Garry R Buettner

Garry R Buettner

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Garry R Buettner

Publications by authors named "Garry R Buettner"

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100Publications

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Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Free Radic Biol Med 2018 Aug 22;124:408-419. Epub 2018 Jun 22.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States; Palo Alto Veterans Administration, Palo Alto, CA, United States. Electronic address:

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August 2018

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Redox Biol 2018 Jun 8. Epub 2018 Jun 8.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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June 2018

Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

Free Radic Biol Med 2018 May 27;120:356-367. Epub 2018 Mar 27.

Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA. Electronic address:

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May 2018

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Redox Biol 2018 04 26;14:82-87. Epub 2017 Aug 26.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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April 2018

Redox active metals and HO mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Redox Biol 2018 04 28;14:417-422. Epub 2017 Sep 28.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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April 2018

Pharmacologic ascorbate (P-AscH) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.

Clin Exp Metastasis 2018 Feb 2;35(1-2):37-51. Epub 2018 Feb 2.

Department of Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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February 2018

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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January 2018

Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.

Aging Cell 2017 Oct 31;16(5):1136-1145. Epub 2017 Jul 31.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.

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October 2017

Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy.

PLoS One 2017 20;12(1):e0170442. Epub 2017 Jan 20.

Department of Bioengineering, University of California, Riverside, Riverside, California, United States of America.

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August 2017

Tumor cells have decreased ability to metabolize HO: Implications for pharmacological ascorbate in cancer therapy.

Redox Biol 2016 12 28;10:274-284. Epub 2016 Oct 28.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA; Free Radical & Radiation Biology Program in the Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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December 2016

Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma.

Redox Biol 2016 08 13;8:298-304. Epub 2016 Feb 13.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, B180 Medical Laboratories, The University of Iowa, Iowa City, IA 52242-1181, United States. Electronic address:

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August 2016

Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite.

Chem Res Toxicol 2016 07 15;29(7):1098-107. Epub 2016 Jun 15.

Department of Pharmaceutical Sciences and Experimental Therapeutics, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa , 115 South Grand Avenue, Iowa City, Iowa 52242-1112, United States.

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July 2016

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

PLoS One 2015 14;10(7):e0132572. Epub 2015 Jul 14.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, Iowa, 52242, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, 52242, United States of America.

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May 2016

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

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February 2016

Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids.

Environ Sci Pollut Res Int 2016 Feb 23;23(3):2138-47. Epub 2015 Sep 23.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, 100 Oakdale Campus, Iowa, IA, 52242, USA.

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February 2016

Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol.

Environ Sci Technol 2015 Dec 16;49(24):14120-8. Epub 2015 Nov 16.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology , Linggong Road 2, Dalian 116024, China.

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December 2015

In vivo imaging of free radicals produced by multivitamin-mineral supplements.

BMC Nutr 2015 Dec 14;1. Epub 2015 Nov 14.

Noxygen Science Transfer & Diagnostics GmbH, Elzach, Germany.

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December 2015

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

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August 2015

Role of labile iron in the toxicity of pharmacological ascorbate.

Free Radic Biol Med 2015 Jul 7;84:289-295. Epub 2015 Apr 7.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA, USA; Veterans Affairs Medical Center, Iowa City, IA, USA. Electronic address:

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July 2015

Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

Free Radic Biol Med 2015 Jun 26;83:227-37. Epub 2015 Feb 26.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

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June 2015

Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.

Redox Biol 2013 26;2:22-7. Epub 2013 Nov 26.

Free Radical and Radiation Biology Program and ESR Facility, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA ; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA, USA.

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March 2015

Moving free radical and redox biology ahead in the next decade(s).

Authors:
Garry R Buettner

Free Radic Biol Med 2015 Jan 4;78:236-8. Epub 2014 Nov 4.

Free Radical and Radiation Biology, Department of Radiation Oncology and ESR Facility, College of Medicine, The University of Iowa, Iowa City, IA52242-1181, USA. Electronic address:

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January 2015

Heritability of glutathione and related metabolites in stored red blood cells.

Free Radic Biol Med 2014 Nov 7;76:107-13. Epub 2014 Aug 7.

Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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November 2014

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Free Radic Biol Med 2014 Nov 22;76:163-172. Epub 2014 Aug 22.

Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.

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November 2014

Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer.

Free Radic Biol Med 2014 Apr 7;69:357-66. Epub 2014 Feb 7.

Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

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April 2014

The concentration of glutathione in human erythrocytes is a heritable trait.

Free Radic Biol Med 2013 Dec 9;65:742-749. Epub 2013 Aug 9.

Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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December 2013

Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment.

Cell Biochem Biophys 2013 Nov;67(2):477-83

Free Radical and Radiation Biology & ESR Facility, Med Labs B180, The University of Iowa, Iowa City, IA, 52242-1181, USA,

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November 2013

Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

Cancer Res 2013 Aug 13;73(16):5232-41. Epub 2013 Jun 13.

Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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August 2013

Regulation of pancreatic cancer growth by superoxide.

Mol Carcinog 2013 Jul 5;52(7):555-67. Epub 2012 Mar 5.

Departments of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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July 2013

An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells.

Redox Biol 2013 ;1(1):210-217

The University of Iowa, Free Radical and Radiation Biology Program & ESR Facility, Iowa City, IA 52242-1181, USA.

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January 2013

Ascorbic acid: chemistry, biology and the treatment of cancer.

Biochim Biophys Acta 2012 Dec 20;1826(2):443-57. Epub 2012 Jun 20.

Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA.

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December 2012

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

Cancer Res 2012 Aug 18;72(15):3807-16. Epub 2012 Jun 18.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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August 2012

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase.

Biochem J 2012 Jun;444(3):515-27

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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June 2012

Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.

J Pediatr Gastroenterol Nutr 2012 Apr;54(4):471-6

Department of Pediatrics, University of Iowa Carver College of Medicine,200 Hawkins Dr, Iowa City, IA 52242, USA.

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April 2012

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan.

Age (Dordr) 2012 Feb 8;34(1):95-109. Epub 2011 Mar 8.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

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February 2012

The rate of oxygen utilization by cells.

Free Radic Biol Med 2011 Aug 27;51(3):700-12. Epub 2011 May 27.

Free Radical and Radiation Biology Program and ESR Facility, The University of Iowa, Iowa City, IA 52242–1181, USA.

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August 2011

Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.

J Biol Chem 2011 Jul 3;286(30):26978-86. Epub 2011 Jun 3.

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242-1112, USA.

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July 2011

Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance.

Free Radic Biol Med 2011 Jun 1;50(12):1726-7. Epub 2011 Apr 1.

Free Radical and Radiation Biology Graduate Program, Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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June 2011

Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide.

Authors:
Garry R Buettner

Anticancer Agents Med Chem 2011 May;11(4):341-6

Free Radical and Radiation Biology, The University of Iowa, Iowa City, 52242-1181, USA.

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May 2011

Introduction to the symposium-in-print: photobiology of the skin and eye in memory of Colin F. Chignell.

Photochem Photobiol 2010 Jul-Aug;86(4):740-1

Department of Natural Sciences, Fordham University, New York City, NY, USA.

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January 2011

Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2.

Chemosphere 2010 Dec 16;81(11):1501-8. Epub 2010 Sep 16.

Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, Iowa City, IA 52242-5000, USA.

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December 2010

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements.

Nutr J 2010 Nov 23;9:61. Epub 2010 Nov 23.

Research & Technology Development, Melaleuca Inc, Idaho Falls, ID 83402, USA.

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November 2010

Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide.

Free Radic Biol Med 2010 Sep 21;49(6):919-62. Epub 2010 May 21.

College of Pharmaceutical Sciences, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Southwest University, Chongqing, 400715, People's Republic of China.

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September 2010

Free radicals produced by the oxidation of gallic acid: An electron paramagnetic resonance study.

Chem Cent J 2010 Aug 5;4:15. Epub 2010 Aug 5.

Free Radical and Radiation Biology, Med Labs B180, The University of Iowa, Iowa City, IA 52242-1181, USA.

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August 2010

Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study.

Carbohydr Res 2010 Jan 2;345(1):132-40. Epub 2009 Oct 2.

The Department of Applied Radiation and Isotopes, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

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January 2010

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.

Clin Cancer Res 2010 Jan 12;16(2):509-20. Epub 2010 Jan 12.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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January 2010

Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha.

Antioxid Redox Signal 2009 Jun;11(6):1249-63

Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.

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June 2009

Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones.

Proc Natl Acad Sci U S A 2009 Jun 2;106(24):9725-30. Epub 2009 Jun 2.

Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242-5000, USA.

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June 2009

UVA/B-induced formation of free radicals from decabromodiphenyl ether.

Environ Sci Technol 2009 Apr;43(7):2581-8

Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, Free Radical and Radiation Biology Program, ESR Facility, and Hygienic Laboratory, The University of Iowa, Iowa City, Iowa 52242, USA.

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April 2009

Aging augments mitochondrial susceptibility to heat stress.

Am J Physiol Regul Integr Comp Physiol 2009 Mar 14;296(3):R812-20. Epub 2009 Jan 14.

Dept. of Integrative Physiology, The Univ. of Iowa, Iowa City, 52242, USA.

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March 2009

Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones.

J Org Chem 2008 Nov 8;73(21):8296-304. Epub 2008 Oct 8.

Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, Iowa 52242-5000, USA.

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November 2008

Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells.

Free Radic Biol Med 2008 Oct 22;45(8):1094-102. Epub 2008 Jul 22.

Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

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October 2008

Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies.

Chem Res Toxicol 2008 Jul 13;21(7):1359-67. Epub 2008 Jun 13.

Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242-1101, USA.

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July 2008

Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury.

Am J Physiol Regul Integr Comp Physiol 2008 Apr 13;294(4):R1165-74. Epub 2008 Feb 13.

Department of Integrative Physiology, The University of Iowa, Iowa City, IA, USA.

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April 2008

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide.

Cancer Res 2008 Apr;68(8):2781-8

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242-1181, USA.

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April 2008

The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrations.

Free Radic Res 2007 Nov;41(11):1201-11

Bioengineering Department, University of California, Riverside, CA 92521, USA.

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November 2007

A simple and sensitive assay for ascorbate using a plate reader.

Anal Biochem 2007 Jun 7;365(1):31-9. Epub 2007 Mar 7.

ESR Facility and Free Radical and Radiation Biology, University of Iowa, Iowa City, IA 52242, USA.

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June 2007

Inactivation of anthracyclines by serum heme proteins.

Chem Res Toxicol 2007 Jun 12;20(6):920-6. Epub 2007 May 12.

Department of Internal Medicine, University of Iowa, USA.

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June 2007

Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes.

Am J Physiol Cell Physiol 2007 May 10;292(5):C1906-14. Epub 2007 Jan 10.

The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.

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May 2007

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Proc Natl Acad Sci U S A 2007 May 14;104(21):8749-54. Epub 2007 May 14.

Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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May 2007

Ascorbate reacts with singlet oxygen to produce hydrogen peroxide.

Photochem Photobiol 2006 Nov-Dec;82(6):1634-7

Free Radical and Radiation Biology and The University of Iowa, Iowa City, IA, USA.

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April 2007

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

Antioxid Redox Signal 2006 Jul-Aug;8(7-8):1307-14

Free Radical and Radiation Biology Graduate Program, Department of Radiation Oncology, The University of Iowa, Iowa City, 52242, USA.

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October 2006

A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state.

Free Radic Biol Med 2006 Oct 21;41(8):1338-50. Epub 2006 Jul 21.

Free Radical and Radiation Biology Program, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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October 2006

Nitric oxide decreases the stability of DMPO spin adducts.

Nitric Oxide 2006 Sep 2;15(2):133-41. Epub 2006 May 2.

VA Medical Center-Cincinnati, OH, USA.

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September 2006

Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells.

Free Radic Biol Med 2006 May 19;40(9):1615-27. Epub 2006 Jan 19.

Free Radical and Radiation Biology & ESR Facility, EMRB 68, University of Iowa, Iowa City, IA 52242-1101, USA.

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May 2006

Nitric oxide as a cellular antioxidant: a little goes a long way.

Free Radic Biol Med 2006 Feb 15;40(3):501-6. Epub 2005 Nov 15.

Free Radical and Radiation Biology & ESR Facility, The University of Iowa, Iowa City, IA 52242-1101, USA.

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February 2006

Commentary on "Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation".

Authors:
Garry R Buettner

Free Radic Biol Med 2006 Feb 9;40(4):555-6. Epub 2006 Jan 9.

Free Radical and Radiation Biology, Department of Radiation Oncology, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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February 2006

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Oncogene 2005 Dec;24(55):8154-66

Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.

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December 2005

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

Proc Natl Acad Sci U S A 2005 Sep 12;102(38):13604-9. Epub 2005 Sep 12.

Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2005

Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells.

Arch Biochem Biophys 2005 Aug;440(2):181-90

Department of Medicine, The University of Iowa Carver College of Medicine and Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA.

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August 2005

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

J Biol Chem 2005 Feb 23;280(6):4254-63. Epub 2004 Nov 23.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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February 2005

Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia.

Free Radic Res 2004 Oct;38(10):1119-32

Department of Radiation Oncology, Free Radical and Radiation Biology Program, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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October 2004

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages.

Am J Respir Cell Mol Biol 2004 Jul 12;31(1):43-53. Epub 2004 Feb 12.

Department of Medicine, University of Iowa Roy J. and Lucille A Carver College of Medicine, Iowa City Veterans Administration medical Center, Iowa City, IA 52242, USA.

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July 2004

Detection of lipid radicals using EPR.

Antioxid Redox Signal 2004 Jun;6(3):631-8

Free Radical and Radiation Biology & ESR Facility, The University of Iowa, Iowa City, IA 52242-1101, USA.

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June 2004

Endogenous production and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts.

Nitric Oxide 2004 May;10(3):119-29

Department of Medicine, The University of Iowa Carver College of Medicine and The University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA.

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May 2004

The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion.

Resuscitation 2003 Dec;59(3):345-52

The Cardiovascular Center, Department of Internal Medicine, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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December 2003

L-PhGPx expression can be suppressed by antisense oligodeoxynucleotides.

Arch Biochem Biophys 2003 Sep;417(2):212-8

Free Radical and Radiation Biology, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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September 2003

Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle.

Free Radic Res 2003 Jun;37(6):621-30

Free Radical and Radiation Biology and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1101, USA.

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June 2003

Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice.

Free Radic Biol Med 2003 May;34(9):1153-66

Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.

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May 2003

Free radical and drug oxidation products in an intensive care unit sedative: propofol with sulfite.

Crit Care Med 2003 Mar;31(3):787-92

Department of Anesthesia, University of Iowa, Iowa City, USA.

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March 2003

In vivo detection of transition metals and nitrosyl-heme complexes using ex vivo electron paramagnetic resonance spectroscopy.

Methods Mol Biol 2002 ;196:211-9

Department of Exercise Science, University of Iowa, Iowa City, IA, USA.

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February 2003

Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks.

Resuscitation 2003 Feb;56(2):199-206

Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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February 2003

Electron paramagnetic resonance for quantitation of nitric oxide in aqueous solutions.

Methods Enzymol 2002 ;359:3-18

University of Iowa, Iowa City, Iowa 52242, USA.

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January 2003

Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products.

Pediatr Res 2002 Dec;52(6):964-72

Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA.

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December 2002

Comparing beta-carotene, vitamin E and nitric oxide as membrane antioxidants.

Biol Chem 2002 Mar-Apr;383(3-4):671-81

Free Radical and Radiation Biology and ESR Facility, The University of Iowa, Iowa City 52242-1101, USA.

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November 2002

Role of nitric oxide and membrane phospholipid polyunsaturation in oxidative cell death.

Subcell Biochem 2002 ;36:97-121

Department of Medicine, University of Iowa College of Medicine, Iowa City, IA, USA.

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July 2002

Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism.

Am J Physiol Cell Physiol 2002 Jul;283(1):C273-81

Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA.

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July 2002