Dr Gaetano Leto, Ph.D  - University of Palermo School of Medicine - senior researcher

Dr Gaetano Leto

Ph.D

University of Palermo School of Medicine

senior researcher

Palermo | Italy

Main Specialties: Oncology, Pharmacology

Additional Specialties: pharmacology, cancer chemotherapy

ORCID logohttps://orcid.org/0000-0002-0900-1259


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Dr Gaetano Leto, Ph.D  - University of Palermo School of Medicine - senior researcher

Dr Gaetano Leto

Ph.D

Introduction

Education: Degree in Biological Sciences (1977)

Research and Professional Experience
1975-1977: Student trainee at the Institute of Pharmacology, Faculty of Medicine, University of Palermo, Italy
Feb.1978-Aug.1979: Biologist at the Clinical Chemistry Laboratory unit of the Navy Hospital “B. Falcomatà” La Spezia, Italy
1980-84: Post- graduate fellowship in Pharmacology at the Institute of Pharmacology, Faculty of Medicine, University of Palermo, Italy
March 1985-March1986: Affiliate Researcher at Dept. Exp. Therap., Roswell Park Mermorial Institute, Buffalo, NY, USA
August –December 1987: Affiliate Researcher at Dept. Exp. Therap., Roswell Park Mermorial Institute, Buffalo, NY, USA
August-November 1989: Affiliate Researcher at Dept. Exp. Therap., Roswell Park Mermorial Institute, Buffalo, NY, USA
May 2002 : Senior Researcher in Pharmacology at School of Medicine, University of Palermo, Italy

Academic Institutions
1992:Member of the Metastasis Reserch Society.
1996 :Member of the American Association for Cancer Research.
2003 : Member of the Italian Society of Pharmacology

Primary Affiliation: University of Palermo School of Medicine - Palermo , Italy

Specialties:

Additional Specialties:

Research Interests:


View Dr Gaetano Leto’s Resume / CV

Education

Jul 1977
University of Palermo Italy
Biological Sciences

Experience

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Publications

53Publications

517Reads

545Profile Views

228PubMed Central Citations

Nutrition, obesity and hormones.

91, 2 (Dec. 2018). DOI:https://doi.org/10.4081/jbr.2018.7755.

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale.

Abstract

Obesity is a chronic pathological condition with a multifactorial aetiology, characterised by an excessive body fat accumulation with multiple organ-specific consequences. Emerging evidence highlights that obesity appears to be associated with multiple alterations in the endocrine system. However, the mechanisms underlying the interactions between obesity and this system remain still controversial. This review discusses the impact of obesity on various endocrine systems and, in particular, would provide a general overview on the biochemical changes that may occur in each of these axes in association

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December 2018
11 Reads

On the role of cystatin C in cancer progression.

Life Sci 2018 Jun 12;202:152-160. Epub 2018 Apr 12.

Department of Health Promotion Sciences, School of Medicine, University of Palermo, 90127 Palermo, Italy.

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http://dx.doi.org/10.1016/j.lfs.2018.04.013DOI Listing
June 2018
16 Reads
2.702 Impact Factor

Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.

Cancer Invest 2016 Oct 16;34(9):415-423. Epub 2016 Sep 16.

b Department of Surgical, Oncological and Oral Sciences , School of Medicine, University of Palermo , Palermo , Italy.

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http://dx.doi.org/10.1080/07357907.2016.1222416DOI Listing
October 2016
11 Reads
2 Citations
2.060 Impact Factor

Vitamin D in cancer chemoprevention.

Pharm Biol 2015 9;53(10):1399-434. Epub 2015 Apr 9.

Unit of Physiology and Pharmacology, DIGISPO and.

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http://dx.doi.org/10.3109/13880209.2014.988274DOI Listing
April 2016
11 Reads
5 Citations
1.340 Impact Factor

Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity.

Int J Food Sci Nutr 2014 Nov 30;65(7):886-92. Epub 2014 Jun 30.

Unit of Physiology and Pharmacology, Department DIGISPO, University of Palermo , Italy and.

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http://dx.doi.org/10.3109/09637486.2014.931362DOI Listing
November 2014
12 Reads
1.202 Impact Factor

Follistatin as potential therapeutic target in prostate cancer.

Target Oncol 2013 Dec 1;8(4):215-23. Epub 2013 Mar 1.

Operative Unit of Physiology and Pharmacology, University of Palermo, via Augusto Elia, 3, 90127, Palermo, Italy.

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http://dx.doi.org/10.1007/s11523-013-0268-7DOI Listing
December 2013
6 Reads
6 Citations
3.460 Impact Factor

Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma.

Anticancer Res 2013 Feb;33(2):679-84

Department of Surgical and Oncological Sciences, Via del Vespro 129, 90127 Palermo, Italy.

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February 2013
16 Reads
2 Citations
1.872 Impact Factor

The role of vitamin K in bone remodeling and osteoporosis.

J. Food Res. 2012 1(4):106-123

Journal of Food Research

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October 2012
9 Reads

Serum follistatin in patients with prostate cancer metastatic to the bone.

Clin Exp Metastasis 2010 Dec 11;27(8):549-55. Epub 2010 Jul 11.

Dipartimento di Discipline Chirurgiche ed Oncologiche, Policlinico Universitario 'P. Giaccone', Palermo, Italy.

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http://dx.doi.org/10.1007/s10585-010-9344-xDOI Listing
December 2010
14 Reads
9 Citations
3.491 Impact Factor

Activin A and bone metastasis.

Authors:
Gaetano Leto

J Cell Physiol 2010 Nov;225(2):302-9

Department of Surgery and Oncology, Policlinico Universitario P Giaccone, 90127 Palermo, Italy.

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http://dx.doi.org/10.1002/jcp.22272DOI Listing
November 2010
98 Reads
4 Citations
3.840 Impact Factor

Cathepsin L in metastatic bone disease: therapeutic implications.

Biol Chem 2010 Jun;391(6):655-64

Laboratory of Experimental Chemotherapy, Department of Surgery and Oncology, Policlinico Universitario P. Giaccone, I-90127 Palermo, Italy.

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http://dx.doi.org/10.1515/BC.2010.069DOI Listing
June 2010
7 Reads
10 Citations
3.270 Impact Factor

Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C.

Med Oncol 2009 7;26(1):10-5. Epub 2008 May 7.

Department of Surgery and Oncology, Laboratory of Experimental Chemotherapy and Tumor Markers, Policlinico Universitario P. Giaccone, 90127 Palermo, Italy.

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http://link.springer.com/10.1007/s12032-008-9070-2
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http://dx.doi.org/10.1007/s12032-008-9070-2DOI Listing
May 2009
10 Reads
11 Citations
2.060 Impact Factor

Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeutic implications.

Biomed Pharmacother 2008 Feb 30;62(2):130-5. Epub 2007 Jul 30.

Laboratory of Experimental Chemotherapy, Department of Surgery and Oncology, Policlinico Universitario P. Giaccone, Via del Vespro 129, 90127 Palermo, Italy.

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http://dx.doi.org/10.1016/j.biopha.2007.07.001DOI Listing
February 2008
16 Reads
6 Citations
2.023 Impact Factor

MMP-2, MMP-9 and activin A blood levels in patients with breast cancer or prostate cancer metastatic to the bone.

Anticancer Res 2007 May-Jun;27(3B):1519-25

Section of Clinical Oncology, Policlinico Unversitario "Paolo Giaccone", 90127 Palermo, Italy.

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July 2007
11 Reads
19 Citations
1.872 Impact Factor

Activin A circulating levels in patients with bone metastasis from breast or prostate cancer.

Clin Exp Metastasis 2006 14;23(2):117-22. Epub 2006 Jul 14.

Laboratory of Experimental Chemotherapy, Department of Surgery and Oncology, Policlinico Universitario P Giaccone, Via del Vespro 129, 90127, Palermo, Italy.

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http://dx.doi.org/10.1007/s10585-006-9010-5DOI Listing
December 2006
13 Reads
27 Citations
3.491 Impact Factor

Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases.

Anticancer Res 2006 Jan-Feb;26(1A):23-6

Laboratory of Experimental Chemotherapy and Tumor Markers, Policlinico Universitario P. Giaccone, 90127 Palermo, Italy.

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March 2006
15 Reads
2 Citations
1.872 Impact Factor

Tumor markers in urogynaecological tumors.

Tunis Med 2005 Dec;83 Suppl 12:28

Lab of Exp Chemother and Sect of Clin Oncol, Dept Surgery and Oncology, Policlinico Universitario P Giaccone, Palermo, Italy.

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December 2005
5 Reads

The use of zoledronic acid in patients with bone metastases from prostate carcinoma: effect on analgesic response and bone metabolism biomarkers.

J Chemother 2005 Oct;17(5):555-9

Operative Unit of Medical Oncology, Department of Oncology, Università degli Studi di Palermo, Italy.

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http://www.tandfonline.com/doi/full/10.1179/joc.2005.17.5.55
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http://dx.doi.org/10.1179/joc.2005.17.5.555DOI Listing
October 2005
14 Reads
3 Citations
1.073 Impact Factor

Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.

Clin Exp Metastasis 2004 ;21(2):91-106

Section of Chemotherapy, Department of Oncology, Policlinico Universitario P. Giaccone, Palermo, Italy.

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June 2004
12 Reads
18 Citations
3.491 Impact Factor

Usefulness of alpha-fetoprotein in the diagnosis of hepatocellular carcinoma.

Anticancer Res 2003 Mar-Apr;23(2C):1747-53

Cattedra di Medicina Interna, Cattedra di Metodologia Clinica, Dpt di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Italy.

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July 2003
14 Reads
38 Citations
1.872 Impact Factor

Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.

Int J Biol Markers 2001 Oct-Dec;16(4):245-9

Laboratory of Chemotherapy and Tumor Markers, Regional Reference Center for Biomolecular Characterization of Neoplasms and Genetic Screening of Hereditary Tumors, Palermo, Italy.

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July 2002
9 Reads
1 Citation
1.360 Impact Factor

Prognostic significance of DNA ploidy, S-phase fraction, and tissue levels of aspartic, cysteine, and serine proteases in operable gastric carcinoma.

Clin Cancer Res 2000 Jan;6(1):178-84

Laboratory of Oncobiology, School of Medicine, University of Palermo, Italy.

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January 2000
11 Reads
6 Citations
8.722 Impact Factor

Lysosomal aspartic and cysteine proteinases serum levels in patients with pancreatic cancer or pancreatitis.

Pancreas 1997 Jan;14(1):22-7

Section of Chemotherapy, Faculty of Medicine, University of Palermo, Italy.

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January 1997
13 Reads
5 Citations
2.960 Impact Factor

Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications.

Oncology 1997 Jan-Feb;54(1):79-83

Section of Chemotherapy, School of Medicine, University of Palermo, Italy.

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http://dx.doi.org/10.1159/000227666DOI Listing
January 1997
10 Reads
10 Citations
2.422 Impact Factor

Biological characterization of laryngeal squamous-cell carcinoma.

Anticancer Res 1996 Jul-Aug;16(4B):2257-67

Institute of Pathology R, School of Medicine, University of Palermo, Italy.

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August 1996
13 Reads
2 Citations
1.872 Impact Factor

Cathepsin D, B and L circulating levels as prognostic markers of malignant progression.

Anticancer Res 1996 Jul-Aug;16(4B):2315-9

Section of Chemotherapy, School of Medicine, University of Palermo, Policlinico P. Giaccone, Italy.

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August 1996
8 Reads
12 Citations
1.872 Impact Factor

Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.

Eur J Clin Chem Clin Biochem 1996 Jul;34(7):555-60

Servizio di Chemioterapia, Facoltà di Medicina e Chirurgia, Università di Palermo, Italy.

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July 1996
12 Reads
6 Citations

Flow cytometric DNA analysis and lysosomal cathepsins B and L in locally advanced laryngeal cancer. Relationship with clinicopathologic parameters and prognostic significance.

Cancer 1995 Nov;76(10):1757-64

Institute of Otorhinolaringology B, School of Medicine, University of Palermo, Italy.

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November 1995
9 Reads
4.890 Impact Factor

Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors.

In Vivo 1994 Mar-Apr;8(2):231-6

Institute of Pharmacology, School of Medicine, University of Palermo, Italy.

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November 1994
12 Reads
1 Citation
1.150 Impact Factor

Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.

Int J Oncol 1994 Sep;5(3):509-15

UNIV PALERMO,POLICLIN P GIACCONE,SCH MED,INST CLIN & PHYSIOPATHOL SURG,DEPT CLIN ONCOL,I-90127 PALERMO,ITALY.

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September 1994
9 Reads
1 Citation
3.025 Impact Factor

Pepstatins: aspartic proteinase inhibitors having potential therapeutic applications.

Med Res Rev 1993 Mar;13(2):199-208

Institute of Pharmacology, Faculty of Medicine, University of Palermo, Italy.

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March 1993
10 Reads
2 Citations
8.431 Impact Factor

Cathepsin D in the malignant progression of neoplastic diseases (review).

Anticancer Res 1992 Jan-Feb;12(1):235-40

Institute of Pharmacology, Faculty of Medicine, University of Palermo, Italy.

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May 1992
10 Reads
7 Citations
1.872 Impact Factor

Membrane gangliosides and immuno-mediated cytolysis in drug sensitive and treatment-induced multidrug resistant human ovarian cancer cells.

Anticancer Res 1991 Nov-Dec;11(6):2181-5

Department of Pharmacology, Chemotherapy and Toxicology, University of Milan School of Medicine, Italy.

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February 1992
8 Reads
2 Citations
1.872 Impact Factor

Nephrotoxic effects of pepstatin A. An histoenzymologic study.

Pharmacol Res 1990 Sep-Oct;22 Suppl 1:59-60

Institute of Histology, University of Palermo, Italy.

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March 1991
8 Reads
4.410 Impact Factor

Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.

Anticancer Res 1990 Jan-Feb;10(1):265-9

Institute of Pharmacology, Faculty of Medicine, University of Palermo, Italy.

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June 1990
6 Reads
1 Citation
1.872 Impact Factor

Evaluation of antitumor and antimetastatic activity of pepstatin A in some experimental tumor models.

J Chemother 1989 Jul;1(4 Suppl):1135-8

Institute of Pharmacology, Chair of Chemotherapy and Section of Clinical Oncology, Faculty of Medicine, University of Palermo, Italy.

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July 1989
11 Reads
1 Citation
1.073 Impact Factor

Kinetics of in vivo inhibition of tissue cathepsin D by pepstatin A.

Int J Biochem 1988 ;20(9):917-20

Istituto di Farmacologia, Policlinico P. Giaccone, Palermo, Italy.

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January 1989
8 Reads
1 Citation

Characterization of the metastatic properties of two methylcholanthreine-induced fibrosarcomas in mice

Period Biol 1988, 90(3 ):327-333

Periodicum Biologorum

MC1 and MC2 murine fibrosarcomas, following intramuscular innplantation in mice, release different numbers of tumor cells into the bloodstream and differ in their lung colonization potential following intravenous inoculation. Since these biological properties could be related to a different degree of maligancy, in vivo and in vitro experiments were performed vvith these two tunnors in an attempt to correlate their spontaneous metas-tatic potential with other parameters related to tunnor cell invasion and metastasis. Following intramuscular inplantation the MC2 fibrosarcoma was observed to have a slow but progressive ability to spontaneously metastasize while the MC1 lacked this capability. However, in an in vitro invasion assay the MC2 tunnor cell line vvas not able to degrade extracellular matrix (ECM), nor vas there any evidence for increased MC2 tumor degradative enzyme (8-N-acetylglucosaminidase). On the other hand the MC2 tumor had two different aneuploid subpopulations oftumor cells whereas the MC1 tumor had only diploid and tetraploid populations. These chamges in ploidy may offer an explanation regarding the basis for the higr degree of malignancy found with MC2 tumor andfor demostrated higher metastatic potential of this cell line.

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October 1988
9 Reads

Interaction of human carcinoma cells with extracellular matrix.

UCLA Symposia on Molecular and Cellular Biology.Alan R. Liss, Inc., N.Y., 78:251-260.

Tumor Progression and Metastasis, 1988, G.L. Nicolson and I.J. Fidler (eds), UCLA Symposia on Molecular and Cellular Biology.

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July 1988
9 Reads

The role of histamine in doxorubicin and teniposide-induced cardiotoxicity in dog and mouse.

Tumori 1987 Jun;73(3):279-87

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June 1987
13 Reads
1 Citation
1.090 Impact Factor

Acute myocardial effects of mitoxantrone in the rabbit.

Cancer Treat Rep 1987 May;71(5):529-31

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May 1987
10 Reads

Med. Sci. Res. Biochem. 1987; 15:1471-3

Medical Science Reserach Biochemical

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May 1987
6 Reads

The cell surface as target in cancer chemotherapy.

14th Intl. Cancer Congr. Budapest, 1986, Lapis-Eckhardt (eds), vol. II, 57-66.

Lectures and Symposia 14th Intl. Cancer Congr. Budapest, 1986, Lapis-Eckhardt (eds)

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August 1986
8 Reads

Lysosomal alterations in heart and liver of mice treated with doxorubicin.

Cancer Chemother Pharmacol 1985 ;15(1):26-30

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August 1985
8 Reads
3 Citations
2.770 Impact Factor

: Cardiovascular activity of VM26

. Current Chem. Immunother. 1981; 2:1405-1407.

. Current Chemtherapy and . Immunotherapy

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July 1981
5 Reads

Cardiac activity of VM26 (teniposide) in the dog

Chemioter. Oncol 3: 162-167

Chemioterapia Oncologica

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September 1980
9 Reads

Haemopoietic effects of 7 alpha, 17 beta dimethyltestosterone.

Pharmacol Res Commun 1979 Feb;11(2):81-94

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February 1979
9 Reads
3 Citations

Top co-authors

Carla Flandina
Carla Flandina

Policlinico Universitario P. Giaccone

11
Marilena Crescimanno
Marilena Crescimanno

Policlinico Universitario P. Giaccone

10
A Russo
A Russo

Rizzoli Orthopaedic Institute

7
Giuseppe Badalamenti
Giuseppe Badalamenti

University of Palermo

7
Lorena Incorvaia
Lorena Incorvaia

Section of Clinical Oncology

7
Fabio Fulfaro
Fabio Fulfaro

University of Palermo

5
Francesca M Tumminello
Francesca M Tumminello

Policlinico Universitario P. Giaccone

5
Maria Vittoria Sepporta
Maria Vittoria Sepporta

Università degli Studi di Perugia

4
Francesca Maria Tumminello
Francesca Maria Tumminello

Policlinico Universitario P. Giaccone

4