Gary Kobinger

Gary Kobinger

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Gary Kobinger

Gary Kobinger

Publications by authors named "Gary Kobinger"

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100Publications

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Modeling Ebola Virus Transmission Using Ferrets.

mSphere 2018 Oct 31;3(5). Epub 2018 Oct 31.

Département de microbiologie-infectiologie et d'immunologie, Université Laval, Quebec City, Quebec, Canada

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October 2018

Outbreaks in a Rapidly Changing Central Africa - Lessons from Ebola.

N Engl J Med 2018 Sep 22;379(13):1198-1201. Epub 2018 Aug 22.

From the Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT (V.J.M., E.W., R.F., S.N.S.); the UK Public Health Rapid Support Team, Public Health England-London School of Hygiene and Tropical Medicine, London (D.G.B.); the University of Laval, Quebec, QC, Canada (G.K.); the Bernhard Nocht Institute for Tropical Medicine, Hamburg (C.M.-F.), the German Center for Infection Research, Hamburg (C.M.-F.), and the Institute for Tropical Medicine, University of Tübingen (F.N.) - all in Germany; the Wildlife Conservation Society, Wildlife Health Program, Bronx, NY (S.H.O.); Médecins sans Frontières, Brussels, Belgium (A.S.); the Fondation Congolaise pour la Recherche Medicale and Faculty of Sciences and Technology, University Marien Ngouabi (F.N.), and the Laboratoire National de Santé Publique, Brazzaville (J.-V.M.) - both in the Republic of the Congo; and the Ministry of Health and Social Welfare of Liberia and the Incidence Management System of Liberia, Ebola Case Management Team, Monrovia, Liberia (M.M.).

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September 2018

Zika Virus Vaccines: Challenges and Perspectives.

Vaccines (Basel) 2018 Sep 13;6(3). Epub 2018 Sep 13.

Centre de Recherche en Infectiologie du CHU de Québec-Université Laval, Québec, QC G1V 4G2, Canada.

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September 2018

Taxonomy of the order Mononegavirales: update 2018.

Arch Virol 2018 Aug 11;163(8):2283-2294. Epub 2018 Apr 11.

Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.

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August 2018

In vitro susceptibility of geographically and temporally distinct Zika viruses to favipiravir and ribavirin.

Antivir Ther 2017 11;22(7):613-618. Epub 2017 Jul 11.

Research Center in Infectious Diseases of the CHU of Québec and Laval University, Québec City, QC, Canada.

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July 2018

Testing Experimental Therapies in a Guinea Pig Model for Hemorrhagic Fever.

Methods Mol Biol 2018 ;1604:269-278

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.

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June 2018

Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans.

Zoonoses Public Health 2018 Jun 21. Epub 2018 Jun 21.

Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

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June 2018

Reply to Reisler et al.

Clin Infect Dis 2018 Apr;66(9):1480-1481

National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome.

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April 2018

Assessing Antiviral Countermeasures Using Mouse Models of Ebolavirus Infection.

Methods Mol Biol 2017 ;1628:273-282

Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.

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March 2018

From bench to almost bedside: the long road to a licensed Ebola virus vaccine.

Expert Opin Biol Ther 2018 02 17;18(2):159-173. Epub 2017 Nov 17.

c National Microbiology Laboratory , Public Health Agency of Canada , Winnipeg , MB , Canada.

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February 2018

Empowerment of Women: Closing the Medical Technologies Gender Gap.

J Obstet Gynaecol Can 2018 Jan 12;40(1):78-83. Epub 2017 Sep 12.

Infectious Diseases Research Centre, CHU de Québec-Université Laval and Department of Microbiology, Immunology and Infectiology, Faculty of Medicine, Laval University, Québec City, QC.

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January 2018

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry.

Virology 2018 01 12;513:17-28. Epub 2017 Oct 12.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada. Electronic address:

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January 2018

Syrian Hamsters as a Small Animal Model for Emerging Infectious Diseases: Advances in Immunologic Methods.

Adv Exp Med Biol 2017 ;972:87-101

Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.

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November 2017

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine - Preliminary Report.

N Engl J Med 2017 Oct 4. Epub 2017 Oct 4.

From the Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania (P.T.), and Wistar Institute (K.M., E.L.R., S.B.K., F.I.Z., H.C., D.B.W.), Philadelphia, and Inovio Pharmaceuticals, Plymouth Meeting (S.W., A.S.K., J.B., M.B.) - all in Pennsylvania; GeneOne Life Science, Seoul, South Korea (C.C.R., Y.K.P., C.R., S.E.S., J.N.M.); Infectious Diseases Research Centre-Université Laval, Quebec, QC, Canada (T.R., S.T., G.P.K.); QPS-Miami Research Associates, Miami, (D.K.); and the Department of Medicine, Morristown Medical Center, Morristown, NJ (J.N.M.).

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October 2017

MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika Virus.

Viruses 2017 10 14;9(10). Epub 2017 Oct 14.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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October 2017

Clinical Evaluation of Ebola Virus Disease Therapeutics.

Trends Mol Med 2017 09 17;23(9):820-830. Epub 2017 Aug 17.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

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September 2017

Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses.

AIDS Res Ther 2017 Sep 12;14(1):55. Epub 2017 Sep 12.

Department of Microbiology and Immunology, Western University, London, Canada.

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September 2017

Viral pathogenesis: Unlocking Ebola persistence.

Nat Microbiol 2017 Aug 24;2:17124. Epub 2017 Aug 24.

Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec, Université Laval, 2705 boulevard Laurier Québec City, Québec G1V 2G4, Canada.

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August 2017

HIV-1 envelope glycoprotein stimulates viral transcription and increases the infectivity of the progeny virus through the manipulation of cellular machinery.

Sci Rep 2017 Aug 25;7(1):9487. Epub 2017 Aug 25.

Laboratory of Molecular Human Retrovirology, University of Manitoba, Winnipeg, MB, Canada.

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August 2017

Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time.

Sci Rep 2017 Jun 13;7(1):3390. Epub 2017 Jun 13.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

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June 2017

The ongoing evolution of antibody-based treatments for Ebola virus infection.

Immunotherapy 2017 Mar;9(5):435-450

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.

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March 2017

How to turn competitors into collaborators.

Nature 2017 01;541(7637):283-285

Department of Microbiology & Immunology, Tulane University, New Orleans, Louisiana, USA.

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January 2017

Therapeutics Against Filovirus Infection.

Curr Top Microbiol Immunol 2017 ;411:263-290

Department of Medicine, National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, 620 Albaney Street, Boston, MA, 02118, USA.

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January 2017

Human Adaptation of Ebola Virus during the West African Outbreak.

Cell 2016 11;167(4):1079-1087.e5

School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Electronic address:

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November 2016

BoHV-4-based vector delivering Ebola virus surface glycoprotein.

J Transl Med 2016 11 24;14(1):325. Epub 2016 Nov 24.

Department of Medical-Veterinary Science, University of Parma, Via del Taglio 10, 43126, Parma, Italy.

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November 2016

Environmental Contamination and Persistence of Ebola Virus RNA in an Ebola Treatment Center.

J Infect Dis 2016 10 30;214(suppl 3):S145-S152. Epub 2016 Jun 30.

Public Health Agency of Canada Department of Medical Microbiology Department of Pediatrics and Child Health, University of Manitoba, Winnipeg.

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October 2016

Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.

J Virol 2016 10 29;90(20):9209-23. Epub 2016 Sep 29.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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October 2016

Pathogenicity Comparison Between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques.

J Infect Dis 2016 10 19;214(suppl 3):S281-S289. Epub 2016 Sep 19.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

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October 2016

More Challenges From Ebola: Infection of the Central Nervous System.

J Infect Dis 2016 10;214(suppl 3):S294-S296

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

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October 2016

Vaccines against 'the other' Ebolavirus species.

Expert Rev Vaccines 2016 09 12;15(9):1093-100. Epub 2016 Apr 12.

a Special Pathogens Program, National Microbiology Laboratory , Public Health Agency of Canada , Winnipeg , Canada.

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September 2016

Taxonomy of the order Mononegavirales: update 2016.

Arch Virol 2016 Aug 23;161(8):2351-60. Epub 2016 May 23.

Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.

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August 2016

Diagnosis and management of Ebola samples in the laboratory.

Expert Rev Anti Infect Ther 2016 06 13;14(6):557-67. Epub 2016 May 13.

a Special Pathogens Program, National Microbiology Laboratory , Public Health Agency of Canada , Winnipeg , Canada.

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June 2016

Ebolavirus Evolution: Past and Present.

PLoS Pathog 2015 12;11(11):e1005221. Epub 2015 Nov 12.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

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April 2016

Antibody therapeutics for Ebola virus disease.

Curr Opin Virol 2016 04 27;17:45-49. Epub 2016 Jan 27.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada; Department of Immunology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada.

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April 2016

Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection.

Antiviral Res 2016 Mar 9;127:20-31. Epub 2016 Jan 9.

Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada; Department of Microbiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, 410078, PR China. Electronic address:

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March 2016

Successful Control of Ebola Virus Disease: Analysis of Service Based Data from Rural Sierra Leone.

PLoS Negl Trop Dis 2016 Mar 9;10(3):e0004498. Epub 2016 Mar 9.

National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, Australia.

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March 2016

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus.

Sci Transl Med 2016 Mar;8(329):329ra33

Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

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March 2016

Diagnostic strategies for Ebola virus detection.

Lancet Infect Dis 2016 Mar;16(3):294-5

Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences and Collaborative Innovation Center and State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, China. Electronic address:

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March 2016

Progression of Ebola Therapeutics During the 2014-2015 Outbreak.

Trends Mol Med 2016 Feb 13;22(2):164-173. Epub 2016 Jan 13.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:

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February 2016

Ebola virus is unlikely to become endemic in West Africa.

Nat Microbiol 2016 02 24;1:16007. Epub 2016 Feb 24.

Médecins Sans Frontières, Rue Arbre Benit 46, 1050 Brussels, Belgium.

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February 2016

Development and Characterization of a Guinea Pig-Adapted Sudan Virus.

J Virol 2016 01 21;90(1):392-9. Epub 2015 Oct 21.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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January 2016

Nanozyme-strip for rapid local diagnosis of Ebola.

Biosens Bioelectron 2015 Dec 11;74:134-41. Epub 2015 May 11.

Key Laboratory of Protein and Peptide Pharmaceuticals, CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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December 2015

The emergence of antibody therapies for Ebola.

Hum Antibodies 2015 Dec;23(3-4):49-56

Mapp Biopharmaceutical, Inc. San Diego, CA, USA.

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December 2015

Personal Protective Equipment for Filovirus Epidemics: A Call for Better Evidence.

J Infect Dis 2015 Oct 27;212 Suppl 2:S98-S100. Epub 2015 Mar 27.

Human Factors and Ergonomics Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania.

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October 2015

Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates.

J Infect Dis 2015 Oct 9;212 Suppl 2:S379-83. Epub 2015 May 9.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

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October 2015

Characterization of a Bivalent Vaccine Capable of Inducing Protection Against Both Ebola and Cross-clade H5N1 Influenza in Mice.

J Infect Dis 2015 Oct 28;212 Suppl 2:S435-42. Epub 2015 May 28.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

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October 2015

Optimization of Prime-Boost Vaccination Strategies Against Mouse-Adapted Ebolavirus in a Short-Term Protection Study.

J Infect Dis 2015 Oct 2;212 Suppl 2:S389-97. Epub 2015 Jun 2.

National Microbiology Laboratory, Public Health Agency of Canada University of Manitoba, Winnipeg, Canada.

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October 2015

Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important?.

Hum Vaccin Immunother 2014 ;10(10):2875-84

a National Microbiology Laboratory ; Public health Agency of Canada ; Winnipeg , MB Canada.

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September 2015

EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain.

Science 2015 Aug 6;349(6249):739-42. Epub 2015 Aug 6.

Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

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August 2015

Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak.

Clin Microbiol Rev 2015 Jul;28(3):593-601

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

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July 2015

Intranasal immunization with an adenovirus vaccine protects guinea pigs from Ebola virus transmission by infected animals.

Antiviral Res 2015 Apr 14;116:17-9. Epub 2015 Jan 14.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:

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April 2015

Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates.

Mol Ther 2015 Mar 17;23(3):414-22. Epub 2014 Dec 17.

1] Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada [2] Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, Manitoba, Canada [3] Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.

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March 2015