Gary H Posner

Gary H Posner

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Gary H Posner

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Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs.

Oncotarget 2016 Feb;7(6):7268-79

Center for Stem Cell Biology & Regenerative Medicine, Departments of Pediatrics and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.18632/oncotarget.6896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872784PMC
February 2016

Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Bioorg Med Chem Lett 2015 Jan 27;25(2):245-8. Epub 2014 Nov 27.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277730PMC
January 2015

In vitro combination of anti-cytomegalovirus compounds acting through different targets: role of the slope parameter and insights into mechanisms of Action.

Antimicrob Agents Chemother 2014 25;58(2):986-94. Epub 2013 Nov 25.

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.01972-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910867PMC
September 2014

A thiazole derivative of artemisinin moderately reduces Toxoplasma gondii cyst burden in infected mice.

J Parasitol 2014 Aug 13;100(4):516-21. Epub 2014 Feb 13.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109.

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http://www.bioone.org/doi/abs/10.1645/13-451.1
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http://dx.doi.org/10.1645/13-451.1DOI Listing
August 2014

Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Bioorg Med Chem Lett 2014 Jun 16;24(11):2440-3. Epub 2014 Apr 16.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074917PMC
June 2014

Age- and sex-dependent hormonal modulation of the expression of vitamin D receptor and 25-hydroxyvitamin D 1α hydroxylase in human bone cells.

Expert Rev Endocrinol Metab 2014 May 29;9(3):283-292. Epub 2014 Mar 29.

c Department of Chemistry, The Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1586/17446651.2014.899897DOI Listing
May 2014

The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Bioorg Med Chem Lett 2014 Mar 30;24(5):1285-9. Epub 2014 Jan 30.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.01.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943161PMC
March 2014

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.

Bioorg Med Chem 2013 Jul 22;21(13):3702-7. Epub 2013 Apr 22.

Department of Chemistry, School of Arts and Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2013.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685872PMC
July 2013

Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

J Med Chem 2013 Mar 7;56(6):2630-41. Epub 2013 Mar 7.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA.

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http://dx.doi.org/10.1021/jm400058jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630999PMC
March 2013

Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid.

Photochem Photobiol Sci 2012 Dec;11(12):1825-30

Discipline of Physiology, Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1039/c2pp25208bDOI Listing
December 2012

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Medchemcomm 2012 Dec;3(12):1505-1511

Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1039/C2MD20238GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509744PMC
December 2012

Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

J Med Chem 2012 Sep 27;55(17):7892-9. Epub 2012 Aug 27.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jm3009986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460521PMC
September 2012

An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.

PLoS One 2011 31;6(8):e24334. Epub 2011 Aug 31.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164168PMC
April 2012

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

J Med Chem 2012 Jan 15;55(1):291-6. Epub 2011 Dec 15.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, United States.

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http://dx.doi.org/10.1021/jm201214dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257372PMC
January 2012

Three-component, one-flask synthesis of rhodanines (thiazolidinones).

J Org Chem 2011 Oct 31;76(19):8121-5. Epub 2011 Aug 31.

Department of Chemistry, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, United States.

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http://dx.doi.org/10.1021/jo201561tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184363PMC
October 2011

Cyanocuprates convert carboxylic acids directly into ketones.

Org Lett 2011 Oct 6;13(19):5358-61. Epub 2011 Sep 6.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/ol202237jDOI Listing
October 2011

Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones.

J Org Chem 2011 Jun 20;76(12):5149-55. Epub 2011 May 20.

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jo200795fDOI Listing
June 2011

A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Bioorg Med Chem Lett 2011 May 29;21(9):2773-5. Epub 2010 Sep 29.

Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037442PMC
May 2011

Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.

Virol J 2011 Jan 26;8:40. Epub 2011 Jan 26.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1186/1743-422X-8-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041771PMC
January 2011

α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions.

Org Lett 2010 Oct;12(20):4694-7

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ol102142aDOI Listing
October 2010

Apc(MIN) modulation of vitamin D secosteroid growth control.

Carcinogenesis 2010 Aug 20;31(8):1434-41. Epub 2010 May 20.

Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Northern Ireland, UK.

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http://dx.doi.org/10.1093/carcin/bgq098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915628PMC
August 2010

Vitamin D analogues targeting CYP24 in chronic kidney disease.

J Steroid Biochem Mol Biol 2010 Jul 27;121(1-2):13-9. Epub 2010 Mar 27.

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2010.03.065DOI Listing
July 2010

Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters.

Org Lett 2010 May;12(9):2120-2

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ol100615jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864524PMC
May 2010

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

J Med Chem 2009 Dec;52(23):7458-62

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm9005934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788671PMC
December 2009

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.

Pharmaceuticals (Basel) 2009 Dec 21;2(3):228-235. Epub 2009 Dec 21.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA.

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http://dx.doi.org/10.3390/ph2030228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545PMC
December 2009

Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals.

Mol Carcinog 2009 Aug;48(8):758-72

Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1002/mc.20520DOI Listing
August 2009

'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.

Bioorg Med Chem 2009 Aug 21;17(15):5627-31. Epub 2009 Jun 21.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, United States.

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http://dx.doi.org/10.1016/j.bmc.2009.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713797PMC
August 2009

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

Biochem Pharmacol 2009 Feb 19;77(3):322-36. Epub 2008 Oct 19.

Department of Biological Sciences,110 Mills Godwin Building/45th Street, Old Dominion University, Norfolk, VA 23529, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520800726
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http://dx.doi.org/10.1016/j.bcp.2008.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659783PMC
February 2009

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

J Med Chem 2009 Feb;52(4):1198-203

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm801484vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698029PMC
February 2009

Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.

J Antimicrob Chemother 2009 Jan 6;63(1):146-50. Epub 2008 Nov 6.

Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

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http://jac.oxfordjournals.org/content/63/1/146.full.pdf
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http://www.jac.oxfordjournals.org/cgi/doi/10.1093/jac/dkn451
Publisher Site
http://dx.doi.org/10.1093/jac/dkn451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639242PMC
January 2009

Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters.

Org Lett 2008 Oct 24;10(20):4685-7. Epub 2008 Sep 24.

Department of Chemistry, Johns Hopkins University, 3400 Charles Street, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ol8020513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628291PMC
October 2008

Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.

Nitric Oxide 2008 Sep 22;19(2):184-91. Epub 2008 Apr 22.

German Cancer Research Center, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.niox.2008.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582405PMC
September 2008

Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate.

Bioorg Med Chem 2008 May 6;16(9):5247-53. Epub 2008 Mar 6.

Department of Chemistry, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668193PMC
May 2008

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

J Med Chem 2008 Feb 31;51(4):1035-42. Epub 2008 Jan 31.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm701168hDOI Listing
February 2008

Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway.

J Steroid Biochem Mol Biol 2007 Jun-Jul;105(1-5):140-9. Epub 2007 May 16.

Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2007.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824509PMC
November 2007

Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

J Med Chem 2007 Nov 9;50(23):5824-32. Epub 2007 Oct 9.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1021/jm070882dDOI Listing
November 2007

Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation.

Bioorg Med Chem 2007 Aug 25;15(16):5509-18. Epub 2007 May 25.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2007.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586064PMC
August 2007

Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.

Org Lett 2007 Jul 12;9(14):2673-6. Epub 2007 Jun 12.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1021/ol070960rDOI Listing
July 2007

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

J Med Chem 2007 May 17;50(10):2516-9. Epub 2007 Apr 17.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jm070149mDOI Listing
May 2007

A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cells.

J Pharmacol Exp Ther 2007 Mar 20;320(3):1119-26. Epub 2006 Dec 20.

Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1124/jpet.106.115451DOI Listing
March 2007

Antitumor effects of two less-calcemic vitamin D analogs (Paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells.

Oncology 2006 18;70(6):483-92. Epub 2007 Jan 18.

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, N.Y., USA.

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http://dx.doi.org/10.1159/000098813DOI Listing
March 2007

Unexpected steric effects of "remote" alkyl groups on the rate of conjugate additions to alkyl alpha,beta-ethylenic sulfones, sulfoxides, and esters.

J Org Chem 2007 Mar 7;72(7):2329-34. Epub 2007 Mar 7.

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

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https://pubs.acs.org/doi/10.1021/jo062155g
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http://dx.doi.org/10.1021/jo062155gDOI Listing
March 2007

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.

Antimicrob Agents Chemother 2006 Dec 23;50(12):4206-8. Epub 2006 Oct 23.

Stanley Division of Developmental Neurovirology, Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287-4988, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00793-06
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http://dx.doi.org/10.1128/AAC.00793-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693994PMC
December 2006

Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

J Med Chem 2006 Dec;49(25):7513-7

Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/jm0609925DOI Listing
December 2006

Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.

J Med Chem 2006 Dec;49(26):7836-42

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1021/jm060803iDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545891PMC
December 2006

Less calcemic Vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in the vasculature.

J Steroid Biochem Mol Biol 2006 Nov 6;101(4-5):232-8. Epub 2006 Oct 6.

Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2006.06.023DOI Listing
November 2006

Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3.

Bioorg Med Chem 2006 Sep 12;14(18):6341-8. Epub 2006 Jun 12.

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.05.050DOI Listing
September 2006

Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.

J Med Chem 2006 May;49(9):2731-4

Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm058288wDOI Listing
May 2006

Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a "less-calcemic" analog of 1,25 dihydroxyvitamin D(3): JK 1624F(2)-2 (JKF).

J Steroid Biochem Mol Biol 2006 Feb 10;98(2-3):139-46. Epub 2006 Jan 10.

Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center, 6 Weizman St., Tel-Aviv 64239, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2005.08.016DOI Listing
February 2006

Anticancer effects of the novel 1alpha, 25-dihydroxyvitamin D3 hybrid analog QW1624F2-2 in human neuroblastoma.

J Cell Biochem 2006 Jan;97(1):198-206

Division of Neurosurgery, The Children's Hospital of Philadelphia and The Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/jcb.20629DOI Listing
January 2006

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.

Bioorg Med Chem 2005 Oct;13(19):5569-80

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.06.031DOI Listing
October 2005

Inhibition of prostate cancer-meditated osteoblastic bone lesions by the low-calcemic analog 1alpha-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxy vitamin D3.

J Steroid Biochem Mol Biol 2005 Oct 2;97(1-2):203-11. Epub 2005 Aug 2.

Department of Endocrine Neoplasia and Hormonal Disorders, Unit 435, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2005.06.015DOI Listing
October 2005

New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J.

Org Lett 2005 Sep;7(19):4301-3

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/ol051854xDOI Listing
September 2005

A-ring hydroxymethyl 19-nor analogs of the natural hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.

Bioorg Med Chem 2005 Jun;13(12):3964-76

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.04.010DOI Listing
June 2005

Novel A-ring analogs of the hormone 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation.

Bioorg Med Chem 2005 Apr;13(8):2959-66

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.02.005DOI Listing
April 2005

Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).

J Med Chem 2004 Dec;47(27):6854-63

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1021/jm040129+DOI Listing
December 2004

Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues.

J Steroid Biochem Mol Biol 2004 Aug;91(4-5):241-6

Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2004.04.008DOI Listing
August 2004

A medicinal chemistry perspective on artemisinin and related endoperoxides.

J Med Chem 2004 Jun;47(12):2945-64

Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K.

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http://dx.doi.org/10.1021/jm030571cDOI Listing
June 2004

Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.

Acc Chem Res 2004 Jun;37(6):397-404

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1021/ar020227uDOI Listing
June 2004

Modulation of the response to estradiol-17beta of rat vascular tissues by a non calcemic vitamin D analog.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):339-41

Tel-Aviv Sourasky Medical Center, Institute of Endocrinology, Metabolism and Hypertension, 6 Weizman St., Tel-Aviv 64239, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.022DOI Listing
May 2004

Modulation of response to estrogens in cultured human female bone cells by a non-calcemic Vitamin D analog: changes in nuclear and membranal binding.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):393-5

Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center, 6 Weizman St., Tel-Aviv 64239, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2004.03.005DOI Listing
May 2004

A non-calcemic Vitamin D analog modulates both nuclear and putative membranal estrogen receptors in cultured human vascular smooth muscle cells.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):397-9

Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S096007600400051
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http://dx.doi.org/10.1016/j.jsbmb.2004.03.006DOI Listing
May 2004

Vitamin D analogs as modulators of vitamin D receptor action.

Curr Top Med Chem 2003 ;3(14):1555-72

Department of Endocrine Neoplasia and Hormonal Disorders, Box 435, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.2174/1568026033451691DOI Listing
February 2004

Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

J Med Chem 2004 Feb;47(5):1299-301

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm0303711
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http://dx.doi.org/10.1021/jm0303711DOI Listing
February 2004

Treatment with non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 increases responsiveness to 17beta-estradiol, dihydrotestosterone or raloxifene in primary human osteoblasts.

J Steroid Biochem Mol Biol 2004 Feb;88(2):213-9

Institute of Endocrinology, Sourasky Medical Center, 6 Weizman St. Tel-Aviv 64239, Israel.

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http://dx.doi.org/10.1016/j.jsbmb.2003.11.010DOI Listing
February 2004

Vitamin D and vitamin D analogs as cancer chemopreventive agents.

Nutr Rev 2003 Jul;61(7):227-38

CCS Associates, 2005 Landings Drive, Mountain View, CA 94043, USA.

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http://dx.doi.org/10.1301/nr.2003.jul.227-238DOI Listing
July 2003

A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

J Med Chem 2003 Jun;46(12):2516-33

Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1021/jm020584aDOI Listing
June 2003

Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine.

J Org Chem 2003 Apr;68(8):3049-54

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1021/jo020744qDOI Listing
April 2003

Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

J Med Chem 2003 Mar;46(6):1060-5

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm020461qDOI Listing
March 2003

Malaria: new chemotherapeutic peroxide drugs.

Mini Rev Med Chem 2002 Dec;2(6):573-83

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.2174/1389557023405620DOI Listing
December 2002

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Int J Parasitol 2002 Dec;32(13):1661-7

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.

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http://dx.doi.org/10.1016/s0020-7519(02)00195-9DOI Listing
December 2002

Low-calcemic vitamin D analogs (deltanoids) for human cancer prevention.

Authors:
Gary H Posner

J Nutr 2002 Dec;132(12):3802S-3803S

Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1093/jn/132.12.3802SDOI Listing
December 2002

Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.

J Med Chem 2002 Aug;45(18):3824-8

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218-2685, USA.

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http://dx.doi.org/10.1021/jm020210hDOI Listing
August 2002

Titanium-promoted stereoselective synthesis of hydroindolones from p-quinamines by domino conjugate additions.

Angew Chem Int Ed Engl 2002 Aug;41(15):2753-5

Departamento de Química Orgánica (C-I), Universidad Autónoma Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1002/1521-3773(20020802)41:15<2753::AID-ANIE2753>3.0.CO;2-MDOI Listing
August 2002

2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology.

Bioorg Med Chem 2002 Jul;10(7):2353-65

Department of Chemistry, Krieger School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/s0968-0896(02)00058-5DOI Listing
July 2002

Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing.

J Med Chem 2002 Apr;45(8):1723-30

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

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http://dx.doi.org/10.1021/jm010560oDOI Listing
April 2002

New chemical and biological aspects of artemisinin-derived trioxane dimers.

Bioorg Med Chem 2002 Jan;10(1):227-32

Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/s0968-0896(01)00270-xDOI Listing
January 2002

Antiproliferative Hybrid Analogs of the Hormone 1alpha,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation.

J Org Chem 1997 May;62(10):3299-3314

Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, and Division of Toxicology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205.

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http://dx.doi.org/10.1021/jo970049wDOI Listing
May 1997

Lewis Acid-Promoted, Stereocontrolled, Gram Scale, Diels-Alder Cycloadditions of Electronically Matched 2-Pyrones and Vinyl Ethers: The Critical Importance of Molecular Sieves and the Temperature of Titanium Coordination with the Pyrone.

J Org Chem 1996 Jan;61(2):671-676

Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, and Grace Davison Division, W.R. Grace & Co., Columbia, Maryland 21044.

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http://dx.doi.org/10.1021/jo9515900DOI Listing
January 1996