Gary N Parkinson

Gary N Parkinson

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Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.

Nucleic Acids Res 2020 May 26. Epub 2020 May 26.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.

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http://dx.doi.org/10.1093/nar/gkaa439DOI Listing
May 2020

X-Ray Crystallographic Studies of G-Quadruplex Structures.

Methods Mol Biol 2019 ;2035:131-155

UCL School of Pharmacy, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-9666-7_8DOI Listing
April 2020

Holliday Junctions Formed from Human Telomeric DNA.

J Am Chem Soc 2018 11 30;140(45):15366-15374. Epub 2018 Oct 30.

UCL School of Pharmacy , University College London , London WC1N 1AX , United Kingdom.

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http://dx.doi.org/10.1021/jacs.8b08699DOI Listing
November 2018

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.

Bioorg Med Chem 2018 07 26;26(11):2958-2964. Epub 2018 Apr 26.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.04.050DOI Listing
July 2018

G-Quadruplexes (GQU).

J Nucleic Acids 2018 30;2018:1079191. Epub 2018 Apr 30.

Department of Chemistry, University of St. Thomas, St. Paul, MN, USA.

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http://dx.doi.org/10.1155/2018/1079191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952435PMC
April 2018

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.

J Am Chem Soc 2016 Feb 19;138(4):1226-33. Epub 2016 Jan 19.

UCL School of Pharmacy, University College London , London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1021/jacs.5b10492DOI Listing
February 2016

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome.

FEBS Lett 2015 Jun 13;589(14):1653-68. Epub 2015 May 13.

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.05.003DOI Listing
June 2015

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

J Am Chem Soc 2013 Dec 11;135(51):19319-29. Epub 2013 Dec 11.

UCL School of Pharmacy, University College London , London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1021/ja4101358DOI Listing
December 2013

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation.

Nucleic Acids Res 2012 May 28;40(10):4691-700. Epub 2012 Jan 28.

CRUK Biomolecular Structure Group, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, WC1N 1AX, London, UK.

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http://dx.doi.org/10.1093/nar/gks023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378867PMC
May 2012

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.

J Am Chem Soc 2012 Feb 31;134(5):2723-31. Epub 2012 Jan 31.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London, WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1021/ja2102423DOI Listing
February 2012

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

J Med Chem 2012 Jan 13;55(1):209-22. Epub 2011 Dec 13.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-29 Brunswick Square, London WC1N 1AX, U.K.

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http://dx.doi.org/10.1021/jm201140vDOI Listing
January 2012

The application of DNA and RNA G-quadruplexes to therapeutic medicines.

Chem Soc Rev 2011 Dec 25;40(12):5867-92. Epub 2011 Jul 25.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London, UK WC1N 1AX.

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http://dx.doi.org/10.1039/c1cs15067gDOI Listing
December 2011

A structural analysis of G-quadruplex/ligand interactions.

Biochimie 2011 Aug 26;93(8):1239-51. Epub 2011 May 26.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1016/j.biochi.2011.05.012DOI Listing
August 2011

Structural basis of telomeric RNA quadruplex--acridine ligand recognition.

J Am Chem Soc 2011 Mar 3;133(8):2721-8. Epub 2011 Feb 3.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London, United Kingdom.

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http://dx.doi.org/10.1021/ja109767yDOI Listing
March 2011

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex.

Nucleic Acids Res 2010 Sep 22;38(16):5569-80. Epub 2010 Apr 22.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938214PMC
September 2010

H-NS forms a superhelical protein scaffold for DNA condensation.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15728-32. Epub 2010 Aug 23.

Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Houston, 77030, USA.

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http://dx.doi.org/10.1073/pnas.1006966107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936596PMC
September 2010

Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures.

J Am Chem Soc 2010 Jul;132(27):9328-34

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, WC1N 1AX London, United Kingdom.

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http://dx.doi.org/10.1021/ja100345zDOI Listing
July 2010

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Apr 31;66(Pt 4):421-5. Epub 2010 Mar 31.

Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, England.

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http://dx.doi.org/10.1107/S1744309110004574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852335PMC
April 2010

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.

Chem Commun (Camb) 2009 Dec 13(48):7482-4. Epub 2009 Nov 13.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.

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http://dx.doi.org/10.1039/b901889aDOI Listing
December 2009

Selectivity in ligand recognition of G-quadruplex loops.

Biochemistry 2009 Mar;48(8):1675-80

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://pubs.acs.org/doi/abs/10.1021/bi802233v
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http://dx.doi.org/10.1021/bi802233vDOI Listing
March 2009

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

J Med Chem 2008 Dec;51(24):7751-67

The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1021/jm801245vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967098PMC
December 2008

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Biochemistry 2008 Nov 17;47(45):11818-29. Epub 2008 Oct 17.

Gene Targeting Drug Design Research Group, Spirogen Ltd., and The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK.

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https://pubs.acs.org/doi/10.1021/bi801225q
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http://dx.doi.org/10.1021/bi801225qDOI Listing
November 2008

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.

J Mol Biol 2008 Sep 17;381(5):1145-56. Epub 2008 Jun 17.

The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.06.022DOI Listing
September 2008

Quadruplex DNA crystal structures and drug design.

Biochimie 2008 Aug 19;90(8):1184-96. Epub 2008 Mar 19.

The Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

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http://dx.doi.org/10.1016/j.biochi.2008.03.003DOI Listing
August 2008

Molecular dynamics and principal components analysis of human telomeric quadruplex multimers.

Biophys J 2008 Jul 28;95(1):296-311. Epub 2008 Mar 28.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London, United Kingdom.

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http://dx.doi.org/10.1529/biophysj.107.120501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426654PMC
July 2008

Structural basis of DNA quadruplex recognition by an acridine drug.

J Am Chem Soc 2008 May 6;130(21):6722-4. Epub 2008 May 6.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/ja8016973
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http://dx.doi.org/10.1021/ja8016973DOI Listing
May 2008

Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding.

BMC Struct Biol 2008 Feb 29;8:13. Epub 2008 Feb 29.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://bmcstructbiol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6807-8-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292188PMC
February 2008

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.

Bioorg Med Chem 2008 Jan 25;16(1):354-61. Epub 2007 Sep 25.

Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.09.040DOI Listing
January 2008

Crystallographic studies of quadruplex nucleic acids.

Methods 2007 Dec;43(4):252-63

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S104620230700140
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http://dx.doi.org/10.1016/j.ymeth.2007.08.005DOI Listing
December 2007

Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter.

Nucleic Acids Res 2007 24;35(17):5799-808. Epub 2007 Aug 24.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1093/nar/gkm609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034477PMC
November 2007

Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.

J Am Chem Soc 2007 Aug 28;129(33):10106-7. Epub 2007 Jul 28.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, U.K.

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http://dx.doi.org/10.1021/ja0740869DOI Listing
August 2007

Structural basis for binding of porphyrin to human telomeres.

Biochemistry 2007 Mar 3;46(9):2390-7. Epub 2007 Feb 3.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1021/bi062244nDOI Listing
March 2007

Quadruplex DNA: sequence, topology and structure.

Nucleic Acids Res 2006 29;34(19):5402-15. Epub 2006 Sep 29.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkl655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636468PMC
December 2006

Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures.

Nucleic Acids Res 2006 26;34(7):2117-27. Epub 2006 Apr 26.

CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1093/nar/gkl182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449907PMC
May 2006

Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.

J Am Chem Soc 2006 Apr;128(16):5480-7

Cancer Research U.K. Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1021/ja058577+DOI Listing
April 2006

Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure.

Bioorg Med Chem Lett 2006 Jan 2;16(1):15-9. Epub 2005 Nov 2.

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.036DOI Listing
January 2006

Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove.

Biochemistry 2005 Nov;44(45):14701-8

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/bi051791qDOI Listing
November 2005

Putative DNA quadruplex formation within the human c-kit oncogene.

J Am Chem Soc 2005 Aug;127(30):10584-9

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1021/ja050823uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195896PMC
August 2005

Putative DNA quadruplex formation within the human c-kit oncogene.

J Am Chem Soc 2005 Aug;127(30):10584-9

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.1021/ja050823uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195896PMC
August 2005

The structure of telomeric DNA.

Curr Opin Struct Biol 2003 Jun;13(3):275-83

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK.

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http://dx.doi.org/10.1016/s0959-440x(03)00072-1DOI Listing
June 2003

Structure of a G-quadruplex-ligand complex.

J Mol Biol 2003 Feb;326(1):117-25

Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK.

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http://dx.doi.org/10.1016/s0022-2836(02)01354-2DOI Listing
February 2003

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.

J Mol Biol 2002 Jul;320(2):189-200

The Cancer Research UK Biomolecular Structure Unit, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360200428
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http://dx.doi.org/10.1016/S0022-2836(02)00428-XDOI Listing
July 2002

Crystal structure of parallel quadruplexes from human telomeric DNA.

Nature 2002 Jun 26;417(6891):876-80. Epub 2002 May 26.

The Cancer Research UK Biomolecular Structure Unit, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/nature755DOI Listing
June 2002