Publications by authors named "Gary D Lopaschuk"

100Publications

Insulin directly stimulates mitochondrial glucose oxidation in the heart.

Cardiovasc Diabetol 2020 Dec 7;19(1):207. Epub 2020 Dec 7.

Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.

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December 2020

Ketone metabolism in the failing heart.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 12 10;1865(12):158813. Epub 2020 Sep 10.

Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

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December 2020

Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review.

JACC Basic Transl Sci 2020 Jun 22;5(6):632-644. Epub 2020 Jun 22.

Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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June 2020

SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism.

Am J Physiol Endocrinol Metab 2020 07 29;319(1):E43-E47. Epub 2020 May 29.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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July 2020

Myocardial Ketones Metabolism in Heart Failure.

J Card Fail 2020 Nov 19;26(11):998-1005. Epub 2020 May 19.

Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

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November 2020

Ketones can become the major fuel source for the heart but do not increase cardiac efficiency.

Cardiovasc Res 2020 May 13. Epub 2020 May 13.

Cardiovascular Research Centre Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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May 2020

Empagliflozin improves left ventricular diastolic function of db/db mice.

Biochim Biophys Acta Mol Basis Dis 2020 08 28;1866(8):165807. Epub 2020 Apr 28.

Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany. Electronic address:

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August 2020

Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism.

Biochem J 2019 06 19;476(12):1695-1712. Epub 2019 Jun 19.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada

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June 2019

Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency.

Metabolism 2019 09 14;98:37-48. Epub 2019 Jun 14.

Cardiovascular Research Centre, Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address:

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September 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer's disease.

Drug Des Devel Ther 2019 17;13:1197-1211. Epub 2019 Apr 17.

Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.

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December 2019

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Cardiovasc Res 2019 09;115(11):1606-1616

Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.

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September 2019

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.

Cardiovasc Diabetol 2019 01 9;18(1). Epub 2019 Jan 9.

Cardiovascular Research Centre, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada.

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January 2019

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.

J Mol Cell Cardiol 2019 02 4;127:223-231. Epub 2019 Jan 4.

Cardiovascular Translational Science Institute and the Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address:

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February 2019

A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation.

J Thorac Cardiovasc Surg 2019 01 2;157(1):185-193. Epub 2018 Aug 2.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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January 2019

Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.

Mol Med 2018 03 15;24(1). Epub 2018 Mar 15.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute University of Alberta, Edmonton, Canada.

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March 2018

Metabolic effects of cardiovascular drugs.

Trends Cardiovasc Med 2019 04 7;29(3):176-187. Epub 2018 Aug 7.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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April 2019

Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart.

Am J Physiol Endocrinol Metab 2018 11 14;315(5):E1046-E1052. Epub 2018 Aug 14.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta , Edmonton , Canada.

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November 2018

Loss of Metabolic Flexibility in the Failing Heart.

Front Cardiovasc Med 2018 6;5:68. Epub 2018 Jun 6.

Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.

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June 2018

Treading slowly through hypoxic waters: dichloroacetate to the rescue!

J Physiol 2018 08 23;596(15):2957-2958. Epub 2018 Mar 23.

423 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

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August 2018

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

Biochem J 2018 03 9;475(5):959-976. Epub 2018 Mar 9.

Cardiovascular Translational Science Institute and the Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada T6G 2S2

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March 2018

Decreased Maternal Cardiac Glucose Oxidation: Taking One for the Fetus.

Circ Res 2017 12;121(12):1299-1301

From the Department of Pediatrics, University of Alberta (G.D.L.), Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), and Women and Children's Health Research Institute (J.R.U., G.D.L.), University of Alberta, Edmonton, Canada.

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December 2017

Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.

Mol Metab 2017 08 21;6(8):863-872. Epub 2017 Jun 21.

Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address:

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August 2017

Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction.

Can J Cardiol 2017 07 19;33(7):860-871. Epub 2017 Mar 19.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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July 2017

Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

Cardiovasc Diabetol 2017 04 20;16(1):53. Epub 2017 Apr 20.

Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.

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April 2017

Metabolic Modulators in Heart Disease: Past, Present, and Future.

Authors:
Gary D Lopaschuk

Can J Cardiol 2017 07 21;33(7):838-849. Epub 2016 Dec 21.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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July 2017

Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

Cardiovasc Diabetol 2017 02 8;16(1):21. Epub 2017 Feb 8.

Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.

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February 2017

Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates.

Circ Res 2016 11;119(11):1173-1176

From the Cardiovascular Translational Science Institute (G.D.L., J.R.U.), Alberta Diabetes Institute (G.D.L., J.R.U.), Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), and Department of Pediatrics (G.D.L.), University of Alberta, Edmonton, Canada.

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November 2016

Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders.

Authors:
Gary D Lopaschuk

Ann Nutr Metab 2016 9;68 Suppl 3:15-20. Epub 2016 Dec 9.

Department of Pediatrics, University of Alberta, Edmonton, Alta., Canada.

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December 2017

Empagliflozin's Fuel Hypothesis: Not so Soon.

Cell Metab 2016 08;24(2):200-2

Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, ON M5S, Canada. Electronic address:

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August 2016

Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure.

Biochim Biophys Acta 2016 12 29;1862(12):2211-2220. Epub 2016 Jul 29.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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December 2016

Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis.

PLoS One 2016 21;11(7):e0159682. Epub 2016 Jul 21.

Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.

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July 2017

Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Front Pharmacol 2016 7;7:133. Epub 2016 Jun 7.

Faculty of Pharmacy and Pharmaceutical Sciences, 2-020M Katz Group Centre for Pharmacy and Health Research, University of AlbertaEdmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of AlbertaEdmonton, AB, Canada; Department of Pharmacology, Faculty of Medicine and Dentistry, University of AlbertaEdmonton, AB, Canada.

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July 2016

Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart.

Am J Physiol Heart Circ Physiol 2016 08 3;311(2):H347-63. Epub 2016 Jun 3.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada; and

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August 2016

Preface to the BBA special issue "heart lipid metabolism".

Authors:
Gary D Lopaschuk

Biochim Biophys Acta 2016 10 18;1861(10):1423-4. Epub 2016 May 18.

University of Alberta, Edmonton, Canada.

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October 2016

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

Diabetes 2016 07 13;65(7):1883-91. Epub 2016 May 13.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada Alberta Diabetes Institute, University of Alberta, Edmonton, Canada

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July 2016

Reply to Katlandur, Ozbek, and Keser.

Am J Physiol Endocrinol Metab 2016 05;310(10):E863

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal;

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May 2016

Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes.

Biochim Biophys Acta 2016 10 18;1861(10):1525-34. Epub 2016 Mar 18.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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October 2016

Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.

Am J Physiol Heart Circ Physiol 2015 Nov 4;309(9):H1543-53. Epub 2015 Sep 4.

The Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, Ontario, Canada;

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November 2015

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.

Diabetes 2016 Jan 29;65(1):85-95. Epub 2015 Jul 29.

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada

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January 2016

Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets.

Curr Pharm Des 2015 ;21(25):3654-64

423 Heritage Medical Research Building University of Alberta Edmonton, Alberta T6G 2S2 Canada.

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June 2016

Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency.

Cardiovasc Res 2015 Sep 6;107(4):499-508. Epub 2015 Jul 6.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 9-43 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7 Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada Cardiovascular Research Centre, Alberta, Canada

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September 2015

Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series).

Pulm Circ 2015 Mar;5(1):15-28

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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March 2015

Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts.

Circ Res 2015 Jun 14;117(1):41-51. Epub 2015 May 14.

From the Cardiovascular Translational Science Institute (V.H.L., L.Z., A.H., A.F., B.A.T., W.K., P.F.K., J.S.J., I.M.R., G.D.L.) and Department of Pediatrics (V.H.L., L.Z., A.H., A.F., B.A.T., W.K., P.F.K., J.S.J., I.M.R., G.D.L.), University of Alberta, Edmonton, Canada; and Department of Medical Pharmacology, Ankara University, Ankara, Turkey (A.O.-B.).

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June 2015

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.

Mol Metab 2015 Apr 17;4(4):310-24. Epub 2015 Jan 17.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL, USA ; Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO, USA.

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April 2015

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

Exp Physiol 2015 Jun 14;100(6):730-41. Epub 2015 May 14.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada.

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June 2015

What is good for the circulation also lessens cancer risk.

Eur Heart J 2015 May 15;36(19):1157-62. Epub 2015 Mar 15.

Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

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May 2015

Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.

PLoS One 2015 13;10(3):e0120257. Epub 2015 Mar 13.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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February 2016

Targeting microRNAs to limit myocardial lipid accumulation.

Circ Res 2015 Jan;116(2):229-31

From the Cardiovascular Translational Science Institute (G.D.L., J.R.U.) and Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), University of Alberta, Edmonton, Canada.

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January 2015

Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox.

Diabetes 2015 May 18;64(5):1643-57. Epub 2014 Dec 18.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada

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May 2015

The link between pediatric heart failure and mitochondrial lipids.

J Mol Cell Cardiol 2014 Nov 12;76:71-2. Epub 2014 Aug 12.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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November 2014

Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.

Biochem Soc Trans 2014 Aug;42(4):1043-51

*Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2.

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August 2014

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

J Mol Cell Cardiol 2014 Oct 24;75:76-87. Epub 2014 Jul 24.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK; British Heart Foundation Centre for Research Excellence, University of Oxford, UK. Electronic address:

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October 2014

Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.

Can J Cardiol 2014 Aug 29;30(8):940-4. Epub 2014 Apr 29.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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August 2014

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

Diabetes 2014 Oct 21;63(10):3242-52. Epub 2014 May 21.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO

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October 2014

5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes.

Can J Physiol Pharmacol 2014 Apr 5;92(4):307-14. Epub 2014 Feb 5.

a Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, 8440 112 Street NW, Edmonton, AB T6G 2P4, Canada.

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April 2014

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.

J Pharmacol Exp Ther 2014 Jun 3;349(3):487-96. Epub 2014 Apr 3.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada (J.R.U., W.K., N.F., J.M., L.Z., D.G.L., C.S.W., J.S.J., G.D.L.); and Sarah W. Stedman Nutrition and Metabolism Center (T.R.K., O.R.I., D.M.M.), Department of Medicine (T.R.K., O.R.I., D.M.M.), Department of Pharmacology and Cancer Biology (D.M.M.), Duke University, Durham, North Carolina.

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June 2014

Malonyl CoA: A promising target for the treatment of cardiac disease.

IUBMB Life 2014 Mar 3;66(3):139-146. Epub 2014 Mar 3.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.

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March 2014

Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity.

Am J Physiol Renal Physiol 2014 Apr 19;306(8):F812-21. Epub 2014 Feb 19.

Div. of Cardiology, Dept. of Medicine, Mazankowski Alberta Heart Institute, Univ. of Alberta, 8440 112 St. NW, Edmonton, Alberta, Canada T6G 2B7.

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April 2014

Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation.

Circ Heart Fail 2014 Mar 3;7(2):327-39. Epub 2014 Jan 3.

Department of Pediatrics, Department of Pharmacology, Mazankowski Alberta Heart Institute, Department of Physiology, and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada.

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March 2014

Gut microbiota metabolism of L-carnitine and cardiovascular risk.

Atherosclerosis 2013 Dec 24;231(2):456-61. Epub 2013 Oct 24.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 5-1001-DD, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada. Electronic address:

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December 2013

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.

Cardiovasc Res 2014 Jan 17;101(1):30-8. Epub 2013 Sep 17.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2S2.

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January 2014

Hypothalamic malonyl-CoA and the control of food intake.

Physiol Behav 2013 Oct 27;122:17-24. Epub 2013 Aug 27.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address:

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October 2013

Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure.

J Mol Cell Cardiol 2013 Oct 22;63:98-106. Epub 2013 Jul 22.

Department of Pediatrics, University of Alberta, Edmonton, Canada; Department of Pharmacology, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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October 2013

Cardiac insulin resistance: it's sweeter than you think.

Endocrinology 2013 Aug;154(8):2575-8

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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August 2013

Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.

Circ Heart Fail 2013 Sep 16;6(5):1039-48. Epub 2013 Jul 16.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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September 2013

HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.

Mol Endocrinol 2013 Sep 10;27(9):1564-76. Epub 2013 Jul 10.

Kidney Disease Section, National Institute of Diabetes and Digestive andKidney Diseases, National Institutes of Health,Bethesda, Maryland 20892-1268, USA.

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September 2013

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

Am J Physiol Endocrinol Metab 2013 Aug 4;305(3):E336-47. Epub 2013 Jun 4.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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August 2013

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

Physiol Behav 2013 Jun 13;118:165-70. Epub 2013 May 13.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2S2, Canada.

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June 2013

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4.

Am J Physiol Heart Circ Physiol 2013 Apr 8;304(8):H1103-13. Epub 2013 Feb 8.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

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April 2013

Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1.

J Thorac Cardiovasc Surg 2013 Sep 12;146(3):702-9. Epub 2013 Jan 12.

Division of Cardiac Surgery and Endocrinology, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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September 2013

Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.

Cardiovasc Res 2013 Mar 19;97(4):676-85. Epub 2012 Dec 19.

Division of Cardiology, Department of Medicine, University of Alberta, 8440 112 Street NW, Edmonton, AB, Canada T6G 2B7.

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March 2013

Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.

J Biol Chem 2013 Jan 25;288(2):837-47. Epub 2012 Nov 25.

Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

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January 2013

Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.

Diabetes 2013 Mar 8;62(3):711-20. Epub 2012 Nov 8.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

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March 2013

Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.

Am J Physiol Endocrinol Metab 2012 Dec 16;303(12):E1459-68. Epub 2012 Oct 16.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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December 2012

Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy.

Circ Res 2013 Jan 14;112(1):57-65. Epub 2012 Sep 14.

Center for Cardiovascular Research, UIC College of Medicine, 909 South Wolcott Ave, MC 801, Chicago, IL 60612, USA.

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January 2013

Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.

Biochim Biophys Acta 2013 Apr 31;1833(4):857-65. Epub 2012 Aug 31.

University of Alberta, Edmonton, Canada.

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April 2013

Pyridine nucleotide regulation of cardiac intermediary metabolism.

Circ Res 2012 Aug;111(5):628-41

423 Heritage Medical Research Center, University of Alberta, Edmonton, Canada.

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August 2012

Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease.

Am J Physiol Endocrinol Metab 2012 Oct 14;303(8):E937-49. Epub 2012 Aug 14.

Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.

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October 2012