Gavin Churchyard

Gavin Churchyard

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Gavin Churchyard

Publications by authors named "Gavin Churchyard"

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Lung injury on antiretroviral therapy in adults with HIV/TB.

Clin Infect Dis 2019 Jun 26. Epub 2019 Jun 26.

Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/cid/ciz560DOI Listing
June 2019

Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB.

PLoS Med 2019 Apr 23;16(4):e1002787. Epub 2019 Apr 23.

University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478264PMC
April 2019

A Short Regimen for Rifampin-Resistant Tuberculosis.

N Engl J Med 2019 03 13;380(13):1279-1280. Epub 2019 Mar 13.

From the Aurum Institute, Parktown, and the School of Public Health, University of Witwatersrand, Johannesburg - both in South Africa.

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http://dx.doi.org/10.1056/NEJMe1902904DOI Listing
March 2019

Building a tuberculosis-free world: The Lancet Commission on tuberculosis.

Lancet 2019 Mar 20;393(10178):1331-1384. Epub 2019 Mar 20.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)30024-8DOI Listing
March 2019

A stratified approach to tuberculosis treatment.

Nat Med 2018 11;24(11):1639-1641

Aurum Institute, Johannesburg, South Africa.

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http://www.nature.com/articles/s41591-018-0244-y
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http://dx.doi.org/10.1038/s41591-018-0244-yDOI Listing
November 2018

Cost-effectiveness of Preventive Therapy for Tuberculosis With Isoniazid and Rifapentine Versus Isoniazid Alone in High-Burden Settings.

Clin Infect Dis 2018 09;67(7):1072-1078

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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http://dx.doi.org/10.1093/cid/ciy230DOI Listing
September 2018

Linkage to care among adults being investigated for tuberculosis in South Africa: pilot study of a case manager intervention.

BMJ Open 2018 05 24;8(5):e021111. Epub 2018 May 24.

School of Public Health, Faculty of Health Science, University of Witwatersrand, Johannesburg, Gauteng, South Africa.

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http://dx.doi.org/10.1136/bmjopen-2017-021111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988070PMC
May 2018

Pan-tuberculosis regimens: an argument for.

Lancet Respir Med 2018 04;6(4):239-240

Aurum Institute, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/S2213-2600(18)30096-1DOI Listing
April 2018

Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention.

Tuberculosis (Edinb) 2018 03 22;109:61-68. Epub 2017 Nov 22.

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884308PMC
March 2018

Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection.

PLoS Pathog 2018 02 23;14(2):e1006888. Epub 2018 Feb 23.

Department of Microbiology and Immunology, Sealy Center for Vaccine Development and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841825PMC
February 2018

Impact of Targeted Tuberculosis Vaccination Among a Mining Population in South Africa: A Model-Based Study.

Am J Epidemiol 2017 Dec;186(12):1362-1369

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1093/aje/kwx192DOI Listing
December 2017

The patient costs of care for those with TB and HIV: a cross-sectional study from South Africa.

Health Policy Plan 2017 Nov;32(suppl_4):iv48-iv56

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

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http://dx.doi.org/10.1093/heapol/czw183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886108PMC
November 2017

Research Roadmap for Tuberculosis Transmission Science: Where Do We Go From Here and How Will We Know When We're There?

J Infect Dis 2017 11;216(suppl_6):S662-S668

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1093/infdis/jix353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793854PMC
November 2017

Tuberculosis Infectiousness and Host Susceptibility.

J Infect Dis 2017 11;216(suppl_6):S636-S643

Pulmonary Clinical Medicine Section, Cardiovascular Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/infdis/jix361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853924PMC
November 2017

Strategies to Accelerate HIV Care and Antiretroviral Therapy Initiation After HIV Diagnosis: A Randomized Trial.

J Acquir Immune Defic Syndr 2017 08;75(5):540-547

*Department of Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD; †The Aurum Institute, Johannesburg, South Africa; ‡The University of the Witwatersrand School of Public Health, Johannesburg, South Africa; and §Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000001428DOI Listing
August 2017

Cost-Effectiveness of Automated Digital Microscopy for Diagnosis of Active Tuberculosis.

PLoS One 2016 20;11(6):e0157554. Epub 2016 Jun 20.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157554PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913947PMC
July 2017

Detection and Quantification of Differentially Culturable Tubercle Bacteria in Sputum from Patients with Tuberculosis.

Am J Respir Crit Care Med 2016 12;194(12):1532-1540

1 Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical TB Research, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.1164/rccm.201604-0769OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215032PMC
December 2016

Outcomes of on-site antiretroviral therapy provision in a South African correctional facility.

Int J STD AIDS 2016 11 4;27(13):1153-1161. Epub 2015 May 4.

CAPRISA, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1177/0956462415584467DOI Listing
November 2016

Epidemiologic studies and novel clinical research approaches that impact TB vaccine development.

Tuberculosis (Edinb) 2016 08 11;99 Suppl 1:S21-5. Epub 2016 Jun 11.

South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.tube.2016.05.008DOI Listing
August 2016

Clinic-level factors influencing patient outcomes on antiretroviral therapy in primary health clinics in South Africa.

AIDS 2016 Apr;30(7):1099-109

aThe Aurum Institute, Johannesburg, South Africa bLondon School of Hygiene & Tropical Medicine, London, United Kingdom cSchool of Public Health, University of Witwatersrand, Johannesburg dUniversity of Western Cape, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001014DOI Listing
April 2016

Tuberculosis--advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers.

Lancet Infect Dis 2016 Apr;16(4):e34-46

UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia; Centre for Clinical Microbiology, Division of Infection and Immunity, University College London (UCL), London, UK; National Institute for Health Research Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(16)00070-0DOI Listing
April 2016

Tuberculosis prevention in South Africa.

PLoS One 2015 7;10(4):e0122514. Epub 2015 Apr 7.

TB Modelling Group, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; TB Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122514PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388715PMC
December 2015

Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis.

J Acquir Immune Defic Syndr 2015 Sep;70(1):104-8

*Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom; †Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; ‡The Aurum Institute, Johannesburg, South Africa; §Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom; and ‖School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1097/QAI.0000000000000684DOI Listing
September 2015

Performance of a Novel Algorithm Using Automated Digital Microscopy for Diagnosing Tuberculosis.

Am J Respir Crit Care Med 2015 Jun;191(12):1443-9

3 London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201502-0390OCDOI Listing
June 2015

The economic burden of TB diagnosis and treatment in South Africa.

Soc Sci Med 2015 Apr 27;130:42-50. Epub 2015 Jan 27.

Health Economics Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa.

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https://linkinghub.elsevier.com/retrieve/pii/S02779536150007
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http://dx.doi.org/10.1016/j.socscimed.2015.01.046DOI Listing
April 2015

Safety, tolerability, and immunogenicity of the novel antituberculous vaccine RUTI: randomized, placebo-controlled phase II clinical trial in patients with latent tuberculosis infection.

PLoS One 2014 26;9(2):e89612. Epub 2014 Feb 26.

Archivel Farma, Badalona, Catalonia, Spain ; Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935928PMC
March 2015

Four models of HIV counseling and testing: utilization and test results in South Africa.

PLoS One 2014 11;9(7):e102267. Epub 2014 Jul 11.

The Aurum Institute, Johannesburg, South Africa; Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102267PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094499PMC
March 2015

Regarding the effect of cured tuberculosis disease on longevity.

Int J Tuberc Lung Dis 2015 Mar;19(3):367

1Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.5588/ijtld.14.0852DOI Listing
March 2015

Molecular characterisation of clinical and environmental isolates of Mycobacterium kansasii isolates from South African gold mines.

J Water Health 2015 Mar;13(1):190-202

Department of Clinical Microbiology and Infectious Diseases, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, Johannesburg, South Africa E-mail:

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http://dx.doi.org/10.2166/wh.2014.161DOI Listing
March 2015

Eligibility for isoniazid preventive therapy in South African gold mines.

PLoS One 2013 14;8(11):e81376. Epub 2013 Nov 14.

London School of Hygiene and Tropical Medicine, London, United Kingdom ; The Aurum Institute for Health Research, Johannesburg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828258PMC
February 2015

Implementing a large-scale systematic tuberculosis screening program in correctional facilities in South Africa.

Open Forum Infect Dis 2015 Jan 8;2(1):ofu121. Epub 2015 Jan 8.

The Aurum Institute , Johannesburg , South Africa ; Johns Hopkins University School of Medicine , Baltimore, Maryland.

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http://dx.doi.org/10.1093/ofid/ofu121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396427PMC
January 2015

Tuberculosis vaccines and prevention of infection.

Microbiol Mol Biol Rev 2014 Dec;78(4):650-71

Statistical Center for HIV Research, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/MMBR.00021-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248657PMC
December 2014

Improved services to enrollees into an HIV rural care and treatment center in Tanzania.

Pan Afr Med J 2013 30;16:34. Epub 2013 Sep 30.

Ifakara Health Institute, Bagamoyo, United Republic of Tanzania ; Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.11604/pamj.2013.16.34.1642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932130PMC
November 2014

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.

N Engl J Med 2014 Oct;371(17):1599-608

From St. George's, University of London (A.J., D.A.M., T.S.H., D.C., P.D.B.), Medical Research Council Clinical Trials Unit at University College London (A.J.N., P.P.J.P., H.E.C.), and University College London Centre for Clinical Biology, University College London (A.L.E.B., T.D.M.), London; Aurum Institute (G.J.C., S.C.) and School of Public Health, University of the Witwatersrand (G.J.C.), Johannesburg, and South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health (M.H., H.G.) and Division of Clinical Pharmacology, Department of Medicine (H.M.M., S.P.Z.), University of Cape Town, Cape Town - all in South Africa; Harare City Health Department, Harare (S.M., N.A.S.S.), and Medical Directorate of Mashonaland East, Marondera (S.Z., L.M.) - both in Zimbabwe; CDC, Gaborone, Botswana (J.S., S.N.); and Macha Research Trust, Macha, Zambia (J.H.D.).

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http://dx.doi.org/10.1056/NEJMoa1314210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233406PMC
October 2014

High tuberculosis prevalence in a South African prison: the need for routine tuberculosis screening.

PLoS One 2014 30;9(1):e87262. Epub 2014 Jan 30.

Aurum Institute, Johannesburg, South Africa ; School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087262PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907552PMC
September 2014

Tuberculosis preventive therapy: an underutilised strategy to reduce individual risk of TB and contribute to TB control.

S Afr Med J 2014 Apr 16;104(5):339-43. Epub 2014 Apr 16.

Aurum Institute, Johannesburg, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.7196/samj.8290DOI Listing
April 2014

Aspiring to zero tuberculosis deaths among southern Africa's miners: is there a way forward?

Int J Health Serv 2013 ;43(4):651-64

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2190/HS.43.4.dDOI Listing
February 2014

A trial of mass isoniazid preventive therapy for tuberculosis control.

N Engl J Med 2014 Jan;370(4):301-10

From the Aurum Institute (G.J.C., L.C.) and the School of Public Health, University of the Witwatersrand (G.J.C.) - both in Johannesburg; the London School of Hygiene and Tropical Medicine, London (G.J.C., K.L.F., J.J.L., E.L.C., P.G.-F., R.J.H., A.D.G.); and the Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore (R.E.C.).

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http://www.nejm.org/doi/10.1056/NEJMoa1214289
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http://dx.doi.org/10.1056/NEJMoa1214289DOI Listing
January 2014

Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug-resistant tuberculosis in South Africa.

BMC Infect Dis 2013 Jul 29;13:352. Epub 2013 Jul 29.

Johns Hopkins University School of Medicine, Department of Medicine, Division of Infectious Disease, 1503 East Jefferson St, Room 118, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1186/1471-2334-13-352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733609PMC
July 2013