Publications by authors named "Gang Greg Wang"

33Publications

No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function.

Int J Mol Sci 2020 Dec 14;21(24). Epub 2020 Dec 14.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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December 2020

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.

Nat Commun 2020 07 3;11(1):3339. Epub 2020 Jul 3.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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July 2020

Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen.

Sci Rep 2019 12 9;9(1):18637. Epub 2019 Dec 9.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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December 2019

Structure and regulation of ZCCHC4 in mA-methylation of 28S rRNA.

Nat Commun 2019 11 6;10(1):5042. Epub 2019 Nov 6.

Department of Biochemistry, University of California, Riverside, CA, 92521, USA.

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November 2019

Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.

Cell Chem Biol 2019 10 15;26(10):1365-1379.e22. Epub 2019 Aug 15.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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October 2019

R-loops: formation, function, and relevance to cell stress.

Cell Stress 2019 Jan 21;3(2):38-46. Epub 2019 Jan 21.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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January 2019

A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3A) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.

Cancer Res 2019 07 4;79(14):3583-3594. Epub 2019 Jun 4.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

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July 2019

Understanding histone H3 lysine 36 methylation and its deregulation in disease.

Cell Mol Life Sci 2019 Aug 30;76(15):2899-2916. Epub 2019 May 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.

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August 2019

ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.

Mol Cell 2018 10 27;72(2):341-354.e6. Epub 2018 Sep 27.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

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October 2018

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.

Stem Cell Reports 2018 03 15;10(3):675-683. Epub 2018 Feb 15.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

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March 2018

Structural basis for DNMT3A-mediated de novo DNA methylation.

Nature 2018 02 7;554(7692):387-391. Epub 2018 Feb 7.

Department of Biochemistry, University of California, Riverside, California 92521, USA.

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February 2018

Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia.

Front Oncol 2017 12;7:241. Epub 2017 Oct 12.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.

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October 2017

Gene enhancer deregulation and epigenetic vulnerability.

Oncoscience 2016 21;3(11-12):299-301. Epub 2016 Dec 21.

Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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December 2016

BPTF Is Essential for T Cell Homeostasis and Function.

J Immunol 2016 12 31;197(11):4325-4333. Epub 2016 Oct 31.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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December 2016

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.

Cancer Cell 2016 07 23;30(1):92-107. Epub 2016 Jun 23.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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July 2016

PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.

Cancer Res 2016 Feb 8;76(3):619-29. Epub 2016 Jan 8.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois. Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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February 2016

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

Cell Rep 2015 Sep 20;12(9):1400-6. Epub 2015 Aug 20.

Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA. Electronic address:

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September 2015

Targeting EZH2 and PRC2 dependence as novel anticancer therapy.

Exp Hematol 2015 Aug 28;43(8):698-712. Epub 2015 May 28.

Department of Biochemistry and Biophysics, The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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August 2015

Polycomb genes, miRNA, and their deregulation in B-cell malignancies.

Blood 2015 Feb 7;125(8):1217-25. Epub 2015 Jan 7.

Departments of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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February 2015

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

Cancer Discov 2014 May 17;4(5):564-77. Epub 2014 Feb 17.

1Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda; 2Department of Pathology, Johns Hopkins University, Baltimore, Maryland; 3Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin; and 4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

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May 2014

Tudor: a versatile family of histone methylation 'readers'.

Trends Biochem Sci 2013 Nov 10;38(11):546-55. Epub 2013 Sep 10.

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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November 2013

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

ACS Chem Biol 2013 24;8(6):1324-34. Epub 2013 Apr 24.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, §Department of Biochemistry and Biophysics, School of Medicine, ∥Department of Pharmacology, School of Medicine, ⊥National Institute of Mental Health Psychoactive Drug Screening Program, and ¶Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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August 2014

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.

Mol Cell 2013 Feb 27;49(3):571-82. Epub 2012 Dec 27.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.

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February 2013

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers.

Nat Rev Cancer 2010 Jul;10(7):457-69

Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, The Rockefeller University, BOX 78, New York, NY 10065, USA.

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July 2010