Publications by authors named "Gary A Koretzky"

98Publications

Identifying Key Pathways and Components in Chemokine-Triggered T Lymphocyte Arrest Dynamics Using a Multi-Parametric Global Sensitivity Analysis.

Cell Mol Bioeng 2019 Jun 29;12(3):193-202. Epub 2019 May 29.

Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd St., Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1007/s12195-019-00575-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816696PMC
June 2019

The Loss of TET2 Promotes CD8 T Cell Memory Differentiation.

J Immunol 2018 01 17;200(1):82-91. Epub 2017 Nov 17.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.4049/jimmunol.1700559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736442PMC
January 2018

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.

Arthritis Rheumatol 2017 06;69(6):1135-1143

Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1002/art.40071DOI Listing
June 2017

Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.

PLoS One 2014 10;9(9):e106659. Epub 2014 Sep 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106659PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160212PMC
May 2015

Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

Sci Signal 2014 Aug 26;7(340):ra82. Epub 2014 Aug 26.

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scisignal.2005287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993625PMC
August 2014

The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Sci Signal 2013 Nov 26;6(303):ra102. Epub 2013 Nov 26.

1Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.2004373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096120PMC
November 2013

Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.

Cancer Res 2013 Jun 10;73(12):3566-77. Epub 2013 Apr 10.

Divisions of Hematology/Oncology, Pulmonology, and Rheumatology, Departments of Medicine, and Path and Lab Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686869PMC
June 2013

Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.

Int J Mol Sci 2013 Mar 26;14(4):6649-73. Epub 2013 Mar 26.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/ijms14046649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645659PMC
March 2013

Transient PKCα shuttling to the immunological synapse is governed by DGKζ and regulates L-selectin shedding.

J Cell Sci 2013 May 22;126(Pt 10):2176-86. Epub 2013 Mar 22.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas (CNB/CSIC), 28049 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.118513DOI Listing
May 2013

FoxO-dependent regulation of diacylglycerol kinase α gene expression.

Mol Cell Biol 2012 Oct 13;32(20):4168-80. Epub 2012 Aug 13.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Madrid, Spain.

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http://dx.doi.org/10.1128/MCB.00654-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457341PMC
October 2012

SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.

Eur J Immunol 2012 Oct 10;42(10):2736-43. Epub 2012 Sep 10.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/eji.201142303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902640PMC
October 2012

Diacylglycerol kinase zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow.

Integr Biol (Camb) 2012 Jun 1;4(6):606-14. Epub 2012 May 1.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://xlink.rsc.org/?DOI=c2ib00002d
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http://dx.doi.org/10.1039/c2ib00002dDOI Listing
June 2012

PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Mol Cell Biol 2012 Jun 9;32(12):2268-78. Epub 2012 Apr 9.

The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.00063-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372262PMC
June 2012

An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment.

Langmuir 2012 Jan 4;28(4):2225-37. Epub 2012 Jan 4.

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1021/la203803eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269544PMC
January 2012

The SLP-76 Src homology 2 domain is required for T cell development and activation.

J Immunol 2011 Nov 26;187(9):4459-66. Epub 2011 Sep 26.

Department of Cancer Biology, Signal Transduction Program, Abramson Family Cancer Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.jimmunol.org/content/187/9/4459.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0903379
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http://dx.doi.org/10.4049/jimmunol.0903379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201803PMC
November 2011

The requirements for natural Th17 cell development are distinct from those of conventional Th17 cells.

J Exp Med 2011 Oct 26;208(11):2201-7. Epub 2011 Sep 26.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20110680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201206PMC
October 2011

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

J Clin Invest 2011 Jun 16;121(6):2264-77. Epub 2011 May 16.

Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI43157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104738PMC
June 2011

Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses.

J Biol Chem 2011 Feb 7;286(7):5254-65. Epub 2010 Dec 7.

Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.171884
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http://dx.doi.org/10.1074/jbc.M110.171884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037638PMC
February 2011

Understanding signal integration through targeted mutations of an adapter protein.

FEBS Lett 2010 Dec 21;584(24):4901-9. Epub 2010 Oct 21.

Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008419PMC
December 2010

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.

Blood 2010 Dec 16;116(25):5548-59. Epub 2010 Sep 16.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2010-06-292748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031403PMC
December 2010

Multiple roles of CD4 and CD8 in T cell activation.

Authors:
Gary A Koretzky

J Immunol 2010 Sep;185(5):2643-4

Department of Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1090076DOI Listing
September 2010

Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions.

J Immunol 2010 Sep 4;185(5):2790-9. Epub 2010 Aug 4.

Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.0903740DOI Listing
September 2010

Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.

Mol Cell Biol 2010 Sep 6;30(17):4188-96. Epub 2010 Jul 6.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00305-10
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http://dx.doi.org/10.1128/MCB.00305-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937553PMC
September 2010

Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.

Cold Spring Harb Perspect Biol 2010 Apr 17;2(4):a002501. Epub 2010 Mar 17.

Abramson Family Cancer Institute, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1101/cshperspect.a002501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845197PMC
April 2010

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

Blood 2010 May 30;115(20):4030-8. Epub 2010 Mar 30.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-09-241000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875090PMC
May 2010

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

Cancer Cell 2010 Feb;17(2):148-59

Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830208PMC
February 2010

The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function.

Authors:
Gary A Koretzky

Immune Netw 2009 Jun 30;9(3):75-83. Epub 2009 Jun 30.

Department of Pathology and Laboratory Medicine and Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.4110/in.2009.9.3.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803302PMC
June 2009

Lymphocyte signaling in the Tuscan hills.

Immunity 2009 Nov;31(5):692-5

Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.immuni.2009.11.001DOI Listing
November 2009

Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation.

Immunol Rev 2009 Nov;232(1):99-114

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2009.00825.xDOI Listing
November 2009

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.

J Allergy Clin Immunol 2009 Nov;124(5):1088-98

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778804PMC
November 2009

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

J Exp Med 2009 Nov 2;206(12):2625-39. Epub 2009 Nov 2.

Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20091320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806628PMC
November 2009

Navigating the leukocyte signaling maze guided by Ariadne's thread.

Nat Immunol 2009 Nov;10(11):1134-6

Division of Cell Biology, La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ni1109-1134DOI Listing
November 2009

Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

J Immunol 2009 Apr;182(8):4686-95

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.4049/jimmunol.0803180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922395PMC
April 2009

Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.

Mol Biol Cell 2009 Apr 11;20(7):2049-59. Epub 2009 Feb 11.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1091/mbc.e07-12-1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663923PMC
April 2009

T cell activation.

Annu Rev Immunol 2009 ;27:591-619

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.immunol.021
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http://dx.doi.org/10.1146/annurev.immunol.021908.132706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740335PMC
May 2009

Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.

J Biol Chem 2009 Feb 11;284(7):4429-38. Epub 2008 Dec 11.

Experimental Immunology Branch, NCI, and NIA, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M808679200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640981PMC
February 2009

X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.

Immunol Res 2008 ;42(1-3):145-59

Infectious Diseases Fellowship Training Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s12026-008-8048-7DOI Listing
March 2009

Regulation of T cell integrin function by adapter proteins.

Immunol Res 2008 ;42(1-3):132-44

Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://link.springer.com/10.1007/s12026-008-8047-8
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http://dx.doi.org/10.1007/s12026-008-8047-8DOI Listing
March 2009

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.

J Exp Med 2008 Aug 28;205(8):1775-88. Epub 2008 Jul 28.

Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20080240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525600PMC
August 2008

CD3varepsilon: PeRuSing for positive selection.

Nat Immunol 2008 May;9(5):457-9

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http://dx.doi.org/10.1038/ni0508-457DOI Listing
May 2008

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

Immunity 2008 Mar;28(3):359-69

Cancer Biology, Abramson Family Cancer Research Institute, 427 BRBII/III, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323515PMC
March 2008

Critical roles of the PI3K/Akt signaling pathway in T cell development.

Immunol Lett 2008 Mar 10;116(2):104-10. Epub 2008 Jan 10.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.imlet.2007.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322870PMC
March 2008

Indirect involvement of allergen-captured mast cells in antigen presentation.

Blood 2008 Feb 21;111(3):1489-96. Epub 2007 Nov 21.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2007-07-102111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214744PMC
February 2008

Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.

J Leukoc Biol 2008 Feb 26;83(2):419-29. Epub 2007 Oct 26.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1189/jlb.0507297DOI Listing
February 2008

In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction.

Eur J Immunol 2007 Oct;37(10):2961-72

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/eji.200636855DOI Listing
October 2007

The legacy of the Philadelphia chromosome.

Authors:
Gary A Koretzky

J Clin Invest 2007 Aug;117(8):2030-2

Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI33032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934583PMC
August 2007

Antigen receptor signaling: the Tuscan connection.

Nat Immunol 2007 Aug;8(8):787-90

Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.1038/ni0807-787DOI Listing
August 2007

Compartmentalization of ITAM and integrin signaling by adapter molecules.

Immunol Rev 2007 Aug;218:9-28

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2007.00541.xDOI Listing
August 2007

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

Proc Natl Acad Sci U S A 2007 Jul 3;104(29):12105-10. Epub 2007 Jul 3.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0705285104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924580PMC
July 2007

Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing.

J Immunol 2007 Apr;178(7):4606-14

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.178.7.4606DOI Listing
April 2007

Proximal signaling events in Fc epsilon RI-mediated mast cell activation.

J Allergy Clin Immunol 2007 Mar;119(3):544-52; quiz 553-4

Department of Pathology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.01.017DOI Listing
March 2007

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.

EMBO J 2007 Feb 18;26(3):678-89. Epub 2007 Jan 18.

Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.emboj.7601535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794392PMC
February 2007

Integrins and ITAMs: more than just good neighbors.

Nat Immunol 2006 Dec;7(12):1286-8

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http://dx.doi.org/10.1038/ni1206-1286DOI Listing
December 2006

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

Nat Immunol 2006 Nov 8;7(11):1174-81. Epub 2006 Oct 8.

Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ni1400DOI Listing
November 2006

PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.

Blood 2007 Feb 28;109(3):1147-55. Epub 2006 Sep 28.

Department of Medicine, University of Pennsylvania School of Medicine, and Department of Pathology, Children's Hospital of Philadelphia 19104, USA.

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http://dx.doi.org/10.1182/blood-2006-02-001339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785144PMC
February 2007

Persistence of cooperatively stabilized signaling clusters drives T-cell activation.

Mol Cell Biol 2006 Oct;26(19):7155-66

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/MCB.00507-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592897PMC
October 2006

The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation.

Blood 2007 Jan 14;109(1):168-75. Epub 2006 Sep 14.

Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Japan.

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http://dx.doi.org/10.1182/blood-2005-12-020164DOI Listing
January 2007

Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

Mol Cell Biol 2006 Sep;26(18):6936-49

Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.01040-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592869PMC
September 2006

Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.

J Exp Med 2006 Jun 22;203(6):1471-80. Epub 2006 May 22.

The Signal Transduction Program, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20052424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118304PMC
June 2006

Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection.

J Immunol 2006 Jun;176(11):6681-9

Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.176.11.6681DOI Listing
June 2006

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond.

Nat Rev Immunol 2006 Jan;6(1):67-78

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRBII/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/nri1750
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http://dx.doi.org/10.1038/nri1750DOI Listing
January 2006

Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.

Mol Cell Biol 2006 Mar;26(5):1826-38

Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/MCB.26.5.1826-1838.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430252PMC
March 2006

Functional hierarchy of the N-terminal tyrosines of SLP-76.

J Immunol 2006 Feb;176(4):2430-8

Signal Transduction Program, Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.176.4.2430DOI Listing
February 2006

Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection.

J Exp Med 2005 Oct 26;202(7):893-900. Epub 2005 Sep 26.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20051128
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http://dx.doi.org/10.1084/jem.20051128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213170PMC
October 2005

Regulation of NKT cell development by SAP, the protein defective in XLP.

Nat Med 2005 Mar 13;11(3):340-5. Epub 2005 Feb 13.

Pediatric Oncology, Wood, 4th floor, 3615 Civic Center Boulevard, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nm1189DOI Listing
March 2005

PRAM-1 is required for optimal integrin-dependent neutrophil function.

Mol Cell Biol 2004 Dec;24(24):10923-32

Dept. of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1128/MCB.24.24.10923-10932.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533979PMC
December 2004

The SLP-76 family of adapter proteins.

Semin Immunol 2004 Dec;16(6):379-93

Department of Laboratory Medicine and Pathology, School of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.smim.2004.08.018DOI Listing
December 2004

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.

Immunity 2004 Nov;21(5):693-706

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2004.09.012DOI Listing
November 2004

Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.

J Exp Med 2004 Jul;200(1):25-34

Experimental Immunology Branch, Building 10, Room 4B36, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20040262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213313PMC
July 2004

Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function.

J Immunol 2004 Jun;172(11):6768-74

Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.172.11.6768DOI Listing
June 2004

Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.

J Biol Chem 2004 Apr 13;279(15):15481-90. Epub 2004 Jan 13.

Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M313339200
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http://dx.doi.org/10.1074/jbc.M313339200DOI Listing
April 2004

Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors.

J Leukoc Biol 2004 Mar 23;75(3):541-52. Epub 2003 Dec 23.

Pediatric Oncology, Children's Hospital of Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1189/jlb.0703312DOI Listing
March 2004

Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.

J Immunol 2003 Dec;171(12):6621-9

Signal Transduction Program, The Abramson Family Cancer Research Institute, and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.171.12.6621DOI Listing
December 2003

SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils.

Immunity 2003 Nov;19(5):761-9

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s1074-7613(03)00305-4DOI Listing
November 2003

Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.

Nat Immunol 2003 Sep 27;4(9):882-90. Epub 2003 Jul 27.

The Signal Transduction Program, The Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ni958DOI Listing
September 2003

Regulation of hematopoietic cell development and activation by adapter proteins.

Immunol Res 2003 ;27(2-3):357-66

Abramson Family Cancer Research Institute, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:357DOI Listing
March 2004

Azathioprine: old drug, new actions.

J Clin Invest 2003 Apr;111(8):1122-4

Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1172/JCI18384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152947PMC
April 2003

T cell activation I: proximal events.

Authors:
Gary A Koretzky

Immunol Rev 2003 Feb;191:5-6

Department of Pathology and Laboratory Medicine, Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00030.xDOI Listing
February 2003

Adaptors as central mediators of signal transduction in immune cells.

Nat Immunol 2003 Feb;4(2):110-6

Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA.

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http://dx.doi.org/10.1038/ni0203-110DOI Listing
February 2003

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation.

Proc Natl Acad Sci U S A 2002 Nov 5;99(23):15006-11. Epub 2002 Nov 5.

Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.232058599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137535PMC
November 2002

Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen.

Blood 2002 Oct;100(8):2839-44

Departments of Internal Medicine and Pediatrics, University of Iowa College of Medicine, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1182/blood-2002-04-1234DOI Listing
October 2002

Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.

J Biol Chem 2002 Aug 17;277(34):31089-98. Epub 2002 Jun 17.

Signal Transduction Program, The Abramson Family Cancer Research Institute, Immunology Graduate Program, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M203818200DOI Listing
August 2002

Control of T cell function by positive and negative regulators.

Science 2002 May;296(5573):1639-40

The Abramson Family Cancer Research Institute, Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1071551DOI Listing
May 2002