Gavin Hudson

Gavin Hudson

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Gavin Hudson

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Reversion after replacement of mitochondrial DNA.

Nature 2019 Oct 16;574(7778):E8-E11. Epub 2019 Oct 16.

Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/s41586-019-1623-3DOI Listing
October 2019

Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution.

Mitochondrion 2019 05 9;46:302-306. Epub 2018 Aug 9.

Institute of Genetic Medicine, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK; The Wellcome Centre for Mitochondrial Research, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509278PMC
May 2019

Cell-free mitochondrial DNA in progressive multiple sclerosis.

Mitochondrion 2019 05 8;46:307-312. Epub 2018 Aug 8.

Institute of Genetic Medicine, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK; The Wellcome Centre for Mitochondrial Research, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509276PMC
May 2019

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Authors:
Aldi T Kraja Chunyu Liu Jessica L Fetterman Mariaelisa Graff Christian Theil Have Charles Gu Lisa R Yanek Mary F Feitosa Dan E Arking Daniel I Chasman Kristin Young Symen Ligthart W David Hill Stefan Weiss Jian'an Luan Franco Giulianini Ruifang Li-Gao Fernando P Hartwig Shiow J Lin Lihua Wang Tom G Richardson Jie Yao Eliana P Fernandez Mohsen Ghanbari Mary K Wojczynski Wen-Jane Lee Maria Argos Sebastian M Armasu Ruteja A Barve Kathleen A Ryan Ping An Thomas J Baranski Suzette J Bielinski Donald W Bowden Ulrich Broeckel Kaare Christensen Audrey Y Chu Janie Corley Simon R Cox Andre G Uitterlinden Fernando Rivadeneira Cheryl D Cropp E Warwick Daw Diana van Heemst Lisa de Las Fuentes He Gao Ioanna Tzoulaki Tarunveer S Ahluwalia Renée de Mutsert Leslie S Emery A Mesut Erzurumluoglu James A Perry Mao Fu Nita G Forouhi Zhenglong Gu Yang Hai Sarah E Harris Gibran Hemani Steven C Hunt Marguerite R Irvin Anna E Jonsson Anne E Justice Nicola D Kerrison Nicholas B Larson Keng-Hung Lin Latisha D Love-Gregory Rasika A Mathias Joseph H Lee Matthias Nauck Raymond Noordam Ken K Ong James Pankow Amit Patki Alison Pattie Astrid Petersmann Qibin Qi Rasmus Ribel-Madsen Rebecca Rohde Kevin Sandow Theresia M Schnurr Tamar Sofer John M Starr Adele M Taylor Alexander Teumer Nicholas J Timpson Hugoline G de Haan Yujie Wang Peter E Weeke Christine Williams Hongsheng Wu Wei Yang Donglin Zeng Daniel R Witte Bruce S Weir Nicholas J Wareham Henrik Vestergaard Stephen T Turner Christian Torp-Pedersen Evie Stergiakouli Wayne Huey-Herng Sheu Frits R Rosendaal M Arfan Ikram Oscar H Franco Paul M Ridker Thomas T Perls Oluf Pedersen Ellen A Nohr Anne B Newman Allan Linneberg Claudia Langenberg Tuomas O Kilpeläinen Sharon L R Kardia Marit E Jørgensen Torben Jørgensen Thorkild I A Sørensen Georg Homuth Torben Hansen Mark O Goodarzi Ian J Deary Cramer Christensen Yii-Der Ida Chen Aravinda Chakravarti Ivan Brandslund Klaus Bonnelykke Kent D Taylor James G Wilson Santiago Rodriguez Gail Davies Bernardo L Horta Bharat Thyagarajan D C Rao Niels Grarup Victor G Davila-Roman Gavin Hudson Xiuqing Guo Donna K Arnett Caroline Hayward Dhananjay Vaidya Dennis O Mook-Kanamori Hemant K Tiwari Daniel Levy Ruth J F Loos Abbas Dehghan Paul Elliott Afshan N Malik Robert A Scott Diane M Becker Mariza de Andrade Michael A Province James B Meigs Jerome I Rotter Kari E North

Am J Hum Genet 2019 01 27;104(1):112-138. Epub 2018 Dec 27.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323610PMC
January 2019

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

Ann Neurol 2017 Dec 4;82(6):1016-1021. Epub 2017 Dec 4.

Division of Brain Sciences, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.25099DOI Listing
December 2017

Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.

PLoS Genet 2017 12 18;13(12):e1007126. Epub 2017 Dec 18.

MRC-Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757940PMC
December 2017

Reduced mitochondrial DNA is not a biomarker of depression in Parkinson's disease.

Mov Disord 2016 12 18;31(12):1923-1924. Epub 2016 Oct 18.

Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/mds.26825DOI Listing
December 2016

Reply: Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion.

Brain 2016 Mar 10;139(Pt 3):e18. Epub 2015 Dec 10.

1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 6 Medical Research Council Mitochondrial Biology Unit, Cambridge, UK 7 Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, UK

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http://dx.doi.org/10.1093/brain/awv340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839597PMC
March 2016

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease.

Neurobiol Aging 2016 Feb 5;38:216.e7-216.e10. Epub 2015 Nov 5.

Mitochondrial Research Group, Institute of Genetic Medicine, University of Newcastle Upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759605PMC
February 2016

Somatic mtDNA variation is an important component of Parkinson's disease.

Neurobiol Aging 2016 Feb 6;38:217.e1-217.e6. Epub 2015 Nov 6.

Mitochondrial Research Group, Institute of Genetic Medicine, University of Newcastle Upon Tyne, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759607PMC
February 2016

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.

Ann Neurol 2015 Dec 13;78(6):1000-4. Epub 2015 Nov 13.

Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ana.24515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551217PMC
December 2015

Inherited mtDNA variations are not strong risk factors in human prion disease.

Neurobiol Aging 2015 Oct 10;36(10):2908.e1-3. Epub 2015 Jul 10.

Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542657PMC
October 2015

Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.

Neurosci Lett 2015 May 26;594:66-9. Epub 2015 Mar 26.

Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407898PMC
May 2015

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans.

PLoS Genet 2015 May 14;11(5):e1005040. Epub 2015 May 14.

Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431825PMC
May 2015

Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations.

Genet Med 2014 Dec 5;16(12):962-71. Epub 2014 Jun 5.

Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1038/gim.2014.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272251PMC
December 2014

Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases.

PLoS Genet 2014 May 22;10(5):e1004369. Epub 2014 May 22.

Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031051PMC
May 2014

Mitochondrial DNA and traumatic brain injury.

Ann Neurol 2014 Feb 1;75(2):186-95. Epub 2014 Mar 1.

University College London Cancer Institute, London.

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http://dx.doi.org/10.1002/ana.24116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112718PMC
February 2014

Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study.

Neurology 2014 Jan 20;82(4):308-16. Epub 2013 Dec 20.

From the Institute for Ageing and Health (A.J.Y., G.W.D., M.J.F., D.J.B.), Industrial Statistics Research Unit (S.Y.C.), and Institute of Genetic Medicine (G.H., P.F.C.), Newcastle University; John van Geest Centre for Brain Repair (D.P.B., J.R.E., R.A.B.), Department of Clinical Neurosciences (C.N., S.W.-R., J.B.R.), Behavioural and Clinical Neuroscience Institute (C.N., S.W.-R., J.B.R., T.W.R.), MRC Cognition and Brain Sciences Unit (C.N., S.W.-R., J.B.R.), Departments of Psychiatry (J.T.O.) and Psychology (T.W.R.), University of Cambridge, UK; School of Medicine (T.K.K.), Griffith University, Australia; Paracelsus-Elena-Klinik (B.M.), Kassel, and Göttingen University; Institute for Neuropathology (N.K.), Prion and Dementia Research Unit, University Medical Centre Göttingen, Germany; Centre for Human Psychopharmacology (K.W.), Swinburne University, Melbourne, Australia; and Department of Medicine (D.J.W.), Imperial College London, UK.

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http://www.neurology.org/content/82/4/308.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000006
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929202PMC
January 2014

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

Neurobiol Aging 2013 Dec 30;34(12):2889.e1-4. Epub 2013 Apr 30.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906612PMC
December 2013

Mitochondrial genetics.

Br Med Bull 2013 22;106:135-59. Epub 2013 May 22.

International Centre for Life, Newcastle University, Central Parkway, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/bmb/ldt017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675899PMC
December 2013

Unique mitochondrial DNA in highly inbred feral cattle.

Mitochondrion 2012 Jul 17;12(4):438-40. Epub 2012 May 17.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.mito.2012.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485552PMC
July 2012

Genetic variations within the OPA1 gene are not associated with neuromyelitis optica.

Mult Scler 2012 Feb 9;18(2):240-3. Epub 2011 Aug 9.

Mitochondrial Research Group, Institute of Genetic Medicine, Newcastle University, UK.

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http://dx.doi.org/10.1177/1352458511416838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040403PMC
February 2012

Epigenetics, epidemiology and mitochondrial DNA diseases.

Int J Epidemiol 2012 Feb 28;41(1):177-87. Epub 2012 Jan 28.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.

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http://dx.doi.org/10.1093/ije/dyr232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304530PMC
February 2012

No evidence of substantia nigra telomere shortening in Parkinson's disease.

Neurobiol Aging 2011 Nov 27;32(11):2107.e3-5. Epub 2011 Jul 27.

Mitochondrial Research Group, Institute of Human genetics, University of Newcastle Upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034165PMC
November 2011

Variation in MAPT is not a contributing factor to the incomplete penetrance in LHON.

Mitochondrion 2011 Jul 21;11(4):620-2. Epub 2011 Mar 21.

Institute for Human Genetics, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.mito.2011.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115022PMC
July 2011

Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2.

J Neurol 2010 Sep 20;257(9):1517-23. Epub 2010 Apr 20.

Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1007/s00415-010-5565-9DOI Listing
September 2010

The prevalence and natural history of dominant optic atrophy due to OPA1 mutations.

Ophthalmology 2010 Aug 24;117(8):1538-46, 1546.e1. Epub 2010 Apr 24.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, UK.

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http://dx.doi.org/10.1016/j.ophtha.2009.12.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040407PMC
August 2010

Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease.

Neurosci Lett 2010 Jul 20;479(2):123-5. Epub 2010 May 20.

Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.neulet.2010.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038490PMC
July 2010

Quality of life in patients with leber hereditary optic neuropathy.

Invest Ophthalmol Vis Sci 2009 Jul 28;50(7):3112-5. Epub 2009 Feb 28.

Mitochondrial Research Group, The Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1167/iovs.08-3166DOI Listing
July 2009

Genetic variation in the methylenetetrahydrofolate reductase gene, MTHFR, does not alter the risk of visual failure in Leber's hereditary optic neuropathy.

Mol Vis 2009 1;15:870-5. Epub 2009 May 1.

Mitochondrial Research Group, Institute of Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676202PMC
June 2009

Novel mutations in the TK2 gene associated with fatal mitochondrial DNA depletion myopathy.

Neuromuscul Disord 2008 Jul 27;18(7):557-60. Epub 2008 May 27.

Mitochondrial Research Group, The Medical School, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.nmd.2008.04.014DOI Listing
July 2008

Leber hereditary optic neuropathy.

Expert Opin Med Diagn 2008 Jul;2(7):789-99

Newcastle University, Mitochondrial Research Group, M4014, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK +44 191 222 8233 ; +44 191 222 8553 ;

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http://dx.doi.org/10.1517/17530059.2.7.789DOI Listing
July 2008

POLG1 mutations manifesting as autosomal recessive axonal Charcot-Marie-Tooth disease.

Arch Neurol 2008 Jan;65(1):133-6

Department of Neurology, Essex Center for Neurological Sciences, Queen's Hospital, Romford, England.

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http://dx.doi.org/10.1001/archneurol.2007.4DOI Listing
January 2008

X-Inactivation patterns in females harboring mtDNA mutations that cause Leber hereditary optic neuropathy.

Mol Vis 2007 Dec 21;13:2339-43. Epub 2007 Dec 21.

Mitochondrial Research Group, Newcastle University, UK.

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December 2007

Mitochondrial DNA polymerase-gamma and human disease.

Hum Mol Genet 2006 Oct;15 Spec No 2:R244-52

Mitochondrial Research Group and Institute of Human Genetics, M41014, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/hmg/ddl233DOI Listing
October 2006

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.

Am J Hum Genet 2006 Jun 4;78(6):1026-34. Epub 2006 May 4.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1086/504303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474082PMC
June 2006

A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia.

Neuromuscul Disord 2005 Apr 28;15(4):311-5. Epub 2005 Jan 28.

Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S096089660400351
Publisher Site
http://dx.doi.org/10.1016/j.nmd.2004.12.004DOI Listing
April 2005