Factor

Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia.

Br J Psychiatry 2008 Jun;192(6):424-8

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1192/bjp.bp.107.041723DOI Listing
June 2008
9 Reads
11 Citations
7.991 Impact Factor

Acute tryptophan depletion does not alter central or plasma brain-derived neurotrophic factor in the rat.

Eur Neuropsychopharmacol 2008 May 24;18(5):317-22. Epub 2007 Aug 24.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2007.07.006DOI Listing
May 2008
14 Reads
4.370 Impact Factor

The impact of pharmacogenetics on the development and use of antipsychotic drugs.

Authors:
Gavin P Reynolds

Drug Discov Today 2007 Nov 4;12(21-22):953-9. Epub 2007 Sep 4.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.drudis.2007.07.018DOI Listing
November 2007
7 Reads
8 Citations
6.691 Impact Factor

Sub-chronic phencyclidine administration increases brain-derived neurotrophic factor in the RAT hippocampus.

Schizophr Res 2007 Aug 8;94(1-3):371-2. Epub 2007 Jun 8.

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http://dx.doi.org/10.1016/j.schres.2007.04.032DOI Listing
August 2007
9 Reads
1 Citation
3.923 Impact Factor

Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat.

Psychopharmacology (Berl) 2007 Mar 24;190(4):497-506. Epub 2006 Nov 24.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla, 97 Lisburn Road, Northern Ireland, UK.

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http://dx.doi.org/10.1007/s00213-006-0635-5DOI Listing
March 2007
9 Reads
20 Citations
3.880 Impact Factor

5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activity.

Brain Res 2007 May 24;1149:14-7. Epub 2007 Feb 24.

Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James' Hospital, James Street, Dublin, D8, Ireland.

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http://dx.doi.org/10.1016/j.brainres.2007.02.038DOI Listing
May 2007
9 Reads
7 Citations
2.843 Impact Factor

Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat.

Psychopharmacology (Berl) 2007 Mar 24;190(4):497-506. Epub 2006 Nov 24.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla, 97 Lisburn Road, Northern Ireland, UK.

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http://dx.doi.org/10.1007/s00213-006-0635-5DOI Listing
March 2007
9 Reads
20 Citations
3.880 Impact Factor

Acute and chronic tryptophan depletion differentially regulate central 5-HT1A and 5-HT 2A receptor binding in the rat.

Psychopharmacology (Berl) 2007 Mar 24;190(4):497-506. Epub 2006 Nov 24.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla, 97 Lisburn Road, Northern Ireland, UK.

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http://dx.doi.org/10.1007/s00213-006-0635-5DOI Listing
March 2007
9 Reads
20 Citations
3.880 Impact Factor

Pharmacogenetics of schizophrenia.

Expert Opin Pharmacother 2006 Aug;7(11):1429-40

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1517/14656566.7.11.1429 DOI Listing
August 2006
10 Reads
3 Citations
3.534 Impact Factor

The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and genetics.

J Psychopharmacol 2006 Jul;20(4 Suppl):15-8

Division of Psychiatry and Neuroscience, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1177/1359786806066040DOI Listing
July 2006
8 Reads
24 Citations
3.593 Impact Factor

Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus.

J Psychopharmacol 2006 Jul 9;20(4):577-9. Epub 2006 Jan 9.

Division of Psychiatry and Neuroscience, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1177/0269881106061199DOI Listing
July 2006
8 Reads
4 Citations
3.593 Impact Factor

An in vitro model of inflammatory neurodegeneration and its neuroprotection.

Neurosci Lett 2005 Nov;388(1):39-44

University of Sheffield, Department of Biomedical Science, Western Bank, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1016/j.neulet.2005.06.047DOI Listing
November 2005
10 Reads
2 Citations
2.060 Impact Factor

Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol.

J Psychopharmacol 2005 Nov;19(6):597-601

Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9WL, UK.

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http://dx.doi.org/10.1177/0269881105056641DOI Listing
November 2005
9 Reads
6 Citations
3.593 Impact Factor

The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment.

Prog Neuropsychopharmacol Biol Psychiatry 2005 Jul;29(6):1021-8

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.pnpbp.2005.03.019DOI Listing
July 2005
8 Reads
19 Citations
3.690 Impact Factor

Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis.

Pharmacogenet Genomics 2005 Apr;15(4):195-200

Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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April 2005
12 Reads
47 Citations
3.481 Impact Factor

Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.

Schizophr Res 2005 Mar;73(2-3):147-52

Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1016/j.schres.2004.02.003DOI Listing
March 2005
8 Reads
12 Citations
3.923 Impact Factor

Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response.

Eur Neuropsychopharmacol 2005 Mar;15(2):143-51

Department of Mental Health, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.euroneuro.2004.07.001DOI Listing
March 2005
19 Reads
17 Citations
4.370 Impact Factor

Chronic haloperidol or clozapine treatment does not alter parvalbumin immunoreactivity in the rat frontal cortex or hippocampus.

Neurosci Lett 2005 Jan;373(1):57-60

Department of Mental Health, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Rd, Belfast, BT9 7BL, UK.

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http://dx.doi.org/10.1016/j.neulet.2004.09.057DOI Listing
January 2005
10 Reads
4 Citations
2.060 Impact Factor

Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat.

Eur J Pharmacol 2004 Nov;505(1-3):253-4

Bradford School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK.

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http://dx.doi.org/10.1016/j.ejphar.2004.10.015DOI Listing
November 2004
8 Reads
2 Citations
2.532 Impact Factor

The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders.

Neurosci Lett 2004 Nov;372(1-2):173-7

Division of Psychiatry and Neuroscience, Queen's University Belfast, White Medical Building, Belfast BT97BL, UK.

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http://dx.doi.org/10.1016/j.neulet.2004.09.035DOI Listing
November 2004
17 Reads
26 Citations
2.060 Impact Factor

Receptor mechanisms in the treatment of schizophrenia.

Authors:
Gavin P Reynolds

J Psychopharmacol 2004 Sep;18(3):340-5

Department of Mental Health, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1177/026988110401800303DOI Listing
September 2004
9 Reads
16 Citations
3.593 Impact Factor

Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation.

Biol Psychiatry 2004 Aug;56(4):296-9

Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2004.06.009DOI Listing
August 2004
8 Reads
3 Citations
10.260 Impact Factor

Calcium binding protein markers of GABA deficits in schizophrenia--postmortem studies and animal models.

Neurotox Res 2004 ;6(1):57-61

Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

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August 2004
11 Reads
36 Citations
3.540 Impact Factor

Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia.

Br J Psychiatry 2004 Jan;184:58-62

Department of Psychiatry Nanjing Brain Hospital and Nanjing Medical University, Nanjing, China.

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January 2004
14 Reads
27 Citations
7.991 Impact Factor

Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia.

Psychiatr Genet 2003 Sep;13(3):187-92

Department of Psychiatry, Nanjing Brain Hospital and Nanjing Medical University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1097/01.ypg.0000071600.59979.0eDOI Listing
September 2003
11 Reads
9 Citations
1.941 Impact Factor

N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study.

Biol Psychiatry 2003 Jun;53(12):1138-41

Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

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June 2003
12 Reads
13 Citations
10.260 Impact Factor

Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain.

Am J Psychiatry 2003 Apr;160(4):677-9

Department of Biomedical Science, University of Sheffield, UK.

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http://dx.doi.org/10.1176/appi.ajp.160.4.677DOI Listing
April 2003
12 Reads
17 Citations
12.295 Impact Factor

The increased activity of plasma manganese superoxide dismutase in tardive dyskinesia is unrelated to the Ala-9Val polymorphism.

J Psychiatr Res 2002 Sep-Oct;36(5):317-24

Department of Psychiatry, Nanjing Brain Hospital and Nanjing Medical University, PR China.

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November 2002
11 Reads
8 Citations
3.960 Impact Factor

Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins.

Biol Psychiatry 2002 Oct;52(7):708-15

Department of Biomedical Science, University of Sheffield, United Kingdom.

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October 2002
13 Reads
108 Citations
10.260 Impact Factor

Weight gain, antipsychotic drug treatment and pharmacogenomics.

Authors:
Gavin P Reynolds

Pharmacogenomics 2002 Sep;3(5):567-70

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http://dx.doi.org/10.1517/14622416.3.5.567DOI Listing
September 2002
8 Reads
2 Citations
3.220 Impact Factor

[Association of antipsychotic agent-induced weight gain with a polymorphism of the promotor region of the 5-HT2C receptor gene].

Zhonghua Yi Xue Za Zhi 2002 Aug;82(16):1097-101

Psychiatry Department and Clinical Science Center, Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China.

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August 2002
41 Reads

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism.

Lancet 2002 Jun;359(9323):2086-7

Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1016/S0140-6736(02)08913-4DOI Listing
June 2002
13 Reads
41 Citations
45.220 Impact Factor

A selective reduction in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia patients.

Chin Med J (Engl) 2002 Jun;115(6):819-23

Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, China.

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June 2002
10 Reads
13 Citations
1.020 Impact Factor

A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia.

Schizophr Res 2002 May;55(1-2):1-10

Department of Biomedical Science, University of Sheffield, Western Bank, UK.

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May 2002
12 Reads
104 Citations
3.923 Impact Factor

The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease.

J Neurochem 2002 Apr;81(1):46-59

Department of Pharmacology, University of Cambridge, UK.

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April 2002
21 Reads
33 Citations
4.281 Impact Factor

The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study.

J Psychopharmacol 2002 Mar;16(1):35-7

School of Pharmacy, University of Bradford, UK.

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http://dx.doi.org/10.1177/026988110201600111DOI Listing
March 2002
7 Reads
6 Citations
3.593 Impact Factor

Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells.

Neurosci Lett 2001 Aug;309(3):193-6

Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

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August 2001
5 Reads
5 Citations
2.060 Impact Factor

Plasma homovanillic acid in untreated schizophrenia--relationship with symptomatology and sex.

J Psychiatr Res 2001 Jan-Feb;35(1):23-8

Department of Biomedical Science, University of Sheffield, S10 2TN, Sheffield, UK.

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July 2001
5 Reads
4 Citations
3.960 Impact Factor

GABAergic neuronal subtypes in the human frontal cortex--development and deficits in schizophrenia.

J Chem Neuroanat 2001 Jul;22(1-2):95-100

Department of Biomedical Science, The University of Sheffield, Western Bank, S10 2TN, Sheffield, UK.

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July 2001
6 Reads
37 Citations
2.520 Impact Factor

Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity.

Brain Res Bull 2001 Jul;55(5):579-84

Department of Biomedical Science, University of Sheffield, Sheffield, UK.

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July 2001
11 Reads
35 Citations
2.720 Impact Factor

Increased density of glutamate/N-methyl-D-aspartate receptors in superior temporal cortex in schizophrenia.

Neurosci Lett 2001 May;304(1-2):9-12

Department of Biomedical Science, The University of Sheffield, S10 2TN, Sheffield, UK.

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May 2001
9 Reads
9 Citations
2.060 Impact Factor

Relationship of symptomatology, gender, and antipsychotic drug treatment with plasma homovanillic acid in schizophrenia.

Acta Pharmacol Sin 2001 Jan;22(1):76-80

The Department of Psychiatry, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.

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January 2001
10 Reads
2.500 Impact Factor

The new antipsychotics--some pharmacological aspects of their problems and potential.

Authors:
G P Reynolds

Expert Opin Pharmacother 2000 Jan;1(2):181-5

Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

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http://dx.doi.org/10.1517/14656566.1.2.181 DOI Listing
January 2000
6 Reads
3.534 Impact Factor

Agonist-stimulated GTPgamma[35S] binding to 5-HT(1A) receptors in human post-mortem brain.

Eur J Pharmacol 1999 Dec;386(2-3):313-5

Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK.

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December 1999
10 Reads
2.532 Impact Factor

Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS.

Neuroreport 1999 Nov;10(17):3513-5

Department of Biomedical Science, University of Sheffield, UK.

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November 1999
9 Reads
7 Citations
1.644 Impact Factor

Dopamine receptors, antipsychotic action and schizophrenia.

Authors:
G P Reynolds

J Psychopharmacol 1999 ;13(2):202-3

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http://dx.doi.org/10.1177/026988119901300220DOI Listing
August 1999
8 Reads
1 Citation
3.593 Impact Factor

Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation.

J Neurochem 1999 Apr;72(4):1773-6

Department of Biomedical Science, University of Sheffield, England, UK.

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April 1999
7 Reads
15 Citations
4.281 Impact Factor

Antipsychotic drug affinities at alpha2-adrenoceptor subtypes in post-mortem human brain.

J Psychopharmacol 1998 ;12(2):151-4

Department of Biomedical Science, University of Sheffield, Western Bank, UK.

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http://dx.doi.org/10.1177/026988119801200206DOI Listing
November 1998
4 Reads
3 Citations
3.593 Impact Factor

Transgenic models and subcellular pathology--do they tell us what goes wrong in Huntington's disease?

Mol Psychiatry 1998 May;3(3):192-5

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May 1998
7 Reads
14.500 Impact Factor

Developments in antipsychotic drugs - an update.

Authors:
G P Reynolds

Expert Opin Investig Drugs 1998 Feb;7(2):257-60

Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1517/13543784.7.2.257 DOI Listing
February 1998
7 Reads
5.530 Impact Factor

Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease.

Neurosci Lett 1998 Jan;241(1):53-6

Department of Biomedical Science, University of Sheffield, UK.

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January 1998
6 Reads
20 Citations
2.060 Impact Factor

What is an atypical antipsychotic?

Authors:
G P Reynolds

J Psychopharmacol 1997 ;11(3):195-9

Department of Biomedical Science, University of Sheffield, UK.

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http://dx.doi.org/10.1177/026988119701100301DOI Listing
October 1997
7 Reads
2 Citations
3.593 Impact Factor

Deficits of [3H]D-aspartate binding to glutamate uptake sites in striatal and accumbens tissue in patients with schizophrenia.

Neurosci Lett 1997 Aug;232(1):13-6

Department of Biomedical Science, University of Sheffield, UK.

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August 1997
9 Reads
4 Citations
2.060 Impact Factor

Schizophrenia - advances in drug therapy.

Authors:
G P Reynolds

Expert Opin Investig Drugs 1997 Jul;6(7):857-66

Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

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http://dx.doi.org/10.1517/13543784.6.7.857 DOI Listing
July 1997
7 Reads
5.530 Impact Factor

5-HT receptors, genes and antipsychotic mechanisms.

Authors:
G P Reynolds

J Psychopharmacol 1997 ;11(1):26-7

Department of Biomedical Science, The University of Sheffield, UK.

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http://dx.doi.org/10.1177/026988119701100108DOI Listing
June 1997
9 Reads
3.593 Impact Factor

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics.

Schizophr Res 1997 Apr;24(3):349-55

Department of Biomedical Science, University of Sheffield, UK.

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April 1997
8 Reads
82 Citations
3.923 Impact Factor

Top co-authors

Zhi Jun Zhang
Zhi Jun Zhang

Affiliated ZhongDa Hospital

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Trisha A Jenkins
Trisha A Jenkins

School of Health and Biomedical Sciences

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Michael K Harte
Michael K Harte

Manchester Pharmacy School

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Zhijun Zhang
Zhijun Zhang

Affiliated ZhongDa Hospital

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Samur Thanoi
Samur Thanoi

Naresuan University

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Zahurin Mohamed
Zahurin Mohamed

University of Malaya

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Joanna C Neill
Joanna C Neill

Manchester Pharmacy School

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Stephen J Cooper
Stephen J Cooper

Queen's University of Belfast

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Marie Cahir
Marie Cahir

The Queen's University of Belfast

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