Publications by authors named "Gangning Liang"

97Publications

Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.

Nature 2020 10 23;586(7827):151-155. Epub 2020 Sep 23.

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1038/s41586-020-2747-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540737PMC
October 2020

DNA methylation enables transposable element-driven genome expansion.

Proc Natl Acad Sci U S A 2020 08 27;117(32):19359-19366. Epub 2020 Jul 27.

Center for Epigenetics, Van Andel Institute, Grand Rapids, MI 49503

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http://dx.doi.org/10.1073/pnas.1921719117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431005PMC
August 2020

Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype.

Int J Cancer 2020 Jun 22;146(11):3065-3076. Epub 2020 Feb 22.

Division of Medical Oncology, Department of Internal Medicine, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles, CA.

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http://dx.doi.org/10.1002/ijc.32904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448727PMC
June 2020

Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation.

Hepatology 2019 06 9;69(6):2652-2663. Epub 2019 Apr 9.

Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1002/hep.30557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594079PMC
June 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Eur J Cancer 2019 04 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome.

Genes (Basel) 2019 02 23;10(2). Epub 2019 Feb 23.

Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3390/genes10020172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409524PMC
February 2019

Mother-child transmission of epigenetic information by tunable polymorphic imprinting.

Proc Natl Acad Sci U S A 2018 12 3;115(51):E11970-E11977. Epub 2018 Dec 3.

Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503;

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http://dx.doi.org/10.1073/pnas.1815005115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304996PMC
December 2018

Data integration by multi-tuning parameter elastic net regression.

BMC Bioinformatics 2018 Oct 10;19(1):369. Epub 2018 Oct 10.

Department of Preventive Medicine, USC Keck School of Medicine, 2001 N Soto Street, Los Angeles, CA, 90089, USA.

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http://dx.doi.org/10.1186/s12859-018-2401-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180486PMC
October 2018

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses.

Genome Res 2018 08 3;28(8):1147-1157. Epub 2018 Jul 3.

Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

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http://dx.doi.org/10.1101/gr.234229.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071641PMC
August 2018

Epigenetic landscape change analysis during human EMT sheds light on a key EMT mediator TRIM29.

Oncotarget 2017 Nov 9;8(58):98322-98335. Epub 2017 Oct 9.

Department of Biochemistry, School of Medicine, Konkuk University, Seoul, Korea.

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http://dx.doi.org/10.18632/oncotarget.21681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716732PMC
November 2017

Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells.

Cancer Lett 2017 08 6;401:11-19. Epub 2017 May 6.

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645058PMC
August 2017

DNA methylation aberrancies as a guide for surveillance and treatment of human cancers.

Epigenetics 2017 06 30;12(6):416-432. Epub 2017 Mar 30.

b Department of Biochemistry and Molecular Medicine , University of Southern California, USC Norris Comprehensive Cancer Center , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/15592294.2017.1311434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501209PMC
June 2017

Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters.

Sci Rep 2017 02 8;7:41947. Epub 2017 Feb 8.

Department of Hematology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.

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http://dx.doi.org/10.1038/srep41947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296907PMC
February 2017

Genetic and Epigenetic Alterations in Bladder Cancer.

Int Neurourol J 2016 Nov 22;20(Suppl 2):S84-94. Epub 2016 Nov 22.

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.5213/inj.1632752.376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169086PMC
November 2016

The Role of DNA Methylation in Cancer.

Adv Exp Med Biol 2016 ;945:151-172

Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, 90089, USA.

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http://dx.doi.org/10.1007/978-3-319-43624-1_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409375PMC
June 2017

Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers.

Oncotarget 2017 Jan;8(3):5439-5448

Department of Preventive Medicine, Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.12276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354921PMC
January 2017

Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers.

Mol Cell 2016 05;62(3):422-431

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765163001
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http://dx.doi.org/10.1016/j.molcel.2016.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859934PMC
May 2016

DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells.

Nat Commun 2016 04 28;7:11453. Epub 2016 Apr 28.

Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

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http://www.nature.com/articles/ncomms11453
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http://dx.doi.org/10.1038/ncomms11453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853477PMC
April 2016

Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2'-deoxycytidine.

Sci Rep 2016 Apr 19;6:24545. Epub 2016 Apr 19.

Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/srep24545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835787PMC
April 2016

Unique Role for a DNA Methyltransferase Isoform in Lung Cancer.

EBioMedicine 2015 Oct 14;2(10):1272-3. Epub 2015 Sep 14.

Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.ebiom.2015.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634676PMC
October 2015

Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3.

Sci Rep 2015 Nov 19;5:16714. Epub 2015 Nov 19.

Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/srep16714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652225PMC
November 2015

Outlining the limits of partial nephrectomy.

Transl Androl Urol 2015 Jun;4(3):294-300

USC Institute of Urology, Catherine & Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.3978/j.issn.2223-4683.2015.06.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520710PMC
June 2015

Gene body methylation can alter gene expression and is a therapeutic target in cancer.

Cancer Cell 2014 Oct 25;26(4):577-90. Epub 2014 Sep 25.

Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224113PMC
October 2014

A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence.

Clin Cancer Res 2014 Apr;20(7):1978-89

Authors' Affiliations: Departments of Urology and Preventive Medicine; Program in Genetic, Molecular, and Cellular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles; and Department of Urology, School of Medicine, University of Stanford, Stanford, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2637DOI Listing
April 2014

Reprogramming of the human intestinal epigenome by surgical tissue transposition.

Genome Res 2014 Apr 10;24(4):545-53. Epub 2014 Feb 10.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA;

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http://dx.doi.org/10.1101/gr.166439.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975055PMC
April 2014

Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review.

Clin Rev Allergy Immunol 2014 Oct;47(2):128-35

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan,

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http://dx.doi.org/10.1007/s12016-013-8401-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651002PMC
October 2014

Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells.

PLoS One 2013 6;8(9):e75136. Epub 2013 Sep 6.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy,University of Southern California, Los Angeles, California, United States of America ; Departments of Urology and Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern, California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765366PMC
February 2015

SNF5 is an essential executor of epigenetic regulation during differentiation.

PLoS Genet 2013 Apr 25;9(4):e1003459. Epub 2013 Apr 25.

Departments of Urology and Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636213PMC
April 2013

Functional DNA demethylation is accompanied by chromatin accessibility.

Nucleic Acids Res 2013 Apr 13;41(7):3973-85. Epub 2013 Feb 13.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.

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http://dx.doi.org/10.1093/nar/gkt077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627572PMC
April 2013

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules.

Genome Res 2012 Dec 7;22(12):2497-506. Epub 2012 Sep 7.

Department of Urology, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.143008.112
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http://dx.doi.org/10.1101/gr.143008.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514679PMC
December 2012

Epigenetic alterations in bladder cancer and their potential clinical implications.

Adv Urol 2012 21;2012:546917. Epub 2012 Jun 21.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1155/2012/546917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397159PMC
August 2012

DNA methylation screening identifies driver epigenetic events of cancer cell survival.

Cancer Cell 2012 May;21(5):655-67

Department of Urology, Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395886PMC
May 2012

Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.

PLoS Genet 2012 29;8(3):e1002604. Epub 2012 Mar 29.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315468PMC
September 2012

Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells.

Epigenetics Chromatin 2012 Jan 27;5(1). Epub 2012 Jan 27.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1186/1756-8935-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292817PMC
January 2012

Polycomb-repressed genes have permissive enhancers that initiate reprogramming.

Cell 2011 Dec;147(6):1283-94

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.cell.2011.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240866PMC
December 2011

OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes.

Proc Natl Acad Sci U S A 2011 Aug 15;108(35):14497-502. Epub 2011 Aug 15.

Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1073/pnas.1111309108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167525PMC
August 2011

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter.

Hum Mol Genet 2011 Nov 11;20(22):4299-310. Epub 2011 Aug 11.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1093/hmg/ddr356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196883PMC
November 2011

Creating a flexible multiple microRNA expression vector by linking precursor microRNAs.

Biochem Biophys Res Commun 2011 Jul 24;411(2):276-80. Epub 2011 Jun 24.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, NOR7346, 1441 Eastlake Ave., Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148277PMC
July 2011

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.

PLoS Genet 2011 Feb 3;7(2):e1001286. Epub 2011 Feb 3.

Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1001286
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http://dx.doi.org/10.1371/journal.pgen.1001286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033376PMC
February 2011

Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.

PLoS One 2010 Sep 29;5(9). Epub 2010 Sep 29.

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012994PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947512PMC
September 2010

H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes.

Mol Cell 2010 Sep;39(6):901-11

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947862PMC
September 2010

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue.

Cancer Res 2010 Oct 14;70(20):8169-78. Epub 2010 Sep 14.

Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA.

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http://cancerres.aacrjournals.org/content/early/2010/10/07/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955801PMC
October 2010

Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer.

PLoS Genet 2010 Apr 22;6(4):e1000917. Epub 2010 Apr 22.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1000917
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http://dx.doi.org/10.1371/journal.pgen.1000917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858672PMC
April 2010

Rethinking how DNA methylation patterns are maintained.

Nat Rev Genet 2009 11 30;10(11):805-11. Epub 2009 Sep 30.

Peter A. Jones and Gangning Liang are at the Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9181, USA.

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http://dx.doi.org/10.1038/nrg2651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848124PMC
November 2009

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

Mol Cell Biol 2009 Oct 20;29(19):5366-76. Epub 2009 Jul 20.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, NOR 8302L, 9181, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1128/MCB.00484-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747980PMC
October 2009

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

Mol Cancer Ther 2009 Jun 9;8(6):1579-88. Epub 2009 Jun 9.

Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186068PMC
June 2009

Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer.

Int J Cancer 2009 Aug;125(3):723-9

Jane Anne Nohl Division of Hematology, Center for Blood Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1002/ijc.24384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086885PMC
August 2009

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

Cancer Res 2009 Mar 3;69(6):2623-9. Epub 2009 Mar 3.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3114DOI Listing
March 2009

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.

Biochem Biophys Res Commun 2009 Feb 29;379(3):726-31. Epub 2008 Dec 29.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.12.098DOI Listing
February 2009

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Proc Natl Acad Sci U S A 2008 Sep 27;105(35):12979-84. Epub 2008 Aug 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1073/pnas.0806437105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529074PMC
September 2008

RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking.

Cancer Res 2008 Aug;68(15):6208-14

Department of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536768PMC
August 2008

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.

Nucleic Acids Res 2008 Aug 15;36(14):4689-98. Epub 2008 Jul 15.

Department of Surgery, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1093/nar/gkn455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504308PMC
August 2008

Examination of IGF2 and H19 loss of imprinting in bladder cancer.

Cancer Res 2007 Nov;67(22):10753-8

Division of Hematology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-0329DOI Listing
November 2007

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.

Cancer Cell 2007 Nov;12(5):432-44

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657456PMC
November 2007

Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation.

Nat Protoc 2007 ;2(8):1931-6

Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/nprot.2007.271DOI Listing
December 2007

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides.

Cancer Res 2007 Jul;67(13):6400-8

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0251DOI Listing
July 2007

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

Proc Natl Acad Sci U S A 2006 Sep 8;103(38):14080-5. Epub 2006 Sep 8.

Norris Comprehensive Cancer Center, Departments of Urology and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1073/pnas.0604602103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599915PMC
September 2006

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.

Cancer Cell 2006 Jun;9(6):435-43

Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.04.020DOI Listing
June 2006

Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.

Nat Clin Pract Urol 2005 Oct;2(10):502-10

Department of Biochemistry, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1038/ncpuro0318DOI Listing
October 2005

Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma.

Eur J Cancer 2005 Nov 19;41(17):2769-78. Epub 2005 Oct 19.

Department of Urology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1016/j.ejca.2005.07.019DOI Listing
November 2005

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

Mol Cancer Ther 2005 Oct;4(10):1515-20

USC/Norris Comprehensive Cancer Center, Department of Urology, Biochemistry, and Molecular Biology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0172DOI Listing
October 2005

Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients.

Clin Cancer Res 2004 Nov;10(22):7457-65

Departments of Urology, Clinical Pathology, and Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9176, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0930DOI Listing
November 2004

Preferential response of cancer cells to zebularine.

Cancer Cell 2004 Aug;6(2):151-8

USC/Norris Comprehensive Cancer Center, Departments of Urology, Biochemistry, and Molecular Biology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080400209
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http://dx.doi.org/10.1016/j.ccr.2004.06.023DOI Listing
August 2004

Epigenetics in human disease and prospects for epigenetic therapy.

Nature 2004 May;429(6990):457-63

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Room 8302L, Los Angeles, California 90089-9181, USA.

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http://dx.doi.org/10.1038/nature02625DOI Listing
May 2004

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

Proc Natl Acad Sci U S A 2004 May 3;101(19):7357-62. Epub 2004 May 3.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, CA 90089-9181.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0401866101
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http://dx.doi.org/10.1073/pnas.0401866101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC409923PMC
May 2004

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.

Mol Cancer Res 2004 Jan;2(1):62-72

Urologic Cancer Research Laboratory, Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9181, USA.

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January 2004

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.

Mol Cell Biol 2004 Feb;24(3):1270-8

Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9181, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321446PMC
http://dx.doi.org/10.1128/mcb.24.3.1270-1278.2004DOI Listing
February 2004

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

Cancer Res 2002 Nov;62(22):6456-61

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center and Hospital, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA.

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November 2002

Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.

Gene 2002 Sep;298(1):91-9

Urologic Cancer Research Laboratory, Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 8302L, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1016/s0378-1119(02)00976-9DOI Listing
September 2002

Hypomethylation and hypermethylation of DNA in Wilms tumors.

Oncogene 2002 Sep;21(43):6694-702

Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA.

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http://dx.doi.org/10.1038/sj.onc.1205890DOI Listing
September 2002

Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction.

Methods 2002 Jun;27(2):150-5

Department of Biochemistry and Molecular Biology, Urologic Cancer Research Laboratory, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/s1046-2023(02)00068-3DOI Listing
June 2002

Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.

Cancer Res 2002 Feb;62(4):961-6

USC/Norris Comprehensive Cancer Center, Department of Urology, Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9181, USA.

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February 2002

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.

Mol Cell Biol 2002 Jan;22(2):480-91

USC/Norris Comprehensive Cancer Center, Department of Urology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9181, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139739PMC
http://dx.doi.org/10.1128/mcb.22.2.480-491.2002DOI Listing
January 2002