Publications by authors named "Garrett M Frampton"

87Publications

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers.

Mol Cancer Ther 2020 Oct 3;19(10):2139-2145. Epub 2020 Aug 3.

Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, Department of Medicine, University of California, Moores Cancer Center, La Jolla, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-20-0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541603PMC
October 2020

Genomic Profiling of Prostate Cancers from Men with African and European Ancestry.

Clin Cancer Res 2020 Sep 10;26(17):4651-4660. Epub 2020 Jul 10.

Division of Hematology/Oncology, Department of Medicine; Helen Diller Family Comprehensive Cancer Center; Bakar Computational Health Sciences Institute; Institute for Human Genetics; San Francisco Veterans Affairs Medical Center; University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-4112DOI Listing
September 2020

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.

Cancer Cell 2020 May;37(5):639-654.e6

The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328015PMC
May 2020

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.

PLoS One 2020 6;15(5):e0231999. Epub 2020 May 6.

Department of Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202592PMC
July 2020

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

Microsatellite-Stable Tumors with High Mutational Burden Benefit from Immunotherapy.

Cancer Immunol Res 2019 10 12;7(10):1570-1573. Epub 2019 Aug 12.

University of California San Diego Moores Cancer Center, La Jolla, California.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774837PMC
October 2019

Pan-Cancer Analysis of Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype.

Oncologist 2019 12 10;24(12):1526-1533. Epub 2019 Jul 10.

Johns Hopkins University School of Medicine and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA

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http://dx.doi.org/10.1634/theoncologist.2019-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975947PMC
December 2019

Clinical and Immunological Implications of Frameshift Mutations in Lung Cancer.

J Thorac Oncol 2019 10 22;14(10):1807-1817. Epub 2019 Jun 22.

Leonard M. Miller School of Medicine, University of Miami, Miami, Florida; Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.06.016DOI Listing
October 2019

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy.

Oncoimmunology 2019 24;8(3):1550341. Epub 2018 Dec 24.

Department of Medicine, Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, University of California, Moores Cancer Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1550341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350681PMC
December 2018

GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.

Cancer 2018 10 11;124(20):4080-4089. Epub 2018 Sep 11.

Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, Louisiana Jolla, California.

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http://doi.wiley.com/10.1002/cncr.31724
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http://dx.doi.org/10.1002/cncr.31724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234097PMC
October 2018

Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade.

Cancer Immunol Res 2018 10 7;6(10):1129-1135. Epub 2018 Sep 7.

Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248326PMC
October 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

in Lung Cancers: Analysis of Patient Cases Reveals Recurrent Mutations, Fusions, Kinase Duplications, and Concurrent Alterations.

JCO Precis Oncol 2018 19;2. Epub 2018 Apr 19.

, Vancouver General Hospital, Vancouver, British Columbia, Canada; , , , , , , , , , , , , , , , , , , and , Foundation Medicine, Cambridge, MA; , The Angeles Clinic and Research Institute and Cedars-Sinai Medical Center, Los Angeles; , University of California San Diego, San Diego; , University of California, San Francisco, San Francisco; and , University of California, Irvine, Medical Center, Irvine, CA; , Cleveland Clinic; and , University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH; , Soroka Medical Center and Ben-Gurion University, Beer-Sheve, Israel; , Northwestern University Feinberg School of Medicine Northwestern Medical Center, Chicago, IL; and , Cancer Institute of New Jersey, New Brunswick, NJ.

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http://dx.doi.org/10.1200/PO.17.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446447PMC
April 2018

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.

Mol Cancer Ther 2017 11 23;16(11):2598-2608. Epub 2017 Aug 23.

Division of Hematology/Oncology, Department of Medicine, University of California San Diego, Moores Cancer Center, La Jolla, California.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670009PMC
November 2017

Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report.

J Hematol Oncol 2017 02 28;10(1):64. Epub 2017 Feb 28.

Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis School of Medicine, University of California Davis Comprehensive Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1186/s13045-017-0433-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331657PMC
February 2017

Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations.

J Thorac Oncol 2016 09 22;11(9):1493-502. Epub 2016 Jun 22.

Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, California. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.06.004DOI Listing
September 2016

Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence.

Eur Urol Focus 2018 03 5;4(2):267-269. Epub 2016 Feb 5.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2016.01.010DOI Listing
March 2018

MET 14 Deletion in Sarcomatoid Non-Small-Cell Lung Cancer Detected by Next-Generation Sequencing and Successfully Treated with a MET Inhibitor.

J Thorac Oncol 2015 Dec;10(12):e113-4

*Division of Hematology and Oncology, Linberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill, North Carolina; and †Research and Development, ‡Clinical Bioinformatics Operations, and §Clinical Development, Foundation Medicine Inc., Cambridge, Massachusetts.

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http://dx.doi.org/10.1097/JTO.0000000000000645DOI Listing
December 2015

Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.

Oncologist 2016 Jan 15;21(1):33-9. Epub 2015 Dec 15.

Foundation Medicine, Inc., Cambridge, Massachusetts, USA; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York, USA.

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http://www.foundationmedicine.com/wp-content/uploads/2015/12
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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.2015-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709208PMC
January 2016

Comparing two assays for clinical genomic profiling: the devil is in the data.

Onco Targets Ther 2015 24;8:2237-42. Epub 2015 Aug 24.

Foundation Medicine Inc., Cambridge, MA, USA.

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http://dx.doi.org/10.2147/OTT.S88908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556029PMC
September 2015

Concordance of genomic alterations between primary and recurrent breast cancer.

Mol Cancer Ther 2014 May 7;13(5):1382-9. Epub 2014 Mar 7.

Authors' Affiliations: Departments of Investigational Cancer Therapeutics, Surgical Oncology, Bioinformatics and Computational Biology, Pathology, Systems Biology, and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Foundation Medicine, Cambridge, Massachusetts; Albany Medical College, Albany, New York; Fundacion para la Investigacion; Departments of Hematology-Oncology and Pathology, Hospital Clinico Universitario de Valencia; and INCLIVA Biomedical Research Institute, Valencia, Spain.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348062PMC
May 2014

CpG island structure and trithorax/polycomb chromatin domains in human cells.

Genomics 2012 Nov 20;100(5):320-6. Epub 2012 Jul 20.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.ygeno.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483364PMC
November 2012

SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.

Genes Dev 2009 Nov;23(21):2484-9

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1101/gad.1837309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779743PMC
November 2009

Foxp3 occupancy and regulation of key target genes during T-cell stimulation.

Nature 2007 Feb 21;445(7130):931-5. Epub 2007 Jan 21.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature05478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008159PMC
February 2007

Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arrays.

J Mol Diagn 2005 Feb;7(1):57-64

Division of Graduate Medical Sciences, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867505PMC
http://dx.doi.org/10.1016/S1525-1578(10)60009-8DOI Listing
February 2005

Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin.

Cancer Res 2004 Mar;64(6):2096-104

Department of Genetics and Genomics, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://cancerres.aacrjournals.org/content/canres/64/6/2096.f
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http://dx.doi.org/10.1158/0008-5472.can-03-2029DOI Listing
March 2004

Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data.

BMC Cancer 2003 Nov 27;3:31. Epub 2003 Nov 27.

Department of Genetics & Genomics, Boston University School of Medicine 715 Albany Street, E613 Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1186/1471-2407-3-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC317310PMC
November 2003