Garth L Parham

Garth L Parham

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Garth L Parham

Garth L Parham

Publications by authors named "Garth L Parham"

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A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

Antimicrob Agents Chemother 2015 May 17;59(5):2625-35. Epub 2015 Feb 17.

Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan

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http://dx.doi.org/10.1128/AAC.04757-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394833PMC
May 2015

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013