Publications by authors named "Gaia Spinetti"

71Publications

MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells.

Vasc Biol 2019 12;1(1):H75-H81. Epub 2019 Aug 12.

IRCCS MultiMedica, Milan, Italy.

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http://dx.doi.org/10.1530/VB-19-0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439843PMC
August 2019

Microfluidic Synthesis of Hybrid TiO-Anisotropic Gold Nanoparticles with Visible and Near-Infrared Activity.

ACS Appl Mater Interfaces 2020 Aug 18;12(34):38522-38529. Epub 2020 Aug 18.

National Research Council, CNR-SCITEC, Via G. Fantoli 16/15, Milan 20138, Italy.

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http://dx.doi.org/10.1021/acsami.0c08241DOI Listing
August 2020

Bone marrow fat: friend or foe in people with diabetes mellitus?

Clin Sci (Lond) 2020 04;134(8):1031-1048

Bristol Medical School (Translational Health Sciences), Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol BS2 8HW, U.K.

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http://dx.doi.org/10.1042/CS20200220DOI Listing
April 2020

Bone marrow as a target and accomplice of vascular complications in diabetes.

Diabetes Metab Res Rev 2020 03 15;36 Suppl 1:e3240. Epub 2019 Dec 15.

Bristol Heart Institute, Translational Health Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, UK.

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http://dx.doi.org/10.1002/dmrr.3240DOI Listing
March 2020

Personalized Cardiovascular Regenerative Medicine: Targeting the Extreme Stages of Life.

Front Cardiovasc Med 2019 27;6:177. Epub 2019 Nov 27.

Laboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, Italy.

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http://dx.doi.org/10.3389/fcvm.2019.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890607PMC
November 2019

Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease.

Arterioscler Thromb Vasc Biol 2020 01 12;40(1):34-44. Epub 2019 Sep 12.

Experimental Cardiovascular Medicine, University of Bristol, United Kingdom (M.S., P.M.).

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http://dx.doi.org/10.1161/ATVBAHA.119.312863DOI Listing
January 2020

Role of TPBG (Trophoblast Glycoprotein) Antigen in Human Pericyte Migratory and Angiogenic Activity.

Arterioscler Thromb Vasc Biol 2019 06;39(6):1113-1124

From the Bristol Heart Institute, Bristol Medical School, Translational Health Sciences, University of Bristol, United Kingdom (H.L.S., E.J., W.C., E.A., I.R.-A., A.C.T., V.V.A., G.S.-N., Z.D., M.F., C.R., J.R., G.A., P.M.).

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http://dx.doi.org/10.1161/ATVBAHA.119.312665DOI Listing
June 2019

Bone marrow pericyte dysfunction in individuals with type 2 diabetes.

Diabetologia 2019 07 17;62(7):1275-1290. Epub 2019 Apr 17.

Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Level 7, Upper Maudlin Street, Bristol, BS2 8HW, UK.

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http://link.springer.com/10.1007/s00125-019-4865-6
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http://dx.doi.org/10.1007/s00125-019-4865-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560025PMC
July 2019

The sodium-hydrogen antiporter: a new target to boost post-ischemic angiogenesis in diabetes?

Authors:
Gaia Spinetti

Int J Cardiol 2019 02 2;277:220-221. Epub 2018 Oct 2.

Laboratory of Cardiovascular Research, IRCCS MultiMedica, Via Fantoli 16/15, 20138 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.09.115DOI Listing
February 2019

MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1.

Mol Ther 2018 12 1;26(12):2823-2837. Epub 2018 Sep 1.

Bristol Heart Institute, Translational Health Sciences, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277430PMC
December 2018

Editorial: Mechanisms and Implications of the Aging of Cardiovascular Regenerative Cells.

Front Cardiovasc Med 2018 17;5:93. Epub 2018 Jul 17.

Laboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, Italy.

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http://dx.doi.org/10.3389/fcvm.2018.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056607PMC
July 2018

MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes.

Diabetes 2018 07 27;67(7):1380-1394. Epub 2018 Apr 27.

Bristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, U.K.

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http://dx.doi.org/10.2337/db18-0044DOI Listing
July 2018

Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs.

Antioxid Redox Signal 2018 09 11;29(9):864-879. Epub 2017 Sep 11.

2 School of Clinical Sciences, Bristol Heart Institute, University of Bristol , United Kingdom .

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http://dx.doi.org/10.1089/ars.2017.7294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080119PMC
September 2018

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

Mol Ther 2017 03 1;25(3):679-693. Epub 2017 Feb 1.

Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK; National Heart and Lung Institute, Imperial College London, London SW3 6NP, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016173000
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http://dx.doi.org/10.1016/j.ymthe.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363195PMC
March 2017

The Peter Principle in Cardiovascular Cell Therapy: The Decline of a Theory or the Theory of a Decline.

Circ Res 2016 12;119(12):1283-1285

From the IRCCS MultiMedica, Milan, Italy (G.S.); and Bristol Heart Institute, University of Bristol, United Kingdom (P.M.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.31001
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http://dx.doi.org/10.1161/CIRCRESAHA.116.310017DOI Listing
December 2016

The genetics of exceptional longevity identifies new druggable targets for vascular protection and repair.

Pharmacol Res 2016 12 3;114:169-174. Epub 2016 Nov 3.

University of Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.10.028DOI Listing
December 2016

High-level expression of a recombinant active microbial transglutaminase in Escherichia coli.

BMC Biotechnol 2015 Sep 15;15:84. Epub 2015 Sep 15.

Bio-Ker S.r.l., Sardinia Scientific and Technological Park, Building 3, 09010, Pula, Cagliari, Italy.

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http://dx.doi.org/10.1186/s12896-015-0202-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570659PMC
September 2015

Enhancing Stem Cell Mobility: New Hope for Treatment of Cardiovascular Complications in Patients With Diabetes?

Diabetes 2015 Aug;64(8):2704-7

Bristol Heart Institute, University of Bristol, Bristol, U.K.

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http://dx.doi.org/10.2337/db15-0433DOI Listing
August 2015

Training monocytes by physical exercise: good practice for improving collateral artery development and postischemic outcomes.

Arterioscler Thromb Vasc Biol 2015 Aug;35(8):1733-5

From the Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom (E.A., P.M.); and MultiMedica Research Institute, Milan, Italy (G.S.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306034DOI Listing
August 2015

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.

Circ Res 2015 Jul 1;117(4):333-45. Epub 2015 Jun 1.

From the National Research Council, Institute for Biomedical Technologies, Segrate (MI), Italy (F.V., C.C.S., A.F.); IRCCS Neuromed, Department of Vascular Physiopathology, Pozzilli (IS), Italy (A.C., A.D., M.M., M.A., S.F., C.V.); Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy (A. Malovini, F.M., R.B.); IRCCS Multimedica, Cardiovascular Department, Milan, Italy (A. Maciąg, G.S., E.S., A.A.P.); Department of Translational Medicine, "Federico II" University, Naples, Italy (A.A.); TIGEM (Telethon Institute of Genetics and Medicine), Naples, Italy (A.A.); Department of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom (Z.D., P.M.); Department of Biochemistry and Molecular Pharmacology IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (L.S., P.B.); National Research Council, Institute of Experimental Endocrinology and Oncology (IEOS), Naples, Italy (G.C.); Institute of Clinical Molecular Biology, Christian-Albrechts University and the Schleswig-Holstein University Hospital, Kiel, Germany (S.S., A.N.); Geriatrics Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA (T.P.); Dipartimento di Fisiologia e Farmacologia, Sapienza Università di Roma, Rome, Italy (S.F.); and Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, 84081 Baronissi (SA), Italy (C.V., A.A.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496930PMC
July 2015

Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia.

Arterioscler Thromb Vasc Biol 2015 Mar 8;35(3):675-88. Epub 2015 Jan 8.

From the Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK (M.G., S.C.S., H.L.S., F.R., J.R., E.A., R.K., G.M., A.O., C.R., C.E., G.A., P.M.); The Institute of Cancer Research, Evolutionary Genomics and Modelling Team, Centre for Evolution and Cancer, Sutton, UK (I.S., A.S.); Imperial College, London, UK (P.C., C.E., G.A.); MultiMedica Research Institute, Milan, Italy (G.S.); Cancer Research UK Cambridge Institute, Cambridge, UK (A.T., S.T.); Centro Cardiologico Monzino, Milan, Italy (F.P., M.P.); and Austrian Institute of Technology, Vienna, Austria (M.H., V.K.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304989DOI Listing
March 2015

Reactive oxygen species adversely impacts bone marrow microenvironment in diabetes.

Antioxid Redox Signal 2014 Oct;21(11):1620-33

1 Regenerative Medicine Section, Bristol Heart Institute, School of Clinical Sciences, University of Bristol , Bristol, United Kingdom .

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http://dx.doi.org/10.1089/ars.2014.5944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175424PMC
October 2014

Preclinical and clinical phase I studies of a new recombinant Filgrastim (BK0023) in comparison with Neupogen®.

BMC Pharmacol Toxicol 2014 Feb 21;15. Epub 2014 Feb 21.

Bio-Ker S,r,l,-Multimedica Group, Sardinia Scientific and Technological Park, Building 3, I-09010 Pula Cagliari, Italy.

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http://dx.doi.org/10.1186/2050-6511-15-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942296PMC
February 2014

What's new in regenerative medicine: split up of the mesenchymal stem cell family promises new hope for cardiovascular repair.

J Cardiovasc Transl Res 2012 Oct 11;5(5):689-99. Epub 2012 Aug 11.

Multimedica IRCCS, Milan, Italy.

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http://dx.doi.org/10.1007/s12265-012-9395-2DOI Listing
October 2012

A local proinflammatory signalling loop facilitates adverse age-associated arterial remodeling.

PLoS One 2011 Feb 8;6(2):e16653. Epub 2011 Feb 8.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035650PMC
February 2011

Targeting stem cell niches and trafficking for cardiovascular therapy.

Pharmacol Ther 2011 Jan 20;129(1):62-81. Epub 2010 Oct 20.

Institute of Physiology/Cardiovascular Research, University of Zürich, and Cardiovascular Center, Cardiology, University Hospital Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.pharmthera.2010.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017934PMC
January 2011

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells.

PLoS One 2008 May 21;3(5):e2231. Epub 2008 May 21.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002231PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373882PMC
May 2008

Proinflammatory profile within the grossly normal aged human aortic wall.

Hypertension 2007 Jul 23;50(1):219-27. Epub 2007 Apr 23.

National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.089409DOI Listing
July 2007

Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall.

Arterioscler Thromb Vasc Biol 2006 Jul 11;26(7):1503-9. Epub 2006 May 11.

Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging/NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224-6825, USA.

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http://dx.doi.org/10.1161/01.ATV.0000225777.58488.f2DOI Listing
July 2006

Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.

Am J Pathol 2005 Nov;167(5):1429-42

Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr., 3-B-03, Baltimore, MD 21224-6825, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603787PMC
http://dx.doi.org/10.1016/S0002-9440(10)61229-1DOI Listing
November 2005

Laminar shear stress inhibits CXCR4 expression on endothelial cells: functional consequences for atherogenesis.

FASEB J 2005 Apr 10;19(6):629-31. Epub 2005 Feb 10.

Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy.

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http://dx.doi.org/10.1096/fj.04-2219fjeDOI Listing
April 2005

Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function.

Arterioscler Thromb Vasc Biol 2004 Aug 3;24(8):1397-402. Epub 2004 Jun 3.

Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000134529.65
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http://dx.doi.org/10.1161/01.ATV.0000134529.65173.08DOI Listing
August 2004

In vitro and in vivo models to study chemokine regulation of angiogenesis.

Methods Mol Biol 2004 ;239:223-32

Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy.

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http://dx.doi.org/10.1385/1-59259-435-2:223DOI Listing
March 2004

Analysis of the role of chemokines in angiogenesis.

J Immunol Methods 2003 Feb;273(1-2):83-101

Department of Experimental Medicine and Pathology, University of Rome, Viale Regina Elena 324, La Sapienza 00161, Italy.

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http://dx.doi.org/10.1016/s0022-1759(02)00420-9DOI Listing
February 2003

The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway.

J Leukoc Biol 2003 Jan;73(1):201-7

Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Monti di Creta 104, 00167 Rome, Italy.

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http://dx.doi.org/10.1189/jlb.0302105DOI Listing
January 2003