Publications by authors named "Garry R Buettner"

100Publications

Understanding the Redox Biology of Selenium in the Search of Targeted Cancer Therapies.

Antioxidants (Basel) 2020 May 13;9(5). Epub 2020 May 13.

Department of Internal Medicine, Division of Medical Oncology and Hematology, The University of Iowa Hospital and Clinics. Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/antiox9050420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278812PMC
May 2020

Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments.

Redox Biol 2020 05 29;32:101518. Epub 2020 Mar 29.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, 52242, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2020.101518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150527PMC
May 2020

Response to Ling et al. regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses".

Radiother Oncol 2020 Jun 25;147:241-242. Epub 2020 Mar 25.

Department of Radiation Oncology, University of California, Irvine, United States.

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http://dx.doi.org/10.1016/j.radonc.2020.03.001DOI Listing
June 2020

Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.

Free Radic Biol Med 2020 04 4;150:1-11. Epub 2020 Feb 4.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.01.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299833PMC
April 2020

Hydrogen Peroxide Mediates Artemisinin-Derived C-16 Carba-Dimer-Induced Toxicity of Human Cancer Cells.

Antioxidants (Basel) 2020 Jan 26;9(2). Epub 2020 Jan 26.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/antiox9020108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070254PMC
January 2020

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Cancers (Basel) 2019 Jul 30;11(8). Epub 2019 Jul 30.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Free Radical Metabolism and Imaging Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/cancers11081077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721799PMC
July 2019

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.

Redox Biol 2019 02 26;21:101091. Epub 2018 Dec 26.

Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183094
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http://dx.doi.org/10.1016/j.redox.2018.101091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327911PMC
February 2019

Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

The University of Iowa Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/ijms20010225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337472PMC
January 2019

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue.

Semin Radiat Oncol 2019 01;29(1):25-32

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA; Department of Surgery, Iowa City, IA; University of Iowa Carver College of Medicine, Iowa City, IA; The Holden Comprehensive Cancer Center, Iowa City, IA; Veterans Affairs Medical Center, Iowa City, IA. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310038PMC
January 2019

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Free Radic Biol Med 2018 08 22;124:408-419. Epub 2018 Jun 22.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States; Palo Alto Veterans Administration, Palo Alto, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233711PMC
August 2018

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Redox Biol 2020 Jan 8;28:100935. Epub 2018 Jun 8.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183048
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http://dx.doi.org/10.1016/j.redox.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920117PMC
January 2020

Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

Free Radic Biol Med 2018 05 27;120:356-367. Epub 2018 Mar 27.

Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160292PMC
May 2018

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/antiox7010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789328PMC
January 2018

Redox active metals and HO mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Redox Biol 2018 04 28;14:417-422. Epub 2017 Sep 28.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173058
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http://dx.doi.org/10.1016/j.redox.2017.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651553PMC
April 2018

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Redox Biol 2018 04 26;14:82-87. Epub 2017 Aug 26.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173064
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http://dx.doi.org/10.1016/j.redox.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591450PMC
April 2018

Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.

Aging Cell 2017 10 31;16(5):1136-1145. Epub 2017 Jul 31.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1111/acel.12649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595680PMC
October 2017

Tumor cells have decreased ability to metabolize HO: Implications for pharmacological ascorbate in cancer therapy.

Redox Biol 2016 12 28;10:274-284. Epub 2016 Oct 28.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA; Free Radical & Radiation Biology Program in the Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317163026
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http://dx.doi.org/10.1016/j.redox.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106370PMC
December 2016

Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite.

Chem Res Toxicol 2016 07 15;29(7):1098-107. Epub 2016 Jun 15.

Department of Pharmaceutical Sciences and Experimental Therapeutics, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa , 115 South Grand Avenue, Iowa City, Iowa 52242-1112, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248556PMC
July 2016

Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma.

Redox Biol 2016 08 13;8:298-304. Epub 2016 Feb 13.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, B180 Medical Laboratories, The University of Iowa, Iowa City, IA 52242-1181, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776628PMC
August 2016

In vivo imaging of free radicals produced by multivitamin-mineral supplements.

BMC Nutr 2015 Dec 14;1. Epub 2015 Nov 14.

Noxygen Science Transfer & Diagnostics GmbH, Elzach, Germany.

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http://dx.doi.org/10.1186/s40795-015-0025-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687973PMC
December 2015

Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol.

Environ Sci Technol 2015 Dec 16;49(24):14120-8. Epub 2015 Nov 16.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology , Linggong Road 2, Dalian 116024, China.

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http://dx.doi.org/10.1021/acs.est.5b03637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717839PMC
December 2015

Breaking the dogma: PCB-derived semiquinone free radicals do not form covalent adducts with DNA, GSH, and amino acids.

Environ Sci Pollut Res Int 2016 Feb 23;23(3):2138-47. Epub 2015 Sep 23.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, 100 Oakdale Campus, Iowa, IA, 52242, USA.

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http://dx.doi.org/10.1007/s11356-015-5007-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767158PMC
February 2016

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

PLoS One 2015 14;10(7):e0132572. Epub 2015 Jul 14.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, Iowa, 52242, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, 52242, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501792PMC
May 2016

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537815PMC
August 2015

Role of labile iron in the toxicity of pharmacological ascorbate.

Free Radic Biol Med 2015 Jul 7;84:289-295. Epub 2015 Apr 7.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA, USA; Veterans Affairs Medical Center, Iowa City, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739508PMC
July 2015

Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

Free Radic Biol Med 2015 Jun 26;83:227-37. Epub 2015 Feb 26.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441864PMC
June 2015

Moving free radical and redox biology ahead in the next decade(s).

Authors:
Garry R Buettner

Free Radic Biol Med 2015 Jan 4;78:236-8. Epub 2014 Nov 4.

Free Radical and Radiation Biology, Department of Radiation Oncology and ESR Facility, College of Medicine, The University of Iowa, Iowa City, IA52242-1181, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331124PMC
January 2015

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

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http://dx.doi.org/10.1007/s00204-014-1407-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441874PMC
February 2016

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Free Radic Biol Med 2014 Nov 22;76:163-172. Epub 2014 Aug 22.

Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364304PMC
November 2014

Heritability of glutathione and related metabolites in stored red blood cells.

Free Radic Biol Med 2014 Nov 7;76:107-13. Epub 2014 Aug 7.

Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252477PMC
November 2014

Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer.

Free Radic Biol Med 2014 Apr 7;69:357-66. Epub 2014 Feb 7.

Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981470PMC
April 2014

Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.

Redox Biol 2013 26;2:22-7. Epub 2013 Nov 26.

Free Radical and Radiation Biology Program and ESR Facility, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA ; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1016/j.redox.2013.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881203PMC
March 2015

The concentration of glutathione in human erythrocytes is a heritable trait.

Free Radic Biol Med 2013 Dec 9;65:742-749. Epub 2013 Aug 9.

Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859832PMC
December 2013

An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells.

Redox Biol 2013 ;1(1):210-217

The University of Iowa, Free Radical and Radiation Biology Program & ESR Facility, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1016/j.redox.2013.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736862PMC
January 2013

Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

Cancer Res 2013 Aug 13;73(16):5232-41. Epub 2013 Jun 13.

Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745518PMC
August 2013

Ascorbic acid: chemistry, biology and the treatment of cancer.

Biochim Biophys Acta 2012 Dec 20;1826(2):443-57. Epub 2012 Jun 20.

Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA, USA.

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http://dx.doi.org/10.1016/j.bbcan.2012.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608474PMC
December 2012

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

Cancer Res 2012 Aug 18;72(15):3807-16. Epub 2012 Jun 18.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429130PMC
August 2012

Regulation of pancreatic cancer growth by superoxide.

Mol Carcinog 2013 Jul 5;52(7):555-67. Epub 2012 Mar 5.

Departments of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1002/mc.21891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375391PMC
July 2013

Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment.

Cell Biochem Biophys 2013 Nov;67(2):477-83

Free Radical and Radiation Biology & ESR Facility, Med Labs B180, The University of Iowa, Iowa City, IA, 52242-1181, USA,

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http://dx.doi.org/10.1007/s12013-011-9320-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661692PMC
November 2013

Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.

J Pediatr Gastroenterol Nutr 2012 Apr;54(4):471-6

Department of Pediatrics, University of Iowa Carver College of Medicine,200 Hawkins Dr, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1097/MPG.0b013e3182334fdfDOI Listing
April 2012

The rate of oxygen utilization by cells.

Free Radic Biol Med 2011 Aug 27;51(3):700-12. Epub 2011 May 27.

Free Radical and Radiation Biology Program and ESR Facility, The University of Iowa, Iowa City, IA 52242–1181, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147247PMC
August 2011

Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.

J Biol Chem 2011 Jul 3;286(30):26978-86. Epub 2011 Jun 3.

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242-1112, USA.

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http://dx.doi.org/10.1074/jbc.M111.249532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143656PMC
July 2011

Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance.

Free Radic Biol Med 2011 Jun 1;50(12):1726-7. Epub 2011 Apr 1.

Free Radical and Radiation Biology Graduate Program, Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128375PMC
June 2011

Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide.

Authors:
Garry R Buettner

Anticancer Agents Med Chem 2011 May;11(4):341-6

Free Radical and Radiation Biology, The University of Iowa, Iowa City, 52242-1181, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131414PMC
http://dx.doi.org/10.2174/187152011795677544DOI Listing
May 2011

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan.

Age (Dordr) 2012 Feb 8;34(1):95-109. Epub 2011 Mar 8.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs11357-011-92
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http://link.springer.com/10.1007/s11357-011-9223-7
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http://dx.doi.org/10.1007/s11357-011-9223-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260369PMC
February 2012

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements.

Nutr J 2010 Nov 23;9:61. Epub 2010 Nov 23.

Research & Technology Development, Melaleuca Inc, Idaho Falls, ID 83402, USA.

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http://dx.doi.org/10.1186/1475-2891-9-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002910PMC
November 2010

Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2.

Chemosphere 2010 Dec 16;81(11):1501-8. Epub 2010 Sep 16.

Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, Iowa City, IA 52242-5000, USA.

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http://dx.doi.org/10.1016/j.chemosphere.2010.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622869PMC
December 2010

Free radicals produced by the oxidation of gallic acid: An electron paramagnetic resonance study.

Chem Cent J 2010 Aug 5;4:15. Epub 2010 Aug 5.

Free Radical and Radiation Biology, Med Labs B180, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://ccj.springeropen.com/articles/10.1186/1752-153X-4-15
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http://dx.doi.org/10.1186/1752-153X-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924338PMC
August 2010

Introduction to the symposium-in-print: photobiology of the skin and eye in memory of Colin F. Chignell.

Photochem Photobiol 2010 Jul-Aug;86(4):740-1

Department of Natural Sciences, Fordham University, New York City, NY, USA.

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http://dx.doi.org/10.1111/j.1751-1097.2010.00784.xDOI Listing
January 2011

Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide.

Free Radic Biol Med 2010 Sep 21;49(6):919-62. Epub 2010 May 21.

College of Pharmaceutical Sciences, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, Southwest University, Chongqing, 400715, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936108PMC
September 2010

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.

Clin Cancer Res 2010 Jan 12;16(2):509-20. Epub 2010 Jan 12.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807999PMC
January 2010

Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study.

Carbohydr Res 2010 Jan 2;345(1):132-40. Epub 2009 Oct 2.

The Department of Applied Radiation and Isotopes, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

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http://dx.doi.org/10.1016/j.carres.2009.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695485PMC
January 2010

Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones.

Proc Natl Acad Sci U S A 2009 Jun 2;106(24):9725-30. Epub 2009 Jun 2.

Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242-5000, USA.

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http://dx.doi.org/10.1073/pnas.0810352106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689812PMC
June 2009

UVA/B-induced formation of free radicals from decabromodiphenyl ether.

Environ Sci Technol 2009 Apr;43(7):2581-8

Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, Free Radical and Radiation Biology Program, ESR Facility, and Hygienic Laboratory, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1021/es8022978DOI Listing
April 2009

Aging augments mitochondrial susceptibility to heat stress.

Am J Physiol Regul Integr Comp Physiol 2009 Mar 14;296(3):R812-20. Epub 2009 Jan 14.

Dept. of Integrative Physiology, The Univ. of Iowa, Iowa City, 52242, USA.

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http://dx.doi.org/10.1152/ajpregu.90708.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665848PMC
March 2009

Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha.

Antioxid Redox Signal 2009 Jun;11(6):1249-63

Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1089/ars.2008.2407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842115PMC
June 2009

Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones.

J Org Chem 2008 Nov 8;73(21):8296-304. Epub 2008 Oct 8.

Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, Iowa 52242-5000, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629131PMC
November 2008

Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells.

Free Radic Biol Med 2008 Oct 22;45(8):1094-102. Epub 2008 Jul 22.

Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614346PMC
October 2008

Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies.

Chem Res Toxicol 2008 Jul 13;21(7):1359-67. Epub 2008 Jun 13.

Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242-1101, USA.

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http://dx.doi.org/10.1021/tx8000175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740386PMC
July 2008

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide.

Cancer Res 2008 Apr;68(8):2781-8

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633869PMC
April 2008

Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury.

Am J Physiol Regul Integr Comp Physiol 2008 Apr 13;294(4):R1165-74. Epub 2008 Feb 13.

Department of Integrative Physiology, The University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1152/ajpregu.00719.2007DOI Listing
April 2008

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Proc Natl Acad Sci U S A 2007 May 14;104(21):8749-54. Epub 2007 May 14.

Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0702854104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885574PMC
May 2007

Inactivation of anthracyclines by serum heme proteins.

Chem Res Toxicol 2007 Jun 12;20(6):920-6. Epub 2007 May 12.

Department of Internal Medicine, University of Iowa, USA.

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http://dx.doi.org/10.1021/tx700002fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617216PMC
June 2007

A simple and sensitive assay for ascorbate using a plate reader.

Anal Biochem 2007 Jun 7;365(1):31-9. Epub 2007 Mar 7.

ESR Facility and Free Radical and Radiation Biology, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.ab.2007.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129083PMC
June 2007

Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes.

Am J Physiol Cell Physiol 2007 May 10;292(5):C1906-14. Epub 2007 Jan 10.

The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1152/ajpcell.00550.2006DOI Listing
May 2007

A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state.

Free Radic Biol Med 2006 Oct 21;41(8):1338-50. Epub 2006 Jul 21.

Free Radical and Radiation Biology Program, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443724PMC
October 2006

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

Antioxid Redox Signal 2006 Jul-Aug;8(7-8):1307-14

Free Radical and Radiation Biology Graduate Program, Department of Radiation Oncology, The University of Iowa, Iowa City, 52242, USA.

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http://dx.doi.org/10.1089/ars.2006.8.1307DOI Listing
October 2006

Ascorbate reacts with singlet oxygen to produce hydrogen peroxide.

Photochem Photobiol 2006 Nov-Dec;82(6):1634-7

Free Radical and Radiation Biology and The University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1562/2006-01-12-RN-774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147043PMC
April 2007

Nitric oxide decreases the stability of DMPO spin adducts.

Nitric Oxide 2006 Sep 2;15(2):133-41. Epub 2006 May 2.

VA Medical Center-Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.niox.2006.03.004DOI Listing
September 2006

Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells.

Free Radic Biol Med 2006 May 19;40(9):1615-27. Epub 2006 Jan 19.

Free Radical and Radiation Biology & ESR Facility, EMRB 68, University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626188PMC
May 2006

Commentary on "Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation".

Authors:
Garry R Buettner

Free Radic Biol Med 2006 Feb 9;40(4):555-6. Epub 2006 Jan 9.

Free Radical and Radiation Biology, Department of Radiation Oncology, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2324064PMC
February 2006

Nitric oxide as a cellular antioxidant: a little goes a long way.

Free Radic Biol Med 2006 Feb 15;40(3):501-6. Epub 2005 Nov 15.

Free Radical and Radiation Biology & ESR Facility, The University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258411PMC
February 2006

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Oncogene 2005 Dec;24(55):8154-66

Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1038/sj.onc.1208986DOI Listing
December 2005