Publications by authors named "Ganapathy Sivadas"

10 Publications

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Multidisciplinary Approach for the Management of Mandibular Canines with Rare Configuration.

J Pharm Bioallied Sci 2020 Aug 28;12(Suppl 1):S635-S639. Epub 2020 Aug 28.

Department of Pedodontics, Faculty of Dentistry, Asian Institute of Medical, Science and Technology University, Bedong, Kedah, Malaysia.

It is very rare (2%-6% cases) for a mandibular canine to have two root canals and the incidence of finding two roots with two root canals in a mandibular canine that too bilaterally is almost negligible. This case report discusses the presence and multidisciplinary management of such rarest configuration in both mandibular canines of a female patient. This case shows the importance of recognition of anatomical variations in successful accomplishment of root canal treatment.
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http://dx.doi.org/10.4103/jpbs.JPBS_82_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595556PMC
August 2020

Can Herbal Extracts Serve as Antibacterial Root Canal Irrigating Solutions? Antimicrobial Efficacy of , , , and Sodium Hypochlorite on Biofilms Formed on Tooth Substrate: Study.

J Pharm Bioallied Sci 2020 Aug 28;12(Suppl 1):S423-S429. Epub 2020 Aug 28.

Department of Pedodontics, Faculty of Dentistry, Asian Institute of Medical Science and Technology University, Bedong, Malaysia.

Aim: The purpose of this study was to evaluate the antimicrobial efficacy of , , and on biofilms formed on the tooth substrate. Sodium hypochlorite was used as a positive control. DMSO (dimethyl sulfoxide), the vehicle for the herbal extracts, was used as the negative control.

Materials And Methods: Extracted human teeth were biomechanically prepared, vertically sectioned, placed in the tissue culture wells exposing the root canal surface to to form a biofilm. At the end of the third week, all groups were treated for 15 min with the test solutions and the control. The results were analyzed both quantitatively and qualitatively.

Results: Statistical analysis was performed by using one-way analysis of variance and compared by the Mann-Whitney test using the Statistical Package for the Social Sciences (SPSS) software, version 20.0. The qualitative assay with the 3-week biofilm on the canal portion showed complete inhibition of bacterial growth for NaOCl, whereas samples treated with herbal solutions showed significant reduction of bacterial growth compared to control group, which showed 139.9 × 10 CFU/mL among the experimental herbal solutions groups. has shown maximum bacterial count followed by and .

Conclusion: NaOCl 5% showed maximum antibacterial activity against 3-week biofilm on tooth substrate. , , and showed statistically significant antibacterial activity against 3-week biofilm. The use of herbal alternatives might prove to be advantageous considering the several undesirable characteristics of NaOCl.
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http://dx.doi.org/10.4103/jpbs.JPBS_127_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595561PMC
August 2020

Intentional replantation with 180° rotation of a complicated crown-root fracture: A Case Report.

Trauma Case Rep 2020 Jun 11;27:100306. Epub 2020 May 11.

Sri Sankara Dental College, Varkala, Kerala, India.

Complicated crown root fractures are mostly difficult to treat and have a poor prognosis. To restore the biological space, intentional replantation may be chosen when other immediate treatment options are not viable. Intentional replantation with tooth rotation consists of extraction, 180° rotation and replantation, thereby maintaining the biological width. This article presents management of a maxillary central incisor with complicated crown root fracture with open apex. The tooth was rotated and splinted for one week. The apex was closed with mineral trioxide aggregate (MTA) followed by obturation and post placement. The incompletely obturated adjacent tooth was non-surgically managed by retreatment. Finally, glass fibre post followed by crown with indirect composite built up was made. Patient was followed up every three months for the next two years without any complications.
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http://dx.doi.org/10.1016/j.tcr.2020.100306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218210PMC
June 2020

Comparative Evaluation of Erosive Potential of Various Frozen and Unfrozen Fruit Juices on Primary Teeth Enamel: An Study.

J Pharm Bioallied Sci 2019 May;11(Suppl 2):S463-S467

Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Kedah, Malaysia.

Background: Changing lifestyle pattern and food habits has a deteriorating effect on dental tissues. Dental erosion is a pathological wear of hard tissues of teeth with increased consumption of acidic and carbonated drinks. Susceptibility to erosion in primary dentition is more compared to permanent dentition due to softer and disordered crystal structure of enamel.

Objectives: The main aim of the study was to determine and compare the erosive potential of different fruit juices in frozen/unfrozen forms on primary teeth by studying the calcium dissolution.

Materials And Methods: pH of four different juices (pure) - apple, orange, citrus limetta (musumbi) and grapes were determined using a digital pH meter. The titratable acidity of these in frozen and unfrozen forms were determined by adding 0.2 ml of 1M NaOH to these to raise to pH=5.5(critical pH) and pH =7(neutral pH). Forty eight caries free deciduous anterior teeth specimens were prepared to study the calcium dissolution by atomic absorption spectrophotometer. The results were analysed for statistical significance using One-way Repeated Measures ANOVA and pair wise multiple comparison with Bonferroni correction.

Results: Total titratable acidity and calcium dissolution were found to be significantly more in the initial thawed fruit juices.

Conclusion: Frozen fruit juices had more buffering capacity and erosive potential than unfrozen forms. The study concluded that sucking on frozen fruit juices is more damaging to teeth than unfrozen forms because more of erosion is expected to occur in a frozen state.
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http://dx.doi.org/10.4103/JPBS.JPBS_78_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555365PMC
May 2019

A Comparative Evaluation of Five Obturation Techniques in the Management of Simulated Internal Resorptive Cavities: An Study.

J Pharm Bioallied Sci 2019 May;11(Suppl 2):S450-S456

Department of Preventive Dental Science, College of Dentistry, King Khalid University, Abha, Saudi Arabia.

Background: Root resorption is the loss of dental hard tissues as a result of clastic activities. It might be broadly classified into external or internal resorption by the location of the resorption in relation to the root surface. the various techniques used these days for filling internal resorption include warm condensation, vertical condensation, core techniques, thermoplasticized gutta-percha, warm vertical compaction, and cold lateral condensation.

Objectives: The aims and objectives of this study were to compare the quality of root fillings in artificially created internal resorption cavities filled with warm vertical compaction, lateral condensation, Obtura II along with System B, E and Q plus along with System B, and Thermafil, and to calculate the percentage of gutta-percha, sealer, and voids using an ImageJ software.

Results: Results between the warm vertical compaction (group I), lateral condensation (group II), Obtura II with System B (group III), E and Q plus with System B (group IV), and Thermafil (group V), group III showed the highest percentage of gutta-percha plus sealer and gutta-percha, and least number of voids, which was statistically significant ( < 0.000).

Conclusion: It can be concluded that Obtura II along with System B was found to be the most suitable obturation technique for the management of teeth exhibiting internal resorption. Thermafil was found to give the poorest obturation quality when used to fill the teeth with internal resorption. Similarly, lateral condensation technique was observed to show maximum sealer and hence was not ideal for the management of internal resorptive cavities.
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http://dx.doi.org/10.4103/JPBS.JPBS_75_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555363PMC
May 2019

Levels of Mercury in Fish-Eating Children, With and Without Amalgam Restoration.

J Pharm Bioallied Sci 2019 May;11(Suppl 2):S397-S401

Department of Oral Pathology, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Kedah, Malaysia.

Background: Mercury is a naturally occurring metal that exists in three forms: elemental (metallic), inorganic, and organic mercury. Amalgam, which is an alloy of inorganic mercury, is used as a restorative material in dentistry. Organic mercury gets ingested in the body mainly by the consumption of seafood. Mercury is also stated to cause various adverse health effects such as gastrointestinal disturbances, dermatitis, muscle weakness, and neurological disorders. In recent years, the use of amalgam has become a controversy stating the various adverse effects of mercury. Hence, the study was conducted to determine and compare the variation in levels of organic and inorganic mercury in fish-eating children before and after placement of amalgam restoration.

Materials And Methods: Seventy-five subjects, 42 males (56%) and 35 females (44%) of age group ranging 7-13 years, living in South Canara district of Karnataka, India, were selected as a part of the study. Hair and urine samples were collected for estimation of organic and inorganic levels of mercury, respectively. Informed consent was collected from all the participating subjects.

Results: On comparison between organic and inorganic mercury levels during the study period, the concentration of organic mercury in hair samples was greater irrespective of amalgam restorations present (1.172 and 0.085, respectively; < 0.001).

Conclusion: Thus inorganic levels of mercury do not seem to pose a threat as much as the organic levels observed in hair, which remain fairly constant for a longer period of time. Hence in a coastal region where this study was undertaken and fish being a staple food, the risk could probably be attributed to more of an organic toxicity than an inorganic one. Thus amalgam is relatively safe to be practiced and the controversy against it should be reevaluated.
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http://dx.doi.org/10.4103/JPBS.JPBS_44_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555354PMC
May 2019

Endodontic Management of a Severely Dilacerated Mandibular Third Molar: Case Report and Clinical Considerations.

Case Rep Dent 2018 8;2018:7594147. Epub 2018 Oct 8.

Department of Oral Pathology, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Kedah, Malaysia.

This article aims at providing an insight to the clinical modifications required for the endodontic management of severely dilacerated mandibular third molar. A 35-year-old patient was referred for the root canal treatment of the mandibular left third molar. An intraoral periapical radiograph revealed a severe curvature in both the canals. A wide trapezoidal access was prepared following the use of intermediate-sized files for apical preparation. Owing to increased flexibility, Hero Shaper NITI files were used for the biomechanical preparation and single cone obturation was carried out. Third molars owing to their most posterior location-limited access coupled with a severe curvature pose utmost clinical challenges require meticulous skill, advanced technology, and patience to achieve success.
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http://dx.doi.org/10.1155/2018/7594147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196887PMC
October 2018

"Ormocer an innovative technology": A replacement for conventional cements and veneer? A comparative analysis.

Eur J Dent 2017 Jan-Mar;11(1):58-63

Department of Oral Pathology, AIMST University, Kedah, Malaysia.

Objective: This study was designed to assess shear bond strength (SBS) of ormocer flowable (OF) resin as a luting agent, ormocer as an indirect veneer material with portrayal of modes of failures using scanning electron microscope (SEM).

Materials And Methods: Sixty maxillary central incisors were divided into Group I, II, and III with 20 samples each based on luting cement used. They were OF, self-adhesive (SA) cement, and total etch (TE) cement. These groups were subdivided into "a" and "b" of ten each based on the type of veneering materials used. Veneer discs were fabricated using Ormocer restorative (O) and pressable ceramic (C). Specimens were thermocycled and loaded under universal testing machine for SBS. The statistical analysis was done using one-way ANOVA Tukey honest significant difference method.

Results: A significant difference was observed between the Groups I and II ( < 0.05). The highest mean bond strength when using ormocer veneer was obtained with the Group Ia (19.11 ± 1.92 Mpa) and lowest by Group IIa (8.1 ± 1.04 Mpa), whereas the highest mean bond strength while using ceramic veneer was of similar range for Group Ib (18.04 ± 4.08 Mpa) and Group IIIb (18.07 ± 1.40 Mpa). SEM analysis revealed OF and TE presented mixed type of failure when compared with SA where failure mode was totally adhesive.

Conclusion: OF was found equally efficient like TE. Bond strength of ormocer as a veneer was not inferior to ceramic making it one of the promising additions in the field of dentistry.
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http://dx.doi.org/10.4103/ejd.ejd_113_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379836PMC
April 2017

Congenital Hemifacial Hyperplasia: Clinical Presentation and Literature Review.

Case Rep Dent 2016 24;2016:5260645. Epub 2016 Oct 24.

Chettinad Dental College & Research Institute, Kancheepuram, India.

Hemifacial hyperplasia is a rare congenital malformation characterized by noticeable unilateral excess development of hard and soft tissues of the face. Asymmetry in Congenital Hemifacial Hyperplasia (CHH) is usually evident at birth and accentuated at the age of puberty. The affected side grows exponentially as compared to the unaffected side. Multiple tissue involvement has resulted due to etiological heterogeneity like heredity, chromosomal abnormalities, altered intrauterine environment, and endocrine dysfunctions. As this lesion is rarely seen in our routine clinical practice, we present a case of hemifacial hyperplasia with reported orofacial features that supplement existing clinical knowledge. This paper also adds knowledge to the readers regarding detailed investigation procedures which has complemented our diagnosis. Further emphasis has been placed on periodic approach to its diagnosis and multidisciplinary management following correct diagnosis.
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http://dx.doi.org/10.1155/2016/5260645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098060PMC
October 2016

Salivary Amylase as a Marker of Salivary Gland Function in Patients Undergoing Radiotherapy for Oral Cancer.

J Clin Lab Anal 2017 May 17;31(3). Epub 2016 Sep 17.

Department of Pedodontics & Preventive Dentistry, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Kedah, Malaysia.

Background: The aim of this study was to evaluate salivary amylase in patients with primary oral cancer undergoing radiotherapy as the main modality of treatment.

Materials/methods: The study was conducted on ten histologically proven cases of oral cancer undergoing radiotherapy. Stimulated whole saliva was collected at three stages of radiotherapy-0, 3, and 6 weeks. Salivary amylase was estimated using Henry-Chiamori method and comparison was made with appropriate age- and gender-matched controls.

Results: Salivary amylase levels showed significant decrease in healthy subjects when compared to oral cancer patients (P < 0.001). The latter group also showed changing trend with initial decrease from 0 to 3 weeks followed by increase from 3 to 6 weeks following radiotherapy (P < 0.0528).

Conclusions: The trend in changes in the levels of salivary amylase could be used as a surrogate marker of salivary gland function in patients with oral cancer undergoing radiotherapy as primary treatment.
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http://dx.doi.org/10.1002/jcla.22048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817105PMC
May 2017
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