Gary A Churchill

Gary A Churchill

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Gary A Churchill

Gary A Churchill

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Cleaning Genotype Data from Diversity Outbred Mice.

G3 (Bethesda) 2019 05 7;9(5):1571-1579. Epub 2019 May 7.

The Jackson Laboratory, Bar Harbor, Maine 04609.

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http://dx.doi.org/10.1534/g3.119.400165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505173PMC
May 2019

A multi-tissue full lifespan epigenetic clock for mice.

Aging (Albany NY) 2018 10;10(10):2832-2854

Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.18632/aging.101590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224226PMC
October 2018

How mice are indispensable for understanding obesity and diabetes genetics.

Curr Opin Endocrinol Diabetes Obes 2017 Apr;24(2):83-91

aDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin bThe Jackson Laboratory, Bar Harbor, Maine cPacific Northwest Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/MED.0000000000000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837807PMC
April 2017

Eric Lander and David Botstein on Mapping Quantitative Traits.

Authors:
Gary A Churchill

Genetics 2016 05 5;203(1):1-3. Epub 2016 May 5.

The Jackson Laboratory, Bar Harbor, Maine 04609

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http://dx.doi.org/10.1534/genetics.116.189803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858765PMC
May 2016

Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.

J Gerontol A Biol Sci Med Sci 2016 Feb 22;71(2):170-7. Epub 2014 Dec 22.

The Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine.

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http://dx.doi.org/10.1093/gerona/glu223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707687PMC
February 2016

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.

PLoS Genet 2016 Feb 1;12(2):e1005805. Epub 2016 Feb 1.

The Jackson Laboratory, Bar Harbor, Maine, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734753PMC
February 2016

The Mouse Universal Genotyping Array: From Substrains to Subspecies.

G3 (Bethesda) 2015 Dec 18;6(2):263-79. Epub 2015 Dec 18.

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1534/g3.115.022087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751547PMC
December 2015

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database.

Mamm Genome 2015 Oct 19;26(9-10):511-20. Epub 2015 Aug 19.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.

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http://dx.doi.org/10.1007/s00335-015-9595-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602074PMC
October 2015

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping.

G3 (Bethesda) 2015 Jul 28;5(10):2021-6. Epub 2015 Jul 28.

Departments of Human Genetics, Medicine, Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095-1679

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http://dx.doi.org/10.1534/g3.115.020784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592984PMC
July 2015

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity.

Environ Health Perspect 2015 Mar 6;123(3):237-45. Epub 2014 Nov 6.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Resources (DHHS), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1408202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348743PMC
March 2015

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

PLoS Genet 2015 Feb 13;11(2):e1004850. Epub 2015 Feb 13.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1004850
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http://dx.doi.org/10.1371/journal.pgen.1004850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334553PMC
February 2015

Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung.

Genetics 2014 Oct 11;198(2):735-45. Epub 2014 Aug 11.

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1534/genetics.114.168138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196624PMC
October 2014

When are results too good to be true?

Authors:
Gary A Churchill

Genetics 2014 Oct;198(2):447-8

The Jackson Laboratory, Bar Harbor, Maine 04609.

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http://dx.doi.org/10.1534/genetics.114.169912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196601PMC
October 2014

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene.

Mamm Genome 2014 Jun 5;25(5-6):211-22. Epub 2014 Apr 5.

IGERT Program in Functional Genomics, Graduate School of Biomedical Sciences and Engineering, The University of Maine, Orono, ME, 04469, USA,

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http://dx.doi.org/10.1007/s00335-014-9508-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032469PMC
June 2014

Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait.

Am J Physiol Renal Physiol 2014 Jun 9;306(11):F1296-307. Epub 2014 Apr 9.

Laboratory of Voiding Dysfunction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachuesetts;

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http://dx.doi.org/10.1152/ajprenal.00074.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042106PMC
June 2014

Misleading results: don't blame the mice.

Authors:
Gary A Churchill

Science 2014 Jan;343(6169):370

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1126/science.343.6169.370-aDOI Listing
January 2014

Relationship between obesity phenotypes and genetic determinants in a mouse model for juvenile obesity.

Physiol Genomics 2013 Sep 6;45(18):817-26. Epub 2013 Aug 6.

Breeding Biology and Molecular Genetics, Department for Crop and Animal Sciences, Humboldt-Universität zu Berlin, Berlin, Germany; and.

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http://dx.doi.org/10.1152/physiolgenomics.00058.2013DOI Listing
September 2013

Adaptive evolution and effective population size in wild house mice.

Mol Biol Evol 2012 Oct 3;29(10):2949-55. Epub 2012 Apr 3.

Department of Ecology and Evolutionary Biology, University of Arizona, USA.

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http://dx.doi.org/10.1093/molbev/mss105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457769PMC
October 2012

Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.

Am J Physiol Renal Physiol 2012 Oct 1;303(7):F972-81. Epub 2012 Aug 1.

Novartis Institute for BioMedical Research, 1 Health Plaza, Bldg. 437, Rm. 4331, East Hanover, NJ 07936, USA.

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http://dx.doi.org/10.1152/ajprenal.00690.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469684PMC
October 2012

The Diversity Outbred mouse population.

Mamm Genome 2012 Oct 15;23(9-10):713-8. Epub 2012 Aug 15.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1007/s00335-012-9414-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524832PMC
October 2012

What can causal networks tell us about metabolic pathways?

PLoS Comput Biol 2012 5;8(4):e1002458. Epub 2012 Apr 5.

State University of New York at Buffalo, Buffalo, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1002458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320578PMC
August 2012

Ten years of the Collaborative Cross.

Genetics 2012 Feb;190(2):291-4

Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA.

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http://www.genetics.org/content/genetics/190/2/291.full.pdf
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http://www.genetics.org/cgi/doi/10.1534/genetics.111.138032
Publisher Site
http://dx.doi.org/10.1534/genetics.111.138032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276648PMC
February 2012

A general Bayesian approach to analyzing diallel crosses of inbred strains.

Genetics 2012 Feb;190(2):413-35

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7265, USA.

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http://dx.doi.org/10.1534/genetics.111.132563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276624PMC
February 2012

Imputation of single-nucleotide polymorphisms in inbred mice using local phylogeny.

Genetics 2012 Feb;190(2):449-58

Department of Computer Science, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1534/genetics.111.132381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276610PMC
February 2012

Ten years of the collaborative cross.

G3 (Bethesda) 2012 Feb 1;2(2):153-6. Epub 2012 Feb 1.

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http://dx.doi.org/10.1534/g3.111.001891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284322PMC
February 2012

The collaborative cross: a recombinant inbred mouse population for the systems genetic era.

ILAR J 2011 ;52(1):24-31

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/ilar.52.1.24DOI Listing
July 2011

The future of model organisms in human disease research.

Nat Rev Genet 2011 07 18;12(8):575-82. Epub 2011 Jul 18.

Medical Research Council Clinical Sciences Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nrg3047DOI Listing
July 2011

Architecture of energy balance traits in emerging lines of the Collaborative Cross.

Am J Physiol Endocrinol Metab 2011 Jun 22;300(6):E1124-34. Epub 2011 Mar 22.

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1152/ajpendo.00707.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118585PMC
June 2011

Stochastic variation of transcript abundance in C57BL/6J mice.

BMC Genomics 2011 Mar 30;12:167. Epub 2011 Mar 30.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1186/1471-2164-12-167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082245PMC
March 2011

Uncovering genes and regulatory pathways related to urinary albumin excretion.

J Am Soc Nephrol 2011 Jan 28;22(1):73-81. Epub 2010 Oct 28.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1681/ASN.2010050561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014036PMC
January 2011

Critical reasoning on causal inference in genome-wide linkage and association studies.

Trends Genet 2010 Dec 15;26(12):493-8. Epub 2010 Oct 15.

Groningen Bioinformatics Centre, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.tig.2010.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991400PMC
December 2010

Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice.

Physiol Genomics 2010 Nov 21;42A(4):228-34. Epub 2010 Sep 21.

The Jackson Laboratory, Bar Harbor, Maine, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00044.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008368PMC
November 2010

Coordinated expression domains in mammalian genomes.

PLoS One 2010 Aug 18;5(8):e12158. Epub 2010 Aug 18.

The Jackson Laboratory, Center for Genome Dynamics, Bar Harbor, Maine, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923606PMC
August 2010

CGDSNPdb: a database resource for error-checked and imputed mouse SNPs.

Database (Oxford) 2010 Jul 6;2010:baq008. Epub 2010 Jul 6.

Center for Genome Dynamics, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1093/database/baq008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911843PMC
July 2010

Effects of atherogenic diet on hepatic gene expression across mouse strains.

Physiol Genomics 2009 Nov 11;39(3):172-82. Epub 2009 Aug 11.

The Jackson Laboratory, Bar Harbor, Maine 04605, USA.

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http://dx.doi.org/10.1152/physiolgenomics.90350.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789673PMC
November 2009

Importance of randomization in microarray experimental designs with Illumina platforms.

Nucleic Acids Res 2009 Sep 17;37(17):5610-8. Epub 2009 Jul 17.

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1093/nar/gkp573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761262PMC
September 2009

Identification of genetic loci involved in diabetes using a rat model of depression.

Mamm Genome 2009 Aug 22;20(8):486-97. Epub 2009 Aug 22.

Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s00335-009-9211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775460PMC
August 2009

Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone.

BMC Genomics 2009 Apr 7;10:150. Epub 2009 Apr 7.

Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montréal (IRCM) and Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1186/1471-2164-10-150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679052PMC
April 2009

What are microarrays teaching us about sleep?

Trends Mol Med 2009 Feb 21;15(2):79-87. Epub 2009 Jan 21.

University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molmed.2008.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942088PMC
February 2009

Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both.

Physiol Genomics 2009 Jan 4;36(2):114-26. Epub 2008 Nov 4.

Breeding Biology and Molecular Genetics, Institute of Animal Sciences, Humboldt-Universität zu Berlin, Invalidenstrasse 42, Berlin, Germany.

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http://dx.doi.org/10.1152/physiolgenomics.90277.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636925PMC
January 2009

An imputed genotype resource for the laboratory mouse.

Mamm Genome 2008 Mar 27;19(3):199-208. Epub 2008 Feb 27.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1007/s00335-008-9098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725522PMC
March 2008

Statistical design and the analysis of gene expression microarray data.

Genet Res 2007 Dec;89(5-6):509-14

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1017/S0016672308009713DOI Listing
December 2007