Garth A Kinberger

Garth A Kinberger

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Garth A Kinberger

Garth A Kinberger

Publications by authors named "Garth A Kinberger"

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Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.

Bioorg Med Chem Lett 2018 12 10;28(23-24):3774-3779. Epub 2018 Oct 10.

Ionis Pharmaceuticals, Inc., 2855 Gazelle Ct., Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2018.10.011DOI Listing
December 2018

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Bioorg Med Chem Lett 2016 08 28;26(15):3690-3. Epub 2016 May 28.

Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.084DOI Listing
August 2016

Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.

J Am Chem Soc 2016 07 12;138(28):8694-7. Epub 2016 Jul 12.

Department of Integrative Computational and Structural Biology, The Scripps Research Institute , La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jacs.6b04454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993527PMC
July 2016

Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Bioorg Med Chem Lett 2016 06 27;26(12):2817-2820. Epub 2016 Apr 27.

Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.04.063DOI Listing
June 2016

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.

Nucleic Acids Res 2016 05 3;44(8):3892-907. Epub 2016 Mar 3.

Department of Core Antisense Research, IONIS Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1093/nar/gkw144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856991PMC
May 2016

A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.

Bioorg Med Chem Lett 2016 May 17;26(9):2194-7. Epub 2016 Mar 17.

Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.03.070DOI Listing
May 2016

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

Bioorg Med Chem Lett 2015 Oct 8;25(19):4127-30. Epub 2015 Aug 8.

Medicinal Chemistry, Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2015.08.019DOI Listing
October 2015

Single-stranded siRNAs activate RNAi in animals.

Cell 2012 Aug;150(5):883-94

Core Antisense Research, Isis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1016/j.cell.2012.08.014DOI Listing
August 2012

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

J Org Chem 2010 Mar;75(5):1569-81

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1896 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jo902560fDOI Listing
March 2010

Facile and efficient assembly of collagen-like triple helices on a TRIS scaffold.

Bioorg Chem 2007 Aug 21;35(4):327-37. Epub 2007 Mar 21.

The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, CA, USA.

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http://dx.doi.org/10.1016/j.bioorg.2007.01.003DOI Listing
August 2007

Fe(III)-binding collagen mimetics.

Inorg Chem 2006 Feb;45(3):961-3

Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/ic0520059DOI Listing
February 2006

Collagen mimetic dendrimers.

J Am Chem Soc 2002 Dec;124(51):15162-3

Department of Chemistry and Biochemistry, University of California - San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1021/ja021203lDOI Listing
December 2002