Gavin Ha

Gavin Ha

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Gavin Ha

Gavin Ha

Publications by authors named "Gavin Ha"

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Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Cancer Cell 2018 04 2;33(4):676-689.e3. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Cancer Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA; Department of Pathology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028190PMC
April 2018

Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.

J Clin Oncol 2018 02 3;36(6):543-553. Epub 2018 Jan 3.

Daniel G. Stover, Ohio State University Comprehensive Cancer Center, Columbus, OH; Heather A. Parsons, Gavin Ha, William T. Barry, Hao Guo, Atish D. Choudhury, Melissa E. Hughes, Deborah A. Dillon, Ann H. Partridge, Nikhil Wagle, Ian E. Krop, Todd R. Golub, Eric P. Winer, Sara M. Tolaney, and Nancy U. Lin, Dana-Farber Cancer Institute; Gad Getz, Massachusetts General Hospital, Boston; Gavin Ha, Samuel S. Freeman, Atish D. Choudhury, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Denisse Rotem, Nikhil Wagle, Gad Getz, Todd R. Golub, and Viktor A. Adalsteinsson, Broad Institute of Harvard and Massachusetts Institute of Technology; and J. Christopher Love, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1200/JCO.2017.76.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815405PMC
February 2018

Patient-derived xenografts undergo mouse-specific tumor evolution.

Nat Genet 2017 Nov 9;49(11):1567-1575. Epub 2017 Oct 9.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659952PMC
November 2017

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

Nat Commun 2016 07 4;7:12160. Epub 2016 Jul 4.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ncomms12160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932194PMC
July 2016

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.

Nat Commun 2015 Oct 5;6:8554. Epub 2015 Oct 5.

Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3.

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http://dx.doi.org/10.1038/ncomms9554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600750PMC
October 2015

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Nature 2015 Feb 26;518(7539):422-6. Epub 2014 Nov 26.

1] Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada [3] Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada [4] Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.

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http://dx.doi.org/10.1038/nature13952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864027PMC
February 2015

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genome Res 2014 Nov 24;24(11):1881-93. Epub 2014 Jul 24.

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Computer Science, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada;

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http://dx.doi.org/10.1101/gr.180281.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216928PMC
November 2014

PyClone: statistical inference of clonal population structure in cancer.

Nat Methods 2014 Apr 16;11(4):396-8. Epub 2014 Mar 16.

1] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada. [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/nmeth.2883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864026PMC
April 2014

Distinguishing somatic and germline copy number events in cancer patient DNA hybridized to whole-genome SNP genotyping arrays.

Methods Mol Biol 2013 ;973:355-72

Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/978-1-62703-281-0_22DOI Listing
July 2013

Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts.

Clin Cancer Res 2011 Feb 19;17(4):783-91. Epub 2010 Nov 19.

Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, British Columbia, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1382DOI Listing
February 2011

SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors.

Bioinformatics 2010 Mar 3;26(6):730-6. Epub 2010 Feb 3.

Department of Molecular Oncology Breast Cancer Research Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btq040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832826PMC
March 2010