Publications by authors named "Garry R Buettner"

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Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].
Redox Biol 2018 Jun 8. Epub 2018 Jun 8.
Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.
Redox Biol 2018 Apr 26;14:82-87. Epub 2017 Aug 26.
Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Redox active metals and HO mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.
Redox Biol 2018 Apr 28;14:417-422. Epub 2017 Sep 28.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Pharmacologic ascorbate (P-AscH) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.
Clin Exp Metastasis 2018 Feb 2;35(1-2):37-51. Epub 2018 Feb 2.
Department of Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.
Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.
Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.
Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

Monohydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) and Dihydroxylated Polybrominated Biphenyls (Di-OH-PBBs): Novel Photoproducts of 2,6-Dibromophenol.
Environ Sci Technol 2015 Dec 16;49(24):14120-8. Epub 2015 Nov 16.
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology , Linggong Road 2, Dalian 116024, China.

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.
Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

Role of labile iron in the toxicity of pharmacological ascorbate.
Free Radic Biol Med 2015 Jul 7;84:289-295. Epub 2015 Apr 7.
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA, USA; Veterans Affairs Medical Center, Iowa City, IA, USA. Electronic address:


Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.
Free Radic Biol Med 2015 Jun 26;83:227-37. Epub 2015 Feb 26.
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:


Heritability of glutathione and related metabolites in stored red blood cells.
Free Radic Biol Med 2014 Nov 7;76:107-13. Epub 2014 Aug 7.
Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:


Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer.
Free Radic Biol Med 2014 Apr 7;69:357-66. Epub 2014 Feb 7.
Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, The University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:


UVA/B-induced formation of free radicals from decabromodiphenyl ether.
Environ Sci Technol 2009 Apr;43(7):2581-8
Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, Free Radical and Radiation Biology Program, ESR Facility, and Hygienic Laboratory, The University of Iowa, Iowa City, Iowa 52242, USA.

Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells.
Free Radic Biol Med 2008 Oct 22;45(8):1094-102. Epub 2008 Jul 22.
Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proc Natl Acad Sci U S A 2007 May 14;104(21):8749-54. Epub 2007 May 14.
Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.
Oncogene 2005 Dec;24(55):8154-66
Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Proc Natl Acad Sci U S A 2005 Sep 12;102(38):13604-9. Epub 2005 Sep 12.
Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.
J Biol Chem 2005 Feb 23;280(6):4254-63. Epub 2004 Nov 23.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages.
Am J Respir Cell Mol Biol 2004 Jul 12;31(1):43-53. Epub 2004 Feb 12.
Department of Medicine, University of Iowa Roy J. and Lucille A Carver College of Medicine, Iowa City Veterans Administration medical Center, Iowa City, IA 52242, USA.

The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion.
Resuscitation 2003 Dec;59(3):345-52
The Cardiovascular Center, Department of Internal Medicine, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.
PLoS One 2015 14;10(7):e0132572. Epub 2015 Jul 14.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, Iowa, 52242, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, 52242, United States of America.

Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite.
Chem Res Toxicol 2016 07 15;29(7):1098-107. Epub 2016 Jun 15.
Department of Pharmaceutical Sciences and Experimental Therapeutics, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa , 115 South Grand Avenue, Iowa City, Iowa 52242-1112, United States.

Tumor cells have decreased ability to metabolize HO: Implications for pharmacological ascorbate in cancer therapy.
Redox Biol 2016 12 28;10:274-284. Epub 2016 Oct 28.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA; Free Radical & Radiation Biology Program in the Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:



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