Ganesha Rai

Ganesha Rai

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Ganesha Rai

Ganesha Rai

Publications by authors named "Ganesha Rai"

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49Publications

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Cancer Cell 2018 12 21;34(6):939-953.e9. Epub 2018 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310147PMC
December 2018

Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl.

ACS Omega 2018 Oct 10;3(10):12985-12998. Epub 2018 Oct 10.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acsomega.8b01868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644404PMC
October 2018

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Bioorg Med Chem 2018 05 27;26(8):1727-1739. Epub 2018 Feb 27.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmc.2018.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891386PMC
May 2018

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.

ACS Comb Sci 2017 10 5;19(10):646-656. Epub 2017 Sep 5.

Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin , Milwaukee, Wisconsin 53211, United States.

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http://dx.doi.org/10.1021/acscombsci.7b00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643073PMC
October 2017

A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.

Cancer Res 2016 07 4;76(14):4183-91. Epub 2016 Jun 4.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland. Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea. Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033673PMC
July 2016

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.

Retrovirology 2016 Feb 16;13:11. Epub 2016 Feb 16.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1186/s12977-016-0244-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833PMC
February 2016

Discovery of a novel general anesthetic chemotype using high-throughput screening.

Anesthesiology 2015 Feb;122(2):325-33

From the Department of Anesthesiology and Critical Care (A.R.M.-W., W.B., R.G.E.) and Department of Pharmacology (B.P.W.), University of Pennsylvania, Philadelphia, Pennsylvania; National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland (G.R., W.A.L., A.S., A.J., D.J.M.); and College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania (D.F.L.).

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http://dx.doi.org/10.1097/ALN.0000000000000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300529PMC
February 2015

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

Nat Commun 2014 Nov 12;5:5165. Epub 2014 Nov 12.

1] University Chemical Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK [2] Cancer Research UK, Li Ka Shing Centre, Cambridge Institute, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1038/ncomms6165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258842PMC
November 2014

Biochemical assays for the discovery of TDP1 inhibitors.

Mol Cancer Ther 2014 Aug 14;13(8):2116-26. Epub 2014 Jul 14.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute;

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126877PMC
August 2014

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

J Med Chem 2014 May 13;57(10):4035-48. Epub 2014 May 13.

Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/jm401915rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033661PMC
May 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1311846111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926026PMC
February 2014

In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility.

Am J Trop Med Hyg 2014 Jan 2;90(1):71-4. Epub 2013 Dec 2.

Department of Pediatrics and Program in International Child Health, Yale University School of Medicine, New Haven, Connecticut; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana; Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland; Yale School of Public Health, Yale University, New Haven, Connecticut.

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.12-0547
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http://dx.doi.org/10.4269/ajtmh.12-0547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886431PMC
January 2014

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.

Sci Transl Med 2013 Jan;5(167):167ra5

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778723PMC
January 2013

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Medchemcomm 2012 Dec;3(12):1505-1511

Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1039/C2MD20238GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509744PMC
December 2012

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

J Med Chem 2012 Apr 28;55(7):3101-12. Epub 2012 Mar 28.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1021/jm201537dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515842PMC
April 2012

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.

Mol Pharmacol 2012 Mar 9;81(3):420-30. Epub 2011 Dec 9.

Department of Medicine, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1124/mol.111.075630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286293PMC
March 2012

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

J Med Chem 2011 Aug 8;54(15):5485-97. Epub 2011 Jul 8.

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-3370, United States.

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http://dx.doi.org/10.1021/jm2005089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150642PMC
August 2011

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

J Med Chem 2010 Oct;53(20):7392-404

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/jm1008852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966298PMC
October 2010

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):4878-83. Epub 2010 Mar 1.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA.

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http://dx.doi.org/10.1073/pnas.0909141107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841876PMC
March 2010

Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.

Tetrahedron Lett 2009 Apr;50(15):1710-1713

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721338PMC
http://dx.doi.org/10.1016/j.tetlet.2009.01.120DOI Listing
April 2009

(18)F-Labeled benzylideneaniline derivatives as new ligands for beta-amyloid plaque imaging in Alzheimer's disease.

Nucl Med Biol 2009 Feb;36(2):107-16

Department of Nuclear Medicine, Seoul National University College of Medicine and Institute of Radiation Medicine, Jongno-gu, Seoul 110-744, South Korea.

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http://dx.doi.org/10.1016/j.nucmedbio.2008.11.004DOI Listing
February 2009

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Assay Drug Dev Technol 2008 Aug;6(4):551-5

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.liebertpub.com/doi/10.1089/adt.2008.149
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http://dx.doi.org/10.1089/adt.2008.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669305PMC
August 2008

Synthesis and evaluation of benzothiophene derivatives as ligands for imaging beta-amyloid plaques in Alzheimer's disease.

Nucl Med Biol 2006 Aug;33(6):811-20

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, South Korea.

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http://dx.doi.org/10.1016/j.nucmedbio.2006.06.006DOI Listing
August 2006

An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK).

Nucl Med Biol 2006 Jul 12;33(5):677-83. Epub 2006 Jun 12.

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-744, Korea.

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http://dx.doi.org/10.1016/j.nucmedbio.2006.04.004DOI Listing
July 2006

Preparation of 18F-human serum albumin: a simple and efficient protein labeling method with 18F using a hydrazone-formation method.

Bioconjug Chem 2005 Sep-Oct;16(5):1329-33

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1021/bc050086rDOI Listing
December 2005