Gavin P Dunn

Gavin P Dunn

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Gavin P Dunn

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Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: Patterns of care and treatment outcomes.

Radiother Oncol 2018 08 27;128(2):266-273. Epub 2018 Jun 27.

Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, United States. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.06.017DOI Listing
August 2018

Direct puncture Onyx embolization of a large calvarial metastasis with intracranial extension: Case report.

Interv Neuroradiol 2018 Apr 9;24(2):220-224. Epub 2017 Nov 9.

2 12275 Department of Neurological Surgery, Washington University , St. Louis, MO, USA.

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http://dx.doi.org/10.1177/1591019917740353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847004PMC
April 2018

Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient.

Cold Spring Harb Mol Case Stud 2018 04 2;4(2). Epub 2018 Apr 2.

Institute for Genomic Medicine, Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio 43205, USA.

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http://molecularcasestudies.cshlp.org/lookup/doi/10.1101/mcs
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http://dx.doi.org/10.1101/mcs.a002444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880262PMC
April 2018

Focused Ultrasound-enabled Brain Tumor Liquid Biopsy.

Sci Rep 2018 04 26;8(1):6553. Epub 2018 Apr 26.

Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.

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http://dx.doi.org/10.1038/s41598-018-24516-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919906PMC
April 2018

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress.

Cell Rep 2018 01;22(2):512-522

Department of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053654PMC
January 2018

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

Management of intracranial melanomas in the era of precision medicine.

Oncotarget 2017 Oct 13;8(51):89326-89347. Epub 2017 Jul 13.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.19223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687693PMC
October 2017

Genomic profile of human meningioma cell lines.

PLoS One 2017 26;12(5):e0178322. Epub 2017 May 26.

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178322PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446134PMC
September 2017

Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.

Neurosurgery 2017 09;64(CN_suppl_1):165-176

The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington Univer-sity School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1093/neuros/nyx321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287409PMC
September 2017

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

Cell Commun Signal 2017 09 18;15(1):34. Epub 2017 Sep 18.

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12964-017-0189-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604305PMC
September 2017

Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.

Oral Oncol 2017 08 14;71:169-176. Epub 2016 Oct 14.

Department of Otolaryngology, Washington University School of Medicine, St. Louis, United States; Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2016.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423853PMC
August 2017

Applied Cancer Immunogenomics: Leveraging Neoantigen Discovery in Glioblastoma.

Cancer J 2017 Mar/Apr;23(2):125-130

From the *Division of Oncology, Department of Medicine, †The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital, ‡Center for Human Immunology and Immunotherapy Programs, and Departments of §Neurological Surgery and ∥Pathology and Immunology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/PPO.0000000000000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605294PMC
May 2017

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

ACS Med Chem Lett 2016 Oct 18;7(10):944-949. Epub 2016 Aug 18.

Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts 02142, United States; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066158PMC
October 2016

Genomic landscape of intracranial meningiomas.

J Neurosurg 2016 09 15;125(3):525-35. Epub 2016 Jan 15.

Department of Neurosurgery, Brigham and Women's Hospital;

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http://dx.doi.org/10.3171/2015.6.JNS15591DOI Listing
September 2016

High incidence of TERT mutation in brain tumor cell lines.

Brain Tumor Pathol 2016 Jul 9;33(3):222-7. Epub 2016 Mar 9.

Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s10014-016-0257-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605295PMC
July 2016

Spontaneous Resorption of a Penetrating Orbital Bone Fracture Fragment.

Ophthalmic Plast Reconstr Surg 2015 Sep-Oct;31(5):e123-5

*Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary; †Department of Ophthalmology, Harvard Medical School; ‡Massachusetts Eye and Ear Infirmary; §Department of Radiology/Neuroradiology, Harvard Medical School; ‖Department of Neurosurgery, Massachusetts General Hospital; ¶Department of Neurosurgery, Harvard Medical School; #Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary; and **Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.

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http://pdfs.journals.lww.com/op-rs/2015/09000/Spontaneous_Re
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http://dx.doi.org/10.1097/IOP.0000000000000146DOI Listing
May 2016

Principles of immunology and its nuances in the central nervous system.

Neuro Oncol 2015 Nov;17 Suppl 7:vii3-vii8

Department of Neurological Surgery, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri (G.P.D.); Department of Neurological Surgery, Brain Tumor Immunotherapy Center, University of California, San Francisco, Helen Diller Family Cancer Research Building HD 472, San Francisco, California (H.O.).

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http://dx.doi.org/10.1093/neuonc/nov175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625893PMC
November 2015

Surgical Revascularization in North American Adults with Moyamoya Phenomenon: Long-Term Angiographic Follow-up.

J Stroke Cerebrovasc Dis 2015 Jul 9;24(7):1597-608. Epub 2015 May 9.

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465995PMC
July 2015

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.

Cell Rep 2015 Jun 11;11(11):1809-21. Epub 2015 Jun 11.

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481182PMC
June 2015

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer.

Mol Cancer Res 2015 Mar 3;13(3):502-9. Epub 2014 Nov 3.

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369154PMC
March 2015

Stereotactic laser ablation of high-grade gliomas.

Neurosurg Focus 2014 Dec;37(6):E1

Departments of Neurosurgery.

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http://dx.doi.org/10.3171/2014.9.FOCUS14471DOI Listing
December 2014

Molecular and cellular heterogeneity: the hallmark of glioblastoma.

Neurosurg Focus 2014 Dec;37(6):E11

Departments of Neurological Surgery.

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http://dx.doi.org/10.3171/2014.9.FOCUS14521DOI Listing
December 2014

Emerging insights into barriers to effective brain tumor therapeutics.

Front Oncol 2014 21;4:126. Epub 2014 Jul 21.

Department of Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, MD , USA.

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http://dx.doi.org/10.3389/fonc.2014.00126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104487PMC
August 2014

Three-dimensional brain surface visualization for epilepsy surgery of focal cortical dysplasia.

J Clin Neurosci 2014 Jul 13;21(7):1230-2. Epub 2013 Dec 13.

Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit Street, White 502, Boston, MA 02114, USA; Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2013.12.004DOI Listing
July 2014

A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.

Clin Cancer Res 2014 Jun 25;20(11):2873-84. Epub 2014 Mar 25.

Authors' Affiliations: Departments of Cell Biology and Physiology, Otolaryngology, Genetics, Pathology and Immunology, and Neurosurgery; The Genome Institute, Washington University School of Medicine; and John Cochran VA Medical Center, St. Louis, MissouriAuthors' Affiliations: Departments of Cell Biology and Physiology, Otolaryngology, Genetics, Pathology and Immunology, and Neurosurgery; The Genome Institute, Washington University School of Medicine; and John Cochran VA Medical Center, St. Louis, Missouri

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096804PMC
June 2014

Emerging insights into head and neck cancer metastasis.

Head Neck 2013 Nov 22;35(11):1669-78. Epub 2012 Dec 22.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/hed.23202DOI Listing
November 2013

From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma.

Neurosurg Focus 2013 Feb;34(2):E2

Departments of Neurosurgery, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.3171/2012.12.FOCUS12355DOI Listing
February 2013

Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1.

J Neurosurg 2013 Jan 26;118(1):142-8. Epub 2012 Oct 26.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.3171/2012.9.JNS101610DOI Listing
January 2013

Dual ipsilateral craniotomies through a single incision for the surgical management of multiple intracranial aneurysms.

World Neurosurg 2012 Mar-Apr;77(3-4):502-6. Epub 2011 Nov 7.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S187887501100871
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http://dx.doi.org/10.1016/j.wneu.2011.07.005DOI Listing
August 2012

Cancer immunoediting in malignant glioma.

Neurosurgery 2012 Aug;71(2):201-22; discussion 222-3

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1227/NEU.0b013e31824f840dDOI Listing
August 2012

ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.

Cancer Res 2012 Jan 15;72(1):365-74. Epub 2011 Nov 15.

Department of Otolaryngology and John Cochran VA Medical Center, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286642PMC
January 2012

Cancer immunoediting of the NK group 2D ligand H60a.

J Immunol 2011 Oct 29;187(7):3538-45. Epub 2011 Aug 29.

Department of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.4049/jimmunol.1100413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178735PMC
October 2011

Type I interferon is selectively required by dendritic cells for immune rejection of tumors.

J Exp Med 2011 Sep 19;208(10):1989-2003. Epub 2011 Sep 19.

Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

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http://dx.doi.org/10.1084/jem.20101158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182061PMC
September 2011

Surgical treatment of a large fusiform distal anterior cerebral artery aneurysm with In Situ end-to-side A3-A3 bypass graft and aneurysm trapping: case report and review of the literature.

Neurosurgery 2011 Feb;68(2):E587-91; discussion E591

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1227/NEU.0b013e3182036012DOI Listing
February 2011

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM.

Proc Natl Acad Sci U S A 2010 Jun 7;107(25):11501-6. Epub 2010 Jun 7.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1001613107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895056PMC
June 2010

An historical context of modern principles in the management of intracranial injury from projectiles.

Neurosurg Focus 2010 May;28(5):E23

Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.3171/2010.2.FOCUS1038DOI Listing
May 2010

Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.

Adv Immunol 2006 ;90:1-50

Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, 3002 Victoria, Australia.

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http://dx.doi.org/10.1016/S0065-2776(06)90001-7DOI Listing
May 2009

Giant cell tumor of the thoracic spine: case report and review of the literature.

Surg Neurol 2009 Feb 22;71(2):228-33; discussion 233. Epub 2008 Jan 22.

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.surneu.2007.07.056DOI Listing
February 2009

Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers.

Cancer Immun 2008 Dec 4;8:16. Epub 2008 Dec 4.

Department of Otolaryngology/Head and Neck Surgery and John Cochran VA Medical Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935779PMC
December 2008

Spontaneous regression of cutaneous head and neck melanoma: implications for the immunologic control of neoplasia.

Head Neck 2008 Feb;30(2):267-72

Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/hed.20701DOI Listing
February 2008

Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma.

Cancer Immun 2007 Aug 13;7:12. Epub 2007 Aug 13.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935751PMC
August 2007

Mycotic pseudoaneurysm of the internal maxillary artery: case report and review of the literature.

Arch Otolaryngol Head Neck Surg 2007 Apr;133(4):402-6

Medical Scientist Training Program, Washington University School of Medicine, St Louis, MO, USA.

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http://archotol.ama-assn.org/cgi/reprint/133/4/402.pdf
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http://archotol.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archotol.133.4.402DOI Listing
April 2007

Interferons, immunity and cancer immunoediting.

Nat Rev Immunol 2006 Nov;6(11):836-48

Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nri1961DOI Listing
November 2006

Interferon-gamma and cancer immunoediting.

Immunol Res 2005 ;32(1-3):231-45

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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August 2006

A critical function for type I interferons in cancer immunoediting.

Nat Immunol 2005 Jul 12;6(7):722-9. Epub 2005 Jun 12.

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ni1213DOI Listing
July 2005

IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression.

Cancer Res 2005 Apr;65(8):3447-53

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4316DOI Listing
April 2005

The three Es of cancer immunoediting.

Annu Rev Immunol 2004 ;22:329-60

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1146/annurev.immunol.22.012703.104803DOI Listing
August 2004

The immunobiology of cancer immunosurveillance and immunoediting.

Immunity 2004 Aug;21(2):137-48

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.immuni.2004.07.017DOI Listing
August 2004

Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly.

Proc Natl Acad Sci U S A 2003 Nov 12;100(24):14309-14. Epub 2003 Nov 12.

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1835673100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC283588PMC
November 2003

Cancer immunoediting: from immunosurveillance to tumor escape.

Nat Immunol 2002 Nov;3(11):991-8

Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://www.nature.com/articles/ni1102-991
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http://dx.doi.org/10.1038/ni1102-991DOI Listing
November 2002