Garret A FitzGerald

Garret A FitzGerald

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Garret A FitzGerald

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Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Front Immunol 2018 5;9:2565. Epub 2018 Nov 5.

Perelman School of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02565
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http://dx.doi.org/10.3389/fimmu.2018.02565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230677PMC
September 2019

Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

J Pharmacol Exp Ther 2019 Sep 27;370(3):416-426. Epub 2019 Jun 27.

Department of Neuroscience, Imaging, and Clinical Sciences and Center for Research on Aging and Translational Medicine, "G. d'Annunzio" University School of Medicine, Chieti, Italy (A.Sa., A.B., A.C., M.D., S.T., P.G.-L., T.S., L.D.F., R.F., P.B., S.A., P.P.); Department of Systems Pharmacology and Translational Therapeutics and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (E.R., G.A.F.); Departments of General Pathology (V.A., A.Sg.) and Pharmacology (C.P.), Catholic University School of Medicine, Rome, Italy; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China (G.L., Y.G.); and Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China (Y.Y.)

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http://dx.doi.org/10.1124/jpet.119.259382DOI Listing
September 2019

Circadian control of lung inflammation in influenza infection.

Nat Commun 2019 Sep 11;10(1):4107. Epub 2019 Sep 11.

Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-019-11400-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739310PMC
September 2019

Dosing time matters.

Science 2019 08;365(6453):547-549

Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/science.aax7621DOI Listing
August 2019

Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.

J Pharmacol Exp Ther 2019 Jul 16;370(1):18-24. Epub 2019 Apr 16.

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China (L.C., T.J.); School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China (G.Y.); Institute for Translational Medicine and Therapeutics (L.C., G.Y., S.Y.T., G.A.F.) and Cardiovascular Institute (T.W., G.A.F.), University of Pennsylvania, Philadelphia, Pennsylvania; and State Key Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Q.W., M.W.)

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http://dx.doi.org/10.1124/jpet.118.256057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540703PMC
July 2019

Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions.

JCI Insight 2019 Apr 11;5. Epub 2019 Apr 11.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.125133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542608PMC
April 2019

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury.

Nat Commun 2019 04 23;10(1):1888. Epub 2019 Apr 23.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

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http://dx.doi.org/10.1038/s41467-019-09492-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478873PMC
April 2019

A decade of .

Sci Transl Med 2019 Apr;11(489)

Elazer R. Edelman is co-Chief Scientific Advisor of Science Translational Medicine. He is the Director and Edward J. Poitras Professor, Institute for Medical Engineering and Science at MIT, Cambridge, MA 02139, Professor of Medicine at Harvard Medical School, and Senior Attending Physician in the Division of Cardiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Email:

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aax4327DOI Listing
April 2019

Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice.

J Pharmacol Exp Ther 2018 12 10;367(3):425-432. Epub 2018 Oct 10.

Department of Systems Pharmacology and Translational Therapeutics (W.-L.S., E.R., X.L., T.G., G.A.F.), Institute for Translational Medicine and Therapeutics (W.-L.S., E.R., X.L., T.G., G.R.G., G.A.F.), and Perelman School of Medicine and Department of Genetics (G.R.G.), University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1124/jpet.118.250936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226547PMC
December 2018

Time-Dependent Hypotensive Effect of Aspirin in Mice.

Arterioscler Thromb Vasc Biol 2018 12;38(12):2819-2826

The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania (G.Y., S.T., X.L., G.A.F.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309345PMC
December 2018

Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Circulation 2018 11;138(21):2367-2378

Department of Systems Pharmacology and Translational Therapeutics and the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Philadelphia, PA (E.R., S.Y.T., D.M., S.D.R., H.M., X.L., N.F.L., A.M.W., G.A.F.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291350PMC
November 2018

Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.

FASEB J 2018 10 20;32(10):5326-5337. Epub 2018 Apr 20.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; and.

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http://dx.doi.org/10.1096/fj.201800252RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133703PMC
October 2018

Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.

Sci Rep 2018 08 14;8(1):12097. Epub 2018 Aug 14.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1038/s41598-018-30636-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092371PMC
August 2018

Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2.

Cell Rep 2018 07;24(4):809-814

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5127, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118132PMC
July 2018

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.

J Immunol 2018 06 25;200(12):4004-4011. Epub 2018 Apr 25.

Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435;

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http://dx.doi.org/10.4049/jimmunol.1701145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988963PMC
June 2018

Regulation of amyloid-β dynamics and pathology by the circadian clock.

J Exp Med 2018 04 30;215(4):1059-1068. Epub 2018 Jan 30.

Department of Neurology, Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20172347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881473PMC
April 2018

Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Proc Natl Acad Sci U S A 2018 04 2;115(16):4170-4175. Epub 2018 Apr 2.

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1718635115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910840PMC
April 2018

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.

J Lipid Res 2018 03 4;59(3):564-575. Epub 2018 Jan 4.

Institute for Translational Medicine and Therapeutics University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160

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http://www.jlr.org/lookup/doi/10.1194/jlr.D081414
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http://dx.doi.org/10.1194/jlr.D081414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832923PMC
March 2018

Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.

Circ Res 2018 02;122(4):537-539

From the Institute for Translational Medicine and Therapeutics (T.G., G.A.F.) and Department of Surgery (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.312616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819350PMC
February 2018

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.

J Lipid Res 2018 01 27;59(1):102-112. Epub 2017 Nov 27.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada

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http://dx.doi.org/10.1194/jlr.M080028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748501PMC
January 2018

Flipping the cyclooxygenase () genes reveals isoform-specific compensatory functions.

J Lipid Res 2018 01 27;59(1):89-101. Epub 2017 Nov 27.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada

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http://dx.doi.org/10.1194/jlr.M079996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748500PMC
January 2018

Timing the Microbes: The Circadian Rhythm of the Gut Microbiome.

J Biol Rhythms 2017 Dec 1;32(6):505-515. Epub 2017 Sep 1.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania.

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http://dx.doi.org/10.1177/0748730417729066DOI Listing
December 2017

A Pilot Characterization of the Human Chronobiome.

Sci Rep 2017 12 7;7(1):17141. Epub 2017 Dec 7.

Department of Systems Pharmacology and Translational Therapeutics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41598-017-17362-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719427PMC
December 2017

Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System.

Clin Pharmacol Ther 2017 Oct 17;102(4):611-622. Epub 2017 Aug 17.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/cpt.794
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http://dx.doi.org/10.1002/cpt.794DOI Listing
October 2017

Circadian Clocks and Metabolism: Implications for Microbiome and Aging.

Trends Genet 2017 10 24;33(10):760-769. Epub 2017 Aug 24.

Department of Systems Pharmacology and Translational Therapeutics, ​Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smilow - 10th Floor, Room 122, Building 421, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01689525173012
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http://dx.doi.org/10.1016/j.tig.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610101PMC
October 2017

Guidelines for Genome-Scale Analysis of Biological Rhythms.

J Biol Rhythms 2017 Oct 3;32(5):380-393. Epub 2017 Nov 3.

27 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1177/0748730417728663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692188PMC
October 2017

The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.

Trends Pharmacol Sci 2017 08 23;38(8):733-748. Epub 2017 Jun 23.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676556PMC
August 2017

Time for nonaddictive relief of pain.

Science 2017 Mar 9;355(6329):1026-1027. Epub 2017 Mar 9.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1126/science.aan0088DOI Listing
March 2017

Simulation-based comprehensive benchmarking of RNA-seq aligners.

Nat Methods 2017 02 12;14(2):135-139. Epub 2016 Dec 12.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nmeth.4106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792058PMC
February 2017

Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial.

Circulation 2017 01 13;135(2):113-115. Epub 2016 Nov 13.

From Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225045PMC
January 2017

A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood.

JCI Insight 2016 Aug;1(12)

Department of Systems Pharmacology and Translational Therapeutics and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990354PMC
August 2016

Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.

Circulation 2016 Jul;134(4):328-38

From Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Department of Systems Pharmacology and Translational Therapeutics (S.Y.T., J.M., L.T., S.-C.P., L.C., E.P., G.A.F.); Department of Animal Biology, School of Veterinary Medicine (S.Y.T., G.R.G., J.L.); and Department of Genetics, University of Pennsylvania, Philadelphia (J.M.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963279PMC
July 2016

Measure for Measure: Biomarker standards and transparency.

Sci Transl Med 2016 06;8(343):343fs10

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5158, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aaf8590DOI Listing
June 2016

Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.

Oncotarget 2016 May;7(22):32462-77

Department of Neuroscience, Imaging and Clinical Science, Section of Cardiovascular and Pharmacological Sciences, and CeSI-MeT, "G. d'Annunzio" University, School of Medicine, Chieti, Italy.

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http://dx.doi.org/10.18632/oncotarget.8655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078026PMC
May 2016

Human Platelet Lipidomics: Variance, Visualization, Flux, and Fuel.

Cell Metab 2016 05;23(5):757-9

Institute for Translational Medicine and Therapeutics, 10-123 Smilow Center for Translational Research, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.025DOI Listing
May 2016

Conflict or Confluence of Interest?--Reply.

JAMA 2016 Apr;315(16):1793-4

Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jama.2016.0327DOI Listing
April 2016

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.

Sci Transl Med 2016 Feb 3;8(324):324ra16. Epub 2016 Feb 3.

The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad3305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870001PMC
February 2016

Bidirectional interactions between indomethacin and the murine intestinal microbiota.

Elife 2015 Dec 23;4:e08973. Epub 2015 Dec 23.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.08973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755745PMC
December 2015

Clocks and cardiovascular function.

Methods Enzymol 2015 26;552:211-28. Epub 2014 Dec 26.

Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2014.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765173PMC
November 2015

Confluence, Not Conflict of Interest: Name Change Necessary.

JAMA 2015 Nov;314(17):1791-2

Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jama.2015.12020DOI Listing
November 2015

MEDICINE. Personalization in practice.

Science 2015 Oct;350(6258):282-3

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.aad5204DOI Listing
October 2015

Bioactive products formed in humans from fish oils.

J Lipid Res 2015 Sep 15;56(9):1808-20. Epub 2015 Jul 15.

Institute for Translational Medicine and Therapeutics (ITMAT), Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.

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http://dx.doi.org/10.1194/jlr.M060392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548785PMC
September 2015

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.

Pharmacogenet Genomics 2015 Aug;25(8):416-26

aDepartment of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Departments of bGenetics cBioengineering, Stanford University Medical Center, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498995PMC
August 2015

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10479-84. Epub 2015 Aug 3.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104;

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http://dx.doi.org/10.1073/pnas.1501305112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547234PMC
August 2015

Understanding multicellular function and disease with human tissue-specific networks.

Nat Genet 2015 Jun 27;47(6):569-76. Epub 2015 Apr 27.

1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Computer Science, Princeton University, Princeton, New Jersey, USA. [3] Simons Center for Data Analysis, Simons Foundation, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828725PMC
June 2015

BIOMEDICINE. Bringing PGE₂ in from the cold.

Science 2015 Jun;348(6240):1208-9

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1126/science.aac5515DOI Listing
June 2015

Evolution in translational science: Whither the CTSAs?

Sci Transl Med 2015 Apr;7(284):284fs15

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5158, USA.

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http://dx.doi.org/10.1126/scitranslmed.aab1596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556096PMC
April 2015

PharmGKB summary: ibuprofen pathways.

Pharmacogenet Genomics 2015 Feb;25(2):96-106

aDepartment of Systems Pharmacology and Translational Therapeutics bInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Departments of cGenetics dBioengineering, Stanford University, Stanford, California, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FPC.0000000000000113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401PMC
February 2015

Selective COX-2 inhibitors suppress prostacyclin.

Clin Ther 2014 Dec 23;36(12):2120-2121. Epub 2014 Oct 23.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.clinthera.2014.09.024DOI Listing
December 2014

Circadian Rhythms. Temporal targets of drug action.

Science 2014 Nov;346(6212):921-2

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.aaa2285DOI Listing
November 2014

Time in motion: the molecular clock meets the microbiome.

Cell 2014 Oct;159(3):469-70

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.020DOI Listing
October 2014

I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT.

Diabetes 2014 Sep 10;63(9):2911-23. Epub 2014 Apr 10.

Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China

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http://dx.doi.org/10.2337/db13-1893DOI Listing
September 2014

Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma.

J Allergy Clin Immunol 2014 Aug 22;134(2):306-13. Epub 2014 Jan 22.

Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2013.12.002DOI Listing
August 2014

Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function.

Carcinogenesis 2014 Aug 3;35(8):1788-97. Epub 2014 Mar 3.

Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1093/carcin/bgu053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123643PMC
August 2014

Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.

Proc Natl Acad Sci U S A 2014 May 21;111(18):6828-33. Epub 2014 Apr 21.

The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, The Department of Animal Biology, School of Veterinary Medicine, and The Department of Radiology, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020105PMC
May 2014

Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice.

Circulation 2014 Apr 11;129(17):1761-9. Epub 2014 Feb 11.

Institute for Translational Medicine and Therapeutics (S.Y.T., J.M., J.L., G.A.F.) and Perelman School of Medicine, Department of Animal Biology, School of Veterinary Medicine (L.T., E.P.), University of Pennsylvania, Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006304PMC
April 2014

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Authors:
Vinicius Tragante Michael R Barnes Santhi K Ganesh Matthew B Lanktree Wei Guo Nora Franceschini Erin N Smith Toby Johnson Michael V Holmes Sandosh Padmanabhan Konrad J Karczewski Berta Almoguera John Barnard Jens Baumert Yen-Pei Christy Chang Clara C Elbers Martin Farrall Mary E Fischer Tom R Gaunt Johannes M I H Gho Christian Gieger Anuj Goel Yan Gong Aaron Isaacs Marcus E Kleber Irene Mateo Leach Caitrin W McDonough Matthijs F L Meijs Olle Melander Christopher P Nelson Ilja M Nolte Nathan Pankratz Tom S Price Jonathan Shaffer Sonia Shah Maciej Tomaszewski Peter J van der Most Erik P A Van Iperen Judith M Vonk Kate Witkowska Caroline O L Wong Li Zhang Amber L Beitelshees Gerald S Berenson Deepak L Bhatt Morris Brown Amber Burt Rhonda M Cooper-DeHoff John M Connell Karen J Cruickshanks Sean P Curtis George Davey-Smith Christian Delles Ron T Gansevoort Xiuqing Guo Shen Haiqing Claire E Hastie Marten H Hofker G Kees Hovingh Daniel S Kim Susan A Kirkland Barbara E Klein Ronald Klein Yun R Li Steffi Maiwald Christopher Newton-Cheh Eoin T O'Brien N Charlotte Onland-Moret Walter Palmas Afshin Parsa Brenda W Penninx Mary Pettinger Ramachandran S Vasan Jane E Ranchalis Paul M Ridker Lynda M Rose Peter Sever Daichi Shimbo Laura Steele Ronald P Stolk Barbara Thorand Mieke D Trip Cornelia M van Duijn W Monique Verschuren Cisca Wijmenga Sharon Wyatt J Hunter Young Aeilko H Zwinderman Connie R Bezzina Eric Boerwinkle Juan P Casas Mark J Caulfield Aravinda Chakravarti Daniel I Chasman Karina W Davidson Pieter A Doevendans Anna F Dominiczak Garret A FitzGerald John G Gums Myriam Fornage Hakon Hakonarson Indrani Halder Hans L Hillege Thomas Illig Gail P Jarvik Julie A Johnson John J P Kastelein Wolfgang Koenig Meena Kumari Winfried März Sarah S Murray Jeffery R O'Connell Albertine J Oldehinkel James S Pankow Daniel J Rader Susan Redline Muredach P Reilly Eric E Schadt Kandice Kottke-Marchant Harold Snieder Michael Snyder Alice V Stanton Martin D Tobin André G Uitterlinden Pim van der Harst Yvonne T van der Schouw Nilesh J Samani Hugh Watkins Andrew D Johnson Alex P Reiner Xiaofeng Zhu Paul I W de Bakker Daniel Levy Folkert W Asselbergs Patricia B Munroe Brendan J Keating

Am J Hum Genet 2014 Mar 20;94(3):349-60. Epub 2014 Feb 20.

Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951943PMC
March 2014

Testing cardiovascular drug safety and efficacy in randomized trials.

Circ Res 2014 Mar;114(7):1156-61

From the Departments of Medicine and Pharmacology, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011393PMC
March 2014

Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.

Am J Hum Genet 2014 Feb 23;94(2):198-208. Epub 2014 Jan 23.

Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928659PMC
February 2014

Knitting up the raveled sleave of care.

Sci Transl Med 2013 Nov;5(212):212rv3

Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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November 2013

Niacin, an old drug with a new twist.

J Lipid Res 2013 Oct 15;54(10):2586-94. Epub 2013 Aug 15.

Institute for Translational Medicine and Therapeutics, Departments of Pharmacology and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1194/jlr.R040592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770072PMC
October 2013

GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies.

Clin Pharmacol Drug Dev 2013 Oct 25;2(4):379-86. Epub 2013 Jul 25.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, PA, USA.

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October 2013

Response to letters regarding article, "Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin".

Circulation 2013 Sep;128(12):e191

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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September 2013

Molecular clocks in pharmacology.

Handb Exp Pharmacol 2013 (217):243-60

Department of Neurology, Washington University School of Medicine, 7401 Byron Pl., Saint Louis, MO 63105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684693PMC
July 2013

PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.

J Leukoc Biol 2013 Jul 26;94(1):77-88. Epub 2013 Apr 26.

Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, 1161 21st Ave., T-1218 MCN, Nashville, TN 37232-2650, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685021PMC
July 2013

Insulin Tolerance Test and Hyperinsulinemic-Euglycemic Clamp.

Bio Protoc 2013 May;3(10)

Pharmacology Department, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.21769/bioprotoc.776DOI Listing
May 2013

Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44.

J Invest Dermatol 2013 Apr 29;133(4):881-9. Epub 2012 Nov 29.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593761PMC
April 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Authors:
Santhi K Ganesh Vinicius Tragante Wei Guo Yiran Guo Matthew B Lanktree Erin N Smith Toby Johnson Berta Almoguera Castillo John Barnard Jens Baumert Yen-Pei Christy Chang Clara C Elbers Martin Farrall Mary E Fischer Nora Franceschini Tom R Gaunt Johannes M I H Gho Christian Gieger Yan Gong Aaron Isaacs Marcus E Kleber Irene Mateo Leach Caitrin W McDonough Matthijs F L Meijs Olle Mellander Cliona M Molony Ilja M Nolte Sandosh Padmanabhan Tom S Price Ramakrishnan Rajagopalan Jonathan Shaffer Sonia Shah Haiqing Shen Nicole Soranzo Peter J van der Most Erik P A Van Iperen Jessica Van Setten Jessic A Van Setten Judith M Vonk Li Zhang Amber L Beitelshees Gerald S Berenson Deepak L Bhatt Jolanda M A Boer Eric Boerwinkle Ben Burkley Amber Burt Aravinda Chakravarti Wei Chen Rhonda M Cooper-Dehoff Sean P Curtis Albert Dreisbach David Duggan Georg B Ehret Richard R Fabsitz Myriam Fornage Ervin Fox Clement E Furlong Ron T Gansevoort Marten H Hofker G Kees Hovingh Susan A Kirkland Kandice Kottke-Marchant Abdullah Kutlar Andrea Z Lacroix Taimour Y Langaee Yun R Li Honghuang Lin Kiang Liu Steffi Maiwald Rainer Malik Gurunathan Murugesan Christopher Newton-Cheh Jeffery R O'Connell N Charlotte Onland-Moret Willem H Ouwehand Walter Palmas Brenda W Penninx Carl J Pepine Mary Pettinger Joseph F Polak Vasan S Ramachandran Jane Ranchalis Susan Redline Paul M Ridker Lynda M Rose Hubert Scharnag Nicholas J Schork Daichi Shimbo Alan R Shuldiner Sathanur R Srinivasan Ronald P Stolk Herman A Taylor Barbara Thorand Mieke D Trip Cornelia M van Duijn W Monique Verschuren Cisca Wijmenga Bernhard R Winkelmann Sharon Wyatt J Hunter Young Bernhard O Boehm Mark J Caulfield Daniel I Chasman Karina W Davidson Pieter A Doevendans Garret A Fitzgerald John G Gums Hakon Hakonarson Hans L Hillege Thomas Illig Gail P Jarvik Julie A Johnson John J P Kastelein Wolfgang Koenig Winfried März Braxton D Mitchell Sarah S Murray Albertine J Oldehinkel Daniel J Rader Muredach P Reilly Alex P Reiner Eric E Schadt Roy L Silverstein Harold Snieder Alice V Stanton André G Uitterlinden Pim van der Harst Yvonne T van der Schouw Nilesh J Samani Andrew D Johnson Patricia B Munroe Paul I W de Bakker Xiaofeng Zhu Daniel Levy Brendan J Keating Folkert W Asselbergs

Hum Mol Genet 2013 Apr 8;22(8):1663-78. Epub 2013 Jan 8.

Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

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April 2013

Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.

Circ Res 2013 02 18;112(3):432-40. Epub 2012 Dec 18.

The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104-5158, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565603PMC
February 2013

Platelet microRNAs: Novy Mir* or mired in human complexity?

Circ Res 2013 Feb;112(4):576-8

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February 2013

Between a rock and a hard place: how to align our circadian rhythms?

Circulation 2013 Jan 21;127(1):19-20. Epub 2012 Nov 21.

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January 2013

Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.

Circulation 2013 Jan 30;127(2):233-43. Epub 2012 Nov 30.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546279PMC
January 2013

Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin.

Circulation 2013 Jan 4;127(3):377-85. Epub 2012 Dec 4.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.117283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552520PMC
January 2013

Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.

Circ Res 2013 Jan;112(1):174-94

UCD Conway Institute and Java Clinical Research, University College Dublin, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572712PMC
January 2013

COX-2, the dominant source of prostacyclin.

Proc Natl Acad Sci U S A 2013 Jan 4;110(3):E183. Epub 2013 Jan 4.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549068PMC
January 2013

Obesity in mice with adipocyte-specific deletion of clock component Arntl.

Nat Med 2012 Dec 11;18(12):1768-77. Epub 2012 Nov 11.

Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782286PMC
December 2012

Functionalized low-density lipoprotein nanoparticles for in vivo enhancement of atherosclerosis on magnetic resonance images.

Bioconjug Chem 2012 Nov 1;23(11):2313-9. Epub 2012 Nov 1.

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

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November 2012

Role of thromboxane receptor in C-reactive protein-induced thrombosis.

Arterioscler Thromb Vasc Biol 2012 Oct 9;32(10):2468-74. Epub 2012 Aug 9.

Cardiovascular Research Center, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel.

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October 2012

"What great creation". Interview by Alisa M. Clyne.

Sci Transl Med 2012 Oct;4(154):154cm10

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October 2012

Medicine. Can intellectual property save drug development?

Science 2012 Oct;338(6106):483-4

The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine Translational Research Center, 10th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5158, USA.

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October 2012

(Almost) everything is illuminated: adenosine shines a light on cardioprotection.

Circ Res 2012 Sep;111(8):965-6

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Translational Research Center, Philadelphia, PA 19104-5158, USA.

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September 2012

Vascular COX-2 modulates blood pressure and thrombosis in mice.

Sci Transl Med 2012 May;4(132):132ra54

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882087PMC
May 2012

Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.

J Clin Invest 2012 Apr 12;122(4):1459-68. Epub 2012 Mar 12.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314457PMC
April 2012

Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice.

Proc Natl Acad Sci U S A 2012 Apr 9;109(17):6727-32. Epub 2012 Apr 9.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340044PMC
April 2012