Publications by authors named "Gabriella Sozzi"

100Publications

Beyond Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment.

Pharmaceuticals (Basel) 2020 Nov 13;13(11). Epub 2020 Nov 13.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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November 2020

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups.

Cancers (Basel) 2020 Sep 24;12(10). Epub 2020 Sep 24.

1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS (Scientific Institute for Research, Hospitalization and Healthcare) Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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September 2020

MiRNAs as Players in Rhabdomyosarcoma Development.

Int J Mol Sci 2019 Nov 19;20(22). Epub 2019 Nov 19.

Tumor Genomics Unit, Department of Research; Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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November 2019

c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a.

Cell Death Dis 2019 10 7;10(10):759. Epub 2019 Oct 7.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133, Milan, Italy.

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October 2019

Paradoxical effects of chemotherapy on tumor relapse and metastasis promotion.

Semin Cancer Biol 2020 02 24;60:351-361. Epub 2019 Aug 24.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

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February 2020

Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer.

Cancers (Basel) 2019 Jun 25;11(6). Epub 2019 Jun 25.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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June 2019

Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors.

Cells 2019 01 23;8(2). Epub 2019 Jan 23.

Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di, 20133 Milano, Italy.

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January 2019

Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.

J Thorac Oncol 2019 03 4;14(3):343-357. Epub 2018 Dec 4.

Solid Tumors Program, Centro de Investigación Médica Aplicada, Pamplona, Spain; Navarra Institute for Health Research, Pamplona, Spain; CIBERONC, Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain. Electronic address:

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March 2019

Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer.

BMC Cancer 2018 Sep 18;18(1):899. Epub 2018 Sep 18.

Department of Research, Tumor Genomics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy.

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September 2018

Complement C4d-specific antibodies for the diagnosis of lung cancer.

Oncotarget 2018 Jan 26;9(5):6346-6355. Epub 2017 Dec 26.

Program in Solid Tumors, Center for Applied Medical Research (CIMA), CIBERONC, and Navarra's Health Research Institute (IDISNA), Pamplona, Spain.

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January 2018

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening.

J Vis Exp 2017 10 26(128). Epub 2017 Oct 26.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori.

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October 2017

Baseline and postoperative C-reactive protein levels predict mortality in operable lung cancer.

Eur J Cancer 2017 07 1;79:90-97. Epub 2017 May 1.

Division of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. Electronic address:

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July 2017

Detection of microRNAs Using Chip-Based QuantStudio 3D Digital PCR.

Methods Mol Biol 2017 ;1580:239-247

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133, Milan, Italy.

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February 2018

Inflammatory status and lung function predict mortality in lung cancer screening participants.

Eur J Cancer Prev 2018 07;27(4):289-295

Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, University of Milano-Bicocca, Milan, Italy.

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July 2018

Mutational Profile from Targeted NGS Predicts Survival in LDCT Screening-Detected Lung Cancers.

J Thorac Oncol 2017 06 14;12(6):922-931. Epub 2017 Mar 14.

Department of Experimental Oncology and Molecular Medicine, Unit of Tumour Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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June 2017

mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis.

Int J Mol Sci 2017 Jan 23;18(1). Epub 2017 Jan 23.

Department of Experimental Oncology and Molecular Medicine, Unit of Tumor Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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January 2017

MicroRNA Profile of Lung Tumor Tissues Is Associated with a High Risk Plasma miRNA Signature.

Microarrays (Basel) 2016 Jul 5;5(3). Epub 2016 Jul 5.

Unit of Tumor Genomics, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.

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July 2016

Lung cancer screening with low-dose spiral computed tomography: evidence from a pooled analysis of two Italian randomized trials.

Eur J Cancer Prev 2017 07;26(4):324-329

aThoracic Surgery Department, University Hospital Borgo Trento, Verona bUnit of Thoracic Surgery cUnit of Radiology dUnit of Tumor Genomics, Fondazione IRCCS Istituto Nazionale dei Tumori Milano eDepartment of Clinical Sciences and Community Health fDepartment of Pathology and Laboratory Medicine, University of Milan gRadiology hOncology-Haematology iThoracic Surgery, Humanitas Research Hospital, IRCCS, Milan jRadiology, Humanitas Gavazzeni Hospital, Bergamo kRadiology, University Hospital of Parma, Parma lInfrastruttura Ricerca e Statistica, IRCCS Arcispedale S. Maria Nuova, Reggio Emilia, Italy.

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July 2017

Stopping Smoking Reduces Mortality in Low-Dose Computed Tomography Screening Participants.

J Thorac Oncol 2016 05 24;11(5):693-699. Epub 2016 Feb 24.

Division of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.

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May 2016

Novel method to detect microRNAs using chip-based QuantStudio 3D digital PCR.

BMC Genomics 2015 Oct 23;16:849. Epub 2015 Oct 23.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133, Milan, Italy.

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October 2015

Gene Signatures Stratify Computed Tomography Screening Detected Lung Cancer in High-Risk Populations.

EBioMedicine 2015 Aug 8;2(8):831-40. Epub 2015 Jul 8.

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom.

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August 2015

Combination Treatment with All-Trans Retinoic Acid Prevents Cisplatin-Induced Enrichment of CD133+ Tumor-Initiating Cells and Reveals Heterogeneity of Cancer Stem Cell Compartment in Lung Cancer.

J Thorac Oncol 2015 Jul;10(7):1027-36

*Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, and †Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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July 2015

Recent advances of microRNA-based molecular diagnostics to reduce false-positive lung cancer imaging.

Expert Rev Mol Diagn 2015 Jun 30;15(6):801-13. Epub 2015 Apr 30.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, Milan 20133, Italy.

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June 2015

Potential biomarkers for lung cancer screening.

Transl Lung Cancer Res 2014 Jun;3(3):139-48

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori, via Venezian 1, 20133, Milan, Italy.

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June 2014

Therapeutic use of microRNAs in lung cancer.

Biomed Res Int 2014 16;2014:756975. Epub 2014 Sep 16.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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July 2015

Assessment of circulating microRNAs in plasma of lung cancer patients.

Molecules 2014 Mar 10;19(3):3038-54. Epub 2014 Mar 10.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, Milan 20133, Italy.

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March 2014

Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study.

J Clin Oncol 2014 Mar 13;32(8):768-73. Epub 2014 Jan 13.

Gabriella Sozzi, Mattia Boeri, Carla Verri, Paola Suatoni, Luca Roz, Davide Conte, Michela Grassi, Tumor Genomics Unit; Ugo Pastorino, Thoracic Surgery Unit; Alfonso Marchiano, Radiology Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori; Marta Rossi, Francesca Bravi, Eva Negri, Carlo La Vecchia, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri"; Francesca Bravi and Carlo La Vecchia, University of Milan, Milan; and Nicola Sverzellati, University of Parma, Parma, Italy.

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March 2014

Role of microRNAs in lung cancer: microRNA signatures in cancer prognosis.

Cancer J 2012 May-Jun;18(3):268-74

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

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November 2012

Patient-derived xenografts of non small cell lung cancer: resurgence of an old model for investigation of modern concepts of tailored therapy and cancer stem cells.

J Biomed Biotechnol 2012 4;2012:568567. Epub 2012 Apr 4.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, IRCCS Foundation National Cancer Institute, Via Venezian 1, 20133 Milan, Italy.

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October 2012

Inactivation of both FHIT and p53 cooperate in deregulating proliferation-related pathways in lung cancer.

J Thorac Oncol 2012 Apr;7(4):631-42

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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April 2012

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer.

Proc Natl Acad Sci U S A 2011 Mar 7;108(9):3713-8. Epub 2011 Feb 7.

Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, and Unit of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.

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March 2011

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment.

Proc Natl Acad Sci U S A 2009 Sep 10;106(38):16281-6. Epub 2009 Sep 10.

Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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September 2009

Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib.

J Thorac Oncol 2009 Feb;4(2):266-7

Department of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

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February 2009

Plasma DNA quantification in lung cancer computed tomography screening: five-year results of a prospective study.

Am J Respir Crit Care Med 2009 Jan 11;179(1):69-74. Epub 2008 Sep 11.

Department of Experimental Oncology, Molecular Cytogenetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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January 2009

The role of chromosomal alterations in human cancer development.

J Cell Biochem 2007 Oct;102(2):320-31

Cytogenetic and Molecular Cytogenetic Department, Fondazione IRCCS Istituto Nazional Tumori, Italy.

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October 2007

Radiation effects on development of HER2-positive breast carcinomas.

Clin Cancer Res 2007 Jan;13(1):46-51

Molecular Targeting Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy.

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January 2007

Fragile histidine triad expression in oral squamous cell carcinoma and precursor lesions.

Clin Cancer Res 2006 Nov;12(22):6723-9

School of Dentistry, The University of Manchester, North Manchester General Hospital, UK.

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November 2006

Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool.

Ann N Y Acad Sci 2006 Sep;1075:185-90

Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milano, Italy.

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September 2006

Diadenosines as FHIT-ness instructors.

J Cell Physiol 2006 Aug;208(2):274-81

Department of Experimental Oncology, Molecular Biology Unit, Istituto Nazionale Tumori, Milan, Italy.

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August 2006

Effects of prolonged storage of whole plasma or isolated plasma DNA on the results of circulating DNA quantification assays.

J Natl Cancer Inst 2005 Dec;97(24):1848-50

Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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December 2005