Gary A Piazza

Gary A Piazza

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Gary A Piazza

Gary A Piazza

Publications by authors named "Gary A Piazza"

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70Publications

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Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents.

J Enzyme Inhib Med Chem 2018 Dec;33(1):867-878

b Department of Pharmaceutical Chemistry, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.

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December 2018

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Drug Des Devel Ther 2017 9;11:2333-2346. Epub 2017 Aug 9.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

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May 2018

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

Arch Pharm (Weinheim) 2018 May 14;351(5):e1800018. Epub 2018 Apr 14.

Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt.

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May 2018

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

PLoS One 2017 25;12(7):e0181241. Epub 2017 Jul 25.

Department of Applied Organic Chemistry, National Res earch Centre, (ID: 60014618), Dokki, Giza, Egypt.

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October 2017

Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach.

Med Chem 2016 ;12(5):472-7

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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July 2017

Validation of PDE5 as a Chemoprevention Target.

Authors:
Gary A Piazza

Cancer Prev Res (Phila) 2017 Jul 9;10(7):373-376. Epub 2017 Jun 9.

University of South Alabama Mitchell Cancer Institute, Mobile, Alabama.

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July 2017

The RAS-Effector Interaction as a Drug Target.

Cancer Res 2017 01 6;77(2):221-226. Epub 2017 Jan 6.

Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.

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January 2017

The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer.

J Biomed Res 2017 Jan;31(3):189-196

Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604-1405, USA.

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January 2017

Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells.

Food Funct 2016 Sep;7(9):4012-4019

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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September 2016

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors.

Int J Med Chem 2011 23;2011:562421. Epub 2011 Feb 23.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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July 2016

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α.

Cancer Res 2016 04 5;76(8):2231-42. Epub 2016 Apr 5.

Center for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama. Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama.

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April 2016

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.

J Biomed Res 2016 Mar 20;30(2):120-133. Epub 2015 Nov 20.

Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.

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March 2016

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors.

Arch Pharm (Weinheim) 2016 Feb 20;349(2):104-11. Epub 2015 Dec 20.

Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.

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February 2016

β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.

Oncotarget 2016 Feb;7(5):5353-65

Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA.

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February 2016

Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.

Biochem Biophys Res Commun 2016 Jan 8;469(3):449-55. Epub 2015 Dec 8.

Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA. Electronic address:

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January 2016

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors.

Sci Pharm 2015 Sep 26;84(3):428-446. Epub 2015 Sep 26.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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September 2015

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention.

Am J Physiol Gastrointest Liver Physiol 2015 Jul 28;309(2):G59-70. Epub 2015 May 28.

Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.

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July 2015

Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs.

Curr Pharmacol Rep 2015 Jun;1(3):154-160

University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA.

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June 2015

Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer.

PLoS One 2014 4;9(6):e98370. Epub 2014 Jun 4.

Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, United States of America.

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March 2015

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.

Eur J Med Chem 2013 9;70:273-9. Epub 2013 Oct 9.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Eini, 11562 Cairo, Egypt. Electronic address:

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September 2014

Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.

Arch Pharm (Weinheim) 2014 Sep 1;347(9):650-7. Epub 2014 Jul 1.

Faculty of Pharmacy, Medicinal Chemistry Department, Assiut University, Assiut, Egypt.

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September 2014

Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention.

Med Chem Res 2014 Sep;23(9):4177-4188

Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

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September 2014

NSAIDs inhibit tumorigenesis, but how?

Clin Cancer Res 2014 Mar 5;20(5):1104-13. Epub 2013 Dec 5.

Authors' Affiliations: Department of Pharmacology and Toxicology; Department of Pathology, The University of Alabama at Birmingham, Birmingham; and Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.

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March 2014

The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.

Cancers (Basel) 2014 Feb 26;6(1):436-58. Epub 2014 Feb 26.

Department of Biology, Chemistry, and Mathematics, University of Montevallo, Station 6480, Montevallo, AL 35115, USA.

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February 2014

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Bioorg Med Chem 2013 Dec 1;21(23):7343-56. Epub 2013 Oct 1.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany.

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December 2013

MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells.

Acta Pharmacol Sin 2013 Nov 14;34(11):1374-80. Epub 2013 Oct 14.

Mitchell Cancer Institute, University of South Alabama, Alabama Mobile, USA.

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November 2013

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Mol Cancer Ther 2013 Sep 26;12(9):1848-59. Epub 2013 Jun 26.

Corresponding Author: Gary A. Piazza, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Suite 3029, Mobile, AL 36604.

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September 2013

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

ChemMedChem 2013 Sep 11;8(9):1495-504. Epub 2013 Jul 11.

Pharmaceutical and Medicinal Chemistry, Saarland University, Helmholtz Institute for Pharmaceutical Research Saarland-HIPS, Campus C2.3, 66123 Saarbrücken, Germany.

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September 2013

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs.

Front Oncol 2013 11;3:181. Epub 2013 Jul 11.

Department of Pharmacology and Toxicology, The University of Alabama at Birmingham , Birmingham, AL , USA.

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July 2013

A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.

Mol Cancer Ther 2013 May 26;12(5):663-74. Epub 2013 Feb 26.

Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

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May 2013

MicroRNA and cancer chemoprevention.

Cancer Prev Res (Phila) 2013 May 26;6(5):401-9. Epub 2013 Mar 26.

Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Ave., Mobile, AL 36604, USA.

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May 2013

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.

Eur J Med Chem 2013 May 16;63:826-32. Epub 2013 Mar 16.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.

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May 2013

Hypoxia-regulated microRNAs in human cancer.

Acta Pharmacol Sin 2013 Mar 4;34(3):336-41. Epub 2013 Feb 4.

Mitchell Cancer Institute, University of South Alabama, AL, USA.

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March 2013

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

Arch Pharm (Weinheim) 2013 Jan;346(1):23-33

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

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January 2013

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.

Curr Colorectal Cancer Rep 2012 Dec;8(4):325-330

Department of Biology, Chemistry and Mathematics, University of Montevallo, Station 6480, Montevallo, AL 35115, USA.

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December 2012

New NSAID targets and derivatives for colorectal cancer chemoprevention.

Recent Results Cancer Res 2013 ;191:105-20

Department of Biology, University of Montevallo, Montevallo, AL, USA.

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November 2012

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

Eur J Med Chem 2012 Nov 29;57:329-43. Epub 2012 Sep 29.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance, Al-Tagmoaa Al-Khames, Cairo 11835, Egypt.

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November 2012

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.

PLoS One 2011 16;6(12):e29290. Epub 2011 Dec 16.

Drug Discovery Division, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama, United States of America.

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August 2012

Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents.

Med Chem 2012 May;8(3):392-400

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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May 2012

CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents.

Med Chem 2012 May;8(3):372-83

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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May 2012

Aquaporins mediate the chemoresistance of human melanoma cells to arsenite.

Mol Oncol 2012 Feb 13;6(1):81-7. Epub 2011 Nov 13.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China.

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February 2012

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.

Cancer Prev Res (Phila) 2011 Aug 19;4(8):1275-84. Epub 2011 Apr 19.

Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA

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August 2011

A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells.

J Biomol Screen 2011 Apr 18;16(4):383-93. Epub 2011 Feb 18.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20007, USA.

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April 2011

Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Arch Pharm (Weinheim) 2011 Mar 22;344(3):149-57. Epub 2010 Dec 22.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

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March 2011

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

J Med Chem 2011 Jan 28;54(2):495-509. Epub 2010 Dec 28.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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January 2011

A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

Med Chem 2010 Nov;6(6):374-87

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.

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November 2010

NSAIDs: Old Drugs Reveal New Anticancer Targets.

Pharmaceuticals (Basel) 2010 May 25;3(5):1652-1667. Epub 2010 May 25.

Southern Research Institute, 2000 9th Avenue South, Birmingham AL, 35205, USA.

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May 2010

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

Eur J Med Chem 2010 Apr;45(4):1278-86

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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April 2010

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

Eur J Med Chem 2010 Jan 20;45(1):90-7. Epub 2009 Sep 20.

Department of Parmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

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January 2010

Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.

Arzneimittelforschung 2009 ;59(8):415-21

Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

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October 2009

Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors.

Bioorg Med Chem 2009 Aug 3;17(16):5974-82. Epub 2009 Jul 3.

Department of Pharmaceutical Chemistry, German University in Cairo, Egypt.

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August 2009

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.

Eur J Pharmacol 2009 Jan 9;602(1):8-14. Epub 2008 Nov 9.

Department of Biochemistry, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255-5305, United States.

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January 2009

Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention.

J Urol 2004 Feb;171(2 Pt 2):S59-62; discussion S62-3

University of Texas Health Sciences Center, San Antonio, 78229-3900, USA.

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February 2004

Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells.

J Exp Ther Oncol 2003 Mar-Apr;3(2):83-94

Herbert Irving Comprehensive Cancer Center, 701 West 168th Street, HHSC-1509, New York, NY 10032, USA.

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November 2003

Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

Clin Cancer Res 2003 Oct;9(13):4972-82

Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10021, USA.

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October 2003