Ganesh Moorthy

Ganesh Moorthy

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Ganesh Moorthy

Ganesh Moorthy

Publications by authors named "Ganesh Moorthy"

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Optimization of ultrasound assisted extraction of pectin from custard apple peel: Potential and new source.

Carbohydr Polym 2019 Dec 23;225:115240. Epub 2019 Aug 23.

Department of Molecular Microbiology, Madurai Kamaraj University, Palkalai Nagar, Madurai, Tamil Nadu, 625021, India.

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http://dx.doi.org/10.1016/j.carbpol.2019.115240DOI Listing
December 2019

Evaluation of the Drug-Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP-5862, Using a Physiologically-Based Pharmacokinetic Modeling Approach.

CPT Pharmacometrics Syst Pharmacol 2019 Jul 12;8(7):489-499. Epub 2019 May 12.

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/psp4.12408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656940PMC
July 2019

An improved ultra-high-performance liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma.

Biomed Chromatogr 2019 Jun 7;33(6):e4487. Epub 2019 Feb 7.

Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/bmc.4487DOI Listing
June 2019

Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 8;1105:67-75. Epub 2018 Dec 8.

Center for Clinical Pharmacology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, United States of America; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, United States of America.

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183135
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http://dx.doi.org/10.1016/j.jchromb.2018.12.007DOI Listing
January 2019

A case study of chewed Truvada for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

Antivir Ther 2017 6;22(7):639-641. Epub 2017 Mar 6.

Philadelphia FIGHT Community Health Centers, Philadelphia, PA, USA.

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http://dx.doi.org/10.3851/IMP3151DOI Listing
July 2018

Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.

Clin Cancer Res 2018 06 7;24(11):2585-2593. Epub 2018 Mar 7.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3811DOI Listing
June 2018

Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.

Biomed Chromatogr 2018 Mar 9;32(3). Epub 2017 Nov 9.

Center for Clinical Pharmacology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/bmc.4104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801204PMC
March 2018

Harnessing Meta-analysis to Refine an Oncology Patient Population for Physiology-Based Pharmacokinetic Modeling of Drugs.

Clin Pharmacol Ther 2018 02 20;103(2):271-280. Epub 2017 Nov 20.

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, Massachusetts, USA.

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http://doi.wiley.com/10.1002/cpt.917
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http://dx.doi.org/10.1002/cpt.917DOI Listing
February 2018

Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Nov 28;1067:1-9. Epub 2017 Sep 28.

Center for Clinical Pharmacology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States; Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.jchromb.2017.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662017PMC
November 2017

Optimization of dextran production by Weissella cibaria NITCSK4 using Response Surface Methodology-Genetic Algorithm based technology.

Carbohydr Polym 2017 Oct 21;174:103-110. Epub 2017 Jun 21.

Department of Chemical Engineering, National Institute of Technology Calicut, Kerala-673601, India. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2017.06.021DOI Listing
October 2017

CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.

AIDS 2017 09;31(15):2107-2113

aDepartments of Medicine (Infectious Diseases) bEpidemiology cCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia dDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania eBotswana -UPenn Partnership, Gaborone, Botswana fDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania gFaculty of Medicine, University of Botswana, Gaborone, Botswana hOffice of the Chancellor, Rutgers Biomedical and Health Sciences, Rutgers University New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612381PMC
September 2017

Separation of BSA through FAU-type zeolite ceramic composite membrane formed on tubular ceramic support: Optimization of process parameters by hybrid response surface methodology and biobjective genetic algorithm.

Prep Biochem Biotechnol 2017 Aug 9;47(7):687-698. Epub 2017 Mar 9.

a Department of Chemical Engineering , Indian Institute of Technology Guwahati , Guwahati , Assam , India.

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http://dx.doi.org/10.1080/10826068.2017.1303608DOI Listing
August 2017

Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.

J Acquir Immune Defic Syndr 2017 08;75(4):488-491

*Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA; †Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA; ‡Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; §Metrum Research Group, Tariffville, CT; ‖Botswana-UPenn Partnership, University of Botswana, Gaborone, Botswana; ¶Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; #Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA; **Faculty of Medicine, University of Botswana, Gaborone, Botswana; ††Office of the Chancellor, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ; and ‡‡Department of Medicine (Infectious Diseases), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://Insights.ovid.com/crossref?an=00126334-201708010-0001
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http://dx.doi.org/10.1097/QAI.0000000000001442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524513PMC
August 2017

Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.

Am J Perinatol 2017 07 18;34(8):749-758. Epub 2017 Jan 18.

Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1597996
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http://dx.doi.org/10.1055/s-0036-1597996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342009PMC
July 2017

Ultrasound assisted citric acid mediated pectin extraction from industrial waste of Musa balbisiana.

Ultrason Sonochem 2017 Mar 24;35(Pt A):204-209. Epub 2016 Sep 24.

Department of Biotechnology, Kumaraguru College of Technology, Coimbatore, Tamil Nadu 641049, India.

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http://dx.doi.org/10.1016/j.ultsonch.2016.09.019DOI Listing
March 2017

Ultrasound assisted extraction of pectin from waste Artocarpus heterophyllus fruit peel.

Ultrason Sonochem 2017 01 15;34:525-530. Epub 2016 Jun 15.

Department of Food Process Engineering, SRM University, SRM Nagar, Kattankulathur, Chennai 603203, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.ultsonch.2016.06.015DOI Listing
January 2017

Renal Function Descriptors in Neonates: Which Creatinine-Based Formula Best Describes Vancomycin Clearance?

J Clin Pharmacol 2016 May 18;56(5):528-40. Epub 2015 Dec 18.

Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1002/jcph.650DOI Listing
May 2016

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

J Transl Med 2016 05 26;14(1):148. Epub 2016 May 26.

Division of Allergy and Immunology, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s12967-016-0904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880976PMC
May 2016

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

Br J Clin Pharmacol 2015 Nov 10;80(5):1185-96. Epub 2015 Sep 10.

Division of Clinical Pharmacology, Children's National Medical Center, Washington DC, USA.

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http://dx.doi.org/10.1111/bcp.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631191PMC
November 2015

Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Curr HIV Res 2014 ;12(2):121-31

Divisions of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.

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March 2015

Response surface optimization of ultrasound assisted extraction of pectin from pomegranate peel.

Int J Biol Macromol 2015 Jan 27;72:1323-8. Epub 2014 Oct 27.

Department of Biotechnology, Kamaraj College of Engineering and Technology, Virudhunagar 626 001, Tamil Nadu, India.

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https://linkinghub.elsevier.com/retrieve/pii/S01418130140071
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http://dx.doi.org/10.1016/j.ijbiomac.2014.10.037DOI Listing
January 2015

Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants.

J Thorac Cardiovasc Surg 2014 Dec 22;148(6):2634-41. Epub 2014 Jul 22.

Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2014.06.064DOI Listing
December 2014

A liquid chromatography/tandem mass spectrometry method for determination of obatoclax in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Nov 16;971:30-4. Epub 2014 Sep 16.

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, United States of America; Division of Oncology, The Children's Hospital of Philadelphia, United States of America.

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http://dx.doi.org/10.1016/j.jchromb.2014.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252240PMC
November 2014

A sensitive and selective liquid chromatography/tandem mass spectrometry method for quantitative analysis of efavirenz in human plasma.

PLoS One 2013 5;8(6):e63305. Epub 2013 Jun 5.

Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673986PMC
January 2014

Mining relational paths in integrated biomedical data.

PLoS One 2011 6;6(12):e27506. Epub 2011 Dec 6.

School of Library and Information Science, Indiana University, Bloomington, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027506PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232205PMC
July 2012

Validation of an HPLC method for determination of imatinib mesylate in rat serum and its application in a pharmacokinetic study.

J Chromatogr Sci 2010 May-Jun;48(5):334-41

Formulation Development and Pharmacokinetics Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani, 333031 (Rajasthan), India.

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http://dx.doi.org/10.1093/chromsci/48.5.334DOI Listing
November 2010

A sensitive and selective liquid chromatography/tandem mass spectrometry method for determination of MLN8237 in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Sep 3;878(25):2369-73. Epub 2010 Jul 3.

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15700232100042
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http://dx.doi.org/10.1016/j.jchromb.2010.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940716PMC
September 2010

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

J Pharm Sci 2009 Jan;98(1):362-77

Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Drug Discovery, 1250 South Collegeville Rd, Collegeville, Pennsylvania 19426, USA.

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http://dx.doi.org/10.1002/jps.21469DOI Listing
January 2009

Reversible carboxamide-mediated internal activation at C(6) of 2-chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines.

J Org Chem 2008 Dec;73(23):9511-4

GlaxoSmithKline, Oncology R&D, 5 Moore Drive, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1021/jo8020693DOI Listing
December 2008

Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor.

J Pharm Sci 2006 Dec;95(12):2657-72

Drug Metabolism and Pharmacokinetics, Microbial, Musculoskeletal and Proliferative Diseases, Center of Excellence for Drug Discovery, GlaxoSmithKline R&D, 1250 South Collegeville Rd, Collegeville, PA 19426, USA.

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http://dx.doi.org/10.1002/jps.20681DOI Listing
December 2006