Gautam Goel

Gautam Goel

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Gautam Goel

Gautam Goel

Publications by authors named "Gautam Goel"

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Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Cell Rep 2018 07;24(4):838-850

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156773PMC
July 2018

Facial rash in a 48-year-old woman: Case report of suspected leprosy in the emergency department.

Can Fam Physician 2018 04;64(4):291-293

Assistant Professor in the Division of Emergency Medicine in the Department of Family and Community Medicine and Mount Sinai Hospital at the University of Toronto.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897071PMC
April 2018

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

Int J Rheum Dis 2018 Jan 6;21(1):114-117. Epub 2017 Mar 6.

Department of Statistics, Lucknow University, Lucknow, India.

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http://dx.doi.org/10.1111/1756-185X.13022DOI Listing
January 2018

Drug Misuse in Adolescents Presenting to the Emergency Department.

Pediatr Emerg Care 2017 Jul;33(7):451-456

From the *Divisions of Emergency Medicine and †Clinical Pharmacology and Toxicology, Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; ‡Department of Family and Community Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; §Center for Children's Environmental Toxicology, Yale-New Haven Children's Hospital, Yale University School of Medicine, New Haven, CT; ∥Department of Surgery (Emergency Medicine), UT Southwestern School of Medicine, Dallas, TX; and ¶Department of Medicine, University of Colorado, School of Medicine, and Colorado School of Public Health, Aurora, CO.

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http://dx.doi.org/10.1097/PEC.0000000000000571DOI Listing
July 2017

Heterogeneity in Comparisons of Discontinuation of Tumor Necrosis Factor Antagonists in Rheumatoid Arthritis - A Meta-Analysis.

PLoS One 2016 8;11(12):e0168005. Epub 2016 Dec 8.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145210PMC
July 2017

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.

Cell Rep 2016 11;17(9):2183-2194

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192565PMC
November 2016

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Immunity 2016 06 7;44(6):1392-405. Epub 2016 Jun 7.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936415PMC
June 2016

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3667-75. Epub 2016 Jun 13.

Division of Genetics, Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1602827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932963PMC
June 2016

New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling.

Mol Cell Biol 2016 May 15;36(9):1366-82. Epub 2016 Apr 15.

Department of Signal Transduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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http://dx.doi.org/10.1128/MCB.00064-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836217PMC
May 2016

Mechanisms of Pediatric Inflammatory Bowel Disease.

Annu Rev Immunol 2016 05;34:31-64

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease and.

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http://dx.doi.org/10.1146/annurev-immunol-032414-112151DOI Listing
May 2016

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Proc Natl Acad Sci U S A 2015 Aug 20;112(31):E4281-7. Epub 2015 Jul 20.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1512289112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534235PMC
August 2015

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.

PLoS One 2014 30;9(9):e108777. Epub 2014 Sep 30.

Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108777PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182575PMC
June 2015

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell Rep 2015 Jun 18;11(12):1905-18. Epub 2015 Jun 18.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507440PMC
June 2015

Discovery of a Small-Molecule Probe for V-ATPase Function.

J Am Chem Soc 2015 Apr 20;137(16):5563-8. Epub 2015 Apr 20.

∥Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/jacs.5b02150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416280PMC
April 2015

Multivariate inference of pathway activity in host immunity and response to therapeutics.

Nucleic Acids Res 2014 21;42(16):10288-306. Epub 2014 Aug 21.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA

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http://dx.doi.org/10.1093/nar/gku722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176341PMC
January 2015

Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs.

J Virol 2014 Jan 23;88(1):730-8. Epub 2013 Oct 23.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1128/JVI.02708-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911696PMC
January 2014

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Gastroenterology 2013 Dec 21;145(6):1347-57. Epub 2013 Aug 21.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1053/j.gastro.2013.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840157PMC
December 2013

p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.

J Immunol 2012 Oct 22;189(7):3631-40. Epub 2012 Aug 22.

Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.1103746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780969PMC
October 2012

Can improved glycemic control slow renal function decline at all stages of diabetic nephropathy?

Semin Nephrol 2012 Sep;32(5):423-31

Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.semnephrol.2012.07.004DOI Listing
September 2012

A systems biology viewpoint on autophagy in health and disease.

Curr Opin Gastroenterol 2010 Jul;26(4):302-9

Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1097/MOG.0b013e32833ae2edDOI Listing
July 2010

System estimation from metabolic time-series data.

Bioinformatics 2008 Nov 4;24(21):2505-11. Epub 2008 Sep 4.

Integrative BioSystems Institute and The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732280PMC
November 2008

Biological systems modeling and analysis: a biomolecular technique of the twenty-first century.

J Biomol Tech 2006 Sep;17(4):252-69

The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, 313 Ferst Drive, Suite 4103, Atlanta, GA 30332-0535, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291792PMC
September 2006