Gary D Lopaschuk

Cardiovascular Research Centre, Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address:

View Article and Find Full Text PDF

September 2019

Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer's disease.

Authors:

Mitra Esfandiarei Brikena Hoxha Nicholas A Talley Miranda R Anderson Mustafa F Alkhouli Michaela A Squire Delrae M Eckman Jeganathan Ramesh Babu Gary D Lopaschuk Tom L Broderick

Drug Des Devel Ther 2019 17;13:1197-1211. Epub 2019 Apr 17.

Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.

View Article and Find Full Text PDF

December 2019

Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity.

Authors:

Qutuba G Karwi Liyan Zhang Tariq R Altamimi Cory S Wagg Vaibhav Patel Golam M Uddin Alice R Joerg Raj S Padwal David E Johnstone Arya Sharma Gavin Y Oudit Gary D Lopaschuk

Diabetes Obes Metab 2019 08 4;21(8):1944-1955. Epub 2019 Jun 4.

Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

August 2019

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Authors:

Kim L Ho Liyan Zhang Cory Wagg Rami Al Batran Keshav Gopal Jody Levasseur Teresa Leone Jason R B Dyck John R Ussher Deborah M Muoio Daniel P Kelly Gary D Lopaschuk

Cardiovasc Res 2019 09;115(11):1606-1616

Cardiovascular Research Centre, Faculty of Medicine and Dentistry, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada.

View Article and Find Full Text PDF

September 2019

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.

Authors:

Qutuba G Karwi Liyan Zhang Cory S Wagg Wang Wang Manoj Ghandi Dung Thai Hai Yan John R Ussher Gavin Y Oudit Gary D Lopaschuk

Cardiovasc Diabetol 2019 01 9;18(1). Epub 2019 Jan 9.

Cardiovascular Research Centre, 423 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada.

View Article and Find Full Text PDF

January 2019

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.

Authors:

Tariq R Altamimi Qutuba G Karwi Golam Mezbah Uddin Arata Fukushima Jennifer Q Kwong Jeffery D Molkentin Gary D Lopaschuk

J Mol Cell Cardiol 2019 02 4;127:223-231. Epub 2019 Jan 4.

Cardiovascular Translational Science Institute and the Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address:

View Article and Find Full Text PDF

February 2019

Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.

Authors:

Subodh Verma Sonia Rawat Kim L Ho Cory S Wagg Liyan Zhang Hwee Teoh John E Dyck Golam M Uddin Gavin Y Oudit Eric Mayoux Michael Lehrke Nikolaus Marx Gary D Lopaschuk

JACC Basic Transl Sci 2018 Oct 26;3(5):575-587. Epub 2018 Aug 26.

Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

October 2018

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.

Authors:

Sayantan Jana Hao Zhang Gary D Lopaschuk Darren H Freed Consolato Sergi Paul F Kantor Gavin Y Oudit Zamaneh Kassiri

J Am Heart Assoc 2018 10;7(19):e010427

1 Department of Physiology Faculty of Medicine and Dentistry University of Alberta Edmonton AB.

View Article and Find Full Text PDF

October 2018

A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation.

Authors:

Tariq R Altamimi Biswajit Chowdhury Krishna K Singh Liyan Zhang Mohammad U Mahmood Yi Pan Adrian Quan Hwee Teoh Subodh Verma Gary D Lopaschuk

J Thorac Cardiovasc Surg 2019 01 2;157(1):185-193. Epub 2018 Aug 2.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

January 2019

Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.

Authors:

Natasha Fillmore Jody L Levasseur Arata Fukushima Cory S Wagg Wei Wang Jason R B Dyck Gary D Lopaschuk

Mol Med 2018 03 15;24(1). Epub 2018 Mar 15.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

March 2018

Metabolic effects of cardiovascular drugs.

Authors:

Gabriele Fragasso Alberto Margonato Roberto Spoladore Gary D Lopaschuk

Trends Cardiovasc Med 2019 04 7;29(3):176-187. Epub 2018 Aug 7.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

April 2019

Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart.

Authors:

Natasha Fillmore Cory S Wagg Liyan Zhang Arata Fukushima Gary D Lopaschuk

Am J Physiol Endocrinol Metab 2018 11 14;315(5):E1046-E1052. Epub 2018 Aug 14.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta , Edmonton , Canada.

View Article and Find Full Text PDF

November 2018

Loss of Metabolic Flexibility in the Failing Heart.

Authors:

Qutuba G Karwi Golam M Uddin Kim L Ho Gary D Lopaschuk

Front Cardiovasc Med 2018 6;5:68. Epub 2018 Jun 6.

Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.

View Article and Find Full Text PDF

June 2018

Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism.

Authors:

Arata Fukushima Liyan Zhang Alda Huqi Victoria H Lam Sonia Rawat Tariq Altamimi Cory S Wagg Khushmol K Dhaliwal Lisa K Hornberger Paul F Kantor Ivan M Rebeyka Gary D Lopaschuk

JCI Insight 2018 05 17;3(10). Epub 2018 May 17.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

May 2018

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

Authors:

Michel van Weeghel Desiree Abdurrachim Rianne Nederlof Carmen A Argmann Riekelt H Houtkooper Jacob Hagen Miranda Nabben Simone Denis Jolita Ciapaite Stephen C Kolwicz Gary D Lopaschuk Johan Auwerx Klaas Nicolay Christine Des Rosiers Ronald J Wanders Coert J Zuurbier Jeanine J Prompers Sander M Houten

Cardiovasc Res 2018 08;114(10):1324-1334

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY, USA.

View Article and Find Full Text PDF

August 2018

Treading slowly through hypoxic waters: dichloroacetate to the rescue!

Authors:

Golam Mezbah Uddin Kim L Ho Gary D Lopaschuk

J Physiol 2018 08 23;596(15):2957-2958. Epub 2018 Mar 23.

423 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

View Article and Find Full Text PDF

August 2018

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

Authors:

Tariq R Altamimi Panakkezhum D Thomas Ahmed M Darwesh Natasha Fillmore Mohammad U Mahmoud Liyan Zhang Abhishek Gupta Rami Al Batran John M Seubert Gary D Lopaschuk

Biochem J 2018 03 9;475(5):959-976. Epub 2018 Mar 9.

Cardiovascular Translational Science Institute and the Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada T6G 2S2

View Article and Find Full Text PDF

March 2018

Decreased Maternal Cardiac Glucose Oxidation: Taking One for the Fetus.

Authors:

John R Ussher Gary D Lopaschuk

Circ Res 2017 12;121(12):1299-1301

From the Department of Pediatrics, University of Alberta (G.D.L.), Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), and Women and Children's Health Research Institute (J.R.U., G.D.L.), University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

December 2017

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Authors:

Amy K Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A Rawlings Gary D Lopaschuk Paul T Schumacker E Dale Abel Hossein Ardehali

Nat Commun 2017 08 30;8:16155. Epub 2017 Aug 30.

View Article and Find Full Text PDF

August 2017

Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.

Authors:

Zhimin Chen Guo-Xiao Wang Sara L Ma Dae Young Jung Hyekyung Ha Tariq Altamimi Xu-Yun Zhao Liang Guo Peng Zhang Chun-Rui Hu Ji-Xin Cheng Gary D Lopaschuk Jason K Kim Jiandie D Lin

Mol Metab 2017 08 21;6(8):863-872. Epub 2017 Jun 21.

Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address:

View Article and Find Full Text PDF

August 2017

Why publish in the ?

Am J Physiol Heart Circ Physiol 2017 08 16;313(2):H221-H223. Epub 2017 Jun 16.

New York Medical College, Valhalla, New York.

View Article and Find Full Text PDF

August 2017

Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction.

Authors:

Kirstie A De Jong Gary D Lopaschuk

Can J Cardiol 2017 07 19;33(7):860-871. Epub 2017 Mar 19.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

July 2017

Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

Authors:

Kirstie A De Jong Juliane K Czeczor Smithamol Sithara Kevin McEwen Gary D Lopaschuk Alan Appelbe Kimberly Cukier Mark Kotowicz Sean L McGee

Cardiovasc Diabetol 2017 04 20;16(1):53. Epub 2017 Apr 20.

Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.

View Article and Find Full Text PDF

April 2017

Metabolic Modulators in Heart Disease: Past, Present, and Future.

Authors:

Gary D Lopaschuk

Can J Cardiol 2017 07 21;33(7):838-849. Epub 2016 Dec 21.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

July 2017

Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

Authors:

Kirstie A De Jong Juliane K Czeczor Smithamol Sithara Kevin McEwen Gary D Lopaschuk Alan Appelbe Kimberly Cukier Mark Kotowicz Sean L McGee

Cardiovasc Diabetol 2017 02 8;16(1):21. Epub 2017 Feb 8.

Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.

View Article and Find Full Text PDF

February 2017

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Authors:

Amy K Rines Hsiang-Chun Chang Rongxue Wu Tatsuya Sato Arineh Khechaduri Hidemichi Kouzu Jason Shapiro Meng Shang Michael A Burke Eltyeb Abdelwahid Xinghang Jiang Chunlei Chen Tenley A Rawlings Gary D Lopaschuk Paul T Schumacker E Dale Abel Hossein Ardehali

Nat Commun 2017 01 24;8:14095. Epub 2017 Jan 24.

Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

View Article and Find Full Text PDF

January 2017

Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates.

Authors:

Gary D Lopaschuk John R Ussher

Circ Res 2016 11;119(11):1173-1176

From the Cardiovascular Translational Science Institute (G.D.L., J.R.U.), Alberta Diabetes Institute (G.D.L., J.R.U.), Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), and Department of Pediatrics (G.D.L.), University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

November 2016

Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders.

Authors:

Gary D Lopaschuk

Ann Nutr Metab 2016 9;68 Suppl 3:15-20. Epub 2016 Dec 9.

Department of Pediatrics, University of Alberta, Edmonton, Alta., Canada.

View Article and Find Full Text PDF

December 2017

Empagliflozin's Fuel Hypothesis: Not so Soon.

Authors:

Gary D Lopaschuk Subodh Verma

Cell Metab 2016 08;24(2):200-2

Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, ON M5S, Canada. Electronic address:

View Article and Find Full Text PDF

August 2016

Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure.

Authors:

Arata Fukushima Gary D Lopaschuk

Biochim Biophys Acta 2016 12 29;1862(12):2211-2220. Epub 2016 Jul 29.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

December 2016

Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis.

Authors:

Jody Groenendyk Dukgyu Lee Joanna Jung Jason R B Dyck Gary D Lopaschuk Luis B Agellon Marek Michalak

PLoS One 2016 21;11(7):e0159682. Epub 2016 Jul 21.

Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.

View Article and Find Full Text PDF

July 2017

Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Authors:

Maria K Akhnokh Feng Hua Yang Victor Samokhvalov Kristi L Jamieson Woo Jung Cho Cory Wagg Abhijit Takawale Xiuhua Wang Gary D Lopaschuk Bruce D Hammock Zamaneh Kassiri John M Seubert

Front Pharmacol 2016 7;7:133. Epub 2016 Jun 7.

Faculty of Pharmacy and Pharmaceutical Sciences, 2-020M Katz Group Centre for Pharmacy and Health Research, University of AlbertaEdmonton, AB, Canada; Mazankowski Alberta Heart Institute, University of AlbertaEdmonton, AB, Canada; Department of Pharmacology, Faculty of Medicine and Dentistry, University of AlbertaEdmonton, AB, Canada.

View Article and Find Full Text PDF

July 2016

Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart.

Authors:

Arata Fukushima Osama Abo Alrob Liyan Zhang Cory S Wagg Tariq Altamimi Sonia Rawat Ivan M Rebeyka Paul F Kantor Gary D Lopaschuk

Am J Physiol Heart Circ Physiol 2016 08 3;311(2):H347-63. Epub 2016 Jun 3.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada; and

View Article and Find Full Text PDF

August 2016

Preface to the BBA special issue "heart lipid metabolism".

Authors:

Gary D Lopaschuk

Biochim Biophys Acta 2016 10 18;1861(10):1423-4. Epub 2016 May 18.

University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

October 2016

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

Authors:

John R Ussher Natasha Fillmore Wendy Keung Liyan Zhang Jun Mori Vaninder K Sidhu Arata Fukushima Keshav Gopal David G Lopaschuk Cory S Wagg Jagdip S Jaswal Jason R B Dyck Gary D Lopaschuk

Diabetes 2016 07 13;65(7):1883-91. Epub 2016 May 13.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada Alberta Diabetes Institute, University of Alberta, Edmonton, Canada

View Article and Find Full Text PDF

July 2016

Reply to Katlandur, Ozbek, and Keser.

Authors:

Eugenia Carvalho Gary D Lopaschuk Elisabet Børsheim Ana Burgeiro

Am J Physiol Endocrinol Metab 2016 05;310(10):E863

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal;

View Article and Find Full Text PDF

May 2016

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Circ Res 2016 May 24;118(10):1659-701. Epub 2016 Mar 24.

View Article and Find Full Text PDF

May 2016

Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes.

Authors:

Arata Fukushima Gary D Lopaschuk

Biochim Biophys Acta 2016 10 18;1861(10):1525-34. Epub 2016 Mar 18.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

October 2016

Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure.

Authors:

Yuri M Lopatin Giuseppe M C Rosano Gabriele Fragasso Gary D Lopaschuk Petar M Seferovic Luis Henrique W Gowdak Dragos Vinereanu Magdy Abdel Hamid Patrick Jourdain Piotr Ponikowski

Int J Cardiol 2016 Jan 7;203:909-15. Epub 2015 Nov 7.

Medical University, Clinical Military Hospital, Wroclaw, Poland.

View Article and Find Full Text PDF

January 2016

Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.

Authors:

Mohammed Ali Azam Cory S Wagg Stéphane Massé Talha Farid Patrick F H Lai Marjan Kusha John Asta Rafael Jaimes Sarah Kuzmiak-Glancy Matthew W Kay Gary D Lopaschuk Kumaraswamy Nanthakumar

Am J Physiol Heart Circ Physiol 2015 Nov 4;309(9):H1543-53. Epub 2015 Sep 4.

The Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, Ontario, Canada;

View Article and Find Full Text PDF

November 2015

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.

Authors:

Vaibhav B Patel Jun Mori Brent A McLean Ratnadeep Basu Subhash K Das Tharmarajan Ramprasath Nirmal Parajuli Josef M Penninger Maria B Grant Gary D Lopaschuk Gavin Y Oudit

Diabetes 2016 Jan 29;65(1):85-95. Epub 2015 Jul 29.

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada

View Article and Find Full Text PDF

January 2016

Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets.

Authors:

Arata Fukushima Kenneth Milner Abhishek Gupta Gary D Lopaschuk

Curr Pharm Des 2015 ;21(25):3654-64

423 Heritage Medical Research Building University of Alberta Edmonton, Alberta T6G 2S2 Canada.

View Article and Find Full Text PDF

June 2016

Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency.

Authors:

Waleed G T Masoud Osama Abo Al-Rob Yang Yang Gary D Lopaschuk Alexander S Clanachan

Cardiovasc Res 2015 Sep 6;107(4):499-508. Epub 2015 Jul 6.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, 9-43 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7 Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada Cardiovascular Research Centre, Alberta, Canada

View Article and Find Full Text PDF

September 2015

Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series).

Authors:

Sowndramalingam Sankaralingam Gary D Lopaschuk

Pulm Circ 2015 Mar;5(1):15-28

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

March 2015

Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts.

Authors:

Victoria H Lam Liyan Zhang Alda Huqi Arata Fukushima Brandon A Tanner Arzu Onay-Besikci Wendy Keung Paul F Kantor Jagdip S Jaswal Ivan M Rebeyka Gary D Lopaschuk

Circ Res 2015 Jun 14;117(1):41-51. Epub 2015 May 14.

From the Cardiovascular Translational Science Institute (V.H.L., L.Z., A.H., A.F., B.A.T., W.K., P.F.K., J.S.J., I.M.R., G.D.L.) and Department of Pediatrics (V.H.L., L.Z., A.H., A.F., B.A.T., W.K., P.F.K., J.S.J., I.M.R., G.D.L.), University of Alberta, Edmonton, Canada; and Department of Medical Pharmacology, Ankara University, Ankara, Turkey (A.O.-B.).

View Article and Find Full Text PDF

June 2015

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.

Authors:

Su Gao Ryan P McMillan Qingzhang Zhu Gary D Lopaschuk Matthew W Hulver Andrew A Butler

Mol Metab 2015 Apr 17;4(4):310-24. Epub 2015 Jan 17.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL, USA ; Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO, USA.

View Article and Find Full Text PDF

April 2015

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

Authors:

Natasha Fillmore Wendy Keung Sandra E Kelly Spencer D Proctor Gary D Lopaschuk John R Ussher

Exp Physiol 2015 Jun 14;100(6):730-41. Epub 2015 May 14.

Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

June 2015

What is good for the circulation also lessens cancer risk.

Authors:

Lionel H Opie Gary D Lopaschuk

Eur Heart J 2015 May 15;36(19):1157-62. Epub 2015 Mar 15.

Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

May 2015

Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival.

Authors:

Natasha Fillmore Alda Huqi Jagdip S Jaswal Jun Mori Roxane Paulin Alois Haromy Arzu Onay-Besikci Lavinia Ionescu Bernard Thébaud Evangelos Michelakis Gary D Lopaschuk

PLoS One 2015 13;10(3):e0120257. Epub 2015 Mar 13.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

February 2016

Targeting microRNAs to limit myocardial lipid accumulation.

Authors:

Gary D Lopaschuk John R Ussher

Circ Res 2015 Jan;116(2):229-31

From the Cardiovascular Translational Science Institute (G.D.L., J.R.U.) and Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

January 2015

Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox.

Authors:

Sowndramalingam Sankaralingam Osama Abo Alrob Liyan Zhang Jagdip S Jaswal Cory S Wagg Arata Fukushima Raj S Padwal David E Johnstone Arya M Sharma Gary D Lopaschuk

Diabetes 2015 May 18;64(5):1643-57. Epub 2014 Dec 18.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada

View Article and Find Full Text PDF

May 2015

The link between pediatric heart failure and mitochondrial lipids.

Authors:

Natasha Fillmore Gary D Lopaschuk

J Mol Cell Cardiol 2014 Nov 12;76:71-2. Epub 2014 Aug 12.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

November 2014

Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.

Authors:

Osama Abo Alrob Gary D Lopaschuk

Biochem Soc Trans 2014 Aug;42(4):1043-51

*Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2.

View Article and Find Full Text PDF

August 2014

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

Authors:

Dunja Aksentijević Debra J McAndrew Anja Karlstädt Sevasti Zervou Liam Sebag-Montefiore Rebecca Cross Gillian Douglas Vera Regitz-Zagrosek Gary D Lopaschuk Stefan Neubauer Craig A Lygate

J Mol Cell Cardiol 2014 Oct 24;75:76-87. Epub 2014 Jul 24.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK; British Heart Foundation Centre for Research Excellence, University of Oxford, UK. Electronic address:

View Article and Find Full Text PDF

October 2014

Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.

Authors:

John R Ussher Natasha Fillmore Wendy Keung Jun Mori Donna L Beker Cory S Wagg Jagdip S Jaswal Gary D Lopaschuk

Can J Cardiol 2014 Aug 29;30(8):940-4. Epub 2014 Apr 29.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

View Article and Find Full Text PDF

August 2014

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

BMC Cardiovasc Disord 2014 Jul 25;14:91. Epub 2014 Jul 25.

Mazankowski Alberta Heart Institute, 2C2 WMC, 8440-112 Street, Edmonton, AB, Canada.

View Article and Find Full Text PDF

July 2014

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.

Authors:

Osama Abo Alrob Sowndramalingam Sankaralingam Cary Ma Cory S Wagg Natasha Fillmore Jagdip S Jaswal Michael N Sack Richard Lehner Mahesh P Gupta Evangelos D Michelakis Raj S Padwal David E Johnstone Arya M Sharma Gary D Lopaschuk

Cardiovasc Res 2014 Sep 25;103(4):485-97. Epub 2014 Jun 25.

Mazankowski Alberta Heart Institute, University of Alberta, 423 Heritage Medical Research Building, Edmonton, AB, Canada T6G 2S2

View Article and Find Full Text PDF

September 2014

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

Authors:

Su Gao Ryan P McMillan Jordi Jacas Qingzhang Zhu Xuesen Li Ganesh K Kumar Núria Casals Fausto G Hegardt Paul D Robbins Gary D Lopaschuk Matthew W Hulver Andrew A Butler

Diabetes 2014 Oct 21;63(10):3242-52. Epub 2014 May 21.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO

View Article and Find Full Text PDF

October 2014

5'-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes.

Authors:

Christopher T Lee John R Ussher Askar Mohammad Anna Lam Gary D Lopaschuk

Can J Physiol Pharmacol 2014 Apr 5;92(4):307-14. Epub 2014 Feb 5.

a Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, 8440 112 Street NW, Edmonton, AB T6G 2P4, Canada.

View Article and Find Full Text PDF

April 2014

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.

Authors:

John R Ussher Wendy Keung Natasha Fillmore Timothy R Koves Jun Mori Liyan Zhang David G Lopaschuk Olga R Ilkayeva Cory S Wagg Jagdip S Jaswal Deborah M Muoio Gary D Lopaschuk

J Pharmacol Exp Ther 2014 Jun 3;349(3):487-96. Epub 2014 Apr 3.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada (J.R.U., W.K., N.F., J.M., L.Z., D.G.L., C.S.W., J.S.J., G.D.L.); and Sarah W. Stedman Nutrition and Metabolism Center (T.R.K., O.R.I., D.M.M.), Department of Medicine (T.R.K., O.R.I., D.M.M.), Department of Pharmacology and Cancer Biology (D.M.M.), Duke University, Durham, North Carolina.

View Article and Find Full Text PDF

June 2014

Plasma fatty acid levels in children during extracorporeal membrane oxygenation support--a pilot study.

Authors:

Liyan Zhang Xiaoyang Yu Andriy Cheypesh Ivan M Rebeyka Don Granoski Gary D Lopaschuk Jia Li

J Extra Corpor Technol 2013 Dec;45(4):242-7

View Article and Find Full Text PDF

December 2013

Malonyl CoA: A promising target for the treatment of cardiac disease.

Authors:

Natasha Fillmore Gary D Lopaschuk

IUBMB Life 2014 Mar 3;66(3):139-146. Epub 2014 Mar 3.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.

View Article and Find Full Text PDF

March 2014

Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity.

Authors:

Jun Mori Vaibhav B Patel Tharmarajan Ramprasath Osama Abo Alrob Jessica DesAulniers James W Scholey Gary D Lopaschuk Gavin Y Oudit

Am J Physiol Renal Physiol 2014 Apr 19;306(8):F812-21. Epub 2014 Feb 19.

Div. of Cardiology, Dept. of Medicine, Mazankowski Alberta Heart Institute, Univ. of Alberta, 8440 112 St. NW, Edmonton, Alberta, Canada T6G 2B7.

View Article and Find Full Text PDF

April 2014

Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation.

Authors:

Jun Mori Vaibhav B Patel Osama Abo Alrob Ratnadeep Basu Tariq Altamimi Jessica Desaulniers Cory S Wagg Zamaneh Kassiri Gary D Lopaschuk Gavin Y Oudit

Circ Heart Fail 2014 Mar 3;7(2):327-39. Epub 2014 Jan 3.

Department of Pediatrics, Department of Pharmacology, Mazankowski Alberta Heart Institute, Department of Physiology, and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

March 2014

Gut microbiota metabolism of L-carnitine and cardiovascular risk.

Authors:

John R Ussher Gary D Lopaschuk Arduino Arduini

Atherosclerosis 2013 Dec 24;231(2):456-61. Epub 2013 Oct 24.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, 5-1001-DD, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada. Electronic address:

View Article and Find Full Text PDF

December 2013

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.

Authors:

Waleed G T Masoud John R Ussher Wei Wang Jagdip S Jaswal Cory S Wagg Jason R Dyck Craig A Lygate Stefan Neubauer Alexander S Clanachan Gary D Lopaschuk

Cardiovasc Res 2014 Jan 17;101(1):30-8. Epub 2013 Sep 17.

Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2S2.

View Article and Find Full Text PDF

January 2014

Hypothalamic malonyl-CoA and the control of food intake.

Authors:

Su Gao Timothy H Moran Gary D Lopaschuk Andrew A Butler

Physiol Behav 2013 Oct 27;122:17-24. Epub 2013 Aug 27.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address:

View Article and Find Full Text PDF

October 2013

Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure.

Authors:

Jun Mori Liyan Zhang Gavin Y Oudit Gary D Lopaschuk

J Mol Cell Cardiol 2013 Oct 22;63:98-106. Epub 2013 Jul 22.

Department of Pediatrics, University of Alberta, Edmonton, Canada; Department of Pharmacology, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

October 2013

Cardiac insulin resistance: it's sweeter than you think.

Authors:

John R Ussher Gary D Lopaschuk

Endocrinology 2013 Aug;154(8):2575-8

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

August 2013

Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.

Authors:

Liyan Zhang Jagdip S Jaswal John R Ussher Sowndramalingam Sankaralingam Cory Wagg Michael Zaugg Gary D Lopaschuk

Circ Heart Fail 2013 Sep 16;6(5):1039-48. Epub 2013 Jul 16.

Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

September 2013

HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression, and reduces PDC activity.

Authors:

Shashi Shrivastav Liyan Zhang Koji Okamoto Hewang Lee Claudia Lagranha Yoshifusa Abe Ashok Balasubramanyam Gary D Lopaschuk Tomoshige Kino Jeffrey B Kopp

Mol Endocrinol 2013 Sep 10;27(9):1564-76. Epub 2013 Jul 10.

Kidney Disease Section, National Institute of Diabetes and Digestive andKidney Diseases, National Institutes of Health,Bethesda, Maryland 20892-1268, USA.

View Article and Find Full Text PDF

September 2013

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

Authors:

Su Gao Dolors Serra Wendy Keung Fausto G Hegardt Gary D Lopaschuk

Am J Physiol Endocrinol Metab 2013 Aug 4;305(3):E336-47. Epub 2013 Jun 4.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

August 2013

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice.

Authors:

Vernon W Dolinsky Subhadeep Chakrabarti Troy J Pereira Tatsujiro Oka Jody Levasseur Donna Beker Beshay N Zordoky Jude S Morton Jeevan Nagendran Gary D Lopaschuk Sandra T Davidge Jason R B Dyck

Biochim Biophys Acta 2013 Oct 22;1832(10):1723-33. Epub 2013 May 22.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

October 2013

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

Authors:

Su Gao Núria Casals Wendy Keung Timothy H Moran Gary D Lopaschuk

Physiol Behav 2013 Jun 13;118:165-70. Epub 2013 May 13.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2S2, Canada.

View Article and Find Full Text PDF

June 2013

Calreticulin induces dilated cardiomyopathy.

Authors:

Dukgyu Lee Tatsujiro Oka Beth Hunter Alison Robinson Sylvia Papp Kimitoshi Nakamura Wattamon Srisakuldee Barbara E Nickel Peter E Light Jason R B Dyck Gary D Lopaschuk Elissavet Kardami Michal Opas Marek Michalak

PLoS One 2013 20;8(2):e56387. Epub 2013 Feb 20.

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

View Article and Find Full Text PDF

August 2013

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4.

Authors:

Jun Mori Osama Abo Alrob Cory S Wagg Robert A Harris Gary D Lopaschuk Gavin Y Oudit

Am J Physiol Heart Circ Physiol 2013 Apr 8;304(8):H1103-13. Epub 2013 Feb 8.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

View Article and Find Full Text PDF

April 2013

Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1.

Authors:

Krishna K Singh Praphulla C Shukla Bobby Yanagawa Adrian Quan Fina Lovren Yi Pan Cory S Wagg Hwee Teoh Gary D Lopaschuk Subodh Verma

J Thorac Cardiovasc Surg 2013 Sep 12;146(3):702-9. Epub 2013 Jan 12.

Division of Cardiac Surgery and Endocrinology, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

View Article and Find Full Text PDF

September 2013