Gal Bitan

Gal Bitan

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Gal Bitan

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Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation.

Acta Neuropathol Commun 2019 Aug 20;7(1):135. Epub 2019 Aug 20.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 635 Charles E. Young Dr. South, Rm 415, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s40478-019-0783-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700776PMC
August 2019

Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size.

Methods Mol Biol 2018 ;1779:3-12

Department of Neurology, Molecular Biology Institute, Brain Research Institute, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7816-8_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490168PMC
July 2019

Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins.

Methods Mol Biol 2018 ;1777:369-386

Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7811-3_24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459406PMC
February 2019

A Label-Free Platform for Identification of Exosomes from Different Sources.

ACS Sens 2019 Feb 31;4(2):488-497. Epub 2019 Jan 31.

Jonsson Comprehensive Cancer Center , University of California Los Angeles , Los Angeles , California 90024 , United States.

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http://dx.doi.org/10.1021/acssensors.8b01564DOI Listing
February 2019

Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.

ACS Chem Biol 2018 09 30;13(9):2794-2807. Epub 2018 Aug 30.

Department of Neurology , University of British Columbia (UBC) , Vancouver , British Columbia V6T 2B5 , Canada.

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http://dx.doi.org/10.1021/acschembio.8b00729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475120PMC
September 2018

The molecular tweezer CLR01 inhibits Ebola and Zika virus infection.

Antiviral Res 2018 04 8;152:26-35. Epub 2018 Feb 8.

Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; U-PEP and Core Facility Functional Peptidomics, Ulm University, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.02.003DOI Listing
April 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.

J Am Heart Assoc 2017 Aug 8;6(8). Epub 2017 Aug 8.

Division of Molecular Cardiovascular Biology, the Heart Institute, Cincinnati Children's Hospital, Cincinnati, OH

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https://www.ahajournals.org/doi/10.1161/JAHA.117.006182
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http://dx.doi.org/10.1161/JAHA.117.006182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586456PMC
August 2017

Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light.

Sci Rep 2017 03 9;7:44157. Epub 2017 Mar 9.

Electrical Engineering Department, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/srep44157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343455PMC
March 2017

Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes.

Anal Biochem 2017 Feb 31;518:78-85. Epub 2016 Oct 31.

Department of Neurology, David Geffen School of Medicine, and Molecular Biology Institute and Brain Research Institute, University of California, Los Angeles, CA 90095, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474095PMC
February 2017

Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation.

Chem Commun (Camb) 2016 Oct 22;52(76):11318-34. Epub 2016 Aug 22.

Faculty of Chemistry, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1039/c6cc04640aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026632PMC
October 2016

Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity.

ACS Chem Neurosci 2016 07 5;7(7):845-56. Epub 2016 Jul 5.

Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles , Neuroscience Research Building 1, Room 451 635 Charles E. Young Drive South, Los Angeles, California 90095-7334, United States.

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http://dx.doi.org/10.1021/acschemneuro.6b00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450937PMC
July 2016

Reducing synuclein accumulation improves neuronal survival after spinal cord injury.

Exp Neurol 2016 Apr 13;278:105-15. Epub 2016 Feb 13.

Marine Biological Laboratory, The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Woods Hole, MA 02543, United States. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788542PMC
April 2016

Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?

J Phys Chem B 2016 Mar 16;120(8):1615-23. Epub 2015 Oct 16.

Department of Chemistry and Biochemistry and ∥Department of Physics, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.jpcb.5b08177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777659PMC
March 2016

Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity.

ACS Chem Neurosci 2015 Dec 19;6(12):1941-55. Epub 2015 Oct 19.

Department of Neurology, David Geffen School of Medicine at UCLA , 635 Charles E. Young Drive South, Room 445, Los Angeles, California, 90095, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844016PMC
December 2015

Toxicity inhibitors protect lipid membranes from disruption by Aβ42.

ACS Chem Neurosci 2015 Nov 9;6(11):1860-9. Epub 2015 Sep 9.

Department of Chemistry, Ben Gurion University of the Negev , Beer Sheva 84105, Israel.

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http://dx.doi.org/10.1021/acschemneuro.5b00200DOI Listing
November 2015

The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.

Biochemistry 2015 Jun 11;54(24):3729-38. Epub 2015 Jun 11.

†Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel 69978.

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http://pubs.acs.org/doi/10.1021/bi501092p
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http://dx.doi.org/10.1021/bi501092pDOI Listing
June 2015

Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03.

J Phys Chem B 2015 Apr 16;119(14):4831-41. Epub 2015 Mar 16.

†Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.jpcb.5b00692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415044PMC
April 2015

Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models.

Curr Pharm Des 2014 ;20(15):2469-83

Department of Neurology, David Geffen School of Medicine at UCLA, Neuroscience Research Building 1, Room 451, 635 Charles E. Young Drive South, Los Angeles, CA 90095-7334, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261945PMC
http://dx.doi.org/10.2174/13816128113199990496DOI Listing
February 2015

A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease.

PLoS One 2013 13;8(11):e80355. Epub 2013 Nov 13.

Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America ; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080355PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827415PMC
July 2014

Molecular tweezers targeting transthyretin amyloidosis.

Neurotherapeutics 2014 Apr;11(2):450-61

IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal.

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http://link.springer.com/10.1007/s13311-013-0256-8
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http://dx.doi.org/10.1007/s13311-013-0256-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996111PMC
April 2014

Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

J Biol Chem 2014 Apr 24;289(15):10727-37. Epub 2014 Feb 24.

From the Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48823.

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http://dx.doi.org/10.1074/jbc.M113.524520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036189PMC
April 2014

Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.

BMC Pharmacol Toxicol 2014 Apr 16;15:23. Epub 2014 Apr 16.

Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-7334, USA.

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http://dx.doi.org/10.1186/2050-6511-15-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996151PMC
April 2014

Tranilast binds to aβ monomers and promotes aβ fibrillation.

Biochemistry 2013 Jun 31;52(23):3995-4002. Epub 2013 May 31.

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute (RPI), Troy, NY 12180, USA.

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http://dx.doi.org/10.1021/bi400426tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082028PMC
June 2013

Effects of different amyloid β-protein analogues on synaptic function.

Neurobiol Aging 2013 Apr 6;34(4):1032-44. Epub 2012 Oct 6.

Institute of Human Physiology, Università Cattolica, Rome, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.06.027DOI Listing
April 2013

Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations.

Dement Geriatr Cogn Disord 2012 14;33(4):219-25. Epub 2012 May 14.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095-7334, USA.

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http://dx.doi.org/10.1159/000338546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568669PMC
November 2012

Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins.

Methods Mol Biol 2012 ;849:11-21

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-551-0_2DOI Listing
August 2012

Preparation of stable amyloid β-protein oligomers of defined assembly order.

Methods Mol Biol 2012 ;849:23-31

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-551-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767166PMC
August 2012

Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.

ACS Chem Neurosci 2012 Jun 7;3(6):451-8. Epub 2012 Mar 7.

Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1021/cn200133xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386858PMC
June 2012

A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

ACS Chem Neurosci 2012 Jun 16;3(6):473-81. Epub 2012 Mar 16.

Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1021/cn3000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382451PMC
June 2012

Design of β-amyloid aggregation inhibitors from a predicted structural motif.

J Med Chem 2012 Apr 15;55(7):3002-10. Epub 2012 Mar 15.

Department of Chemistry, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1021/jm201332pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766731PMC
April 2012

A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

ChemMedChem 2012 Mar 3;7(3):515-22. Epub 2012 Feb 3.

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA), 635 Charles E. Young Drive S., Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/cmdc.201100584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517043PMC
March 2012

Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms.

ChemMedChem 2012 Mar 9;7(3):359-74. Epub 2012 Feb 9.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 635 Charles E. Young Drive South/NRB 455, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/cmdc.201100585DOI Listing
March 2012

Aβ(39-42) modulates Aβ oligomerization but not fibril formation.

Biochemistry 2012 Jan 23;51(1):108-17. Epub 2011 Dec 23.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/bi201520bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271797PMC
January 2012

Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.

Biochemistry 2011 Dec 14;50(49):10687-97. Epub 2011 Nov 14.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, Kansas 66045, United States.

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http://dx.doi.org/10.1021/bi201426bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235361PMC
December 2011

C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42.

J Med Chem 2011 Dec 28;54(24):8451-60. Epub 2011 Nov 28.

Department of Neurology, David Geffen School of Medicine, Brain Research Institute, University of California, Los Angeles, 635 Charles E. Young Drive South, Los Angeles, California 90095-7334, United States.

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http://pubs.acs.org/doi/abs/10.1021/jm200982p
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http://dx.doi.org/10.1021/jm200982pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240737PMC
December 2011

Rational design of β-sheet ligands against Aβ42-induced toxicity.

J Am Chem Soc 2011 Mar 7;133(12):4348-58. Epub 2011 Mar 7.

Universität Duisburg-Essen, Fachbereich Chemie, Universitätstrasse 5, 45117 Essen, Germany.

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http://dx.doi.org/10.1021/ja107675nDOI Listing
March 2011

Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.

Biochem J 2011 Jan;433(2):323-32

Department of Neurology, University of California at Los Angeles, 90025, USA.

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http://dx.doi.org/10.1042/BJ20101391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767168PMC
January 2011

Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.

Biochemistry 2010 Aug;49(30):6358-64

Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, 635 Charles E.Young Drive S., Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1021/bi100773gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912417PMC
August 2010

Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity.

J Neurochem 2010 Jun 20;113(5):1252-62. Epub 2010 Mar 20.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06692.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908238PMC
June 2010

Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease.

J Vis Exp 2010 May 13(39). Epub 2010 May 13.

Department of Neurology, David Geffen School of Medicine.

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http://dx.doi.org/10.3791/1955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918391PMC
May 2010

Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.

Biochemistry 2010 Feb;49(6):1259-67

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 635 Charles E. Young Drive, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1021/bi902075hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831638PMC
February 2010

RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.

PLoS One 2009 Nov 10;4(11):e7694. Epub 2009 Nov 10.

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007694PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770325PMC
November 2009

The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study.

J Mol Biol 2009 Mar 23;387(2):492-501. Epub 2009 Jan 23.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9501, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712569PMC
March 2009

Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides.

J Vis Exp 2009 Jan 12(23). Epub 2009 Jan 12.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA.

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http://dx.doi.org/10.3791/1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763294PMC
January 2009

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):14175-80. Epub 2008 Sep 8.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.0807163105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544597PMC
September 2008

Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice.

Neurobiol Aging 2007 Jun 24;28(6):813-23. Epub 2006 May 24.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.04.007DOI Listing
June 2007

Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins.

Authors:
Gal Bitan

Methods Enzymol 2006 ;413:217-36

UCLA, Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)13012-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782599PMC
November 2006

Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach.

Acc Chem Res 2006 Sep;39(9):635-45

Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.

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http://pubs.acs.org/doi/abs/10.1021/ar050063s
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September 2006

Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?

Expert Rev Neurother 2006 Sep;6(9):1293-306

Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Neuroscience Research Building 1, Room 455, 635 Charles E. Young Drive South Los Angeles, CA 90095-7334, USA.

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http://dx.doi.org/10.1586/14737175.6.9.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715564PMC
September 2006

Amyloid beta-protein monomer structure: a computational and experimental study.

Protein Sci 2006 Mar;15(3):420-8

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9501, USA.

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http://doi.wiley.com/10.1110/ps.051762406
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http://dx.doi.org/10.1110/ps.051762406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249763PMC
March 2006

En route to early diagnosis of Alzheimer's disease--are we there yet?

Trends Biotechnol 2005 Nov 12;23(11):531-3. Epub 2005 Sep 12.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.tibtech.2005.09.002DOI Listing
November 2005

Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays.

Methods Mol Biol 2005 ;299:3-9

Center for Neurologic Diseases, Brigham and Women's Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1385/1-59259-874-9:003DOI Listing
July 2005

Determination of Peptide oligomerization state using rapid photochemical crosslinking.

Methods Mol Biol 2005 ;299:11-8

Center for Neurologic Diseases, Brigham and Women's Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.

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July 2005

Neurotoxic protein oligomers--what you see is not always what you get.

Amyloid 2005 Jun;12(2):88-95

Department of Neurology, David Geffen School of Medicine at UCLA, 90095-7334, USA.

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http://www.tandfonline.com/doi/full/10.1080/1350612050010695
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June 2005

Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

J Am Chem Soc 2005 Feb;127(7):2075-84

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9501, USA.

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http://dx.doi.org/10.1021/ja044531pDOI Listing
February 2005

Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.

Acc Chem Res 2004 Jun;37(6):357-64

Center for Neurologic Diseases, Brigham and Women's Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

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http://pubs.acs.org/doi/abs/10.1021/ar000214l
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June 2004

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.

J Am Chem Soc 2003 Dec;125(50):15359-65

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0349296
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December 2003

Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

J Biol Chem 2003 Sep 2;278(37):34882-9. Epub 2003 Jul 2.

Center for Neurologic Diseases, Brigham and Women's Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M300825200DOI Listing
September 2003

Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.

J Clin Invest 2003 Aug;112(3):415-22

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI18104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166296PMC
August 2003

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

Proc Natl Acad Sci U S A 2003 Jan 27;100(1):330-5. Epub 2002 Dec 27.

Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.222681699
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140968PMC
January 2003

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.

J Neurosci Res 2002 Sep;69(5):567-77

Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/jnr.10328DOI Listing
September 2002

Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids.

J Org Chem 1997 Jan;62(2):411-416

Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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January 1997