Gad Getz

Gad Getz

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Gad Getz

Gad Getz

Publications by authors named "Gad Getz"

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Predicting and affecting response to cancer therapy based on pathway-level biomarkers.

Nat Commun 2020 Jul 3;11(1):3296. Epub 2020 Jul 3.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1038/s41467-020-17090-yDOI Listing
July 2020

Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences.

Cell 2020 Mar 20;180(5):915-927.e16. Epub 2020 Feb 20.

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210002PMC
March 2020

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

Nature 2020 02 5;578(7793):102-111. Epub 2020 Feb 5.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-1965-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054214PMC
February 2020

Proteogenomic Characterization of Endometrial Carcinoma.

Cell 2020 Feb 13;180(4):729-748.e26. Epub 2020 Feb 13.

Institute for Systems Genetics, NYU School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233456PMC
February 2020

Passenger Hotspot Mutations in Cancer.

Cancer Cell 2019 09;36(3):288-301.e14

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.08.002DOI Listing
September 2019

Analyzing Frequently Mutated Genes and the Association With Tumor Mutation Load.

JAMA Oncol 2019 04;5(4):577

Cancer Center, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamaoncol.2019.0127DOI Listing
April 2019

A (fire)cloud-based DNA methylation data preprocessing and quality control platform.

BMC Bioinformatics 2019 Mar 29;20(1):160. Epub 2019 Mar 29.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12859-019-2750-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440105PMC
March 2019

p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity.

J Cell Biol 2018 09 22;217(9):3183-3201. Epub 2018 Jun 22.

GI Cell Biology Research Laboratory, Boston Children's Hospital and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1083/jcb.201710058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122998PMC
September 2018

Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.

Cancer Cell 2018 08;34(2):242-255.e5

Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Thyroid Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121811PMC
August 2018

Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer.

J Clin Oncol 2018 02 3;36(6):543-553. Epub 2018 Jan 3.

Daniel G. Stover, Ohio State University Comprehensive Cancer Center, Columbus, OH; Heather A. Parsons, Gavin Ha, William T. Barry, Hao Guo, Atish D. Choudhury, Melissa E. Hughes, Deborah A. Dillon, Ann H. Partridge, Nikhil Wagle, Ian E. Krop, Todd R. Golub, Eric P. Winer, Sara M. Tolaney, and Nancy U. Lin, Dana-Farber Cancer Institute; Gad Getz, Massachusetts General Hospital, Boston; Gavin Ha, Samuel S. Freeman, Atish D. Choudhury, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Denisse Rotem, Nikhil Wagle, Gad Getz, Todd R. Golub, and Viktor A. Adalsteinsson, Broad Institute of Harvard and Massachusetts Institute of Technology; and J. Christopher Love, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1200/JCO.2017.76.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815405PMC
February 2018

Comparison of algorithms for the detection of cancer drivers at subgene resolution.

Nat Methods 2017 Aug 17;14(8):782-788. Epub 2017 Jul 17.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nmeth.4364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935266PMC
August 2017

Genomic complexity of multiple myeloma and its clinical implications.

Nat Rev Clin Oncol 2017 02 17;14(2):100-113. Epub 2016 Aug 17.

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, HIM 237, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrclinonc.2016.122DOI Listing
February 2017

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

Cancer Cell 2016 Nov 3;30(5):750-763. Epub 2016 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 540, 44 Binney Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127278PMC
November 2016

Analysis of protein-coding genetic variation in 60,706 humans.

Nature 2016 08;536(7616):285-91

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://www.nature.com/articles/nature19057
Publisher Site
http://dx.doi.org/10.1038/nature19057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018207PMC
August 2016