Publications by authors named "Garry R Smith"

25Publications

Dipeptide Prodrugs of the Glutamate Modulator Riluzole.

ACS Med Chem Lett 2018 Jul 15;9(7):752-756. Epub 2018 Jun 15.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047042PMC
July 2018

Chemokines and 'bath salts': CXCR4 receptor antagonist reduces rewarding and locomotor-stimulant effects of the designer cathinone MDPV in rats.

Drug Alcohol Depend 2018 05 10;186:75-79. Epub 2018 Mar 10.

Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911211PMC
May 2018

Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG).

Psychopharmacology (Berl) 2017 Jun 1;234(11):1671-1681. Epub 2017 Mar 1.

Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s00213-017-4568-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433920PMC
June 2017

High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.

ACS Comb Sci 2016 08 20;18(8):461-74. Epub 2016 Jul 20.

Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acscombsci.6b00033DOI Listing
August 2016

Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.

Neuropharmacology 2016 09 13;108:111-9. Epub 2016 Apr 13.

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, United States; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912874PMC
September 2016

Synthesis of lemonose derivatives: methyl 4-amino-3-O,4-N-carbonyl-2,4,6-trideoxy-3-C-methyl-α-l-lyxo-pyranoside and its phenyl thioglycoside.

Carbohydr Res 2015 May 9;409:63-8. Epub 2015 Apr 9.

Department of Chemistry, Villanova University, Villanova, PA 19085, United States. Electronic address:

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http://dx.doi.org/10.1016/j.carres.2015.03.006DOI Listing
May 2015

Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates.

Neuropharmacology 2015 Apr 9;91:109-16. Epub 2014 Dec 9.

Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418799PMC
April 2015

8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A.

Curr Top Med Chem 2014 ;14(18):2094-102

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.2174/1568026614666141022095114DOI Listing
July 2015

Inhibition of botulinum neurotoxin BoNT/A.

Curr Top Med Chem 2014 ;14(18):2043

Current Topics in Medicinal Chemistry The Scripps Research Institute La Jolla, CA USA.

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http://dx.doi.org/10.2174/1568026614666141022095612DOI Listing
July 2015

Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats.

Br J Pharmacol 2015 Feb 15;172(3):883-94. Epub 2014 Dec 15.

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bph.12951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301696PMC
February 2015

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.

Bioorg Med Chem Lett 2014 Feb 9;24(4):1116-21. Epub 2014 Jan 9.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States.

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http://dx.doi.org/10.1016/j.bmcl.2014.01.001DOI Listing
February 2014

Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.

J Med Chem 2014 Feb 15;57(3):669-76. Epub 2014 Jan 15.

Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jm4012164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983388PMC
February 2014

Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties.

J Mol Neurosci 2014 Mar 26;52(3):446-58. Epub 2013 Nov 26.

Fox Chase Chemical Diversity Center, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA, 18902, USA,

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http://dx.doi.org/10.1007/s12031-013-0180-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945118PMC
March 2014

Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards the β-exosite.

Bioorg Med Chem Lett 2012 Jun 11;22(11):3754-7. Epub 2012 Apr 11.

Fox Chase Chemical Diversity Center, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352981PMC
June 2012

Small molecule anticonvulsant agents with potent in vitro neuroprotection.

J Mol Neurosci 2012 Jun 26;47(2):368-79. Epub 2012 Apr 26.

Advanced Neural Dynamics, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1007/s12031-012-9765-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377984PMC
June 2012

Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors Through Rational Design.

ACS Chem Neurosci 2011 Jun;2(6):288-293

Department of Chemistry and Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://pubs.acs.org/doi/10.1021/cn200021q
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http://dx.doi.org/10.1021/cn200021qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129992PMC
June 2011

Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies.

ARKIVOC 2010 Jun;2010:175-188

Fox Chase Chemical Diversity Center, Inc., Pennsylvania Center for Drug Discovery, Pennsylvania Biotechnology Center, Doylestown, PA 18902 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106444PMC
June 2010

Hit triage using efficiency indices after screening of compound libraries in drug discovery.

Curr Top Med Chem 2009 ;9(18):1718-24

Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.2174/156802609790102365DOI Listing
September 2010

The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008).

Expert Opin Ther Pat 2009 Oct;19(10):1449-53

ALS Biopharma, LLC, 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1517/13543770903185920DOI Listing
October 2009

In vivo canine cardiac electrophysiologic profile of 1,4-benzodiazepine IKs blockers.

J Cardiovasc Pharmacol 2003 Jul;42(1):105-12

Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

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http://dx.doi.org/10.1097/00005344-200307000-00016DOI Listing
July 2003