Gad Frankel

Gad Frankel

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Gad Frankel

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Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism.

Authors:
Caroline Mullineaux-Sanders Julia Sanchez-Garrido Eve G D Hopkins Avinash R Shenoy Rachael Barry Gad Frankel

Nat Rev Microbiol 2019 Nov 20;17(11):701-715. Epub 2019 Sep 20.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41579-019-0252-zDOI Listing
November 2019

Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease.

Authors:
Danielle Carson Rachael Barry Eve G D Hopkins Theodoros I Roumeliotis Diego García-Weber Caroline Mullineaux-Sanders Eran Elinav Cécile Arrieumerlou Jyoti S Choudhary Gad Frankel

Cell Microbiol 2019 Oct 14:e13126. Epub 2019 Oct 14.

Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1111/cmi.13126DOI Listing
October 2019

OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo.

Authors:
Joshua L C Wong Maria Romano Louise E Kerry Hok-Sau Kwong Wen-Wen Low Stephen J Brett Abigail Clements Konstantinos Beis Gad Frankel

Nat Commun 2019 Sep 2;10(1):3957. Epub 2019 Sep 2.

Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41467-019-11756-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718652PMC
September 2019

A nanobody targeting the translocated intimin receptor inhibits the attachment of enterohemorrhagic E. coli to human colonic mucosa.

Authors:
David Ruano-Gallego Daniel A Yara Lorenza Di Ianni Gad Frankel Stephanie Schüller Luis Ángel Fernández

PLoS Pathog 2019 Aug 29;15(8):e1008031. Epub 2019 Aug 29.

Department of Microbial Biotechnology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus UAM-Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.1371/journal.ppat.1008031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738647PMC
August 2019

The Type III Secretion System of Pathogenic Escherichia coli.

Authors:
Sabrina L Slater Agnes M Sågfors Dominic J Pollard David Ruano-Gallego Gad Frankel

Curr Top Microbiol Immunol 2018;416:51-72

Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.

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http://dx.doi.org/10.1007/82_2018_116DOI Listing
June 2019

Determination of In Vivo Interactomes of Dot/Icm Type IV Secretion System Effectors by Tandem Affinity Purification.

Authors:
Ernest C So Aurélie Mousnier Gad Frankel Gunnar N Schroeder

Methods Mol Biol 2019 ;1921:289-303

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1007/978-1-4939-9048-1_19DOI Listing
June 2019

The Galleria mellonella Infection Model for Investigating the Molecular Mechanisms of Legionella Virulence.

Authors:
Gad Frankel Gunnar N Schroeder

Methods Mol Biol 2019 ;1921:333-346

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1007/978-1-4939-9048-1_22DOI Listing
June 2019

The . Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin.

Authors:
Melanie A McDowell Alexander Mp Byrne Elli Mylona Rebecca Johnson Agnes Sagfors Valerie F Crepin Susan Lea Gad Frankel

Life Sci Alliance 2019 06 29;2(3). Epub 2019 May 29.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK

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http://dx.doi.org/10.26508/lsa.201800272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545606PMC
June 2019

Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection.

Authors:
Eve G D Hopkins Theodoros I Roumeliotis Caroline Mullineaux-Sanders Jyoti S Choudhary Gad Frankel

MBio 2019 04 2;10(2). Epub 2019 Apr 2.

Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom

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http://dx.doi.org/10.1128/mBio.00062-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445932PMC
April 2019

Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.

Authors:
Philippa J Goddard Julia Sanchez-Garrido Sabrina L Slater Mohini Kalyan David Ruano-Gallego Olivier Marchès Luis Ángel Fernández Gad Frankel Avinash R Shenoy

Cell Rep 2019 Apr;27(4):1008-1017.e6

Department of Medicine, Medical Research Council Centre for Molecular Bacteriology & Infection, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486487PMC
April 2019

The effector LtpM is a new type of phosphoinositide-activated glucosyltransferase.

Authors:
Nadezhda Levanova Corinna Mattheis Danielle Carson Ka-Ning To Thomas Jank Gad Frankel Klaus Aktories Gunnar Neels Schroeder

J Biol Chem 2019 02 20;294(8):2862-2879. Epub 2018 Dec 20.

the MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom, and

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http://dx.doi.org/10.1074/jbc.RA118.005952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393602PMC
February 2019

More than 18,000 effectors in the genus genome provide multiple, independent combinations for replication in human cells.

Authors:
Laura Gomez-Valero Christophe Rusniok Danielle Carson Sonia Mondino Ana Elena Pérez-Cobas Monica Rolando Shivani Pasricha Sandra Reuter Jasmin Demirtas Johannes Crumbach Stephane Descorps-Declere Elizabeth L Hartland Sophie Jarraud Gordon Dougan Gunnar N Schroeder Gad Frankel Carmen Buchrieser

Proc Natl Acad Sci U S A 2019 02 18;116(6):2265-2273. Epub 2019 Jan 18.

Institut Pasteur, Biologie des Bactéries Intracellulaires, 75724 Paris, France;

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http://dx.doi.org/10.1073/pnas.1808016116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369783PMC
February 2019

Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Authors:
James P R Connolly Sabrina L Slater Nicky O'Boyle Robert J Goldstone Valerie F Crepin David Ruano-Gallego Pawel Herzyk David G E Smith Gillian R Douce Gad Frankel Andrew J Roe

Nat Commun 2018 11 29;9(1):5148. Epub 2018 Nov 29.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1038/s41467-018-07612-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265335PMC
November 2018

Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

Authors:
James P R Connolly Sabrina L Slater Nicky O'Boyle Robert J Goldstone Valerie F Crepin David Ruano-Gallego Pawel Herzyk David G E Smith Gillian R Douce Gad Frankel Andrew J Roe

Nat Commun 2018 10 10;9(1):4187. Epub 2018 Oct 10.

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.

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http://www.nature.com/articles/s41467-018-06701-4
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http://dx.doi.org/10.1038/s41467-018-06701-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180029PMC
October 2018

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.

Authors:
Cedric N Berger Valerie F Crepin Theodoros I Roumeliotis James C Wright Nicolas Serafini Meirav Pevsner-Fischer Lu Yu Eran Elinav James P Di Santo Jyoti S Choudhary Gad Frankel

PLoS Pathog 2018 10 26;14(10):e1007406. Epub 2018 Oct 26.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom.

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http://dx.plos.org/10.1371/journal.ppat.1007406
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http://dx.doi.org/10.1371/journal.ppat.1007406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221368PMC
October 2018

Typhoidal Salmonella: Distinctive virulence factors and pathogenesis.

Authors:
Rebecca Johnson Elli Mylona Gad Frankel

Cell Microbiol 2018 09 9;20(9):e12939. Epub 2018 Aug 9.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/cmi.12939DOI Listing
September 2018

Multitalented EspB of enteropathogenic Escherichia coli (EPEC) enters cells autonomously and induces programmed cell death in human monocytic THP-1 cells.

Authors:
Doreen Baumann Helen Salia Lilo Greune Stephanie Norkowski Britta Körner Zina M Uckeley Gad Frankel Marianne Guenot Christian Rüter M Alexander Schmidt

Int J Med Microbiol 2018 Apr 12;308(3):387-404. Epub 2018 Mar 12.

Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung - ZMBE, Westfälische Wilhelms-Universität Münster, Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2018.03.005DOI Listing
April 2018

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

Authors:
Dominic J Pollard Cedric N Berger Ernest C So Lu Yu Kate Hadavizadeh Patricia Jennings Edward W Tate Jyoti S Choudhary Gad Frankel

MBio 2018 04 10;9(2). Epub 2018 Apr 10.

Centre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London United Kingdom, London, United Kingdom

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http://dx.doi.org/10.1128/mBio.00170-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893879PMC
April 2018

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.

Authors:
Rebecca Johnson Matt Ravenhall Derek Pickard Gordon Dougan Alexander Byrne Gad Frankel

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.00490-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820949PMC
March 2018

Sieving through gut models of colonization resistance.

Authors:
Caroline Mullineaux-Sanders Jotham Suez Eran Elinav Gad Frankel

Nat Microbiol 2018 02 22;3(2):132-140. Epub 2018 Jan 22.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK.

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http://dx.doi.org/10.1038/s41564-017-0095-1DOI Listing
February 2018

Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic .

Authors:
Athina G Portaliou Konstantinos C Tsolis Maria S Loos Vassileia Balabanidou Josep Rayo Alexandra Tsirigotaki Valerie F Crepin Gad Frankel Charalampos G Kalodimos Spyridoula Karamanou Anastassios Economou

EMBO J 2017 12 6;36(23):3517-3531. Epub 2017 Nov 6.

Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium

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http://emboj.embopress.org/lookup/doi/10.15252/embj.20179751
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http://dx.doi.org/10.15252/embj.201797515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709732PMC
December 2017

Citrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa.

Authors:
Caroline Mullineaux-Sanders James W Collins David Ruano-Gallego Maayan Levy Meirav Pevsner-Fischer Izabela T Glegola-Madejska Agnes M Sågfors Joshua L C Wong Eran Elinav Valerie F Crepin Gad Frankel

Cell Rep 2017 Dec;21(12):3381-3389

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173175
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http://dx.doi.org/10.1016/j.celrep.2017.11.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746604PMC
December 2017

Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.

Authors:
Cedric N Berger Valerie F Crepin Theodoros I Roumeliotis James C Wright Danielle Carson Meirav Pevsner-Fischer R Christopher D Furniss Gordon Dougan Mally Dori-Bachash Lu Yu Abigail Clements James W Collins Eran Elinav Gerald J Larrouy-Maumus Jyoti S Choudhary Gad Frankel

Cell Metab 2017 Nov 5;26(5):738-752.e6. Epub 2017 Oct 5.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695859PMC
November 2017

Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors.

Authors:
Massiel Cepeda-Molero Cedric N Berger Alistair D S Walsham Samuel J Ellis Simon Wemyss-Holden Stephanie Schüller Gad Frankel Luis Ángel Fernández

PLoS Pathog 2017 Oct 30;13(10):e1006706. Epub 2017 Oct 30.

Department of Microbial Biotechnology. Centro Nacional de Biotecnología, CNB-CSIC. Darwin 3, Campus UAM, Cantoblanco, Madrid, Spain.

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https://dx.doi.org/10.1371/journal.ppat.1006706
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http://dx.doi.org/10.1371/journal.ppat.1006706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685641PMC
October 2017

The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.

Authors:
Pamela Sandu Valerie F Crepin Hauke Drechsler Andrew D McAinsh Gad Frankel Cedric N Berger

Infect Immun 2017 09 18;85(9). Epub 2017 Aug 18.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://iai.asm.org/lookup/doi/10.1128/IAI.00244-17
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http://dx.doi.org/10.1128/IAI.00244-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563575PMC
September 2017

Non-invasive three-dimensional imaging of Escherichia coli K1 infection using diffuse light imaging tomography combined with micro-computed tomography.

Authors:
Luci A Witcomb Julie Czupryna Kevin P Francis Gad Frankel Peter W Taylor

Methods 2017 08 15;127:62-68. Epub 2017 May 15.

University College London School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.05.005DOI Listing
August 2017

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

Authors:
Rebecca Johnson Alexander Byrne Cedric N Berger Elizabeth Klemm Valerie F Crepin Gordon Dougan Gad Frankel

J Bacteriol 2017 02 30;199(4). Epub 2017 Jan 30.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/JB.00647-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287405PMC
February 2017

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Authors:
Jaclyn S Pearson Cristina Giogha Sabrina Mühlen Ueli Nachbur Chi L L Pham Ying Zhang Joanne M Hildebrand Clare V Oates Tania Wong Fok Lung Danielle Ingle Laura F Dagley Aleksandra Bankovacki Emma J Petrie Gunnar N Schroeder Valerie F Crepin Gad Frankel Seth L Masters James Vince James M Murphy Margaret Sunde Andrew I Webb John Silke Elizabeth L Hartland

Nat Microbiol 2017 Feb 13;2:17024. Epub 2017 Feb 13.

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http://dx.doi.org/10.1038/nmicrobiol.2017.24DOI Listing
February 2017

Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses.

Authors:
Angelique Ale Valerie F Crepin James W Collins Nicholas Constantinou Maryam Habibzay Ann C Babtie Gad Frankel Michael P H Stumpf

Infect Immun 2017 Jan 29;85(1). Epub 2016 Dec 29.

Department of Life Sciences, Centre for Integrative Systems Biology, Imperial College London, London, United Kingdom

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http://iai.asm.org/lookup/doi/10.1128/IAI.00606-16
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http://dx.doi.org/10.1128/IAI.00606-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203651PMC
January 2017

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Authors:
Jaclyn S Pearson Cristina Giogha Sabrina Mühlen Ueli Nachbur Chi L L Pham Ying Zhang Joanne M Hildebrand Clare V Oates Tania Wong Fok Lung Danielle Ingle Laura F Dagley Aleksandra Bankovacki Emma J Petrie Gunnar N Schroeder Valerie F Crepin Gad Frankel Seth L Masters James Vince James M Murphy Margaret Sunde Andrew I Webb John Silke Elizabeth L Hartland

Nat Microbiol 2017 01 13;2:16258. Epub 2017 Jan 13.

Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.

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http://www.nature.com/articles/nmicrobiol2016258
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http://dx.doi.org/10.1038/nmicrobiol.2016.258DOI Listing
January 2017

The Type III Secretion System Effector SeoC of Salmonella enterica subsp. salamae and S. enterica subsp. arizonae ADP-Ribosylates Src and Inhibits Opsonophagocytosis.

Authors:
Dominic J Pollard Joanna C Young Valentina Covarelli Silvia Herrera-León Thomas R Connor Maria Fookes Danielle Walker Aurora Echeita Nicholas R Thomson Cedric N Berger Gad Frankel

Infect Immun 2016 Dec 18;84(12):3618-3628. Epub 2016 Nov 18.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.00704-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116738PMC
December 2016

Citrobacter rodentium mouse model of bacterial infection.

Authors:
Valerie F Crepin James W Collins Maryam Habibzay Gad Frankel

Nat Protoc 2016 10 8;11(10):1851-76. Epub 2016 Sep 8.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nprot.2016.100DOI Listing
October 2016

Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection.

Authors:
R Christopher D Furniss Sabrina Slater Gad Frankel Abigail Clements

J Mol Biol 2016 08 31;428(17):3399-407. Epub 2016 May 31.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, SW7 2AZ. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013874PMC
August 2016

The Rab-binding Profiles of Bacterial Virulence Factors during Infection.

Authors:
Ernest C So Gunnar N Schroeder Danielle Carson Corinna Mattheis Aurélie Mousnier Malgorzata Broncel Edward W Tate Gad Frankel

J Biol Chem 2016 Mar 11;291(11):5832-43. Epub 2016 Jan 11.

From the MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London SW7 2AZ, United Kingdom, Department of Chemistry, Institute of Chemical Biology, Imperial College, London SW7 2AZ, United Kingdom

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http://dx.doi.org/10.1074/jbc.M115.700930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786718PMC
March 2016

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Authors:
Gunnar N Schroeder Philipp Aurass Clare V Oates Edward W Tate Elizabeth L Hartland Antje Flieger Gad Frankel

Infect Immun 2015 Oct 27;83(10):3989-4002. Epub 2015 Jul 27.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.00785-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567653PMC
October 2015

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.

Authors:
Ernest C So Corinna Mattheis Edward W Tate Gad Frankel Gunnar N Schroeder

Can J Microbiol 2015 Sep 6;61(9):617-35. Epub 2015 May 6.

a MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1139/cjm-2015-0166DOI Listing
September 2015

Tir Triggers Expression of CXCL1 in Enterocytes and Neutrophil Recruitment during Citrobacter rodentium Infection.

Authors:
Valerie F Crepin Maryam Habibzay Izabela Glegola-Madejska Marianne Guenot James W Collins Gad Frankel

Infect Immun 2015 Sep 15;83(9):3342-54. Epub 2015 Jun 15.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, United Kingdom

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http://iai.asm.org/lookup/doi/10.1128/IAI.00291-15
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http://dx.doi.org/10.1128/IAI.00291-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534649PMC
September 2015

Older leaves of lettuce (Lactuca spp.) support higher levels of Salmonella enterica ser. Senftenberg attachment and show greater variation between plant accessions than do younger leaves.

Authors:
Paul J Hunter Robert K Shaw Cedric N Berger Gad Frankel David Pink Paul Hand

FEMS Microbiol Lett 2015 Jun 7;362(11). Epub 2015 May 7.

Harper-Adams University, Newport, Shropshire TF10 8NB, UK.

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https://academic.oup.com/femsle/article/doi/10.1093/femsle/f
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http://dx.doi.org/10.1093/femsle/fnv077DOI Listing
June 2015

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.

Authors:
Fernanda Schreiber Sally Kay Gad Frankel Simon Clare David Goulding Esther van de Vosse Jaap T van Dissel Richard Strugnell Guy Thwaites Robert A Kingsley Gordon Dougan Stephen Baker

Sci Rep 2015 Jan 22;5:7947. Epub 2015 Jan 22.

1] The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom [3] The London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1038/srep07947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302301PMC
January 2015

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.

Authors:
Joanna C Young Abigail Clements Alexander E Lang James A Garnett Diana Munera Ana Arbeloa Jaclyn Pearson Elizabeth L Hartland Stephen J Matthews Aurelie Mousnier David J Barry Michael Way Andreas Schlosser Klaus Aktories Gad Frankel

Nat Commun 2014 Dec 19;5:5887. Epub 2014 Dec 19.

MRC Centre for Molecular Bacteriology and Infection, Imperial College, SW7 2AZ London, UK.

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http://dx.doi.org/10.1038/ncomms6887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284639PMC
December 2014

Enterohaemorrhagic Escherichia coli inhibits recycling endosome function and trafficking of surface receptors.

Authors:
Abigail Clements Charlotte A Stoneham R Christopher D Furniss Gad Frankel

Cell Microbiol 2014 Nov 7;16(11):1693-705. Epub 2014 Jul 7.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College, London, UK.

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http://dx.doi.org/10.1111/cmi.12319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336558PMC
November 2014

The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.

Authors:
Mitchell A Pallett Cedric N Berger Jaclyn S Pearson Elizabeth L Hartland Gad Frankel

Infect Immun 2014 Nov 2;82(11):4878-88. Epub 2014 Sep 2.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.02131-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249332PMC
November 2014

The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.

Authors:
Naoko Satoh-Takayama Nicolas Serafini Thomas Verrier Abdessalem Rekiki Jean-Christophe Renauld Gad Frankel James P Di Santo

Immunity 2014 Nov 6;41(5):776-88. Epub 2014 Nov 6.

Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France; Inserm U668, 75724 Paris, France. Electronic address:

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November 2014

Fermented dairy products modulate Citrobacter rodentium-induced colonic hyperplasia.

Authors:
James W Collins Christian Chervaux Benoit Raymond Muriel Derrien Rémi Brazeilles Artemis Kosta Isabelle Chambaud Valerie F Crepin Gad Frankel

J Infect Dis 2014 Oct 4;210(7):1029-41. Epub 2014 Apr 4.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiu205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157696PMC
October 2014

Citrobacter rodentium: infection, inflammation and the microbiota.

Authors:
James W Collins Kristie M Keeney Valerie F Crepin Vijay A K Rathinam Katherine A Fitzgerald B Brett Finlay Gad Frankel

Nat Rev Microbiol 2014 Sep 4;12(9):612-23. Epub 2014 Aug 4.

Medical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Flowers Building, Imperial College, London SW7 2AZ, UK.

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http://www.nature.com/articles/nrmicro3315
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September 2014

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases.

Authors:
Aurélie Mousnier Gunnar N Schroeder Charlotte A Stoneham Ernest C So James A Garnett Lu Yu Steve J Matthews Jyoti S Choudhary Elizabeth L Hartland Gad Frankel

MBio 2014 Aug 12;5(4). Epub 2014 Aug 12.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/mBio.01148-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145681PMC
August 2014

The Locus of Enterocyte Effacement and Associated Virulence Factors of Enterohemorrhagic Escherichia coli.

Authors:
Mark P Stevens Gad M Frankel

Microbiol Spectr 2014 Aug;2(4):EHEC-0007-2013

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, SW7 2AZ, United Kingdom.

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August 2014

Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.

Authors:
George X Song-Zhao Naren Srinivasan Johanna Pott Dilair Baban Gad Frankel Kevin J Maloy

Mucosal Immunol 2014 Jul 27;7(4):763-774. Epub 2013 Nov 27.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1038/mi.2013.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048180PMC
July 2014

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

Authors:
Marta Wlodarska Christoph A Thaiss Roni Nowarski Jorge Henao-Mejia Jian-Ping Zhang Eric M Brown Gad Frankel Maayan Levy Meirav N Katz William M Philbrick Eran Elinav B Brett Finlay Richard A Flavell

Cell 2014 Feb;156(5):1045-59

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017640PMC
February 2014

Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.

Authors:
Yushuan Lai Ilan Rosenshine John M Leong Gad Frankel

Cell Microbiol 2013 Nov 3;15(11):1796-808. Epub 2013 Sep 3.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1111/cmi.12179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036124PMC
November 2013

LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1.

Authors:
Clare R Harding Corinna Mattheis Aurélie Mousnier Clare V Oates Elizabeth L Hartland Gad Frankel Gunnar N Schroeder

Infect Immun 2013 Nov 3;81(11):4261-70. Epub 2013 Sep 3.

MRC Centre for Molecular Bacteriology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1128/IAI.01054-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811825PMC
November 2013

Use of Galleria mellonella as a model organism to study Legionella pneumophila infection.

Authors:
Clare R Harding Gunnar N Schroeder James W Collins Gad Frankel

J Vis Exp 2013 Nov 22(81):e50964. Epub 2013 Nov 22.

Center for Molecular Bacteriology and Infection, Imperial College London.

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http://dx.doi.org/10.3791/50964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923569PMC
November 2013

A type III effector antagonizes death receptor signalling during bacterial gut infection.

Authors:
Jaclyn S Pearson Cristina Giogha Sze Ying Ong Catherine L Kennedy Michelle Kelly Keith S Robinson Tania Wong Fok Lung Ashley Mansell Patrice Riedmaier Clare V L Oates Ali Zaid Sabrina Mühlen Valerie F Crepin Olivier Marches Ching-Seng Ang Nicholas A Williamson Lorraine A O'Reilly Aleksandra Bankovacki Ueli Nachbur Giuseppe Infusini Andrew I Webb John Silke Andreas Strasser Gad Frankel Elizabeth L Hartland

Nature 2013 Sep;501(7466):247-51

Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1038/nature12524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836246PMC
September 2013

Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors.

Authors:
Benoit Raymond Joanna C Young Mitchell Pallett Robert G Endres Abigail Clements Gad Frankel

Trends Microbiol 2013 Aug 16;21(8):430-41. Epub 2013 Jul 16.

Department of Life Sciences, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.tim.2013.06.008DOI Listing
August 2013

4D multimodality imaging of Citrobacter rodentium infections in mice.

Authors:
James William Collins Jeffrey A Meganck Chaincy Kuo Kevin P Francis Gad Frankel

J Vis Exp 2013 Aug 13(78). Epub 2013 Aug 13.

MRC Centre for Molecular Bacteriology and Infection, Division of Cell & Molecular Biology, Imperial College London.

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http://dx.doi.org/10.3791/50450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855914PMC
August 2013

The Dot/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A/J mice.

Authors:
Clare R Harding Charlotte A Stoneham Ralf Schuelein Hayley Newton Clare V Oates Elizabeth L Hartland Gunnar N Schroeder Gad Frankel

Infect Immun 2013 Jul 6;81(7):2598-605. Epub 2013 May 6.

MRC Centre for Molecular Bacteriology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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http://iai.asm.org/lookup/doi/10.1128/IAI.00296-13
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http://dx.doi.org/10.1128/IAI.00296-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697626PMC
July 2013

Subcellular localization of legionella Dot/Icm effectors.

Authors:
Adam J Vogrin Aurelie Mousnier Gad Frankel Elizabeth L Hartland

Methods Mol Biol 2013 ;954:333-44

Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-62703-161-5_20DOI Listing
April 2013

The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi.

Authors:
Philipp Aurass Maren Schlegel Omar Metwally Clare R Harding Gunnar N Schroeder Gad Frankel Antje Flieger

J Biol Chem 2013 Apr 1;288(16):11080-92. Epub 2013 Mar 1.

Division of Bacterial Infections, Robert Koch-Institut, Burgstrasse 37, 38855 Wernigerode, Germany.

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http://dx.doi.org/10.1074/jbc.M112.426049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630882PMC
April 2013

EspZ of enteropathogenic and enterohemorrhagic Escherichia coli regulates type III secretion system protein translocation.

Authors:
Cedric N Berger Valerie F Crepin Kobi Baruch Aurelie Mousnier Ilan Rosenshine Gad Frankel

MBio 2012 2;3(5). Epub 2012 Oct 2.

Centre for Molecular Bacteriology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1128/mBio.00317-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518918PMC
January 2013

The motor protein myosin 1G functions in FcγR-mediated phagocytosis.

Authors:
Anna E Dart Sylvain Tollis Michael D Bright Gad Frankel Robert G Endres

J Cell Sci 2012 Dec 4;125(Pt 24):6020-9. Epub 2012 Oct 4.

Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1242/jcs.109561DOI Listing
December 2012

Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity.

Authors:
James W Collins Ali R Akin Artemis Kosta Ning Zhang Mark Tangney Kevin P Francis Gad Frankel

Microbiology 2012 Nov 17;158(Pt 11):2826-34. Epub 2012 Aug 17.

Centre for Molecular Bacteriology and Infection, Division of Cell and Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, UK.

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http://mic.microbiologyresearch.org/content/journal/micro/10
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http://dx.doi.org/10.1099/mic.0.060830-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541765PMC
November 2012

Infection strategies of enteric pathogenic Escherichia coli.

Authors:
Abigail Clements Joanna C Young Nicholas Constantinou Gad Frankel

Gut Microbes 2012 Mar-Apr;3(2):71-87. Epub 2012 Mar 1.

Centre for Molecular Microbiology and Infection, Imperial College, London, UK.

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http://dx.doi.org/10.4161/gmic.19182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370951PMC
September 2012

Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coli.

Authors:
Diana Munera Eric Martinez Svetlana Varyukhina Arvind Mahajan Jesus Ayala-Sanmartin Gad Frankel

Biochem J 2012 Aug;445(3):383-92

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20120533
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568301PMC
August 2012

Legionella pneumophila pathogenesis in the Galleria mellonella infection model.

Authors:
Clare R Harding Gunnar N Schroeder Stuart Reynolds Artemis Kosta James W Collins Aurélie Mousnier Gad Frankel

Infect Immun 2012 Aug 29;80(8):2780-90. Epub 2012 May 29.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1128/IAI.00510-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434583PMC
August 2012

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).

Authors:
Alexander R C Wong Benoit Raymond James W Collins Valerie F Crepin Gad Frankel

Cell Microbiol 2012 Jul 16;14(7):1051-70. Epub 2012 Mar 16.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://doi.wiley.com/10.1111/j.1462-5822.2012.01778.x
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http://dx.doi.org/10.1111/j.1462-5822.2012.01778.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977065PMC
July 2012

FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.

Authors:
Barbara Nesta Glen Spraggon Christopher Alteri Danilo Gomes Moriel Roberto Rosini Daniele Veggi Sara Smith Isabella Bertoldi Ilaria Pastorello Ilaria Ferlenghi Maria Rita Fontana Gad Frankel Harry L T Mobley Rino Rappuoli Mariagrazia Pizza Laura Serino Marco Soriani

MBio 2012 10;3(2). Epub 2012 Apr 10.

Novartis Vaccines and Diagnostics Srl, Siena, Italy.

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http://dx.doi.org/10.1128/mBio.00010-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324786PMC
June 2012

The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.

Authors:
Alexander R C Wong Abigail Clements Benoit Raymond Valerie F Crepin Gad Frankel

MBio 2012 17;3(1). Epub 2012 Jan 17.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, United Kingdom.

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http://mbio.asm.org/cgi/doi/10.1128/mBio.00250-11
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374388PMC
May 2012

Translation of a minigene in the 5' leader sequence of the enterohaemorrhagic Escherichia coli LEE1 transcription unit affects expression of the neighbouring downstream gene.

Authors:
Md Shahidul Islam Robert K Shaw Gad Frankel Mark J Pallen Stephen J W Busby

Biochem J 2012 Jan;441(1):247-53

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.

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http://dx.doi.org/10.1042/BJ20110912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262186PMC
January 2012

Legionella pneumophila secretes a mitochondrial carrier protein during infection.

Authors:
Pavel Dolezal Margareta Aili Janette Tong Jhih-Hang Jiang Carlo M T Marobbio Carlo M Marobbio Sau Fung Lee Ralf Schuelein Simon Belluzzo Eva Binova Aurelie Mousnier Gad Frankel Giulia Giannuzzi Ferdinando Palmieri Kipros Gabriel Thomas Naderer Elizabeth L Hartland Trevor Lithgow

PLoS Pathog 2012 Jan 5;8(1):e1002459. Epub 2012 Jan 5.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1002459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252375PMC
January 2012

The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner.

Authors:
Benoit Raymond Valerie F Crepin James W Collins Gad Frankel

Cell Microbiol 2011 Dec 14;13(12):1881-93. Epub 2011 Sep 14.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, UK.

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http://doi.wiley.com/10.1111/j.1462-5822.2011.01666.x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977063PMC
December 2011

PAK4 phosphorylates myosin regulatory light chain and contributes to Fcγ receptor-mediated phagocytosis.

Authors:
Michael D Bright Gad Frankel

Int J Biochem Cell Biol 2011 Dec 3;43(12):1776-81. Epub 2011 Sep 3.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.biocel.2011.08.015DOI Listing
December 2011

Cellulose mediates attachment of Salmonella enterica Serovar Typhimurium to tomatoes.

Authors:
Robert K Shaw Iñigo Lasa Begoña M García Mark J Pallen Jay C D Hinton Cedric N Berger Gad Frankel

Environ Microbiol Rep 2011 Oct 30;3(5):569-73. Epub 2011 May 30.

Centre for Molecular Microbiology and Infection, Imperial College, London, UK Instituto de Agrobiotecnología, UPNA-CSIC-Gobierno de Navarra, Campus de Arrosadia, Pamplona, Spain Centre for Systems Biology, Department of Biosciences University of Birmingham, Birmingham, UK Department of Microbiology, School of Genetics and Microbiology, Trinity College, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1758-2229.2011.00263.xDOI Listing
October 2011

BopC is a type III secreted effector protein of Burkholderia pseudomallei.

Authors:
Sunsiree Muangman Sunee Korbsrisate Veerachat Muangsombut Varintip Srinon Natalie Lazar Adler Gunnar N Schroeder Gad Frankel Edouard E Galyov

FEMS Microbiol Lett 2011 Oct 10;323(1):75-82. Epub 2011 Aug 10.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1111/j.1574-6968.2011.02359.xDOI Listing
October 2011

EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function.

Authors:
Abigail Clements Katherine Smollett Sau Fung Lee Elizabeth L Hartland Martin Lowe Gad Frankel

Cell Microbiol 2011 Sep 11;13(9):1429-39. Epub 2011 Jul 11.

Centre for Molecular Microbiology and Infection, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1462-5822.2011.01631.xDOI Listing
September 2011

Salmonella bongori provides insights into the evolution of the Salmonellae.

Authors:
Maria Fookes Gunnar N Schroeder Gemma C Langridge Carlos J Blondel Caterina Mammina Thomas R Connor Helena Seth-Smith Georgios S Vernikos Keith S Robinson Mandy Sanders Nicola K Petty Robert A Kingsley Andreas J Bäumler Sean-Paul Nuccio Inés Contreras Carlos A Santiviago Duncan Maskell Paul Barrow Tom Humphrey Antonino Nastasi Mark Roberts Gad Frankel Julian Parkhill Gordon Dougan Nicholas R Thomson

PLoS Pathog 2011 Aug 18;7(8):e1002191. Epub 2011 Aug 18.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1002191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158058PMC
August 2011

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.

Authors:
Alexander R C Wong Jaclyn S Pearson Michael D Bright Diana Munera Keith S Robinson Sau Fung Lee Gad Frankel Elizabeth L Hartland

Mol Microbiol 2011 Jun 5;80(6):1420-38. Epub 2011 May 5.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2011.07661.xDOI Listing
June 2011

Salmonella enterica strains belonging to O serogroup 1,3,19 induce chlorosis and wilting of Arabidopsis thaliana leaves.

Authors:
Cedric N Berger Derek J Brown Robert K Shaw Florencia Minuzzi Bart Feys Gad Frankel

Environ Microbiol 2011 May 23;13(5):1299-308. Epub 2011 Feb 23.

Divisions of Cell and Molecular Biology, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/j.1462-2920.2011.02429.xDOI Listing
May 2011

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation.

Authors:
Jaclyn S Pearson Patrice Riedmaier Olivier Marchès Gad Frankel Elizabeth L Hartland

Mol Microbiol 2011 Apr 22;80(1):219-30. Epub 2011 Feb 22.

Department of Microbiology and Immunology, University of Melbourne, Melbourne, Vic. 3010, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178796PMC
April 2011

Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.

Authors:
Nicola K Petty Theresa Feltwell Derek Pickard Simon Clare Ana L Toribio Maria Fookes Kevin Roberts Rita Monson Satheesh Nair Robert A Kingsley Richard Bulgin Siouxsie Wiles David Goulding Thomas Keane Craig Corton Nicola Lennard David Harris David Willey Richard Rance Lu Yu Jyoti S Choudhary Carol Churcher Michael A Quail Julian Parkhill Gad Frankel Gordon Dougan George P C Salmond Nicholas R Thomson

PLoS Pathog 2011 Apr 7;7(4):e1002018. Epub 2011 Apr 7.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1002018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072379PMC
April 2011

Enteropathogenic and enterohemorrhagic Escherichia coli type III secretion effector EspV induces radical morphological changes in eukaryotic cells.

Authors:
Ana Arbeloa Clare V Oates Oliver Marchès Elizabeth L Hartland Gad Frankel

Infect Immun 2011 Mar 28;79(3):1067-76. Epub 2010 Dec 28.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom.

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http://iai.asm.org/lookup/doi/10.1128/IAI.01003-10
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http://dx.doi.org/10.1128/IAI.01003-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067504PMC
March 2011

Flagella mediate attachment of enterotoxigenic Escherichia coli to fresh salad leaves.

Authors:
Robert K Shaw Cedric N Berger Mark J Pallen Asa Sjöling Gad Frankel

Environ Microbiol Rep 2011 Feb;3(1):112-7

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK Centre for Systems Biology, Department of Biosciences, University of Birmingham, Birminghan, UK Department of Microbiology and Immunology, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/j.1758-2229.2010.00195.xDOI Listing
February 2011

Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.

Authors:
Eric Martinez Gunnar N Schroeder Cedric N Berger Sau Fung Lee Keith S Robinson Luminita Badea Nandi Simpson Randy A Hall Elizabeth L Hartland Valerie F Crepin Gad Frankel

Cell Microbiol 2010 Dec;12(12):1718-31

Centre for Molecular Microbiology and Infection, Imperial College London, UK.

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http://dx.doi.org/10.1111/j.1462-5822.2010.01503.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015060PMC
December 2010

Direct injection of functional single-domain antibodies from E. coli into human cells.

Authors:
Ana Blanco-Toribio Serge Muyldermans Gad Frankel Luis Ángel Fernández

PLoS One 2010 Dec 8;5(12):e15227. Epub 2010 Dec 8.

Department of Microbial Biotechnology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Campus Cantoblanco Universidad Autónoma de Madrid (UAM), Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015227PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999559PMC
December 2010

SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal.

Authors:
Rasha Younis Lewis E H Bingle Sarah Rollauer Diana Munera Stephen J Busby Steven Johnson Janet E Deane Susan M Lea Gad Frankel Mark J Pallen

J Bacteriol 2010 Nov 10;192(22):6093-8. Epub 2010 Sep 10.

School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1128/JB.00760-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976445PMC
November 2010

Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins.

Authors:
Gunnar N Schroeder Nicola K Petty Aurélie Mousnier Clare R Harding Adam J Vogrin Bryan Wee Norman K Fry Timothy G Harrison Hayley J Newton Nicholas R Thomson Scott A Beatson Gordon Dougan Elizabeth L Hartland Gad Frankel

J Bacteriol 2010 Nov 10;192(22):6001-16. Epub 2010 Sep 10.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976443PMC
November 2010

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.

Authors:
Anna Vossenkämper Olivier Marchès Peter D Fairclough Gary Warnes Andrew J Stagg James O Lindsay Paul C Evans Le A Luong Nicholas M Croft Sandhia Naik Gad Frankel Thomas T MacDonald

J Immunol 2010 Oct 10;185(7):4118-27. Epub 2010 Sep 10.

Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London.

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http://dx.doi.org/10.4049/jimmunol.1000500DOI Listing
October 2010

Fresh fruit and vegetables as vehicles for the transmission of human pathogens.

Authors:
Cedric N Berger Samir V Sodha Robert K Shaw Patricia M Griffin David Pink Paul Hand Gad Frankel

Environ Microbiol 2010 Sep 15;12(9):2385-97. Epub 2010 Jul 15.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1462-2920.2010.02297.xDOI Listing
September 2010

Efa-1/LifA mediates intestinal colonization of calves by enterohaemorrhagic Escherichia coli O26 : H- in a manner independent of glycosyltransferase and cysteine protease motifs or effects on type III secretion.

Authors:
Victoria Deacon Francis Dziva Pauline M van Diemen Gad Frankel Mark P Stevens

Microbiology 2010 Aug 13;156(Pt 8):2527-36. Epub 2010 May 13.

Enteric Bacterial Pathogens Laboratory, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK.

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http://mic.microbiologyresearch.org/content/journal/micro/10
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August 2010

N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins.

Authors:
Diana Munera Valerie F Crepin Olivier Marches Gad Frankel

J Bacteriol 2010 Jul 16;192(13):3534-9. Epub 2010 Apr 16.

Flowers Building, Imperial College, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1128/JB.00046-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897685PMC
July 2010

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B.

Authors:
Keith S Robinson Aurelie Mousnier Cordula Hemrajani Neil Fairweather Cedric N Berger Gad Frankel

Microbiology 2010 Jun 11;156(Pt 6):1815-23. Epub 2010 Mar 11.

Division of Cell and Molecular Biology, Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1099/mic.0.037259-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068670PMC
June 2010

Toward gene therapy for cystic fibrosis using a lentivirus pseudotyped with Sendai virus envelopes.

Authors:
Katsuyuki Mitomo Uta Griesenbach Makoto Inoue Lucinda Somerton Cuixiang Meng Eiji Akiba Toshiaki Tabata Yasuji Ueda Gad M Frankel Raymond Farley Charanjit Singh Mario Chan Felix Munkonge Andrea Brum Stefania Xenariou Sara Escudero-Garcia Mamoru Hasegawa Eric W F W Alton

Mol Ther 2010 Jun 23;18(6):1173-82. Epub 2010 Mar 23.

DNAVEC Corporation, Tsukuba, Japan.

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http://dx.doi.org/10.1038/mt.2010.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889732PMC
June 2010

EspM2 is a RhoA guanine nucleotide exchange factor.

Authors:
Ana Arbeloa James Garnett James Lillington Richard R Bulgin Cedric N Berger Susan M Lea Steve Matthews Gad Frankel

Cell Microbiol 2010 May 21;12(5):654-64. Epub 2009 Dec 21.

Centre for Molecular Microbiology and Infection, Imperial College London, UK.

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http://dx.doi.org/10.1111/j.1462-5822.2009.01423.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871174PMC
May 2010

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Authors:
Hayley J Newton Jaclyn S Pearson Luminita Badea Michelle Kelly Mark Lucas Gavan Holloway Kylie M Wagstaff Michelle A Dunstone Joan Sloan James C Whisstock James B Kaper Roy M Robins-Browne David A Jans Gad Frankel Alan D Phillips Barbara S Coulson Elizabeth L Hartland

PLoS Pathog 2010 May 13;6(5):e1000898. Epub 2010 May 13.

Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.

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https://dx.plos.org/10.1371/journal.ppat.1000898
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869321PMC
May 2010

Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.

Authors:
Richard Bulgin Benoit Raymond James A Garnett Gad Frankel Valerie F Crepin Cedric N Berger Ana Arbeloa

Infect Immun 2010 Apr 1;78(4):1417-25. Epub 2010 Feb 1.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, United Kingdom.

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http://iai.asm.org/cgi/doi/10.1128/IAI.01250-09
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849395PMC
April 2010

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection.

Authors:
Cordula Hemrajani Cedric N Berger Keith S Robinson Olivier Marchès Aurelie Mousnier Gad Frankel

Proc Natl Acad Sci U S A 2010 Feb 26;107(7):3129-34. Epub 2010 Jan 26.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0911609106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840288PMC
February 2010

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo.

Authors:
Valérie F Crepin Francis Girard Stephanie Schüller Alan D Phillips Aurelie Mousnier Gad Frankel

Mol Microbiol 2010 Jan 2;75(2):308-23. Epub 2009 Nov 2.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK.

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http://doi.wiley.com/10.1111/j.1365-2958.2009.06938.x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814079PMC
January 2010

The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.

Authors:
Nicola K Petty Richard Bulgin Valerie F Crepin Ana M Cerdeño-Tárraga Gunnar N Schroeder Michael A Quail Nicola Lennard Craig Corton Andrew Barron Louise Clark Ana L Toribio Julian Parkhill Gordon Dougan Gad Frankel Nicholas R Thomson

J Bacteriol 2010 Jan 6;192(2):525-38. Epub 2009 Nov 6.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://jb.asm.org/content/early/2009/11/06/JB.01144-09.full.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805327PMC
January 2010

Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.

Authors:
Roy R Chaudhuri Mohammed Sebaihia Jon L Hobman Mark A Webber Denisse L Leyton Martin D Goldberg Adam F Cunningham Anthony Scott-Tucker Paul R Ferguson Christopher M Thomas Gad Frankel Christoph M Tang Edward G Dudley Ian S Roberts David A Rasko Mark J Pallen Julian Parkhill James P Nataro Nicholas R Thomson Ian R Henderson

PLoS One 2010 Jan 20;5(1):e8801. Epub 2010 Jan 20.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808357PMC
January 2010

The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.

Authors:
Richard Bulgin Ana Arbeloa David Goulding Gordon Dougan Valerie F Crepin Benoit Raymond Gad Frankel

PLoS Pathog 2009 Dec 11;5(12):e1000683. Epub 2009 Dec 11.

Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.ppat.1000683
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782363PMC
December 2009

Fresh produce as a potential vector for bacterial human pathogens.

Authors:
Gad Frankel Robert K Shaw David Pink Cedric N Berger Paul Hand

Microb Biotechnol 2009 Nov 15;2(6):595-7. Epub 2009 Jul 15.

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http://dx.doi.org/10.1111/j.1751-7915.2009.00137.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815314PMC
November 2009