Gary Yellen

Gary Yellen

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Gary Yellen

Gary Yellen

Publications by authors named "Gary Yellen"

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40Publications

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Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism.

Authors:
Gary Yellen

J Cell Biol 2018 Jul 11;217(7):2235-2246. Epub 2018 May 11.

Department of Neurobiology, Harvard Medical School, Boston, MA.

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July 2018

Live cell imaging of cytosolic NADH/NAD ratio in hepatocytes and liver slices.

Am J Physiol Gastrointest Liver Physiol 2018 01 12;314(1):G97-G108. Epub 2017 Oct 12.

Department of Neurobiology, Harvard Medical School , Boston, Massachusetts.

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January 2018

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy.

Epilepsia 2018 01 23;59(1):e1-e4. Epub 2017 Nov 23.

Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

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January 2018

Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake.

Cell Metab 2017 Aug;26(2):361-374.e4

Department of Neurobiology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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August 2017

Cytosolic NADH-NAD(+) Redox Visualized in Brain Slices by Two-Photon Fluorescence Lifetime Biosensor Imaging.

Antioxid Redox Signal 2016 10 18;25(10):553-63. Epub 2016 Mar 18.

Department of Neurobiology, Harvard Medical School , Boston, Massachusetts.

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October 2016

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.

Elife 2016 05 13;5. Epub 2016 May 13.

Department of Neurobiology, Harvard Medical School, Boston, United States.

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May 2016

Corrigendum: A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging.

Front Pharmacol 2016 25;7:46. Epub 2016 Feb 25.

Howard Hughes Medical InstituteBoston, MA, USA; Department of Neurobiology, Harvard Medical SchoolBoston, MA, USA.

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March 2016

Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy.

Epilepsy Res 2015 Dec 24;118:22-8. Epub 2015 Oct 24.

NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom; Epilepsy Society, Chalfont St Peter, United Kingdom.

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December 2015

Imaging changes in the cytosolic ATP-to-ADP ratio.

Methods Enzymol 2014 ;547:355-71

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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August 2015

Quantitative two-photon imaging of fluorescent biosensors.

Curr Opin Chem Biol 2015 Aug 12;27:24-30. Epub 2015 Jun 12.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States.

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August 2015

The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.

Am J Physiol Cell Physiol 2015 Feb 3;308(3):C264-76. Epub 2014 Dec 3.

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts.

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February 2015

Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.

J Neurosci 2014 Dec;34(49):16336-47

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and

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December 2014

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio.

Nat Commun 2013 ;4:2550

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.

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May 2014

Live-cell imaging of cytosolic NADH-NAD+ redox state using a genetically encoded fluorescent biosensor.

Methods Mol Biol 2014 ;1071:83-95

Department of Neurobiology, Harvard Medical School, Cambridge, MA, USA.

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April 2014

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging.

Front Pharmacol 2014 2;5:56. Epub 2014 Apr 2.

Howard Hughes Medical Institute Boston, MA, USA ; Department of Neurobiology, Harvard Medical School Boston, MA, USA.

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April 2014

The ketogenic diet: metabolic influences on brain excitability and epilepsy.

Trends Neurosci 2013 Jan 8;36(1):32-40. Epub 2012 Dec 8.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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January 2013

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.

J Gen Physiol 2012 Nov 15;140(5):469-79. Epub 2012 Oct 15.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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November 2012

Structural changes during HCN channel gating defined by high affinity metal bridges.

J Gen Physiol 2012 Sep;140(3):279-91

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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September 2012

Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain.

Prog Brain Res 2012 ;196:235-63

Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

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July 2012

Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor.

Cell Metab 2011 Oct;14(4):545-54

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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October 2011

Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor.

J Am Chem Soc 2011 Jul 9;133(26):10034-7. Epub 2011 Jun 9.

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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July 2011

Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.

J Neurosci 2011 Jun;31(23):8689-96

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2011

A genetically encoded fluorescent reporter of ATP:ADP ratio.

Nat Methods 2009 Feb 4;6(2):161-6. Epub 2009 Jan 4.

Department of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, Massachusetts 02115, USA.

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February 2009

Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet.

Authors:
Gary Yellen

Epilepsia 2008 Nov;49 Suppl 8:80-2

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. gary

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November 2008

Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels.

J Neurosci 2007 Apr;27(14):3618-25

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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April 2007

Cooperative gating between single HCN pacemaker channels.

J Gen Physiol 2006 Nov 16;128(5):561-7. Epub 2006 Oct 16.

Department of Neurobiology Harvard Medical School, Boston, MA 02115, USA.

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November 2006

Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.

J Gen Physiol 2006 Sep 14;128(3):273-82. Epub 2006 Aug 14.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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September 2006

Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.

J Gen Physiol 2006 Feb;127(2):183-90

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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February 2006

Status of the intracellular gate in the activated-not-open state of shaker K+ channels.

J Gen Physiol 2005 Nov;126(5):419-28

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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November 2005

A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.

Bioinformatics 2004 Jul 12;20(10):1565-72. Epub 2004 Feb 12.

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

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July 2004

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

Nature 2004 Apr;428(6985):864-8

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.

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April 2004

Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.

Neuron 2004 Mar;41(5):737-44

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.

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March 2004

Movements near the gate of a hyperpolarization-activated cation channel.

J Gen Physiol 2003 Nov 13;122(5):501-10. Epub 2003 Oct 13.

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115. email:

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November 2003

The voltage-gated potassium channels and their relatives.

Authors:
Gary Yellen

Nature 2002 Sep;419(6902):35-42

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.

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September 2002

Fast and slow voltage sensor movements in HERG potassium channels.

J Gen Physiol 2002 Mar;119(3):275-93

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

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March 2002

Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.

J Gen Physiol 2002 Jan;119(1):83-91

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

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January 2002