Publications by authors named "Gareth Brown"

13 Publications

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Top 100 most influential manuscripts in erectile dysfunction.

Urologia 2021 Feb 25:391560321993559. Epub 2021 Feb 25.

Cwm Taf Morgannwg University Health Board, Abercynon, UK.

Erectile dysfunction (ED) is a common condition encountered by an array of subspecialists and is the most cited research topic within the field of andrology. This bibliometric analysis aims to identify the most influential papers that inform current clinical practice and likely shape future research. The Thompson Reuters Web of Science citation database was interrogated using search terms to cover the breadth of erectile dysfunction. Results were ranked according to citation number with country of origin, journal, topic, year of publication, author and institution also analysed. The search criteria matched 12,570 manuscripts. The top 100 highest citation ranged from 3013 to 161 (median 229.5). The most cited manuscript reports the prevalence and risk factors of ED within the Massachusetts Male Aging Study. The most manuscripts were published by the ( = 15) with a total of 7913 citations. Institutions from the USA contributed the majority ( = 55) with the UK ( = 14) second. The most common theme represented was epidemiology ( = 46) followed by treatment ( = 27). This analysis provides a list of the most influential manuscripts within ED and illustrates what can be considered a 'highly citable' paper. The most influential papers in Erectile Dysfunction remain seminal works from the end of the last century. The most cited manuscript has been cited 194 times in the last 17 months showing its continued value. Only one paper published within the last decade has reached the top twenty exemplifying the relative lack of novel influential publications.
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http://dx.doi.org/10.1177/0391560321993559DOI Listing
February 2021

The 100 most influential manuscripts in andrology: a bibliometric analysis.

Basic Clin Androl 2018 12;28:15. Epub 2018 Dec 12.

2Department of Urology, Cwm Taf University Health Board, Royal Glamorgan Hospital, Llantrisant, CF72 8XR UK.

Background: As the specialty of Andrology expands it is important to establish the most important studies that have shaped, and continue to shape, current research and clinical practice. Bibliometric analysis involving a citation rank list is an established means by which to identify the published material within a given field that has greatest intellectual influence. This bibliometric analysis sought to identify the 100 most influential manuscripts in Andrology, as well as the key research themes that have shaped contemporary understanding and management of andrological conditions.

Methods: The Thompson Reuters Web of Science citation indexing database was interrogated using a number of search terms chosen to reflect the full spectrum of andrological practice. Results were ranked according to citation number and further analysed according to subject, first and senior author, journal, year of publication, institution and country of origin.

Results: The Web of Science search returned a total of 24,128 manuscripts. Citation number of the top 100 articles ranged from 2819 to 218 (median 320). The most cited manuscript (by Feldman et al., The Journal of Urology 1994; 2819 citations) reported the prevalence and risk factors for erectile dysfunction (ED) in the Massachusetts Male Ageing Study. The Journal of Urology published the highest number of manuscripts ( = 11), followed by the New England Journal of Medicine ( = 10). The most common theme represented within the top 100 manuscripts was erectile dysfunction ( = 46), followed jointly by hypogonadism and male factor infertility ( = 24 respectively).

Conclusion: Erectile dysfunction should be considered the most widely researched, published and cited field within andrological practice. This study provides a list of the most influential manuscripts in andrology and serves as a reference of what comprises a 'highly citable' paper for both researchers and clinicians.
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http://dx.doi.org/10.1186/s12610-018-0080-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290538PMC
December 2018

British Association of Urological Surgeons (BAUS) consensus document for the management of male genital emergencies - testicular trauma.

BJU Int 2018 06 10;121(6):840-844. Epub 2018 Apr 10.

Department of Urology and NIHR Biomedical Research Centre, University College London Hospital, London, UK.

Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery. A series of consensus statements have been developed by an expert consensus comprising British Association of Urological Surgeons (BAUS) Section of Andrology and Genitourethral Surgery together with experts from units throughout the UK. Testicular trauma requires prompt investigation and treatment in order to prevent the development of subfertility or hypogonadism. This series of consensus statements provide guidance for UK practice.
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http://dx.doi.org/10.1111/bju.14163DOI Listing
June 2018

Emergency Management of Priapism in the United Kingdom: A Survey of Current Practice.

J Sex Med 2018 Apr 14;15(4):476-479. Epub 2018 Feb 14.

Department of Urology, Cwm Taf University Health Board, Royal Glamorgan Hospital, Llantrisant, UK; Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.

Background: Despite its importance, current practice in the emergency management of priapism in the United Kingdom is unknown.

Aim: To evaluate current practice in the emergency management of priapism in the United Kingdom.

Methods: All "full," "associate urological specialist," and "trainee" members of the British Association of Urological Surgeons (BAUS; leading membership-based organization for practitioners of urologic surgery in the United Kingdom) were invited to participate in an online survey. Questions related to the emergency management of priapism, access to tertiary andrology services, and use of guidelines.

Outcomes: Key outcome measures included frequency of encountered cases, access to specialist andrology support, confidence in key management steps, and use of current guidelines.

Results: 213 of 1,304 (16.3%) eligible members completed the survey. Most reported managing 1 case annually (median = 1, range = 0->10). Only 7.0% transferred patients to a tertiary center and 87.8% believed they could access specialist andrology advice if required. Respondents were less confident in performing intracavernosal phenylephrine instillation (88.7%) compared with corporal aspiration (98.1%), with confidence lowest among trainee members. Only 68.5% reported performing the distal shunt procedure. Of the 212 respondents that chose to answer questions relating to guidelines, only 155 (73.1%) were aware of their existence, with those published by the European Association of Urology being most popular (53.8%). 205 (96.2%) respondents expressed an interest in the development of a UK-specific guideline, with 162 of 212 (76.4%) stating they would use this in practice.

Clinical Implications: Urologists in the United Kingdom support the development of UK-specific guidance on the emergency management of priapism for use within the context of the National Health Service.

Strengths And Limitations: This is the first study to assess current practice in the emergency management of priapism in the United Kingdom. Its strength is that most UK urologists were invited to participate through collaboration with the BAUS. Although the response rate of 16.3% is acceptable for a national survey of this nature, responses were self-reported, rendering them susceptible to bias.

Conclusion: This study demonstrates that some UK urologists lack confidence in key steps in the emergency management of priapism and identifies a strong level of support for the development of up-to-date UK-specific guidance. Bullock N, Steggall M, Brown G. Emergency Management of Priapism in the United Kingdom: A Survey of Current Practice. J Sex Med 2018;15:476-479.
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http://dx.doi.org/10.1016/j.jsxm.2018.01.013DOI Listing
April 2018

British Association of Urological Surgeons (BAUS) consensus document for the management of male genital emergencies - penile fracture.

BJU Int 2018 07 2;122(1):26-28. Epub 2018 Apr 2.

Department of Urology and NIHR Biomedical Research Centre, University College London Hospital, London, UK.

Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery. The aim of these consensus statements is to provide best practice guidance for urological surgeons based in the UK which are developed by an expert consensus. Penile fracture is a rare emergency and in most cases requires prompt exploration and repair to prevent erectile dysfunction and penile curvature.
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http://dx.doi.org/10.1111/bju.14167DOI Listing
July 2018

BAUS consensus document for the management of male genital emergencies: priapism.

BJU Int 2018 06 10;121(6):835-839. Epub 2018 Apr 10.

Department of Urology, Leicester General Hospital, Leicester, UK.

Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery. A series of consensus statements have been developed by an expert consensus committee comprising members of the BAUS Section of Andrology and Genitourethral Surgery together with experts from urology units throughout the UK. Priapism requires prompt assessment and treatment and these consensus statements provide guidance for UK practice.
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http://dx.doi.org/10.1111/bju.14140DOI Listing
June 2018

British Association of Urological Surgeons (BAUS) consensus document for the management of male genital emergencies - penile amputation.

BJU Int 2018 05 25;121(5):699-702. Epub 2018 Mar 25.

Department of Urology and NIHR Biomedical Research Centre University College London Hospital, London, UK.

Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery. A series of consensus statements have been developed by an expert consensus committee comprising members of the British Association of Urological Surgeons (BAUS) Section of Andrology and Genitourethral Surgery together with experts from urology units throughout the UK. Penile amputation is a rare genital emergency, which requires prompt intervention and microsurgical reconstruction. The consensus statements will outline the management of these cases for non-specialist units, as well as recommendations for reconstruction for specialists.
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http://dx.doi.org/10.1111/bju.14135DOI Listing
May 2018

Global impacts of energy demand on the freshwater resources of nations.

Proc Natl Acad Sci U S A 2015 Dec 16;112(48):E6707-16. Epub 2015 Nov 16.

Centre for Biological Sciences, University of Southampton, Highfield Campus, Southampton SO17 1BJ, United Kingdom;

The growing geographic disconnect between consumption of goods, the extraction and processing of resources, and the environmental impacts associated with production activities makes it crucial to factor global trade into sustainability assessments. Using an empirically validated environmentally extended global trade model, we examine the relationship between two key resources underpinning economies and human well--being-energy and freshwater. A comparison of three energy sectors (petroleum, gas, and electricity) reveals that freshwater consumption associated with gas and electricity production is largely confined within the territorial boundaries where demand originates. This finding contrasts with petroleum, which exhibits a varying ratio of territorial to international freshwater consumption, depending on the origin of demand. For example, although the United States and China have similar demand associated with the petroleum sector, international freshwater consumption is three times higher for the former than the latter. Based on mapping patterns of freshwater consumption associated with energy sectors at subnational scales, our analysis also reveals concordance between pressure on freshwater resources associated with energy production and freshwater scarcity in a number of river basins globally. These energy-driven pressures on freshwater resources in areas distant from the origin of energy demand complicate the design of policy to ensure security of fresh water and energy supply. Although much of the debate around energy is focused on greenhouse gas emissions, our findings highlight the need to consider the full range of consequences of energy production when designing policy.
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http://dx.doi.org/10.1073/pnas.1507701112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672781PMC
December 2015

Expansion of HCV treatment access to people who have injected drugs through effective translation of research into public health policy: Scotland's experience.

Int J Drug Policy 2015 Nov 6;26(11):1041-9. Epub 2015 Jun 6.

School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK; Health Protection Scotland, Glasgow, UK.

Seven years have elapsed since the Scottish Government launched its Hepatitis C Action Plan - a Plan to improve services to prevent transmission of infection, particularly among people who inject drugs (PWID), identify those infected and ensure those infected receive optimal treatment. The Plan was underpinned by industrial scale funding (around £100 million, in addition to the general NHS funding, will have been invested by 2015), and a web of accountable national and local multi-disciplinary multi-agency networks responsible for the planning, development and delivery of services. Initiatives ranged from the introduction of testing in specialist drug services through finger-prick blood sampling by non-clinical staff, to the setting of government targets to ensure rapid scale-up of antiviral therapy. The Plan was informed by comprehensive national monitoring systems, indicating the extent of the problem not just in terms of numbers infected, diagnosed and treated but also the more penetrative data on the number advancing to end-stage liver disease and death, and also through compelling modelling work demonstrating the potential beneficial impact of scaling-up therapy and the mounting cost of not acting. Achievements include around 50% increase in the proportion of the infected population diagnosed (38% to 55%); a sustained near two-and-a-half fold increase in the annual number of people initiated onto therapy (470 to 1050) with more pronounced increases among PWID (300 to 840) and prisoners (20 to 140); and reversing of an upward trend in the overall number of people living with chronic infection. The Action Plan has demonstrated that a Government-backed, coordinated and invested approach can transform services and rapidly improve the lives of thousands. Cited as "an impressive example of a national strategy" by the Global Commission on Drug Policy, the Scottish Plan has also provided fundamental insights of international relevance into the management of HCV among PWID.
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http://dx.doi.org/10.1016/j.drugpo.2015.05.019DOI Listing
November 2015

Megalourethra as a rare cause for erectile dysfunction.

Radiol Case Rep 2015 17;10(2):1072. Epub 2016 Feb 17.

consultant urologist, Royal Glamorgan Hospital, Ynysmaerdy, Wales.

MRI findings of megalourethra have not previously been reported. We present a case of an adult presenting with lifelong erectile dysfunction secondary to poor development of the corpus spongiosum and corpora cavernosa. The pathogenesis, typical presentation, and treatment of megalourethra, as well as the use of modern imaging techniques to aid in the diagnosis and treatment of this disease are discussed.
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http://dx.doi.org/10.2484/rcr.v10i2.1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921168PMC
July 2016

Communicating chemical congregation: a molecular AND logic gate with three chemical inputs as a "lab-on-a-molecule" prototype.

J Am Chem Soc 2006 Apr;128(15):4950-1

School of Chemistry and Chemical Engineering, Queen's University, Belfast BT9 5AG, Northern Ireland.

We demonstrate the first three-input molecular AND logic gate based on three chemical inputs as a direct way of detecting congregations of chemical species. The AND gate operates in water and responds to Na+, H+, and Zn2+ inputs with an enhanced fluorescence signal when pre-set concentration thresholds are exceeded. Future "lab-on-a-molecule" devices could have application in medicine for rapid disease screening.
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http://dx.doi.org/10.1021/ja058295+DOI Listing
April 2006

The formation of ReS(2) inorganic fullerene-like structures containing Re(4) parallelogram units and metal-metal bonds.

J Am Chem Soc 2002 Oct;124(39):11580-1

Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, U.K., OX1 3QR.

The encapsulation of ReO(x) within ReS(2) inorganic fullerene-like cages is described for the first time. The encapsulate was prepared by the sulfidization of both hand-milled and ball-milled samples of ReO(2); partial conversion of the oxide to the sulfide was achieved with the degree of sulfidization depending on the exposure to the sulfidizing agent, H(2)S.
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http://dx.doi.org/10.1021/ja0261630DOI Listing
October 2002