Publications by authors named "Garrett Frampton"

100Publications

Tumor mutational burden is not predictive of cytotoxic chemotherapy response.

Oncoimmunology 2020 Jun 24;9(1):1781997. Epub 2020 Jun 24.

Center for Personalized Cancer Therapy and Division of Hematology and Oncology, UC San Diego Moores Cancer Center, San Diego, CA, USA.

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http://dx.doi.org/10.1080/2162402X.2020.1781997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458654PMC
June 2020

High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers.

Mol Cancer Ther 2020 Oct 3;19(10):2139-2145. Epub 2020 Aug 3.

Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, Department of Medicine, University of California, Moores Cancer Center, La Jolla, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-20-0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541603PMC
October 2020

Genomic Profiling of Prostate Cancers from Men with African and European Ancestry.

Clin Cancer Res 2020 Sep 10;26(17):4651-4660. Epub 2020 Jul 10.

Division of Hematology/Oncology, Department of Medicine; Helen Diller Family Comprehensive Cancer Center; Bakar Computational Health Sciences Institute; Institute for Human Genetics; San Francisco Veterans Affairs Medical Center; University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-4112DOI Listing
September 2020

MHC-I genotype and tumor mutational burden predict response to immunotherapy.

Genome Med 2020 05 19;12(1):45. Epub 2020 May 19.

Division of Hematology/Oncology Center for Personalized Cancer Therapy, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1186/s13073-020-00743-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236948PMC
May 2020

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.

Cancer Cell 2020 May;37(5):639-654.e6

The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328015PMC
May 2020

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.

PLoS One 2020 6;15(5):e0231999. Epub 2020 May 6.

Department of Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202592PMC
July 2020

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis.

Clin Sarcoma Res 2019 11;9:12. Epub 2019 Sep 11.

1Department of Medicine (Oncology), Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 USA.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-019-0122-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739971PMC
September 2019

Microsatellite-Stable Tumors with High Mutational Burden Benefit from Immunotherapy.

Cancer Immunol Res 2019 10 12;7(10):1570-1573. Epub 2019 Aug 12.

University of California San Diego Moores Cancer Center, La Jolla, California.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774837PMC
October 2019

Pan-Cancer Analysis of Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype.

Oncologist 2019 12 10;24(12):1526-1533. Epub 2019 Jul 10.

Johns Hopkins University School of Medicine and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA

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http://dx.doi.org/10.1634/theoncologist.2019-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975947PMC
December 2019

Clinical and Immunological Implications of Frameshift Mutations in Lung Cancer.

J Thorac Oncol 2019 10 22;14(10):1807-1817. Epub 2019 Jun 22.

Leonard M. Miller School of Medicine, University of Miami, Miami, Florida; Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.06.016DOI Listing
October 2019

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy.

Oncoimmunology 2019 24;8(3):1550341. Epub 2018 Dec 24.

Department of Medicine, Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, University of California, Moores Cancer Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1550341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350681PMC
December 2018

GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers.

Cancer 2018 10 11;124(20):4080-4089. Epub 2018 Sep 11.

Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, Louisiana Jolla, California.

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http://doi.wiley.com/10.1002/cncr.31724
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http://dx.doi.org/10.1002/cncr.31724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234097PMC
October 2018

Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade.

Cancer Immunol Res 2018 10 7;6(10):1129-1135. Epub 2018 Sep 7.

Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248326PMC
October 2018

Clinical Activity of Crizotinib in Lung Adenocarcinoma Harboring a Rare ZCCHC8-ROS1 Fusion.

J Thorac Oncol 2018 08;13(8):e148-e150

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Floria. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.03.028DOI Listing
August 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

in Lung Cancers: Analysis of Patient Cases Reveals Recurrent Mutations, Fusions, Kinase Duplications, and Concurrent Alterations.

JCO Precis Oncol 2018 19;2. Epub 2018 Apr 19.

, Vancouver General Hospital, Vancouver, British Columbia, Canada; , , , , , , , , , , , , , , , , , , and , Foundation Medicine, Cambridge, MA; , The Angeles Clinic and Research Institute and Cedars-Sinai Medical Center, Los Angeles; , University of California San Diego, San Diego; , University of California, San Francisco, San Francisco; and , University of California, Irvine, Medical Center, Irvine, CA; , Cleveland Clinic; and , University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH; , Soroka Medical Center and Ben-Gurion University, Beer-Sheve, Israel; , Northwestern University Feinberg School of Medicine Northwestern Medical Center, Chicago, IL; and , Cancer Institute of New Jersey, New Brunswick, NJ.

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http://dx.doi.org/10.1200/PO.17.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446447PMC
April 2018

First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.

J Clin Oncol 2017 Oct 30;35(30):3391-3400. Epub 2017 Aug 30.

Matthew P. Goetz, Vera J. Suman, Joel M. Reid, Don W. Northfelt, Michael A. Mahr, Andrew T. Ralya, Mary Kuffel, Sarah A. Buhrow, Stephanie L. Safgren, Renee M. McGovern, John Black, Travis Dockter, Tufia Haddad, Charles Erlichman, Alex A. Adjei, Dan Visscher, Benjamin R. Kipp, Minetta C. Liu, John R. Hawse, Matthew M. Ames, and James N. Ingle, Mayo Clinic, Rochester, MN; Zachary R. Chalmers and Garrett Frampton, Foundation Medicine, Cambridge, MA; and John R. Hawse, James H. Doroshow, Jerry M. Collins, and Howard Streicher, National Cancer Institute, Bethesda, MD.

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http://ascopubs.org/doi/10.1200/JCO.2017.73.3246
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http://dx.doi.org/10.1200/JCO.2017.73.3246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648176PMC
October 2017

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.

Mol Cancer Ther 2017 11 23;16(11):2598-2608. Epub 2017 Aug 23.

Division of Hematology/Oncology, Department of Medicine, University of California San Diego, Moores Cancer Center, La Jolla, California.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670009PMC
November 2017

Correlation Between Molecular Subclassifications of Clear Cell Renal Cell Carcinoma and Targeted Therapy Response.

Eur Urol Focus 2016 Jun 9;2(2):204-209. Epub 2015 Dec 9.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2015.11.007DOI Listing
June 2016

Next Generation Sequencing Reveals Potentially Actionable Alterations in the Majority of Patients with Lymphoid Malignancies.

JCO Precis Oncol 2017 06 27;1. Epub 2017 Apr 27.

Department of Medicine, Division of Hematology/Oncology, and Center for Personalized Cancer Therapy, University of California San Diego, Moores Cancer Center.

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http://dx.doi.org/10.1200/PO.16.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495179PMC
June 2017

Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report.

J Hematol Oncol 2017 02 28;10(1):64. Epub 2017 Feb 28.

Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis School of Medicine, University of California Davis Comprehensive Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1186/s13045-017-0433-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331657PMC
February 2017

Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy.

NPJ Genom Med 2016 19;1. Epub 2016 Oct 19.

Department of Medicine, Division of Hematology/Oncology, University of California, La Jolla, CA, USA; Center for Personalized Cancer Therapy, University of California San Diego, Moores Cancer Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npjgenmed.2016.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142752PMC
October 2016

Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations.

J Thorac Oncol 2016 09 22;11(9):1493-502. Epub 2016 Jun 22.

Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, California. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.06.004DOI Listing
September 2016

Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence.

Eur Urol Focus 2018 03 5;4(2):267-269. Epub 2016 Feb 5.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2016.01.010DOI Listing
March 2018

MET 14 Deletion in Sarcomatoid Non-Small-Cell Lung Cancer Detected by Next-Generation Sequencing and Successfully Treated with a MET Inhibitor.

J Thorac Oncol 2015 Dec;10(12):e113-4

*Division of Hematology and Oncology, Linberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill, North Carolina; and †Research and Development, ‡Clinical Bioinformatics Operations, and §Clinical Development, Foundation Medicine Inc., Cambridge, Massachusetts.

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http://dx.doi.org/10.1097/JTO.0000000000000645DOI Listing
December 2015

Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.

Oncologist 2016 Jan 15;21(1):33-9. Epub 2015 Dec 15.

Foundation Medicine, Inc., Cambridge, Massachusetts, USA; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA; Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York, USA.

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http://www.foundationmedicine.com/wp-content/uploads/2015/12
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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.2015-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709208PMC
January 2016

Comparing two assays for clinical genomic profiling: the devil is in the data.

Onco Targets Ther 2015 24;8:2237-42. Epub 2015 Aug 24.

Foundation Medicine Inc., Cambridge, MA, USA.

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http://dx.doi.org/10.2147/OTT.S88908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556029PMC
September 2015

Concordance of genomic alterations between primary and recurrent breast cancer.

Mol Cancer Ther 2014 May 7;13(5):1382-9. Epub 2014 Mar 7.

Authors' Affiliations: Departments of Investigational Cancer Therapeutics, Surgical Oncology, Bioinformatics and Computational Biology, Pathology, Systems Biology, and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Foundation Medicine, Cambridge, Massachusetts; Albany Medical College, Albany, New York; Fundacion para la Investigacion; Departments of Hematology-Oncology and Pathology, Hospital Clinico Universitario de Valencia; and INCLIVA Biomedical Research Institute, Valencia, Spain.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348062PMC
May 2014

CpG island structure and trithorax/polycomb chromatin domains in human cells.

Genomics 2012 Nov 20;100(5):320-6. Epub 2012 Jul 20.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.ygeno.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483364PMC
November 2012