Garrett M Brodeur

Garrett M Brodeur

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Garrett M Brodeur

Garrett M Brodeur

Publications by authors named "Garrett M Brodeur"

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The effectiveness of Wilms tumor screening in Beckwith-Wiedemann spectrum.

J Cancer Res Clin Oncol 2019 Dec 4;145(12):3115-3123. Epub 2019 Oct 4.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, USA.

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http://dx.doi.org/10.1007/s00432-019-03038-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876630PMC
December 2019

Gastrointestinal Polyposis in Pediatric Patients.

J Pediatr Gastroenterol Nutr 2019 Sep;69(3):273-280

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/MPG.0000000000002421DOI Listing
September 2019

Comprehensive evaluation of context dependence of the prognostic impact of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project.

Pediatr Blood Cancer 2019 Aug 21;66(8):e27819. Epub 2019 May 21.

Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.27819DOI Listing
August 2019

Earlier Colorectal Cancer Screening May Be Necessary In Patients With Li-Fraumeni Syndrome.

Gastroenterology 2019 01 19;156(1):273-274. Epub 2018 Sep 19.

Division of Gastroenterology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2018.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309491PMC
January 2019

Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor.

Pediatr Blood Cancer 2018 10 22;65(10):e27296. Epub 2018 Jun 22.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.27296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107414PMC
October 2018

Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.

Clin Cancer Res 2018 06 7;24(11):2585-2593. Epub 2018 Mar 7.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3811DOI Listing
June 2018

Spontaneous regression of neuroblastoma.

Cell Tissue Res 2018 May 5;372(2):277-286. Epub 2018 Jan 5.

Division of Oncology, Department of Pediatrics, the Children's Hospital of Philadelphia, University of Pennsylvania/Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00441-017-2761-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920563PMC
May 2018

The Future of Surveillance in the Context of Cancer Predisposition: Through the Murky Looking Glass.

Clin Cancer Res 2017 Nov;23(21):e133-e137

Children's Hospital of Philadelphia, and the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2026DOI Listing
November 2017

Management of adrenal masses in patients with Beckwith-Wiedemann syndrome.

Pediatr Blood Cancer 2017 Aug 9;64(8). Epub 2017 Jan 9.

Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944603PMC
August 2017

Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.

Clin Cancer Res 2017 Jun;23(12):e62-e67

Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0595DOI Listing
June 2017

The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.

Ann Neurol 2016 07 30;80(1):13-23. Epub 2016 Apr 30.

Department of Pediatrics, University of Rochester Medical Center, Rochester, NY.

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http://dx.doi.org/10.1002/ana.24659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419586PMC
July 2016

Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.

Oncotarget 2016 Mar;7(13):15977-85

Division of Oncology and Hematology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.7434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941291PMC
March 2016

Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma.

Mol Cancer 2015 Aug 7;14:150. Epub 2015 Aug 7.

Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania School of Medicine, CTRB Rm. 3018, 3501 Civic Center Blvd, Philadelphia, PA, 19104 - 4302, USA.

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http://dx.doi.org/10.1186/s12943-015-0425-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527355PMC
August 2015

The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.

Biochem J 2015 Jun;468(2):345-52

*Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia 19104, PA, U.S.A.

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http://dx.doi.org/10.1042/BJ20150030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487910PMC
June 2015

Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma.

Cancer Lett 2015 May 12;360(2):205-12. Epub 2015 Feb 12.

Division of Oncology, The Children's Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361245PMC
May 2015

TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts.

Cancer Chemother Pharmacol 2015 Jan 14;75(1):131-41. Epub 2014 Nov 14.

Oncology Research, The Children's Hospital of Philadelphia, CTRB Rm. 3018, 3501 Civic Center Blvd., Philadelphia, PA, 19104-4302, USA.

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http://dx.doi.org/10.1007/s00280-014-2627-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282593PMC
January 2015

Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease.

Hum Mutat 2014 Dec 7;35(12):1459-68. Epub 2014 Nov 7.

Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/humu.22688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247247PMC
December 2014

Mechanisms of neuroblastoma regression.

Nat Rev Clin Oncol 2014 Dec 21;11(12):704-13. Epub 2014 Oct 21.

Division of Oncology, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104-4302, USA.

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http://dx.doi.org/10.1038/nrclinonc.2014.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244231PMC
December 2014

Therapeutic targets for neuroblastomas.

Expert Opin Ther Targets 2014 Mar 6;18(3):277-92. Epub 2014 Jan 6.

Children's Hospital of Philadelphia, Division of Oncology , CTRB Rm. 3018, 3501 Civic Center Blvd., Philadelphia, PA 19104-4302 , USA +1 215 590 2817 ; +1 215 590 3770 ;

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http://dx.doi.org/10.1517/14728222.2014.867946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241359PMC
March 2014

Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines.

In Vitro Cell Dev Biol Anim 2014 Mar 30;50(3):188-93. Epub 2014 Jan 30.

Department of General, Thoracic, and Fetal Surgery, The Children's Hospital of Philadelphia, 34th and Civic Center Blvd. Wood Center, 5th Floor, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11626-013-9716-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243461PMC
March 2014

CHD5 is required for spermiogenesis and chromatin condensation.

Mech Dev 2014 Feb 16;131:35-46. Epub 2013 Nov 16.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; The Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mod.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965579PMC
February 2014

Role of CHD5 in human cancers: 10 years later.

Cancer Res 2014 Feb 13;74(3):652-8. Epub 2014 Jan 13.

Authors' Affiliations: Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia; and The University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965582PMC
February 2014

Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages.

Cancer 2014 Jan 14;120(2):172-80. Epub 2013 Nov 14.

Department of Medicine and Cancer Center, Howard University, College of Medicine, Washington, District of Columbia.

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http://dx.doi.org/10.1002/cncr.28316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947327PMC
January 2014

Clinical significance of NTRK family gene expression in neuroblastomas.

Pediatr Blood Cancer 2012 Aug 11;59(2):226-32. Epub 2011 Oct 11.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/pbc.23343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258457PMC
August 2012

A three-gene expression signature model for risk stratification of patients with neuroblastoma.

Clin Cancer Res 2012 Apr 10;18(7):2012-23. Epub 2012 Feb 10.

Developmental Tumor Biology Laboratory, Hospital Sant Joan de Deu, Edificio Docente 4th Floor, 08950 Esplugues de Llobregat, Barcelona 08950, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240975PMC
April 2012

Mechanisms of CHD5 Inactivation in neuroblastomas.

Clin Cancer Res 2012 Mar 31;18(6):1588-97. Epub 2012 Jan 31.

Division of Oncology, the Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306487PMC
March 2012

Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma.

Cancer Chemother Pharmacol 2011 Dec 12;68(6):1469-75. Epub 2011 Apr 12.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00280-011-1623-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135359PMC
December 2011

Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study.

Cancer Chemother Pharmacol 2011 Oct 22;68(4):1057-65. Epub 2011 Feb 22.

Department of Pediatrics and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00280-011-1581-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238911PMC
October 2011

Knowing your ABCCs: novel functions of ABCC transporters.

J Natl Cancer Inst 2011 Aug 28;103(16):1207-8. Epub 2011 Jul 28.

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http://dx.doi.org/10.1093/jnci/djr277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156804PMC
August 2011

The effect of P75 on Trk receptors in neuroblastomas.

Cancer Lett 2011 Jun 17;305(1):76-85. Epub 2011 Mar 17.

Division of Oncology, The Children's Hospital of Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.canlet.2011.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070806PMC
June 2011

Getting into the AKT.

J Natl Cancer Inst 2010 Jun 12;102(11):747-9. Epub 2010 May 12.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djq171DOI Listing
June 2010

Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma.

Clin Cancer Res 2010 Mar 23;16(5):1478-85. Epub 2010 Feb 23.

Division of Oncology and Biostatistics and Data Management Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831131PMC
March 2010

Trk receptor expression and inhibition in neuroblastomas.

Clin Cancer Res 2009 May 5;15(10):3244-50. Epub 2009 May 5.

Division of Oncology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238907PMC
May 2009

Identification of ALK as a major familial neuroblastoma predisposition gene.

Nature 2008 Oct 24;455(7215):930-5. Epub 2008 Aug 24.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature07261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672043PMC
October 2008

CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas.

J Natl Cancer Inst 2008 Jul 24;100(13):940-9. Epub 2008 Jun 24.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1093/jnci/djn176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483574PMC
July 2008

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.

Mol Cancer Res 2008 May;6(5):735-42

Division of Oncology, Children's Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760152PMC
May 2008

Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.

J Clin Oncol 2008 Feb;26(6):913-8

Children's Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1200/JCO.2007.13.9493DOI Listing
February 2008

Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor.

Cancer Res 2005 Nov;65(21):9868-75

Division of Oncology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2426DOI Listing
November 2005

Chromosome 1p and 11q deletions and outcome in neuroblastoma.

N Engl J Med 2005 Nov;353(21):2243-53

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104-4318, USA.

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http://dx.doi.org/10.1056/NEJMoa052399DOI Listing
November 2005

Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.

J Clin Oncol 2005 Sep 22;23(27):6466-73. Epub 2005 Aug 22.

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2005.05.582DOI Listing
September 2005

Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma.

Oncogene 2005 Apr;24(16):2684-94

Division of Oncology, The Children's Hospital of Philadelphia, 3516 Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.onc.1208306DOI Listing
April 2005

Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34.

Oncogene 2004 Jan;23(4):1014-20

The Fels Institute for Molecular Biology and Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1038/sj.onc.1206623DOI Listing
January 2004

Neuroblastoma: biological insights into a clinical enigma.

Nat Rev Cancer 2003 Mar;3(3):203-16

Division of Oncology, The Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA.

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http://www.nature.com/articles/nrc1014
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http://dx.doi.org/10.1038/nrc1014DOI Listing
March 2003

CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system.

Oncogene 2003 Feb;22(7):1002-11

Division of Oncology, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.onc.1206211DOI Listing
February 2003

Resistance to chemotherapy mediated by TrkB in neuroblastomas.

Cancer Res 2002 Nov;62(22):6462-6

Division of Oncology, the Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA.

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http://cancerres.aacrjournals.org/content/62/22/6462.full.pd
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November 2002

No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.

Cancer Res 2002 Nov;62(22):6481-4

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.

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November 2002

Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13.

Cancer Res 2002 Nov;62(22):6651-8

Department of Pediatrics, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, Pennsylvania 19104-4318, USA.

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November 2002

Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells.

Cancer Res 2002 Mar;62(6):1802-8

Division of Oncology, The Children's Hospital of Philadelphia and Department of Pediatrics, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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March 2002

Significance of intratumoral genetic heterogeneity in neuroblastomas.

Med Pediatr Oncol 2002 Feb;38(2):112-3

Division of Oncology, The Children's Hospital of Philadelphia, Abramson Research Center, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1002/mpo.1282DOI Listing
February 2002