Professor Garth D Ehrlich, PhD, FAAAS - Drexel University College of Medicine - Professor

Professor Garth D Ehrlich

PhD, FAAAS

Drexel University College of Medicine

Professor

Philadelphia, PA | United States

Main Specialties: Biochemical Genetics, Biology, Biotechnology, Infectious Disease, Medical Microbiology

Additional Specialties: Microbial genomics: chronic bacterial pathogenesis

ORCID logohttps://orcid.org/0000-0003-0341-8771


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Professor Garth D Ehrlich, PhD, FAAAS - Drexel University College of Medicine - Professor

Professor Garth D Ehrlich

PhD, FAAAS

Introduction

Dr Ehrlich is Professor of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery at Drexel University College of Medicine (DUCoM) in Philadelphia, PA, USA. He also directs: the Center for Genomic Sciences (CGS); the Center for Advanced Microbial Processing (CAMP); and the Center for Surgical Infections and Biofilms within the Institute for Molecular Medicine and Infectious Disease at DUCoM. In addition, he directs the Core Genomics Facility for the Drexel University as a whole. CGS scientists utilize a broad array of comparative genomic techniques and bioinformatic tools, many developed in-house, to identify and characterize both virulence genes within pathogens, and susceptibility genes to pathogens within their hosts. Dr Ehrlich is also one of the founders of the field of Clinical Molecular Diagnostics (MDx), having been involved in the original application of PCR for the detection of human retroviruses in 19851. He founded the MDx Division at UPMC and used these experiences to author the first text book/lab manual for infectious disease (ID) MDx2. Together with a team of like-minded pioneers he was one of the founders of the Association for Molecular Pathology and served as the first co-chair of the ID section. Dr Ehrlich counts among his major contributions to science the mapping and cloning of several major human disease genes3,4, and the re-writing of much of our understanding of chronic bacterial pathogenesis5,6. The latter began with his promulgation of the biofilm paradigm to explain many facets of chronic mucosal microbial infections7-9. Working with Chris Post, he started his explorations into chronic middle-ear disease in children in the early 90’s which he has since repeatedly generalized such that it is now widely accepted that the vast majority of all chronic microbial infections are biofilm-associated10,11. He also advanced the Distributed Genome Hypothesis (DGH12,13) to explain the enormous clinical variability among strains of a bacterial species, which together with the biofilm paradigm form the bases for his rubric of Bacterial Plurality3,4. His work in human genetics combined with the laboratory resources necessary to test the DGH have resulted in his having played a role in the development of several waves of genomic technology over the last quarter century including microsatellite mapping, microarrays, and next-generation sequencing. More recently he has developed the concept of bacterial population-level virulence factors and has for the first time within the field of bacterial genomics used statistical genetics and machine learning algorithms approaches to identify unannotated distributed genes that are associated with virulence. These computational methodologies provides a non-biased, top-down approach to prioritize the annotation of hypothetical genes14. Coincident with the recent relocation of his research enterprise to DUCOM he founded CAMP which functions as a collaborative multi-discipline facility for exploitation of a suite of technological advances, many developed within the CGS, which permit the identification, cloning, heterologous expression, and biochemical verification of commercially important biosynthetic and biodegradative pathways from what he refers to as the “Genomic Dark Matter”. This approach came out his successful collaborative studies with Dr. David Sherman at the University of Michigan wherein they used multiple omics technologies (and developed the term meta-omics) to isolate and characterize all of the genes for a novel biosynthetic pathway for an important anti-cancer drug from an unculturable endosymbiotic bacterium of a tunicate15. Over the past several years Dr Ehrlich has overseen the development of a novel ultra-high-fidelity microbiome assay that provides quantitative, species-specific analyses of microbial consortia using whole-gene 16S amplification and sequencing on the Pacific Biosciences third generation long-read sequencing platform16. When combined with a state-of-the art bioinformatics pipeline that takes advantage of novel pathway- algorithms and a custom database, developed in-house, this system provides unprecedented accuracy. In collaboration with Dr Curtis Harris at the NCI, Dr Ehrlich and his team applied this high-fidelity microbiome assay to identify bacterial species-specific changes to the lung microbiome associated with a specific TP-53 mutation – providing the first microbial biomarker for cancer17. Dr Ehrlich’s lifelong interest in emergent MDx and “omic” technologies led to his recent appointment as Director of the Meta-Omics Core Facility at the Sidney Kimmel Cancer Center, a consortium NCI-designated Cancer Center involving Thomas Jefferson University and Drexel University. Dr Ehrlich’s latest paradigm-changing hypothesis is that Alzheimer’s disease results from a combination of chronic bacterial infections of the brain (primarily originating from the periodontium) and the brain’s anti-microbial and inflammatory responses to these infections. Dr. Ehrlich was elected as fellow of the American Association for the Advancement of Science in 2014, and has won numerous awards for his research and teaching.

1. Kwok, S., Mack. D.H., Mullis, K.B., Poiesz, B., Ehrlich, G., Blair, D., Friedman-Kien, A., and Sninsky J.J.: Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer cleavage detection. J. Virology, 61:1690-1694, May 1987.
2. Ehrlich, G.D., and Greenberg, S.J.: PCR-Based Diagnostics In Infectious Disease. Boston: Blackwell Scientific Publications, 1994, 697 pages
3. Preston, R.A., Post, J.C., Keats, B.J.B., Aston, C.E., Ferrell, R.E., Priest, J., Nouri, N., Losken, H.W., Morris, C.A., Hurtt, M.R., Mulvihill, J.J., and Ehrlich, G.D. A gene for Crouzon craniofacial dysostosis maps to the long arm of chromosome 10. Nature Genetics 7:149-153, 1994
4. Whitcomb, D.C., Gorry, M.C., Preston, R.A., Furey, W.F., Sossenheimer, J.J., Ulrich, C.D., Martin, S.P., Gates, L.K. Jr., Amann, S.T., Toskes, P.P., Liddle, R., McGrath, K. Uomo, G., Post, J.C., and Ehrlich, G.D.^ Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nature Genetics 14:145, 1996.
5. Ehrlich, G.D.^, Ahmed, A., Earl, J., Hiller, N..L, Costerton, J.W., Stoodley, P., Post, J.C., DeMeo, P., and Hu, .FZ. The Distributed Genome Hypothesis as a Rubric for Understanding Evolution in situ During Chronic Infectious Processes. FEMS Immunology and Medical Microbiology. 2010 Aug;59(3):269-79.
6. Ehrlich, G.D., Hu, F.Z., Shen, K., Stoodley, P., Post, J.C., Bacterial Plurality as a General Mechanism Driving Persistence in Chronic Infections. Clinical Orthopaedics and Related Research 437:20-24, 2005.
7. Rayner, M.G., Zhang, Y., Gorry, M.C., Chen, Y., Post, J.C., and Ehrlich, G.D. Evidence of bacterial metabolic activity in culture-negative otitis media with effusion. JAMA 279:296-299, 1998.
8. Ehrlich, G.D., Veeh, R., Wang, X., Costerton, J.W., Hayes, J.D., Hu, F.Z., Daigle, B.J., Ehrlich, M.D., Post, J.C. Mucosal Biofilm Formation on Middle-ear Mucosa in the Chinchilla Model of Otitis Media. JAMA 287:1710-1715, 2002.
9. Hall-Stoodley, L., Hu, F.Z., Stoodley, P., Nistico, L., Link, T.R., Burrows, A., Post, J.C. Ehrlich, G.D., and Kerschner, K.E. Direct Detection of Bacterial Biofilms on the Middle-Ear Mucosa of Children With Chronic Otitis Media. JAMA 296:202-211, 2006.
10. Costerton, J.W., Veeh, R., Shirtliff, M., Pasmore, M., Post, J.C. and Ehrlich, G.D. The application of biofilm science to the study and control of chronic bacterial infections. Journal of Clinical Investigation 112(10):1466-77 2003
11. Wolcott, R.D., and Ehrlich, G.D. Biofilms and Chronic Infections. 2008 JAMA Jun *11;299(22):2682-4
12. Hogg, J.S., Hu, F.Z., Janto, B., Boissy, R., Gladitz, J., Swierczek, N., Hayes, J., Keefe, R., Yu, S., Post, J.C., and Ehrlich, G.D. Characterization and Modelling of the Haemophilus influenzae Core and Supra-Genome based on the Complete Genomic Sequences of Rd and 12 clinical Nontypeable16 Strains. Genome Biology. 8(6)R103, 2007
13. Hiller, N.L., Ahmed, A., Powell, E., Eutsey, R.E., Earl, J., Martin, D., Janto, B., Hogg, J.S., Boissy, R., Barbadora, K., Post, J.C., Hu, F.Z., and Ehrlich, G.D. Generation of Genic Diversity among Streptococcus pneumoniae Strains via Horizontal Gene Transfer during a Chronic Polyclonal Pediatric Infection. PLoS Pathogens 6(9): e1001108, 2010
14. Kress-Bennett, J., Hiller, N.L., Eutsey, R., Powell, E., Longwell, M.J., Hillman, T., Blackwell, T., Byers, B., Post, J.C., Hu, F.Z., Ehrlich, G.D., and Janto, B. Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae PLoS ONE 11(3):e0149891, 2016
15. Rath, C.M., Janto, B., Earl, J., Ahmed, A., Hu, F.Z., Hiller, N.L., Dahlgren, M., Kreft, M., Yu, F., Wolff, J.J., Kweon, H.K., Christiansen, M.A., Håkansson, K., Williams, R.M., Ehrlich, G.D., Sherman, D.H. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chemical Biology 6(11):1244-56, 2011.
16. Earl, J.P., Krol, J., Balashov, S.V., Bhat, A., Hammond, J., Sen, B., Limbo, J, Reed, D.R., Cohen, N., Ehrlich, G.D*., and Mell, J.C*. Development and Validation of Ultra-High-Fidelity Microbiome Analysis Pipeline based on full 16S Gene Sequencing on the PacBio. Microbiome 6(1):190. 2018. doi: 10.1186/s40168-018-0569-2
17. Greathouse, K.L., White, J.R., Vargas, A.J., Bliskovsky, V.V., Beck, J.A., von Muhlinen, N., Polley, E.C., Bowman, E.D., Khan, M.A., Robles, A.I., Cooks, T., Ryan, B.M., Dzutsev, A.H., Trinchieri, G., Pineda, M.A., Bilke, S., Meltzer, P.S., Hokenstad, A.N.., Stickrod, T.M., Walther-Antonio, M.R., Earl, J.P., Mell, J.C., Krol, J.E., Balashov, S.V., Bhat, A.S., Ehrlich, G.D., Valm, A., Deming, C., Conlan, S., Oh, J., Jegre, J.A., and Harris, C.C. Microbiome-TP53 GeneInteraction in Human Lung Cancer. Genome Biology 19:123, 2018.

Primary Affiliation: Drexel University College of Medicine - Philadelphia, PA , United States

Specialties:

Additional Specialties:

Research Interests:


View Professor Garth D Ehrlich’s Resume / CV

Education

Aug 1987
Syracuse University
PhD
Biology
Jul 1978
SUNY Upstate
Post Doc
Human Retrovirology
May 1977
Alfred University
BA
cum laude, biology departmental honors

Experience

Nov 2014
Elected Fellow AAAS

Theoretical work in chronic bacterial pathogenesis

Publications

103Publications

872Reads

69Profile Views

The Rise of Noninvasive Diagnostic Technologies.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2019 Apr;23(4):229

1 Department of Microbiology and Immunology and Drexel University College of Medicine, Philadelphia, Pennsylvania.

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https://www.liebertpub.com/doi/10.1089/gtmb.2019.29044.gde
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http://dx.doi.org/10.1089/gtmb.2019.29044.gdeDOI Listing
April 2019
1 Read

Raising the Bar at GTMB.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2019 03;23(3):151-152

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2019.0042DOI Listing
March 2019
1 Read

Broad-Spectrum and Personalized Guide RNAs for CRISPR/Cas9 HIV-1 Therapeutics.

AIDS Res Hum Retroviruses 2018 Nov 27;34(11):950-960. Epub 2018 Aug 27.

1 Department of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/AID.2017.0274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238604PMC
November 2018
7 Reads
2.325 Impact Factor

Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes.

Microbiome 2018 10 23;6(1):190. Epub 2018 Oct 23.

Department of Microbiology & Immunology, Centers for Genomic Sciences and Advanced Microbial Processing, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA, 19102, USA.

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https://microbiomejournal.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s40168-018-0569-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199724PMC
October 2018
5 Reads

The Future Is Today.

Genet Test Mol Biomarkers 2018 May;22(5):279-280

2 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine; Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine; and Core Genomics Facility, Drexel University College of Medicine; Meta-omics Core Facility, Sidney Kimmel Cancer Center; Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2018.0107DOI Listing
May 2018
9 Reads

Development of a Trio of Potential Biomarkers for Cancer Prognosis.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2018 01;22(1):1-2

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2017.0276DOI Listing
January 2018
5 Reads

Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.

Ann Clin Microbiol Antimicrob 2017 Nov 16;16(1):75. Epub 2017 Nov 16.

Center for Surgical Infections & Biofilms, Institute of Molecular Medicine and Infectious diseases, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA.

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http://dx.doi.org/10.1186/s12941-017-0248-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691885PMC
November 2017
13 Reads
1.514 Impact Factor

Novel Genetic Markers for Common Degenerative Orthopedic Diseases.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2017 10;21(10):577

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2017.29036.gdeDOI Listing
October 2017
4 Reads

Changing of the Guard at GTMB.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2017 08;21(8):455

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2017.29033.gdeDOI Listing
August 2017
1 Read

Phenotypic diversity and genotypic flexibility of during long-term chronic infection of cystic fibrosis lungs.

Genome Res 2017 04 21;27(4):650-662. Epub 2017 Mar 21.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.213363.116
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http://dx.doi.org/10.1101/gr.213363.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378182PMC
April 2017
13 Reads
14.630 Impact Factor

Biobanking: Where Science and Society Meet.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2017 03;21(3):127

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2017.29028.gdeDOI Listing
March 2017
1 Read

The Chinchilla Research Resource Database: resource for an otolaryngology disease model.

Database (Oxford) 2016 12;2016. Epub 2016 May 12.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI, USA Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1093/database/baw073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865329PMC
January 2017
1 Read
3.372 Impact Factor

Polymerase Chain Reaction-Electrospray-Time-of-Flight Mass Spectrometry Versus Culture for Bacterial Detection in Septic Arthritis and Osteoarthritis.

Genet Test Mol Biomarkers 2016 Dec 17;20(12):721-731. Epub 2016 Oct 17.

5 Institute for Molecular Medicine and Infectious Disease, Center for Genomic Sciences, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2016.0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180073PMC
December 2016
11 Reads

Next-Generation Molecular Diagnostics Provide Evidence Suggestive of a Role for Nontraditional Bacterial Pathogens in Osteoarthritis of the Knee.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2016 Dec;20(12):719-720

1 Departments of Microbiology and Immunology, and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2016.29024.gdeDOI Listing
December 2016
1 Read

Complete Genome Sequence of Aggregatibacter actinomycetemcomitans Strain IDH781.

Genome Announc 2016 Nov 10;4(6). Epub 2016 Nov 10.

Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA

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http://dx.doi.org/10.1128/genomeA.01285-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105115PMC
November 2016
5 Reads

Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae.

PLoS One 2016 15;11(3):e0149891. Epub 2016 Mar 15.

Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149891PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792463PMC
July 2016
10 Reads
3.234 Impact Factor

Debunking the Myth of the Genetic Superman.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2016 Jun 26;20(6):273. Epub 2016 May 26.

1 Departments of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2016.29015.gdeDOI Listing
June 2016
2 Reads

The Paradox of Dickkopf-1: Tumor Suppressor and Tumor Enhancer.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2016 Apr 18;20(4):163-4. Epub 2016 Mar 18.

1 Department of Microbiology and Immunology, Head and Neck Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2016.29012.gdeDOI Listing
April 2016
1 Read

Comparative Genomic Analyses of the Moraxella catarrhalis Serosensitive and Seroresistant Lineages Demonstrate Their Independent Evolution.

Genome Biol Evol 2016 Apr 6;8(4):955-74. Epub 2016 Apr 6.

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA

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http://dx.doi.org/10.1093/gbe/evw039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860680PMC
April 2016
28 Reads
4.229 Impact Factor

Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study.

J Urol 2016 Feb 26;195(2):356-62. Epub 2015 Sep 26.

Departments of Microbiology & Immunology and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.juro.2015.09.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770794PMC
February 2016
15 Reads
4.471 Impact Factor

A Potential Role for Aromatase Levels in Coronary Heart Disease.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2016 Jan;20(1)

1 Department of Microbiology and Immunology, Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1089/gtmb.2016.29009.gdeDOI Listing
January 2016
1 Read

MicroRNAs Come of Age in Diagnostics.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2015 Dec 12;19(12):647. Epub 2015 Nov 12.

1 Department of Microbiology and Immunology, Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Diseases, Drexel University College of Medicine , Philadelphia, PA.

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http://dx.doi.org/10.1089/gtmb.2015.29007.gdeDOI Listing
December 2015
1 Read

Developing the Scientific Infrastructure to Produce Ethnogenetically-Specific Personalized Medicine.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2015 Sep 26;19(9):465-6. Epub 2015 Aug 26.

Department of Microbiology and Immunology, Center for Genomic Sciences, Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2015.29003.gdeDOI Listing
September 2015
1 Read

Search for Microorganisms in Men with Urologic Chronic Pelvic Pain Syndrome: A Culture-Independent Analysis in the MAPP Research Network.

J Urol 2015 Jul 14;194(1):127-35. Epub 2015 Jan 14.

Departments of Microbiology & Immunology and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.juro.2015.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475477PMC
July 2015
3 Reads
4.471 Impact Factor

Genetic Stabilization of the Drug-Resistant PMEN1 Pneumococcus Lineage by Its Distinctive DpnIII Restriction-Modification System.

MBio 2015 Jun 16;6(3):e00173. Epub 2015 Jun 16.

Center of Excellence in Biofilm Research, Allegheny Health Network, Pittsburgh, Pennsylvania, USA Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.00173-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471560PMC
June 2015
9 Reads
6.786 Impact Factor

Development and validation of an Haemophilus influenzae supragenome hybridization (SGH) array for transcriptomic analyses.

PLoS One 2014 7;9(10):e105493. Epub 2014 Oct 7.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America; Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America; Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105493PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188559PMC
June 2015
8 Reads
3.234 Impact Factor

Expanding the Scope of our Journal to Include Molecular Diagnostics for Infectious Diseases.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2015 May;19(5):225

Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2015.28999.gdeDOI Listing
May 2015
1 Read

Diagnostics are the vanguard of medicine.

Authors:
Garth D Ehrlich

Genet Test Mol Biomarkers 2015 Apr;19(4):173

Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute of Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel College of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/gtmb.2015.1565DOI Listing
April 2015
6 Reads

Biofilm-based implant infections in orthopaedics.

Adv Exp Med Biol 2015 ;830:29-46

Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Bologna, Italy,

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http://link.springer.com/10.1007/978-3-319-11038-7_2
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http://dx.doi.org/10.1007/978-3-319-11038-7_2DOI Listing
April 2015
8 Reads

The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.

J Invest Dermatol 2015 Mar 20;135(3):718-27. Epub 2014 Oct 20.

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324084PMC
http://dx.doi.org/10.1038/jid.2014.455DOI Listing
March 2015
8 Reads
7.216 Impact Factor

Death and transfiguration in static Staphylococcus epidermidis cultures.

PLoS One 2014 25;9(6):e100002. Epub 2014 Jun 25.

Center for Electron Microscopy and Microanalysis, University of Southern California, Los Angeles, California, and Oak Crest Institute of Science, Pasadena, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100002PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070908PMC
February 2015
9 Reads
3.234 Impact Factor

Streptococcus pneumoniae Supragenome Hybridization Arrays for Profiling of Genetic Content and Gene Expression.

Curr Protoc Microbiol 2015 Feb 2;36:9D.4.1-20. Epub 2015 Feb 2.

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/9780471729259.mc09d04s36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388488PMC
February 2015
6 Reads

Can we trust intraoperative culture results in nonunions?

J Orthop Trauma 2014 Jul;28(7):384-90

*Department of Orthopaedic Surgery, Allegheny General Hospital, Pittsburgh, PA; †Department of Orthopaedic Surgery, Allegheny General Hospital, Drexel University College of Medicine and Temple University School of Medicine, Pittsburgh, PA; ‡Division of Orthopaedic Trauma, Allegheny General Hospital, Pittsburgh, PA; §Department of Orthopaedic Surgery, Temple University School of Medicine, Pittsburgh, PA; ‖Department of Orthopaedic Surgery, Drexel University College of Medicine, Pittsburgh, PA; ¶Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA; **Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA; and ††Penn State University, State College, PA.

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July 2014
5 Reads
1.540 Impact Factor

Virulence potential and genome-wide characterization of drug resistant Streptococcus pneumoniae clones selected in vivo by the 7-valent pneumococcal conjugate vaccine.

PLoS One 2013 19;8(9):e74867. Epub 2013 Sep 19.

Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal ; Laboratory of Microbiology, The Rockefeller University, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777985PMC
June 2014
6 Reads
3.234 Impact Factor

What role do periodontal pathogens play in osteoarthritis and periprosthetic joint infections of the knee?

J Appl Biomater Funct Mater 2014 Jun 12;12(1):13-20. Epub 2014 Jun 12.

3 Department of Otolaryngology, Drexel University College of Medicine, Philadelphia, PA - USA.

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http://dx.doi.org/10.5301/jabfm.5000203DOI Listing
June 2014
3 Reads
0.905 Impact Factor

There is a specific response to pH by isolates of Haemophilus influenzae and this has a direct influence on biofilm formation.

BMC Microbiol 2014 Feb 21;14:47. Epub 2014 Feb 21.

Research Centre for Infectious Diseases, The University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938079PMC
February 2014
1 Read
2.729 Impact Factor

The time is now for gene- and genome-based bacterial diagnostics: "you say you want a revolution".

JAMA Intern Med 2013 Aug;173(15):1405-6

Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania2Departments of Microbiology and Immunology and Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Pittsburgh, Pennsylvania.

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August 2013
2 Reads

The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection.

BMC Infect Dis 2013 May 8;13:210. Epub 2013 May 8.

Department of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654890PMC
May 2013
14 Reads
2.613 Impact Factor

Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection.

PLoS One 2012 6;7(9):e44730. Epub 2012 Sep 6.

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435294PMC
March 2013
7 Reads
3.234 Impact Factor

Bill Costerton: leader as servant.

FEMS Immunol Med Microbiol 2012 Dec;66(3):269-72

Department of Microbial Pathogenesis, Dental School, University of Maryland-Baltimore, Baltimore, MD, USA.

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December 2012
9 Reads
3.078 Impact Factor

Successful identification of pathogens by polymerase chain reaction (PCR)-based electron spray ionization time-of-flight mass spectrometry (ESI-TOF-MS) in culture-negative periprosthetic joint infection.

J Bone Joint Surg Am 2012 Dec;94(24):2247-54

Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA.

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December 2012
2 Reads
5.280 Impact Factor

From Koch's postulates to biofilm theory. The lesson of Bill Costerton.

Int J Artif Organs 2012 Oct;35(10):695-9

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October 2012
3 Reads
1.448 Impact Factor

Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment.

Environ Microbiol 2012 Aug 5;14(8):2200-11. Epub 2012 Jun 5.

Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.

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August 2012
3 Reads
6.201 Impact Factor

Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4.

Environ Microbiol 2011 Dec 27;13(12):3289-309. Epub 2011 Sep 27.

Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences and Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, PA 15212, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228905PMC
December 2011
16 Reads
6.201 Impact Factor

Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods.

J Clin Microbiol 2011 Nov 31;49(11):3812-9. Epub 2011 Aug 31.

Case Western Reserve University, University Hospitals Case Medical Center, Department of Dermatology, Cleveland, OH 44106, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209111PMC
November 2011
3 Reads
3.993 Impact Factor

Orthopaedic biofilm infections.

Curr Orthop Pract 2011 Nov;22(6):558-563

National Centre for Advanced Tribology, University of Southampton, Southampton, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272669PMC
November 2011
15 Reads

Demonstration of Bacillus cereus in orthopaedic-implant-related infection with use of a multi-primer polymerase chain reaction-mass spectrometric assay: report of two cases.

J Bone Joint Surg Am 2011 Aug;93(15):e85

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.

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August 2011
8 Reads
5.280 Impact Factor

Characterization of a mixed MRSA/MRSE biofilm in an explanted total ankle arthroplasty.

FEMS Immunol Med Microbiol 2011 Jun 22;62(1):66-74. Epub 2011 Mar 22.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA.

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June 2011
13 Reads
3.078 Impact Factor

New methods for the detection of orthopedic and other biofilm infections.

FEMS Immunol Med Microbiol 2011 Mar 18;61(2):133-40. Epub 2011 Jan 18.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA, USA.

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March 2011
7 Reads
3.078 Impact Factor

Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates.

BMC Genomics 2011 Jan 26;12:70. Epub 2011 Jan 26.

Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA.

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http://dx.doi.org/10.1186/1471-2164-12-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045334PMC
January 2011
5 Reads
3.986 Impact Factor

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis.

BMC Microbiol 2010 Nov 17;10:294. Epub 2010 Nov 17.

Center for Biofilm Engineering and Department of Chemical and Biological Engineering, PO Box 173980, Montana State University-Bozeman, Bozeman, Montana 59717-3980, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998477PMC
November 2010
3 Reads
2.729 Impact Factor

Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds.

Cell Stress Chaperones 2010 Nov;15(6):819-26

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.

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http://dx.doi.org/10.1007/s12192-010-0190-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024067PMC
November 2010
6 Reads
3.163 Impact Factor

Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluid.

BMC Res Notes 2010 Oct 13;3:259. Epub 2010 Oct 13.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1186/1756-0500-3-259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967558PMC
October 2010
5 Reads

The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes.

FEMS Immunol Med Microbiol 2010 Aug 28;59(3):269-79. Epub 2010 May 28.

Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910629PMC
August 2010
8 Reads
3.078 Impact Factor

Direct demonstration of Staphylococcus biofilm in an external ventricular drain in a patient with a history of recurrent ventriculoperitoneal shunt failure.

Pediatr Neurosurg 2010 Aug 28;46(2):127-32. Epub 2010 Jul 28.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA 15212-4772, USA.

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http://dx.doi.org/10.1159/000319396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939992PMC
August 2010
5 Reads
0.497 Impact Factor

Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa.

Ann Otol Rhinol Laryngol 2010 Apr;119(4):270-8

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee 53226, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910914PMC
http://dx.doi.org/10.1177/000348941011900411DOI Listing
April 2010
7 Reads
1.054 Impact Factor

Pan-genome analysis provides much higher strain typing resolution than multi-locus sequence typing.

Microbiology 2010 Apr 17;156(Pt 4):1060-8. Epub 2009 Dec 17.

Bellingham Research Institute, 218 Chuckanut Point Rd, Bellingham, WA 98229, USA.

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http://dx.doi.org/10.1099/mic.0.035188-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889442PMC
April 2010
1 Read
2.557 Impact Factor

Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility.

PLoS One 2010 Apr 30;5(4):e10063. Epub 2010 Apr 30.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862014PMC
April 2010
5 Reads
3.234 Impact Factor

Expression of receptor for activated C kinase 1 in healing skin and mucosal wounds.

Ann Plast Surg 2010 Feb;64(2):238-41

Wound Healing Program, Center for Genomic Sciences, Allegheny-Singer Research Institute, 320 East North Ave., Pittsburgh, PA 15212, USA.

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http://dx.doi.org/10.1097/SAP.0b013e31819537fcDOI Listing
February 2010
2 Reads
1.458 Impact Factor

Chronic surgical site infection due to suture-associated polymicrobial biofilm.

Surg Infect (Larchmt) 2009 Oct;10(5):457-61

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.

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http://dx.doi.org/10.1089/sur.2008.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956523PMC
October 2009
4 Reads
1.721 Impact Factor

Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages.

J Bacteriol 2009 Aug 5;191(15):4854-62. Epub 2009 Jun 5.

Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1128/JB.01272-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715734PMC
August 2009
2 Reads
2.808 Impact Factor

Biofilm formation by ica-positive and ica-negative strains of Staphylococcus epidermidis in vitro.

Biofouling 2009 ;25(4):367-75

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1080/08927010902803297DOI Listing
May 2009
1 Read
3.415 Impact Factor

Nanoscale structural and mechanical properties of nontypeable Haemophilus influenzae biofilms.

J Bacteriol 2009 Apr 13;191(8):2512-20. Epub 2009 Feb 13.

Center for Nanomedicine, Department of Medicine (Pulmonary and Critical Care Section), University of Chicago, 5841 S Maryland Ave., I-505, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1128/JB.01596-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668387PMC
April 2009
1 Read
2.808 Impact Factor

Gene expression differences in infected and noninfected middle ear complementary DNA libraries.

Arch Otolaryngol Head Neck Surg 2009 Jan;135(1):33-9

Department of Otolaryngology and Communications Disorders, Children's Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1001/archoto.2008.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912141PMC
January 2009
2 Reads
1.748 Impact Factor

Fluorescence "in situ" hybridization for the detection of biofilm in the middle ear and upper respiratory tract mucosa.

Methods Mol Biol 2009 ;493:191-213

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA.

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http://link.springer.com/10.1007/978-1-59745-523-7_12
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http://dx.doi.org/10.1007/978-1-59745-523-7_12DOI Listing
January 2009
18 Reads

Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing.

Cell Stress Chaperones 2008 Dec 9;13(4):527-33. Epub 2008 May 9.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA.

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http://link.springer.com/10.1007/s12192-008-0040-6
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http://dx.doi.org/10.1007/s12192-008-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673928PMC
December 2008
5 Reads
3.163 Impact Factor

What makes pathogens pathogenic.

Genome Biol 2008 24;9(6):225. Epub 2008 Jun 24.

Center for Genomic Sciences, Allegheny General Hospital, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2008-9-6-225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481411PMC
August 2008
2 Reads

Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report.

J Bone Joint Surg Am 2008 Aug;90(8):1751-8

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212-4772, USA.

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https://insights.ovid.com/crossref?an=00004623-200808000-000
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http://dx.doi.org/10.2106/JBJS.G.00838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729478PMC
August 2008
8 Reads
5.280 Impact Factor

Biofilms and chronic infections.

JAMA 2008 Jun;299(22):2682-4

Medical Biofilm Research Institute, 2002 Oxford Ave, Lubbock, TX 79410, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.29
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http://dx.doi.org/10.1001/jama.299.22.2682DOI Listing
June 2008
3 Reads
35.289 Impact Factor

Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's Contracture.

BMC Med Genomics 2008 Apr 23;1:10. Epub 2008 Apr 23.

Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1186/1755-8794-1-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377253PMC
April 2008
5 Reads
2.873 Impact Factor

Population-level virulence factors amongst pathogenic bacteria: relation to infection outcome.

Future Microbiol 2008 Feb;3(1):31-42

Center for Genomic Sciences, Allegheny Singer Research Institute/Allegheny General Hospital, USA.

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http://dx.doi.org/10.2217/17460913.3.1.31DOI Listing
February 2008
2 Reads
4.275 Impact Factor

The role of biofilms in otolaryngologic infections: update 2007.

Curr Opin Otolaryngol Head Neck Surg 2007 Oct;15(5):347-51

Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOO.0b013e3282b97327DOI Listing
October 2007
5 Reads
1.392 Impact Factor

Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media.

BMC Microbiol 2007 Jun 14;7:56. Epub 2007 Jun 14.

Center for Genomic Sciences, Allegheny-Singer Research Institute/Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.

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http://dx.doi.org/10.1186/1471-2180-7-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914350PMC
June 2007
11 Reads
2.729 Impact Factor

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