Publications

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry.
Virology 2018 Jan 12;513:17-28. Epub 2017 Oct 12.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada. Electronic address:

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine - Preliminary Report.
N Engl J Med 2017 Oct 4. Epub 2017 Oct 4.
From the Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania (P.T.), and Wistar Institute (K.M., E.L.R., S.B.K., F.I.Z., H.C., D.B.W.), Philadelphia, and Inovio Pharmaceuticals, Plymouth Meeting (S.W., A.S.K., J.B., M.B.) - all in Pennsylvania; GeneOne Life Science, Seoul, South Korea (C.C.R., Y.K.P., C.R., S.E.S., J.N.M.); Infectious Diseases Research Centre-Université Laval, Quebec, QC, Canada (T.R., S.T., G.P.K.); QPS-Miami Research Associates, Miami, (D.K.); and the Department of Medicine, Morristown Medical Center, Morristown, NJ (J.N.M.).

MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika Virus.
Viruses 2017 Oct 14;9(10). Epub 2017 Oct 14.
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Clinical Evaluation of Ebola Virus Disease Therapeutics.
Trends Mol Med 2017 Sep 17;23(9):820-830. Epub 2017 Aug 17.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Taxonomy of the order Mononegavirales: update 2017.
Arch Virol 2017 Aug 7;162(8):2493-2504. Epub 2017 Apr 7.
Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.




Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.
Syst Biol 2017 May;66(3):463-473
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, 21702 MD, USA.






Environmental Contamination and Persistence of Ebola Virus RNA in an Ebola Treatment Center.
J Infect Dis 2016 Oct 30;214(suppl 3):S145-S152. Epub 2016 Jun 30.
Public Health Agency of Canada Department of Medical Microbiology Department of Pediatrics and Child Health, University of Manitoba, Winnipeg.

Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.
J Virol 2016 Oct 29;90(20):9209-23. Epub 2016 Sep 29.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada


Pathogenicity Comparison Between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques.
J Infect Dis 2016 Oct 19;214(suppl 3):S281-S289. Epub 2016 Sep 19.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.


More Challenges From Ebola: Infection of the Central Nervous System.
J Infect Dis 2016 Oct;214(suppl 3):S294-S296
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.



Taxonomy of the order Mononegavirales: update 2016.
Arch Virol 2016 Aug 23;161(8):2351-60. Epub 2016 May 23.
Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.


Antibody therapeutics for Ebola virus disease.
Curr Opin Virol 2016 Apr 27;17:45-9. Epub 2016 Jan 27.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada; Department of Immunology, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, Manitoba R3E 0J9, Canada.


Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection.
Antiviral Res 2016 Mar 9;127:20-31. Epub 2016 Jan 9.
Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada; Department of Microbiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, 410078, PR China. Electronic address:

Successful Control of Ebola Virus Disease: Analysis of Service Based Data from Rural Sierra Leone.
PLoS Negl Trop Dis 2016 Mar 9;10(3):e0004498. Epub 2016 Mar 9.
National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, Australia.

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus.
Sci Transl Med 2016 Mar;8(329):329ra33
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

Diagnostic strategies for Ebola virus detection.
Lancet Infect Dis 2016 Mar;16(3):294-5
Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences and Collaborative Innovation Center and State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, China. Electronic address:

Progression of Ebola Therapeutics During the 2014-2015 Outbreak.
Trends Mol Med 2016 Feb 13;22(2):164-73. Epub 2016 Jan 13.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:



Nanozyme-strip for rapid local diagnosis of Ebola.
Biosens Bioelectron 2015 Dec 11;74:134-41. Epub 2015 May 11.
Key Laboratory of Protein and Peptide Pharmaceuticals, CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:



Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates.
J Infect Dis 2015 Oct 9;212 Suppl 2:S379-83. Epub 2015 May 9.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada Department of Medical Microbiology Department of Immunology, University of Manitoba, Winnipeg Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

Characterization of a Bivalent Vaccine Capable of Inducing Protection Against Both Ebola and Cross-clade H5N1 Influenza in Mice.
J Infect Dis 2015 Oct 28;212 Suppl 2:S435-42. Epub 2015 May 28.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada Department of Immunology, University of Manitoba, Winnipeg, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

Development and Characterization of a Guinea Pig-Adapted Sudan Virus.
J Virol 2015 Oct 21;90(1):392-9. Epub 2015 Oct 21.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada


EBOLA VACCINE. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain.
Science 2015 Aug 6;349(6249):739-42. Epub 2015 Aug 6.
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.


Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak.
Clin Microbiol Rev 2015 Jul;28(3):593-601
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA


Intranasal immunization with an adenovirus vaccine protects guinea pigs from Ebola virus transmission by infected animals.
Antiviral Res 2015 Apr 14;116:17-9. Epub 2015 Jan 14.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:

Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates.
Mol Ther 2015 Mar 17;23(3):414-22. Epub 2014 Dec 17.
1] Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada [2] Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, Manitoba, Canada [3] Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.


Ebola virus transmission in guinea pigs.
J Virol 2015 Jan 12;89(2):1314-23. Epub 2014 Nov 12.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada Department of Immunology, University of Manitoba, Winnipeg, MB, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus.
J Virol 2014 Nov 20;88(21):12703-14. Epub 2014 Aug 20.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Ebola virus disease in the Democratic Republic of Congo.
N Engl J Med 2014 Nov 15;371(22):2083-91. Epub 2014 Oct 15.
From the Centre International de Recherches Médicales de Franceville, World Health Organization (WHO) Collaborating Center, Franceville, Gabon (G.D.M., N.B., I.L., E.M.L.); Ministry of Health (B.K.I., F.K.), Institut National de Recherche Biomédicale (J.K., P.M.K., J.-J.T.M.), and the WHO (V.M., J.C.), Kinshasa, Democratic Republic of Congo; Centre National de la Recherche Scientifique, Unité Epidémiologie et Physiopathologie des Virus Oncogènes (CNRS UMR3569) (N.B.), Eco-anthropologie et Ethnobiologie, UMR 7206 CNRS-MNHN (A.E.), and Institut Pasteur, Unité de Recherche et d'Expertise Environnement et Risques Infectieux, Cellule d'Intervention Biologique d'Urgence (J.-C.M.), Paris, and Institut de Recherche pour le Développement, Unité Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Controle IRD 224-CNRS 5290-UM1-UM2, Montpellier (E.M.L.) - all in France; Public Health Agency of Canada, Winnipeg (G.K.); and the WHO, Geneva (E.B., S.B., P.F., L.G.-A., J.-M.O.-B., C.D.).


Experimental countermeasures against Ebola virus: current progress and an ethical conundrum.
CMAJ 2014 Oct 19;186(15):1129-30. Epub 2014 Aug 19.
National Microbiology Laboratory (Plummer, Kobinger), Public Health Agency of Canada; Department of Medical Microbiology (Plummer, Wong, Kobinger), University of Manitoba; Department of Immunology (Kobinger), University of Manitoba, Winnipeg, Man.; Department of Pathology and Laboratory Medicine (Kobinger), University of Pennsylvania School of Medicine, Philadelphia, Pa.

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
Nature 2014 Oct 29;514(7520):47-53. Epub 2014 Aug 29.
1] National Laboratory for Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada [2] Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada [3] Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada [4] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents.
Vaccine 2014 Sep 27;32(43):5722-9. Epub 2014 Aug 27.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2 Canada. Electronic address:

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names.
Viruses 2014 Sep 26;6(9):3663-82. Epub 2014 Sep 26.
IViral Special Pathogens Branch, Division of High-Consequence Pathogens Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Post-exposure therapy of filovirus infections.
Trends Microbiol 2014 Aug 30;22(8):456-63. Epub 2014 Apr 30.
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:

Evaluation of transmission risks associated with in vivo replication of several high containment pathogens in a biosafety level 4 laboratory.
Sci Rep 2014 Jul 25;4:5824. Epub 2014 Jul 25.
1] Special Pathogens Program, Public Health Agency of Canada, 1015 Arlington St., Winnipeg. Manitoba [2] Departments of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada [3] Departments of Immunology, University of Manitoba, Winnipeg, MB, Canada [4] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
Immunity 2014 Apr 10;40(4):554-68. Epub 2014 Apr 10.
Department of Medicine, Department of Microbiology & Immunology, Department of Pathology, McGill International TB Centre, McGill University Health Centre and Research Institute, Meakins-Christie Laboratories, 3626 St. Urbain Street, Montreal, Quebec H2X 2P2, Canada. Electronic address:



Human Adaptation of Ebola Virus during the West African Outbreak.
Cell 2016 11;167(4):1079-1087.e5
School of Life Sciences, The University of Nottingham, Nottingham NG7 2RD, UK; NIHR Nottingham Digestive Diseases Biomedical Research Unit, The University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Electronic address:

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