Gavin J Churchyard

Gavin J Churchyard

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Gavin J Churchyard

Gavin J Churchyard

Publications by authors named "Gavin J Churchyard"

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Algorithm-guided empirical tuberculosis treatment for people with advanced HIV (TB Fast Track): an open-label, cluster-randomised trial.

Lancet HIV 2020 Jan 11;7(1):e27-e37. Epub 2019 Nov 11.

TB Centre, London School of Hygiene & Tropical Medicine, London, UK; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(19)30266-8DOI Listing
January 2020

Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB.

PLoS Med 2019 04 23;16(4):e1002787. Epub 2019 Apr 23.

University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478264PMC
April 2019

A Short Regimen for Rifampin-Resistant Tuberculosis.

N Engl J Med 2019 03 13;380(13):1279-1280. Epub 2019 Mar 13.

From the Aurum Institute, Parktown, and the School of Public Health, University of Witwatersrand, Johannesburg - both in South Africa.

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http://dx.doi.org/10.1056/NEJMe1902904DOI Listing
March 2019

A stratified approach to tuberculosis treatment.

Nat Med 2018 11;24(11):1639-1641

Aurum Institute, Johannesburg, South Africa.

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http://www.nature.com/articles/s41591-018-0244-y
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http://dx.doi.org/10.1038/s41591-018-0244-yDOI Listing
November 2018

Cost-effectiveness of Preventive Therapy for Tuberculosis With Isoniazid and Rifapentine Versus Isoniazid Alone in High-Burden Settings.

Clin Infect Dis 2018 09;67(7):1072-1078

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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http://dx.doi.org/10.1093/cid/ciy230DOI Listing
September 2018

Linkage to care among adults being investigated for tuberculosis in South Africa: pilot study of a case manager intervention.

BMJ Open 2018 05 24;8(5):e021111. Epub 2018 May 24.

School of Public Health, Faculty of Health Science, University of Witwatersrand, Johannesburg, Gauteng, South Africa.

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http://dx.doi.org/10.1136/bmjopen-2017-021111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988070PMC
May 2018

Impact of Targeted Tuberculosis Vaccination Among a Mining Population in South Africa: A Model-Based Study.

Am J Epidemiol 2017 Dec;186(12):1362-1369

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1093/aje/kwx192DOI Listing
December 2017

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?

J Infect Dis 2017 11;216(suppl_6):S662-S668

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1093/infdis/jix353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793854PMC
November 2017

Tuberculosis Infectiousness and Host Susceptibility.

J Infect Dis 2017 11;216(suppl_6):S636-S643

Pulmonary Clinical Medicine Section, Cardiovascular Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/infdis/jix361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853924PMC
November 2017

Strategies to Accelerate HIV Care and Antiretroviral Therapy Initiation After HIV Diagnosis: A Randomized Trial.

J Acquir Immune Defic Syndr 2017 08;75(5):540-547

*Department of Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD; †The Aurum Institute, Johannesburg, South Africa; ‡The University of the Witwatersrand School of Public Health, Johannesburg, South Africa; and §Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000001428DOI Listing
August 2017

Outcomes of on-site antiretroviral therapy provision in a South African correctional facility.

Int J STD AIDS 2016 11 4;27(13):1153-1161. Epub 2015 May 4.

CAPRISA, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1177/0956462415584467DOI Listing
November 2016

Epidemiologic studies and novel clinical research approaches that impact TB vaccine development.

Tuberculosis (Edinb) 2016 08 11;99 Suppl 1:S21-5. Epub 2016 Jun 11.

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.tube.2016.05.008DOI Listing
August 2016

Clinic-level factors influencing patient outcomes on antiretroviral therapy in primary health clinics in South Africa.

AIDS 2016 Apr;30(7):1099-109

aThe Aurum Institute, Johannesburg, South Africa bLondon School of Hygiene & Tropical Medicine, London, United Kingdom cSchool of Public Health, University of Witwatersrand, Johannesburg dUniversity of Western Cape, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001014DOI Listing
April 2016

Tuberculosis prevention in South Africa.

PLoS One 2015 7;10(4):e0122514. Epub 2015 Apr 7.

TB Modelling Group, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; TB Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388715PMC
December 2015

Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis.

J Acquir Immune Defic Syndr 2015 Sep;70(1):104-8

*Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom; †Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; ‡The Aurum Institute, Johannesburg, South Africa; §Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom; and ‖School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000000684DOI Listing
September 2015

Performance of a Novel Algorithm Using Automated Digital Microscopy for Diagnosing Tuberculosis.

Am J Respir Crit Care Med 2015 Jun;191(12):1443-9

3 London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201502-0390OCDOI Listing
June 2015

Four models of HIV counseling and testing: utilization and test results in South Africa.

PLoS One 2014 11;9(7):e102267. Epub 2014 Jul 11.

The Aurum Institute, Johannesburg, South Africa; Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102267PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094499PMC
March 2015

Molecular characterisation of clinical and environmental isolates of Mycobacterium kansasii isolates from South African gold mines.

J Water Health 2015 Mar;13(1):190-202

Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, Johannesburg, South Africa E-mail:

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http://dx.doi.org/10.2166/wh.2014.161DOI Listing
March 2015

Eligibility for isoniazid preventive therapy in South African gold mines.

PLoS One 2013 14;8(11):e81376. Epub 2013 Nov 14.

London School of Hygiene and Tropical Medicine, London, United Kingdom ; The Aurum Institute for Health Research, Johannesburg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828258PMC
February 2015

Implementing a large-scale systematic tuberculosis screening program in correctional facilities in South Africa.

Open Forum Infect Dis 2015 Jan 8;2(1):ofu121. Epub 2015 Jan 8.

The Aurum Institute , Johannesburg , South Africa ; Johns Hopkins University School of Medicine , Baltimore, Maryland.

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http://dx.doi.org/10.1093/ofid/ofu121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396427PMC
January 2015

Tuberculosis vaccines and prevention of infection.

Microbiol Mol Biol Rev 2014 Dec;78(4):650-71

Statistical Center for HIV Research, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/MMBR.00021-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248657PMC
December 2014

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.

N Engl J Med 2014 Oct;371(17):1599-608

From St. George's, University of London (A.J., D.A.M., T.S.H., D.C., P.D.B.), Medical Research Council Clinical Trials Unit at University College London (A.J.N., P.P.J.P., H.E.C.), and University College London Centre for Clinical Biology, University College London (A.L.E.B., T.D.M.), London; Aurum Institute (G.J.C., S.C.) and School of Public Health, University of the Witwatersrand (G.J.C.), Johannesburg, and South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health (M.H., H.G.) and Division of Clinical Pharmacology, Department of Medicine (H.M.M., S.P.Z.), University of Cape Town, Cape Town - all in South Africa; Harare City Health Department, Harare (S.M., N.A.S.S.), and Medical Directorate of Mashonaland East, Marondera (S.Z., L.M.) - both in Zimbabwe; CDC, Gaborone, Botswana (J.S., S.N.); and Macha Research Trust, Macha, Zambia (J.H.D.).

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http://dx.doi.org/10.1056/NEJMoa1314210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233406PMC
October 2014

High tuberculosis prevalence in a South African prison: the need for routine tuberculosis screening.

PLoS One 2014 30;9(1):e87262. Epub 2014 Jan 30.

Aurum Institute, Johannesburg, South Africa ; School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087262PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907552PMC
September 2014

Tuberculosis preventive therapy: an underutilised strategy to reduce individual risk of TB and contribute to TB control.

S Afr Med J 2014 Apr 16;104(5):339-43. Epub 2014 Apr 16.

Aurum Institute, Johannesburg, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.7196/samj.8290DOI Listing
April 2014

A trial of mass isoniazid preventive therapy for tuberculosis control.

N Engl J Med 2014 Jan;370(4):301-10

From the Aurum Institute (G.J.C., L.C.) and the School of Public Health, University of the Witwatersrand (G.J.C.) - both in Johannesburg; the London School of Hygiene and Tropical Medicine, London (G.J.C., K.L.F., J.J.L., E.L.C., P.G.-F., R.J.H., A.D.G.); and the Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore (R.E.C.).

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http://www.nejm.org/doi/10.1056/NEJMoa1214289
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http://dx.doi.org/10.1056/NEJMoa1214289DOI Listing
January 2014

Diagnostic accuracy of a urine lipoarabinomannan enzyme-linked immunosorbent assay for screening ambulatory HIV-infected persons for tuberculosis.

J Acquir Immune Defic Syndr 2011 Oct;58(2):219-23

Center for TB Research, Division of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1097/QAI.0b013e31822b75d4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175281PMC
October 2011

Twelve-monthly versus six-monthly radiological screening for active case-finding of tuberculosis: a randomised controlled trial.

Thorax 2011 Feb 23;66(2):134-9. Epub 2010 Nov 23.

Aurum Institute for Health Research, PostNet Suite 300, Private Bag X30500, Houghton 2041, South Africa.

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http://thorax.bmj.com/cgi/doi/10.1136/thx.2010.139048
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http://dx.doi.org/10.1136/thx.2010.139048DOI Listing
February 2011

Contrasting reasons for discontinuation of antiretroviral therapy in workplace and public-sector HIV programs in South Africa.

AIDS Patient Care STDS 2011 Jan;25(1):53-9

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1089/apc.2010.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030909PMC
January 2011

Why have trials of isoniazid preventive therapy among people with HIV infection not demonstrated an effect on mortality?: did close examination of the trees obscure our view of the wood?

AIDS 2010 Nov;24 Suppl 5:S15-8

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1097/01.aids.0000391011.40892.ffDOI Listing
November 2010

Adverse events with isoniazid preventive therapy: experience from a large trial.

AIDS 2010 Nov;24 Suppl 5:S29-36

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1097/01.aids.0000391019.10661.66DOI Listing
November 2010

Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources.

Lancet Infect Dis 2010 Jul;10(7):489-98

Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Cape Town, South Africa.

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http://linkinghub.elsevier.com/retrieve/pii/S147330991070078
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http://dx.doi.org/10.1016/S1473-3099(10)70078-5DOI Listing
July 2010

Contrasting predictors of poor antiretroviral therapy outcomes in two South African HIV programmes: a cohort study.

BMC Public Health 2010 Jul 22;10:430. Epub 2010 Jul 22.

Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1186/1471-2458-10-430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920888PMC
July 2010

Recurrent tuberculosis: relapse, reinfection, and HIV.

J Infect Dis 2010 Mar;201(5):653-5

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1086/650531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407677PMC
March 2010

HIV infection does not affect active case finding of tuberculosis in South African gold miners.

Am J Respir Crit Care Med 2009 Dec 10;180(12):1271-8. Epub 2009 Sep 10.

Aurum Institute for Health Research, Postnet Suite 300, Private Bag X 30500, Houghton, Johannesburg, South Africa 2041.

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http://dx.doi.org/10.1164/rccm.200806-846OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796737PMC
December 2009

Advances in immunotherapy for tuberculosis treatment.

Clin Chest Med 2009 Dec;30(4):769-82, ix

Aurum Institute for Health Research, Suite 300, Private Bag X 30500, Houghton 2041, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.ccm.2009.08.009DOI Listing
December 2009

HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response.

Lancet 2009 Sep 24;374(9693):921-33. Epub 2009 Aug 24.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1016/S0140-6736(09)60916-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803032PMC
September 2009

Achieving the health Millennium Development Goals for South Africa: challenges and priorities.

Lancet 2009 Sep 24;374(9694):1023-1031. Epub 2009 Aug 24.

Reproductive Health and HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Nelson Mandela School of Medicine, University of Kwazulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1016/S0140-6736(09)61122-3DOI Listing
September 2009

The burden of silicosis, pulmonary tuberculosis and COPD among former Basotho goldminers.

Am J Ind Med 2008 Sep;51(9):640-7

School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.

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http://dx.doi.org/10.1002/ajim.20602DOI Listing
September 2008

"That is why I stopped the ART": patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme.

BMC Public Health 2008 Feb 18;8:63. Epub 2008 Feb 18.

Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

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http://dx.doi.org/10.1186/1471-2458-8-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276211PMC
February 2008

Tuberculosis and HIV coinfection: current state of knowledge and research priorities.

J Infect Dis 2007 Aug;196 Suppl 1:S1-3

AIDS Program, Section of Infectious Diseases, Department of Internal Medicine and Epidemiology, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1086/518667DOI Listing
August 2007

Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities.

J Infect Dis 2007 Aug;196 Suppl 1:S52-62

Aurum Institute for Health Research, Marshalltown, South Africa.

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http://dx.doi.org/10.1086/518662DOI Listing
August 2007